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TRIP11 (thyroid hormone receptor interactor 11)

Identity

Other namesCEV14 (clonal evolution related gene on chromosome 14)
HGNC (Hugo) TRIP11
LocusID (NCBI) 9321
Location 14q32.12
Location_base_pair Starts at 92434243 and ends at 92506403 bp from pter ( according to hg19-Feb_2009)  [Mapping]

DNA/RNA

Transcription major transcripts: 7, 9 and 10.5 kb; coding sequence: 2.2 kb

Protein

Description 729 amino acids; contains a N-term leucine zipper and a C-term putative thyroid hormone receptor interacting domain
Expression is wide; high expression in heart, muscle, pancreas; found expressed in hematopoietic cell lines
Function may be a transcriptional factor

Implicated in

Entity t(5;14)(q33;q32)/ANLL --> CEV14 - PDGFRb
Disease poorly known: 1 case of ANLL
Cytogenetics found as an additional anomaly
Hybrid/Mutated Gene 5' CEV14 - 3' PDGFRb
Abnormal Protein leucine zipper from CEV14 fused to the transmembrane domain and the Tyr kinase domain of PDGFRb
  

External links

Nomenclature
HGNC (Hugo)TRIP11   12305
Cards
AtlasCEV14
Entrez_Gene (NCBI)TRIP11  9321  thyroid hormone receptor interactor 11
GeneCards (Weizmann)TRIP11
Ensembl (Hinxton)ENSG00000100815 [Gene_View]  chr14:92434243-92506403 [Contig_View]  TRIP11 [Vega]
AceView (NCBI)TRIP11
Genatlas (Paris)TRIP11
WikiGenes9321
SOURCE (Princeton)NM_004239
Genomic and cartography
GoldenPath (UCSC)TRIP11  -  14q32.12   chr14:92434243-92506403 -  14q31-q32   [Description]    (hg19-Feb_2009)
EnsemblTRIP11 - 14q31-q32 [CytoView]
Mapping of homologs : NCBITRIP11 [Mapview]
OMIM200600   604505   
Gene and transcription
Genbank (Entrez)AF007217 AF011368 AK307489 AL599917 AW002857
RefSeq transcript (Entrez)NM_004239
RefSeq genomic (Entrez)AC_000146 NC_000014 NC_018925 NG_016970 NT_026437 NW_001838113 NW_004929393
Consensus coding sequences : CCDS (NCBI)TRIP11
Cluster EST : UnigeneHs.741740 [ NCBI ]
CGAP (NCI)Hs.741740
Alternative Splicing : Fast-db (Paris)GSHG0009571
Alternative Splicing GalleryENSG00000100815
Gene ExpressionTRIP11 [ NCBI-GEO ]     TRIP11 [ SEEK ]   TRIP11 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15643 (Uniprot)
NextProtQ15643  [Medical]
With graphics : InterProQ15643
Splice isoforms : SwissVarQ15643 (Swissvar)
Domaine pattern : Prosite (Expaxy)GRIP (PS50913)   
Domains : Interpro (EBI)GRIP   
Related proteins : CluSTrQ15643
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
DMDM Disease mutations9321
Blocks (Seattle)Q15643
Human Protein AtlasENSG00000100815
Peptide AtlasQ15643
HPRD05143
IPIIPI00003515   IPI01009865   IPI01026511   IPI01026178   IPI01026303   
Protein Interaction databases
DIP (DOE-UCLA)Q15643
IntAct (EBI)Q15643
FunCoupENSG00000100815
BioGRIDTRIP11
InParanoidQ15643
Interologous Interaction database Q15643
IntegromeDBTRIP11
STRING (EMBL)TRIP11
Ontologies - Pathways
Ontology : AmiGOprotein targeting to Golgi  ventricular septum development  transcription coactivator activity  protein binding  nucleus  Golgi apparatus  cytoskeleton  transcription from RNA polymerase II promoter  membrane  intracellular membrane-bounded organelle  
Ontology : EGO-EBIprotein targeting to Golgi  ventricular septum development  transcription coactivator activity  protein binding  nucleus  Golgi apparatus  cytoskeleton  transcription from RNA polymerase II promoter  membrane  intracellular membrane-bounded organelle  
REACTOMETRIP11
Protein Interaction DatabaseTRIP11
Wikipedia pathwaysTRIP11
Gene fusion - rearrangments
Rearrangement : TICdbPDGFRB [5q32]  -  TRIP11 [14q32.12]
Rearrangement : TICdbTRIP11 [14q32.12]  -  PDGFRB [5q32]
Rearrangement : TICdbTRIP11 [14q32.12]  -  TRIP11 [14q32.12]
Rearrangement : TICdbTRIP11 [14q32.12]  -  TRIP11 [14q32.12]
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)TRIP11
SNP (GeneSNP Utah)TRIP11
SNP : HGBaseTRIP11
Genetic variants : HAPMAPTRIP11
1000_GenomesTRIP11 
ICGC programENSG00000100815 
Cancer Gene: CensusTRIP11 
Somatic Mutations in Cancer : COSMICTRIP11 
CONAN: Copy Number AnalysisTRIP11 
Mutations and Diseases : HGMDTRIP11
OMIM200600    604505   
GENETestsTRIP11
Disease Genetic AssociationTRIP11
Huge Navigator TRIP11 [HugePedia]  TRIP11 [HugeCancerGEM]
Genomic VariantsTRIP11  TRIP11 [DGVbeta]
Exome VariantTRIP11
dbVarTRIP11
ClinVarTRIP11
snp3D : Map Gene to Disease9321
General knowledge
Homologs : HomoloGeneTRIP11
Homology/Alignments : Family Browser (UCSC)TRIP11
Phylogenetic Trees/Animal Genes : TreeFamTRIP11
Chemical/Protein Interactions : CTD9321
Chemical/Pharm GKB GenePA36984
Clinical trialTRIP11
Cancer Resource (Charite)ENSG00000100815
Other databases
Probes
Litterature
PubMed31 Pubmed reference(s) in Entrez
CoreMineTRIP11
iHOPTRIP11

Bibliography

Fusion of the platelet-derived growth factor receptor beta to a novel gene CEV14 in acute myelogenous leukemia after clonal evolution.
Abe A, Emi N, Tanimoto M, Terasaki H, Marunouchi T, Saito H
Blood. 1997 ; 90 (11) : 4271-4277.
PMID 9373237
 
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written02-1998Jean-Loup Huret

Citation

This paper should be referenced as such :
Huret JL . TRIP11 (thyroid hormone receptor interactor 11). Atlas Genet Cytogenet Oncol Haematol. February 1998 .
URL : http://AtlasGeneticsOncology.org/Genes/CEV14.html

The various updated versions of this paper are referenced and archived by INIST as such :
http://documents.irevues.inist.fr/bitstream/handle/2042/32096/02-1998-CEV14.pdf   [ Bibliographic record ]

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Apr 18 17:24:20 CEST 2014

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