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TRIP11 (thyroid hormone receptor interactor 11)

Written1998-02Jean-Loup Huret
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

(Note : for Links provided by Atlas : click)

Identity

Alias (NCBI)CEV14 (clonal evolution related gene on chromosome 14)
HGNC (Hugo) TRIP11
HGNC Alias symbCEV14
Trip230
GMAP-210
GMAP210
HGNC Alias namegolgi-microtubule-associated-protein of 210 kDa
LocusID (NCBI) 9321
Atlas_Id 96
Location 14q32.12  [Link to chromosome band 14q32]
Location_base_pair Starts at 91965991 and ends at 92040059 bp from pter ( according to GRCh38/hg38-Dec_2013)  [Mapping TRIP11.png]
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CATSPERB (14q32.12)::TRIP11 (14q32.12)PDGFRB (5q32)::TRIP11 (14q32.12)TC2N (14q32.12)::TRIP11 (14q32.12)
TRIP11 (14q32.12)::CYP46A1 (14q32.2)TRIP11 (14q32.12)::PDGFRB (5q32)

DNA/RNA

Transcription major transcripts: 7, 9 and 10.5 kb; coding sequence: 2.2 kb

Protein

Description 729 amino acids; contains a N-term leucine zipper and a C-term putative thyroid hormone receptor interacting domain
Expression is wide; high expression in heart, muscle, pancreas; found expressed in hematopoietic cell lines
Function may be a transcriptional factor

Implicated in

Note
  
Entity /AML --> TRIP11 - PDGFRB
Disease poorly known: 1 case of AML
Cytogenetics found as an additional anomaly
Hybrid/Mutated Gene 5' CEV14 - 3' PDGFRb
Abnormal Protein leucine zipper from CEV14 fused to the transmembrane domain and the Tyr kinase domain of PDGFRb
  

Bibliography

Fusion of the platelet-derived growth factor receptor beta to a novel gene CEV14 in acute myelogenous leukemia after clonal evolution.
Abe A, Emi N, Tanimoto M, Terasaki H, Marunouchi T, Saito H
Blood. 1997 ; 90 (11) : 4271-4277.
PMID 9373237
 

Citation

This paper should be referenced as such :
Jean-Loup Huret
TRIP11 (thyroid hormone receptor interactor 11)
Atlas Genet Cytogenet Oncol Haematol. 1998;2(1):9-9.
Free journal version : [ pdf ]   [ DOI ]


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 3 ]
  t(5;14)(q33;q32) PDGFRB::TRIP11
t(5;14)(q33;q24) NIN::PDGFRB
t(13;14)(q12;q32) TRIP11::FLT3


External links

 

