Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

CTGF (connective tissue growth factor)

Identity

Other namesCCN2
Fisp12
betaIG-M2
Hcs24
HBGF-0.8
ecogenin
IGFBP8
IGFBP-rP3
HGNC (Hugo) CTGF
LocusID (NCBI) 1490
Location 6q23.2
Location_base_pair Starts at 132269317 and ends at 132272518 bp from pter ( according to hg19-Feb_2009)  [Mapping]
Note CCN family protein 2/connective tissue growth factor (CCN2/CTGF) was initially identified in the culture supernatant of vascular endothelial cells. Subsequently, the CCN2/CTGF gene has been classified as a representative member of the CCN gene family that is an acronym of the original names of the 3 early members, Cyr61, CTGF and NOV. The mammalian genome contains 6 functional CCN family members, which were renamed based on the proposal of a unified nomenclature. CCN2/CTGF displays multiple functions via interaction with a variety of other molecules. It is important to note that CCN2/CTGF induces the development and regeneration of mesenchymal tissues including bone, cartilage and blood vessels.

DNA/RNA

 
  Structure of human CCN2/CTGF and its mRNA. Abbreviations S, I, V, T, and C denote the coding regions for the signal peptide, IGFBP module, VWC module, TSP1 module and CT module, respectively.
Description Unlike the other CCN family members, the CCN2/CTGF gene is conserved among all of the vertebrates and several invertebrates.
In Drosophila melanogaster, only one gene is designated as ccn, which is thought to have evolved from a prototypic CCN2/CTGF gene. Therefore, CCN2/CTGF may be regarded evolutionarily as an oldest gene in the CCN family. Consistent with such findings, human CCN2/CTGF gene is also quite compact. The total transcribed sequence is as short as 3.2 kb, and contains 4 intronic sequences of less than 400 bp.
Transcription The mature mRNA, 2.3 kb in length, is formed by connecting 5 exons encoding a signal peptide, an IGFBP module, a VWC module, a TSP1 module and CT module in the order. The last exon yields a long 3'-untranslated region of more than1.0 kb on the mRNA, which contains the critical elements for post-transcriptional regulation. The proximal promoter area upstream of the transcription initiation site is known to contain several enhancer elements that are critical for transcriptional regulation.

Protein

 
  Interaction of each module in CCN2/CTGF with other growth factors.
Description The CCN2/CTGF is composed of 4 distinct modules:
  • the N-terminal signal peptide for secretion;
  • insulin-like growth factor binding protein-like (IGFBP) module,
  • von Willebrand factor type-C repeat (VWC) module,
  • thrombospondin type 1 repeat (TSP1) module and
  • the C-terminal cystine knot (CT) module.
    This is consistent with other CCN family proteins. Because of this unique structure, the 6 CCN2/CTGF-related proteins are thought to form a distinct protein class which is distinct from the IGFBP family, despite the involvement of IGFBP module. The involvement of cysteine residues that are also conserved among the CCN family members is a prominent structural characteristic. All of the 4 modules are highly interactive with other biomolecules including growth factors, cell-surface receptor molecules and extracellular matrix components. In addition, the tetramodular construction of these modules provides the structural basis for the multiple functionality of CCN2/CTGF, which is described in another section.
  • Expression CCN2/CTGF is differentially expressed in certain tissues and organs, particularly in the cardiovascular, gonadal, renal and skeletal systems, during development of vertebrates. The cell population that expresses the CCN2/CTGF gene is highly restricted in each tissue; for example, this factor is produced in cartilage primarily by pre-hypertrophic and hypertrophic chondrocytes, in fact, it was previously referred to as hypertrophic chondrocyte-specific protein 24 (Hcs24).
    Localisation In addition to the tissues containing the cells which express this protein described above, CCN2/CTGF is abundantly present in platelets, although its origin is still unknown.
    Function Under the multiple interactions with specific molecular counterparts, CCN2/CTGF conducts the local information network of extracellular signaling molecules and exerts multiple functions, depending upon the microenvironmental conditions. Indeed, CCN2/CTGF promotes both proliferation and differentiation of mesenchymal stem cells, chondrocytes, osteoblasts, periodontal ligament cells, fibroblasts and vascular endothelial cells in vitro. As a result of these effects, this factor enhances wound healing and tissue regeneration of cartilage and bone.
    Homology CCN2/CTGF is structurally homologous to the other 5 CCN family members. The cysteine residues are highly conserved among the members.

