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CLDN10 (claudin 10)

Written2011-12Madhu Lal-Nag
Laboratory of Cellular, Molecular Biology, National Institute on Aging, National Institutes of Health Biomedical Research Center, Baltimore, MD 21224, USA

(Note : for Links provided by Atlas : click)

Identity

Alias_symbol (synonym)OSP-L
CPETRL3
Other alias
HGNC (Hugo) CLDN10
LocusID (NCBI) 9071
Atlas_Id 45827
Location 13q32.1  [Link to chromosome band 13q32]
Location_base_pair Starts at 96085853 and ends at 96232010 bp from pter ( according to hg19-Feb_2009)  [Mapping CLDN10.png]
Fusion genes
(updated 2016)
CLDN10 (13q32.1) / TTC12 (11q23.2)STATH (4q13.3) / CLDN10 (13q32.1)

DNA/RNA

 
  The three different isoforms of claudin 10; claudin 10 (a), claudin 10 (b) and claudin 10 (a_i1).
Transcription Claudin 10 has 3 different transcripts.
NP_878268.1 [NCBI Entrez] claudin-10 isoform a: This variant (a) is the longest transcript and encodes claudin-10 isoform a. Its composition is as follows:
- Exons: 5;
- Transcript length: 2549 bps;
- Translation length: 226 residues.

NP_008915.1 [NCBI Entrez] claudin-10 isoform b precursor: This variant (b) is different from the isoform (a) above in the 5' UTR and 5' coding region. It uses an alternate promoter, compared to variant a. The resulting isoform (b) has a longer and more distinct N-terminus. Its composition is as follows:
- Exons: 5;
- Transcript length: 949 bps;
- Translation length: 228 residues.

NP_001153572.1 [NCBI Entrez] claudin-10 isoform a_i1: This variant (a_v1) uses an alternate in-frame splice site in the 5' coding region, compared to claudin 10 isoform a. The resulting isoform (a_i1) lacks an internal segment near the N-terminus, compared to isoform a. Its composition is as follows:
- Exons: 2;
- Transcript length: 701 bps;
- Translation length: 73 residues AK055855, BG697724, DA636757, DB544708 (source sequences NCBI).

Protein

Note Claudin 10 plays a major role as a component of tight junctions. CLDN10 encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands function as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. They are also critical in maintaining cell polarity and mediating signals. The expression level of this gene is associated with recurrence of primary hepatocellular carcinoma. Six alternatively spliced transcripts encoding different isoforms of CLDN10 have been reported, but not all of them have been recorded.
 
  The four transmembrane, two extracellular, 3 helical and two cytoplasmic domains of claudin protein.
Description 228 amino acids. Modified amino acid residue at position 94 is a phosphoserine. Human and mouse isoforms of CLDN10 have been cloned. Claudin-10 shares between 20 and 45% sequence similarity between other claudin family members at the amino acid level, displaying highest sequence similarity to claudin-15.
CLAUDIN10 is a 4-element fingerprint that provides a signature for claudin-10 proteins. The fingerprint was derived from an initial alignment of 2 sequences: the motifs were drawn from conserved regions spanning virtually the full alignment length, focusing on those sections thatcharacterize claudin-10 and distinguish it from other family members - motif 1 lies in the first TM domain; motif 2 resides within in the second TM domain; motifs 3 spans part of the fourth TM domain and part of the C-terminal region; and motif 4 resides within the cytoplasmic C-terminus.
 
  Sequence similarity between the various claudins showing that claudin 10 has the highest sequence similarity to claudin 15.
Expression At the cell membrane in 85 organs and 13 developmental stages (Bgee)[P78369].
Localisation Cell membrane.
Function From the KEGG pathway.
Claudin 10 as an integral part of tight junction composition plays an important role in Leukocyte migration. They are also important components of cell adhesion molecules and serve as a receptor for the HCV virus via their extracellular loop.
hsa04514: Cell adhesion molecules (CAMs)
hsa04530: Tight junction
hsa04670: Leukocyte transendothelial migration
hsa05160: Hepatitis C
Homology The CLDN10 gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken, and zebrafish.

Mutations

Note Total disease mutations: 0; total SNPs: 5.

Implicated in

Note
  
Entity Hepatocellular carcinoma (HCC)
Prognosis Claudin 10 is highly expressed in patients suffering from HCC and is an independent prognostic survival factor after surgery. It is closely related to microvessel density and angiogenesis.
  
