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TRIP11 (thyroid hormone receptor interactor 11)

Identity

Other namesCEV14 (clonal evolution related gene on chromosome 14)
HGNC (Hugo) TRIP11
LocusID (NCBI) 9321
Location 14q32.12
Location_base_pair Starts at 92434243 and ends at 92506403 bp from pter ( according to hg19-Feb_2009)  [Mapping]

DNA/RNA

Transcription major transcripts: 7, 9 and 10.5 kb; coding sequence: 2.2 kb

Protein

Description 729 amino acids; contains a N-term leucine zipper and a C-term putative thyroid hormone receptor interacting domain
Expression is wide; high expression in heart, muscle, pancreas; found expressed in hematopoietic cell lines
Function may be a transcriptional factor

Implicated in

Entity t(5;14)(q33;q32)/ANLL --> CEV14 - PDGFRb
Disease poorly known: 1 case of ANLL
Cytogenetics found as an additional anomaly
Hybrid/Mutated Gene 5' CEV14 - 3' PDGFRb
Abnormal Protein leucine zipper from CEV14 fused to the transmembrane domain and the Tyr kinase domain of PDGFRb
  

Other Leukemias implicated (Data extracted from papers in the Atlas)

Leukemias t0817q24q22ID1494

External links

Nomenclature
HGNC (Hugo)TRIP11   12305
Cards
AtlasCEV14
Entrez_Gene (NCBI)TRIP11  9321  thyroid hormone receptor interactor 11
GeneCards (Weizmann)TRIP11
Ensembl (Hinxton)ENSG00000100815 [Gene_View]  chr14:92434243-92506403 [Contig_View]  TRIP11 [Vega]
ICGC DataPortalENSG00000100815
cBioPortalTRIP11
AceView (NCBI)TRIP11
Genatlas (Paris)TRIP11
WikiGenes9321
SOURCE (Princeton)NM_004239
Genomic and cartography
GoldenPath (UCSC)TRIP11  -  14q32.12   chr14:92434243-92506403 -  14q31-q32   [Description]    (hg19-Feb_2009)
EnsemblTRIP11 - 14q31-q32 [CytoView]
Mapping of homologs : NCBITRIP11 [Mapview]
OMIM200600   604505   
Gene and transcription
Genbank (Entrez)AF007217 AF011368 AK307489 AL599917 AW002857
RefSeq transcript (Entrez)NM_004239
RefSeq genomic (Entrez)AC_000146 NC_000014 NC_018925 NG_016970 NT_026437 NW_001838113 NW_004929393
Consensus coding sequences : CCDS (NCBI)TRIP11
Cluster EST : UnigeneHs.741740 [ NCBI ]
CGAP (NCI)Hs.741740
Alternative Splicing : Fast-db (Paris)GSHG0009571
Alternative Splicing GalleryENSG00000100815
Gene ExpressionTRIP11 [ NCBI-GEO ]     TRIP11 [ SEEK ]   TRIP11 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15643 (Uniprot)
NextProtQ15643  [Medical]
With graphics : InterProQ15643
Splice isoforms : SwissVarQ15643 (Swissvar)
Domaine pattern : Prosite (Expaxy)GRIP (PS50913)   
Domains : Interpro (EBI)GRIP [organisation]  
Related proteins : CluSTrQ15643
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
DMDM Disease mutations9321
Blocks (Seattle)Q15643
Human Protein AtlasENSG00000100815 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasQ15643
HPRD05143
IPIIPI00003515   IPI01009865   IPI01026511   IPI01026178   IPI01026303   
Protein Interaction databases
DIP (DOE-UCLA)Q15643
IntAct (EBI)Q15643
FunCoupENSG00000100815
BioGRIDTRIP11
InParanoidQ15643
Interologous Interaction database Q15643
IntegromeDBTRIP11
STRING (EMBL)TRIP11
Ontologies - Pathways
Ontology : AmiGOprotein targeting to Golgi  ventricular septum development  transcription coactivator activity  protein binding  nucleus  Golgi apparatus  cytoskeleton  transcription from RNA polymerase II promoter  membrane  regulation of RNA biosynthetic process  
Ontology : EGO-EBIprotein targeting to Golgi  ventricular septum development  transcription coactivator activity  protein binding  nucleus  Golgi apparatus  cytoskeleton  transcription from RNA polymerase II promoter  membrane  regulation of RNA biosynthetic process  
Protein Interaction DatabaseTRIP11
Wikipedia pathwaysTRIP11
Gene fusion - rearrangments
Rearrangement : TICdbTRIP11 [14q32.12]  -  PDGFRB [17q21.2]
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)TRIP11
snp3D : Map Gene to Disease9321
SNP (GeneSNP Utah)TRIP11
SNP : HGBaseTRIP11
Genetic variants : HAPMAPTRIP11
Exome VariantTRIP11
1000_GenomesTRIP11 
ICGC programENSG00000100815 
Cancer Gene: CensusTRIP11 
Somatic Mutations in Cancer : COSMICTRIP11 
CONAN: Copy Number AnalysisTRIP11 
Mutations and Diseases : HGMDTRIP11
Genomic VariantsTRIP11  TRIP11 [DGVbeta]
dbVarTRIP11
ClinVarTRIP11
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM200600    604505   
MedgenTRIP11
GENETestsTRIP11
Disease Genetic AssociationTRIP11
Huge Navigator TRIP11 [HugePedia]  TRIP11 [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneTRIP11
Homology/Alignments : Family Browser (UCSC)TRIP11
Phylogenetic Trees/Animal Genes : TreeFamTRIP11
Chemical/Protein Interactions : CTD9321
Chemical/Pharm GKB GenePA36984
Clinical trialTRIP11
Cancer Resource (Charite)ENSG00000100815
Other databases
Probes
Litterature
PubMed32 Pubmed reference(s) in Entrez
CoreMineTRIP11
iHOPTRIP11
OncoSearchTRIP11

Bibliography

Fusion of the platelet-derived growth factor receptor beta to a novel gene CEV14 in acute myelogenous leukemia after clonal evolution.
Abe A, Emi N, Tanimoto M, Terasaki H, Marunouchi T, Saito H
Blood. 1997 ; 90 (11) : 4271-4277.
PMID 9373237
 
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written02-1998Jean-Loup Huret

Citation

This paper should be referenced as such :
Huret JL
TRIP11 (thyroid hormone receptor interactor 11);
Atlas Genet Cytogenet Oncol Haematol. February 1998
Free online version   Free pdf version   [Bibliographic record ]
URL : http://AtlasGeneticsOncology.org/Genes/CEV14.html

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Jul 26 15:02:51 CEST 2014

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jlhuret@AtlasGeneticsOncology.org.