Nomenclature
HGNC (Hugo)TRIP11   12305
Cards
AtlasCEV14ID96
Entrez_Gene (NCBI)TRIP11    thyroid hormone receptor interactor 11
AliasesACG1A; CEV14; GMAP-210; GMAP210; 
ODCD; ODCD1; TRIP-11; TRIP230
GeneCards (Weizmann)TRIP11
Ensembl hg19 (Hinxton)ENSG00000100815 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000100815 [Gene_View]  ENSG00000100815 [Sequence]  chr14:91965991-92040059 [Contig_View]  TRIP11 [Vega]
ICGC DataPortalENSG00000100815
TCGA cBioPortalTRIP11
AceView (NCBI)TRIP11
Genatlas (Paris)TRIP11
SOURCE (Princeton)TRIP11
Genetics Home Reference (NIH)TRIP11
Genomic and cartography
GoldenPath hg38 (UCSC)TRIP11  -     chr14:91965991-92040059 -  14q32.12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TRIP11  -     14q32.12   [Description]    (hg19-Feb_2009)
GoldenPathTRIP11 - 14q32.12 [CytoView hg19]  TRIP11 - 14q32.12 [CytoView hg38]
ImmunoBaseENSG00000100815
Genome Data Viewer NCBITRIP11 [Mapview hg19]  
OMIM184260   200600   604505   
Gene and transcription
Genbank (Entrez)AF007217 AF011368 AK307489 AL599917 AW002857
RefSeq transcript (Entrez)NM_001321851 NM_004239
Consensus coding sequences : CCDS (NCBI)TRIP11
Gene ExpressionTRIP11 [ NCBI-GEO ]   TRIP11 [ EBI - ARRAY_EXPRESS ]   TRIP11 [ SEEK ]   TRIP11 [ MEM ]
Gene Expression Viewer (FireBrowse)TRIP11 [ Firebrowse - Broad ]
GenevisibleExpression of TRIP11 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9321
GTEX Portal (Tissue expression)TRIP11
Human Protein AtlasENSG00000100815-TRIP11 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15643   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ15643  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15643
PhosPhoSitePlusQ15643
Domaine pattern : Prosite (Expaxy)GRIP (PS50913)   
Domains : Interpro (EBI)GRIP_dom   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)TRIP11
SuperfamilyQ15643
AlphaFold pdb e-kbQ15643   
Human Protein Atlas [tissue]ENSG00000100815-TRIP11 [tissue]
HPRD05143
Protein Interaction databases
DIP (DOE-UCLA)Q15643
IntAct (EBI)Q15643
BioGRIDTRIP11
STRING (EMBL)TRIP11
ZODIACTRIP11
Ontologies - Pathways
QuickGOQ15643
Ontology : AmiGOGolgi membrane  inner acrosomal membrane  outer acrosomal membrane  ventricular septum development  chondrocyte differentiation involved in endochondral bone morphogenesis  transcription coactivator activity  protein binding  nucleoplasm  endoplasmic reticulum-Golgi intermediate compartment  Golgi apparatus  Golgi apparatus  cis-Golgi network  cytoskeleton  cilium  transcription by RNA polymerase II  protein glycosylation  endoplasmic reticulum to Golgi vesicle-mediated transport  Golgi organization  nuclear speck  transport vesicle  small GTPase binding  endoplasmic reticulum-Golgi intermediate compartment membrane  intraciliary transport involved in cilium assembly  positive regulation of transcription, DNA-templated  cartilage development  inner ear receptor cell stereocilium organization  Golgi ribbon formation  vesicle tethering to Golgi  
Ontology : EGO-EBIGolgi membrane  inner acrosomal membrane  outer acrosomal membrane  ventricular septum development  chondrocyte differentiation involved in endochondral bone morphogenesis  transcription coactivator activity  protein binding  nucleoplasm  endoplasmic reticulum-Golgi intermediate compartment  Golgi apparatus  Golgi apparatus  cis-Golgi network  cytoskeleton  cilium  transcription by RNA polymerase II  protein glycosylation  endoplasmic reticulum to Golgi vesicle-mediated transport  Golgi organization  nuclear speck  transport vesicle  small GTPase binding  endoplasmic reticulum-Golgi intermediate compartment membrane  intraciliary transport involved in cilium assembly  positive regulation of transcription, DNA-templated  cartilage development  inner ear receptor cell stereocilium organization  Golgi ribbon formation  vesicle tethering to Golgi  
REACTOMEQ15643 [protein]
REACTOME PathwaysR-HSA-6811438 [pathway]   
NDEx NetworkTRIP11
Atlas of Cancer Signalling NetworkTRIP11
Wikipedia pathwaysTRIP11
Orthology - Evolution
OrthoDB9321
GeneTree (enSembl)ENSG00000100815
Phylogenetic Trees/Animal Genes : TreeFamTRIP11
Homologs : HomoloGeneTRIP11
Homology/Alignments : Family Browser (UCSC)TRIP11
Gene fusions - Rearrangements
Fusion : MitelmanCATSPERB::TRIP11 [14q32.12/14q32.12]  
Fusion : MitelmanTC2N::TRIP11 [14q32.12/14q32.12]  
Fusion : MitelmanTRIP11::CYP46A1 [14q32.12/14q32.2]  
Fusion : MitelmanTRIP11::PDGFRB [14q32.12/5q32]  
Fusion : QuiverTRIP11
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTRIP11 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TRIP11
dbVarTRIP11
ClinVarTRIP11
MonarchTRIP11
1000_GenomesTRIP11 
Exome Variant ServerTRIP11
GNOMAD BrowserENSG00000100815
Varsome BrowserTRIP11
ACMGTRIP11 variants
VarityQ15643
Genomic Variants (DGV)TRIP11 [DGVbeta]
DECIPHERTRIP11 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTRIP11 
Mutations
ICGC Data PortalTRIP11 
TCGA Data PortalTRIP11 
Broad Tumor PortalTRIP11
OASIS PortalTRIP11 [ Somatic mutations - Copy number]
Cancer Gene: CensusTRIP11 
Somatic Mutations in Cancer : COSMICTRIP11  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTRIP11
Mutations and Diseases : HGMDTRIP11
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTRIP11
DgiDB (Drug Gene Interaction Database)TRIP11
DoCM (Curated mutations)TRIP11
CIViC (Clinical Interpretations of Variants in Cancer)TRIP11
OncoKBTRIP11
NCG (London)TRIP11
Cancer3DTRIP11
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM184260    200600    604505   
Orphanet12236   
DisGeNETTRIP11
MedgenTRIP11
Genetic Testing Registry TRIP11
NextProtQ15643 [Medical]
GENETestsTRIP11
Target ValidationTRIP11
Huge Navigator TRIP11 [HugePedia]
ClinGenTRIP11
Clinical trials, drugs, therapy
MyCancerGenomeTRIP11
Protein Interactions : CTDTRIP11
Pharm GKB GenePA36984
PharosQ15643
Clinical trialTRIP11
Miscellaneous
canSAR (ICR)TRIP11
HarmonizomeTRIP11
DataMed IndexTRIP11
Probes
Litterature
PubMed60 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTRIP11
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Oct 8 21:14:56 CEST 2021

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jlhuret@AtlasGeneticsOncology.org.