  
Entity Ovarian cancer
Disease Ovarian cancer in a chicken model to be used as a basis to study the relevance of CLDN10 expression in ovarian cancer in humans.
Prognosis Claudin 10 mRNA expression was significantly upregulated in cancerous chicken ovaries with respect to normal ovaries implicating it in the etiology of this disease.
  

Bibliography

Claudin-10 expression level is associated with recurrence of primary hepatocellular carcinoma.
Cheung ST, Leung KL, Ip YC, Chen X, Fong DY, Ng IO, Fan ST, So S.
Clin Cancer Res. 2005 Jan 15;11(2 Pt 1):551-6.
PMID 15701840
 
Claudin-10 exists in six alternatively spliced isoforms that exhibit distinct localization and function.
Gunzel D, Stuiver M, Kausalya PJ, Haisch L, Krug SM, Rosenthal R, Meij IC, Hunziker W, Fromm M, Muller D.
J Cell Sci. 2009 May 15;122(Pt 10):1507-17. Epub 2009 Apr 21.
PMID 19383724
 
Expression of claudin 10 protein in hepatocellular carcinoma: impact on survival.
Huang GW, Ding X, Chen SL, Zeng L.
J Cancer Res Clin Oncol. 2011 Aug;137(8):1213-8. Epub 2011 Jun 7.
PMID 21647678
 
The claudins.
Lal-Nag M, Morin PJ.
Genome Biol. 2009;10(8):235. Epub 2009 Aug 26. (REVIEW)
PMID 19706201
 
Claudin 10 is a glandular epithelial marker in the chicken model as human epithelial ovarian cancer.
Seo HW, Rengaraj D, Choi JW, Ahn SE, Song YS, Song G, Han JY.
Int J Gynecol Cancer. 2010 Dec;20(9):1465-73.
PMID 21370593
 

Citation

This paper should be referenced as such :
Lal-Nag, M
CLDN10 (claudin 10)
Atlas Genet Cytogenet Oncol Haematol. 2012;16(5):339-341.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Genes/CLDN10ID45827ch13q32.html


