Atlas of Genetics and Cytogenetics in Oncology and Haematology

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TRIP11 (thyroid hormone receptor interactor 11)

Written1998-02Jean-Loup Huret
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

(Note : for Links provided by Atlas : click)


Other aliasCEV14 (clonal evolution related gene on chromosome 14)
LocusID (NCBI) 9321
Atlas_Id 96
Location 14q32.12  [Link to chromosome band 14q32]
Location_base_pair Starts at and ends at bp from pter
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CATSPERB (14q32.12) / TRIP11 (14q32.12)PDGFRB (5q32) / TRIP11 (14q32.12)TC2N (14q32.12) / TRIP11 (14q32.12)
TRIP11 (14q32.12) / CYP46A1 (14q32.2)TRIP11 (14q32.12) / PDGFRB (5q32)


Transcription major transcripts: 7, 9 and 10.5 kb; coding sequence: 2.2 kb


Description 729 amino acids; contains a N-term leucine zipper and a C-term putative thyroid hormone receptor interacting domain
Expression is wide; high expression in heart, muscle, pancreas; found expressed in hematopoietic cell lines
Function may be a transcriptional factor

Implicated in

Entity t(5;14)(q33;q32)/AML --> TRIP11 - PDGFRB
Disease poorly known: 1 case of AML
Cytogenetics found as an additional anomaly
Hybrid/Mutated Gene 5' CEV14 - 3' PDGFRb
Abnormal Protein leucine zipper from CEV14 fused to the transmembrane domain and the Tyr kinase domain of PDGFRb


Fusion of the platelet-derived growth factor receptor beta to a novel gene CEV14 in acute myelogenous leukemia after clonal evolution.
Abe A, Emi N, Tanimoto M, Terasaki H, Marunouchi T, Saito H
Blood. 1997 ; 90 (11) : 4271-4277.
PMID 9373237


This paper should be referenced as such :
Jean-Loup Huret
TRIP11 (thyroid hormone receptor interactor 11)
Atlas Genet Cytogenet Oncol Haematol. 1998;2(1):9-9.
Free journal version : [ pdf ]   [ DOI ]
On line version :

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 7 ]
  t(5;14)(q33;q32) PDGFRB/TRIP11
t(5;14)(q32;q32) TRIP11/PDGFRB
t(13;14)(q12;q32) TRIP11/FLT3
t(5;14)(q33;q32) PDGFRB/TRIP11
t(5;14)(q33;q24) NIN/PDGFRB
t(5;14)(q32;q32) TRIP11/PDGFRB
t(13;14)(q12;q32) TRIP11/FLT3

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 3 ]
  CATSPERB/TRIP11 (14q32)
TC2N/TRIP11 (14q32)
TRIP11/CYP46A1 (14q32)

External links

Genomic and cartography
Gene and transcription
RefSeq transcript (Entrez)
RefSeq genomic (Entrez)
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)9321
Protein : pattern, domain, 3D structure
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Protein Interaction databases
Ontologies - Pathways
Clinical trials, drugs, therapy
canSAR (ICR) (select the gene name)
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Oct 18 17:31:51 CEST 2018

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