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TRIP11 (thyroid hormone receptor interactor 11)

Written1998-02Jean-Loup Huret
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

(Note : for Links provided by Atlas : click)

Identity

Alias_symbol (synonym)CEV14
Trip230
GMAP-210
GMAP210
Other aliasCEV14 (clonal evolution related gene on chromosome 14)
HGNC (Hugo) TRIP11
LocusID (NCBI) 9321
Atlas_Id 96
Location 14q32.12  [Link to chromosome band 14q32]
Location_base_pair Starts at 91965991 and ends at 92040059 bp from pter ( according to hg19-Feb_2009)  [Mapping TRIP11.png]
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CATSPERB (14q32.12) / TRIP11 (14q32.12)PDGFRB (5q32) / TRIP11 (14q32.12)TC2N (14q32.12) / TRIP11 (14q32.12)
TRIP11 (14q32.12) / CYP46A1 (14q32.2)TRIP11 (14q32.12) / PDGFRB (5q32)

DNA/RNA

Transcription major transcripts: 7, 9 and 10.5 kb; coding sequence: 2.2 kb

Protein

Description 729 amino acids; contains a N-term leucine zipper and a C-term putative thyroid hormone receptor interacting domain
Expression is wide; high expression in heart, muscle, pancreas; found expressed in hematopoietic cell lines
Function may be a transcriptional factor

Implicated in

Note
  
Entity t(5;14)(q33;q32)/AML --> TRIP11 - PDGFRB
Disease poorly known: 1 case of AML
Cytogenetics found as an additional anomaly
Hybrid/Mutated Gene 5' CEV14 - 3' PDGFRb
Abnormal Protein leucine zipper from CEV14 fused to the transmembrane domain and the Tyr kinase domain of PDGFRb
  

Bibliography

Fusion of the platelet-derived growth factor receptor beta to a novel gene CEV14 in acute myelogenous leukemia after clonal evolution.
Abe A, Emi N, Tanimoto M, Terasaki H, Marunouchi T, Saito H
Blood. 1997 ; 90 (11) : 4271-4277.
PMID 9373237
 

Citation

This paper should be referenced as such :
Jean-Loup Huret
TRIP11 (thyroid hormone receptor interactor 11)
Atlas Genet Cytogenet Oncol Haematol. 1998;2(1):9-9.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Genes/CEV14ID96.html


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(5;14)(q33;q32) PDGFRB/TRIP11
t(5;14)(q33;q24) NIN/PDGFRB