External links

Nomenclature
HGNC (Hugo)CLDN10   2033
Cards
AtlasCLDN10ID45827ch13q32
Entrez_Gene (NCBI)CLDN10  9071  claudin 10
AliasesCPETRL3; OSP-L
GeneCards (Weizmann)CLDN10
Ensembl hg19 (Hinxton)ENSG00000134873 [Gene_View]  chr13:96085853-96232010 [Contig_View]  CLDN10 [Vega]
Ensembl hg38 (Hinxton)ENSG00000134873 [Gene_View]  chr13:96085853-96232010 [Contig_View]  CLDN10 [Vega]
ICGC DataPortalENSG00000134873
TCGA cBioPortalCLDN10
AceView (NCBI)CLDN10
Genatlas (Paris)CLDN10
WikiGenes9071
SOURCE (Princeton)CLDN10
Genetics Home Reference (NIH)CLDN10
Genomic and cartography
GoldenPath hg19 (UCSC)CLDN10  -     chr13:96085853-96232010 +  13q31-q34   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CLDN10  -     13q31-q34   [Description]    (hg38-Dec_2013)
EnsemblCLDN10 - 13q31-q34 [CytoView hg19]  CLDN10 - 13q31-q34 [CytoView hg38]
Mapping of homologs : NCBICLDN10 [Mapview hg19]  CLDN10 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AF339794 AK055855 AK315737 BC010920 BG697724
RefSeq transcript (Entrez)NM_001160100 NM_006984 NM_182848
RefSeq genomic (Entrez)NC_000013 NC_018924 NT_009952 NW_004929389
Consensus coding sequences : CCDS (NCBI)CLDN10
Cluster EST : UnigeneHs.534377 [ NCBI ]
CGAP (NCI)Hs.534377
Alternative Splicing GalleryENSG00000134873
Gene ExpressionCLDN10 [ NCBI-GEO ]   CLDN10 [ EBI - ARRAY_EXPRESS ]   CLDN10 [ SEEK ]   CLDN10 [ MEM ]
Gene Expression Viewer (FireBrowse)CLDN10 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9071
GTEX Portal (Tissue expression)CLDN10
Protein : pattern, domain, 3D structure
UniProt/SwissProtP78369   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP78369  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP78369
Splice isoforms : SwissVarP78369
PhosPhoSitePlusP78369
Domaine pattern : Prosite (Expaxy)CLAUDIN (PS01346)   
Domains : Interpro (EBI)Claudin    Claudin10    Claudin_CS    PMP22/EMP/MP20/Claudin   
Domain families : Pfam (Sanger)PMP22_Claudin (PF00822)   
Domain families : Pfam (NCBI)pfam00822   
Conserved Domain (NCBI)CLDN10
DMDM Disease mutations9071
Blocks (Seattle)CLDN10
SuperfamilyP78369
Human Protein AtlasENSG00000134873
Peptide AtlasP78369
HPRD13063
IPIIPI00019231   IPI00641946   IPI00043502   
Protein Interaction databases
DIP (DOE-UCLA)P78369
IntAct (EBI)P78369
FunCoupENSG00000134873
BioGRIDCLDN10
STRING (EMBL)CLDN10
ZODIACCLDN10
Ontologies - Pathways
QuickGOP78369
Ontology : AmiGOstructural molecule activity  cytoplasm  plasma membrane  bicellular tight junction  ion transport  cell adhesion  integral component of membrane  calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules  identical protein binding  
Ontology : EGO-EBIstructural molecule activity  cytoplasm  plasma membrane  bicellular tight junction  ion transport  cell adhesion  integral component of membrane  calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules  identical protein binding  
Pathways : KEGGCell adhesion molecules (CAMs)    Tight junction    Leukocyte transendothelial migration    Hepatitis C   
REACTOMEP78369 [protein]
REACTOME Pathways420029 [pathway]   
NDEx NetworkCLDN10
Atlas of Cancer Signalling NetworkCLDN10
Wikipedia pathwaysCLDN10
Orthology - Evolution
OrthoDB9071
GeneTree (enSembl)ENSG00000134873
Phylogenetic Trees/Animal Genes : TreeFamCLDN10
HOVERGENP78369
HOGENOMP78369
Homologs : HomoloGeneCLDN10
Homology/Alignments : Family Browser (UCSC)CLDN10
Gene fusions - Rearrangements
Fusion : MitelmanCLDN10/TTC12 [13q32.1/11q23.2]  
Fusion: TCGACLDN10 13q32.1 TTC12 11q23.2 HNSC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCLDN10 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CLDN10
dbVarCLDN10
ClinVarCLDN10
1000_GenomesCLDN10 
Exome Variant ServerCLDN10
ExAC (Exome Aggregation Consortium)CLDN10 (select the gene name)
Genetic variants : HAPMAP9071
Genomic Variants (DGV)CLDN10 [DGVbeta]
DECIPHER (Syndromes)13:96085853-96232010  ENSG00000134873
CONAN: Copy Number AnalysisCLDN10 
Mutations
ICGC Data PortalCLDN10 
TCGA Data PortalCLDN10 
Broad Tumor PortalCLDN10
OASIS PortalCLDN10 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCLDN10  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCLDN10
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CLDN10
DgiDB (Drug Gene Interaction Database)CLDN10
DoCM (Curated mutations)CLDN10 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CLDN10 (select a term)
intoGenCLDN10
NCG5 (London)CLDN10
Cancer3DCLDN10(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenCLDN10
Genetic Testing Registry CLDN10
NextProtP78369 [Medical]
TSGene9071
GENETestsCLDN10
Huge Navigator CLDN10 [HugePedia]
snp3D : Map Gene to Disease9071
BioCentury BCIQCLDN10
ClinGenCLDN10
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9071
Chemical/Pharm GKB GenePA26558
Clinical trialCLDN10
Miscellaneous
canSAR (ICR)CLDN10 (select the gene name)
Other databaseThe Protein Model Portal
Other databaseModBase
Other databasestring
Other databasephosphoSitePlus
Other databaseStructuralBiologyKnowledgebase
Other databaseThe Human Protein Atlas
Other databaseneXtProt CANCERGENE
Other databaseeggNOG
Other databasePhylogenetic tree of the HBG716859 gene family of HOGENOM database
Other databasePhylogenetic tree of the HBG000643 gene family of HOVERGEN database
Other databaseOMA browser
Other databaseOrthoDB
Other databasephylomeDB
Other databaseBgee
Other databaseCleanEx
Other databaseGenevestigator
Other databaseGermonline
Other databaseKegg
Other databasePanther Classification System
Other databasePfam (Sanger)
Other databasePRINTS View PR01077
Other databasePRINTS View PR01383
Probes
Litterature
PubMed29 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCLDN10
EVEXCLDN10
GoPubMedCLDN10
iHOPCLDN10
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Apr 12 11:29:43 CEST 2017

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