External links

Nomenclature
HGNC (Hugo)TRIP11   12305
Cards
AtlasCEV14ID96
Entrez_Gene (NCBI)TRIP11  9321  thyroid hormone receptor interactor 11
AliasesACG1A; CEV14; GMAP-210; GMAP210; 
TRIP-11; TRIP230
GeneCards (Weizmann)TRIP11
Ensembl hg19 (Hinxton)ENSG00000100815 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000100815 [Gene_View]  chr14:91965991-92040059 [Contig_View]  TRIP11 [Vega]
ICGC DataPortalENSG00000100815
TCGA cBioPortalTRIP11
AceView (NCBI)TRIP11
Genatlas (Paris)TRIP11
WikiGenes9321
SOURCE (Princeton)TRIP11
Genetics Home Reference (NIH)TRIP11
Genomic and cartography
GoldenPath hg38 (UCSC)TRIP11  -     chr14:91965991-92040059 -  14q32.12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TRIP11  -     14q32.12   [Description]    (hg19-Feb_2009)
EnsemblTRIP11 - 14q32.12 [CytoView hg19]  TRIP11 - 14q32.12 [CytoView hg38]
Mapping of homologs : NCBITRIP11 [Mapview hg19]  TRIP11 [Mapview hg38]
OMIM200600   604505   
Gene and transcription
Genbank (Entrez)AF007217 AF011368 AK307489 AL599917 AW002857
RefSeq transcript (Entrez)NM_001321851 NM_004239
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TRIP11
Cluster EST : UnigeneHs.741740 [ NCBI ]
CGAP (NCI)Hs.741740
Alternative Splicing GalleryENSG00000100815
Gene ExpressionTRIP11 [ NCBI-GEO ]   TRIP11 [ EBI - ARRAY_EXPRESS ]   TRIP11 [ SEEK ]   TRIP11 [ MEM ]
Gene Expression Viewer (FireBrowse)TRIP11 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9321
GTEX Portal (Tissue expression)TRIP11
Human Protein AtlasENSG00000100815-TRIP11 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15643   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ15643  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15643
Splice isoforms : SwissVarQ15643
PhosPhoSitePlusQ15643
Domaine pattern : Prosite (Expaxy)GRIP (PS50913)   
Domains : Interpro (EBI)GRIP_dom   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)TRIP11
DMDM Disease mutations9321
Blocks (Seattle)TRIP11
SuperfamilyQ15643
Human Protein Atlas [tissue]ENSG00000100815-TRIP11 [tissue]
Peptide AtlasQ15643
HPRD05143
IPIIPI00003515   IPI01009865   IPI01026511   IPI01026178   IPI01026303   
Protein Interaction databases
DIP (DOE-UCLA)Q15643
IntAct (EBI)Q15643
FunCoupENSG00000100815
BioGRIDTRIP11
STRING (EMBL)TRIP11
ZODIACTRIP11
Ontologies - Pathways
QuickGOQ15643
Ontology : AmiGOprotein targeting to Golgi  Golgi membrane  inner acrosomal membrane  outer acrosomal membrane  ventricular septum development  chondrocyte differentiation involved in endochondral bone morphogenesis  transcription coactivator activity  protein binding  nucleus  Golgi apparatus  cis-Golgi network  cytoskeleton  cilium  transcription from RNA polymerase II promoter  protein glycosylation  Golgi organization  nuclear speck  transport vesicle  intraciliary transport involved in cilium assembly  inner ear receptor stereocilium organization  regulation of nucleic acid-templated transcription  
Ontology : EGO-EBIprotein targeting to Golgi  Golgi membrane  inner acrosomal membrane  outer acrosomal membrane  ventricular septum development  chondrocyte differentiation involved in endochondral bone morphogenesis  transcription coactivator activity  protein binding  nucleus  Golgi apparatus  cis-Golgi network  cytoskeleton  cilium  transcription from RNA polymerase II promoter  protein glycosylation  Golgi organization  nuclear speck  transport vesicle  intraciliary transport involved in cilium assembly  inner ear receptor stereocilium organization  regulation of nucleic acid-templated transcription  
REACTOMEQ15643 [protein]
REACTOME PathwaysR-HSA-6811438 [pathway]   
NDEx NetworkTRIP11
Atlas of Cancer Signalling NetworkTRIP11
Wikipedia pathwaysTRIP11
Orthology - Evolution
OrthoDB9321
GeneTree (enSembl)ENSG00000100815
Phylogenetic Trees/Animal Genes : TreeFamTRIP11
HOVERGENQ15643
HOGENOMQ15643
Homologs : HomoloGeneTRIP11
Homology/Alignments : Family Browser (UCSC)TRIP11
Gene fusions - Rearrangements
Fusion : MitelmanCATSPERB/TRIP11 [14q32.12/14q32.12]  [t(14;14)(q32;q32)]  
Fusion : MitelmanTC2N/TRIP11 [14q32.12/14q32.12]  [t(14;14)(q32;q32)]  
Fusion : MitelmanTRIP11/CYP46A1 [14q32.12/14q32.2]  [t(14;14)(q32;q32)]  
Fusion : MitelmanTRIP11/PDGFRB [14q32.12/5q32]  [t(5;14)(q32;q32)]  
Fusion: TCGACATSPERB 14q32.12 TRIP11 14q32.12 BRCA LUAD
Fusion: TCGATC2N 14q32.12 TRIP11 14q32.12 BRCA
Fusion: TCGATRIP11 14q32.12 CYP46A1 14q32.2 BRCA
Fusion : TICdbTRIP11 [14q32.12]  -  PDGFRB [5q32]
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTRIP11 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TRIP11
dbVarTRIP11
ClinVarTRIP11
1000_GenomesTRIP11 
Exome Variant ServerTRIP11
ExAC (Exome Aggregation Consortium)ENSG00000100815
GNOMAD BrowserENSG00000100815
Genetic variants : HAPMAP9321
Genomic Variants (DGV)TRIP11 [DGVbeta]
DECIPHERTRIP11 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTRIP11 
Mutations
ICGC Data PortalTRIP11 
TCGA Data PortalTRIP11 
Broad Tumor PortalTRIP11
OASIS PortalTRIP11 [ Somatic mutations - Copy number]
Cancer Gene: CensusTRIP11 
Somatic Mutations in Cancer : COSMICTRIP11  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTRIP11
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TRIP11
DgiDB (Drug Gene Interaction Database)TRIP11
DoCM (Curated mutations)TRIP11 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TRIP11 (select a term)
intoGenTRIP11
NCG5 (London)TRIP11
Cancer3DTRIP11(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM200600    604505   
Orphanet12236   
MedgenTRIP11
Genetic Testing Registry TRIP11
NextProtQ15643 [Medical]
TSGene9321
GENETestsTRIP11
Target ValidationTRIP11
Huge Navigator TRIP11 [HugePedia]
snp3D : Map Gene to Disease9321
BioCentury BCIQTRIP11
ClinGenTRIP11
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9321
Chemical/Pharm GKB GenePA36984
Clinical trialTRIP11
Miscellaneous
canSAR (ICR)TRIP11 (select the gene name)
Probes
Litterature
PubMed34 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTRIP11
EVEXTRIP11
GoPubMedTRIP11
iHOPTRIP11
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Oct 12 16:18:52 CEST 2017

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For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.