    Mutations

    Germinal Until today, no association between mutations in the CCN2/CTGF gene and specific genetic diseases has been described. In mouse models, deletion of both CCN2/CTGF alleles results in severe skeletal malformation, leading to respiratory failure upon delivery. Histological and cell biological analysis revealed that the endochondral ossification process was specifically affected by the CCN2/CTGF deletion, particularly at the final stage that is supported by blood vessel invasion. However, no apparent phenotypic complication has been observed in CCN2/CTGF (-/+) heterozygous mice.
    Somatic At present, nearly 30 SNPs have been described in the NCBI database. Among the SNPs, 35.7% and 39.3% of the total cases have been reported to exist outside of the transcribed area and in the areas of untranslated regions (UTRs) and introns, respectively. Mutation/variation in the open reading frame (ORF) was found in 25% of the total. Missense mutation occurred at a frequency of 42.7 %, whereas the other cases were silent. Excluding the UTRs, the IGFBP-encoding 2nd exon has been a hot spot of mutation and variation (57.1% of the one within ORF). In a single case, an African population was analyzed to compute the actual frequency. This demonstrated that the frequency of a mutation in the 3rd exon, which caused a missense change of amino acid 118 from asparagine to serine by an A to G transition, was 1.3%. Including these cases, no association of a SNP in the CCN2/CTGF gene with any particular human disorder has been described until now.

    Implicated in

    Entity Cancers
    Oncogenesis Although the CCN2/CTGF expression is observed in a number of different types of malignant neoplasm, the role of CCN2/CTGF in oncogenesis and its association with malignant phenotypes are quite controversial.
    According to a previous study, a positive correlation was observed between the level of CCN2/CTGF expression and the degree of malignancy in breast cancer and colorectal cancer cases. These findings are consistent with other recent reports describing the contribution of CCN/CTGF in developing bone metastasis of breast cancers. The ability to promote metastasis can be partially ascribed to the angiogenic activity of CCN2/CTGF.
    However, over expression of CCN2/CTGF in cells of the same origin is reported to induce apoptosis. Furthermore, in chondrosarcoma cases, patients with higher CCN2/CTGF expression in tumors survived longer than those with lower CCN2/CTGF expression. These findings are consistent with the observation that overexpression of CCN2/CTGF results in benign conversion of the phenotype in oral squamous carcinoma cells and induces cell cycle arrest in fibroblasts. The observations above suggest that CCN2/CTGF produced by tumor cells may exert paracrine angiogenic and autocrine/intracrine anti-proliferative effects in solid tumors.
      
    Entity Fibrotic disorders.
    Disease Since its initial discovery, CCN2/CTGF has been widely known as a profibrotic factor that is involved in a variety of fibrotic disorders.
    CCN2/CTGF is associated with systemic sclerosis, keloids, pulmonary fibrosis, diabetic renal fibrosis, liver cirrhosis, pancreatic fibrosis, atherosclerosis, myocardial fibrosis, biliary atresia and cataracts.
    Since CCN2/CTGF has a positive role in wound healing and mesenchymal tissue regeneration, the fibrotic changes observed in those diseases may be regarded as a result of dysregulated regeneration of corresponding tissues.
    Prognosis Fibrotic changes are usually irreversible; however, antibody-mediated molecular therapeutics against CCN2/CTGF is currently being developed to prevent the development of fibrotic lesions.
      

    External links

    Nomenclature
    HGNC (Hugo)CTGF   2500
    Cards
    AtlasCTGFID40192ch6q23
    Entrez_Gene (NCBI)CTGF  1490  connective tissue growth factor
    GeneCards (Weizmann)CTGF
    Ensembl (Hinxton)ENSG00000118523 [Gene_View]  chr6:132269317-132272518 [Contig_View]  CTGF [Vega]
    ICGC DataPortalENSG00000118523
    cBioPortalCTGF
    AceView (NCBI)CTGF
    Genatlas (Paris)CTGF
    WikiGenes1490
    SOURCE (Princeton)NM_001901
    Genomic and cartography
    GoldenPath (UCSC)CTGF  -  6q23.2   chr6:132269317-132272518 -  6q23.2   [Description]    (hg19-Feb_2009)
    EnsemblCTGF - 6q23.2 [CytoView]
    Mapping of homologs : NCBICTGF [Mapview]
    OMIM121009   
    Gene and transcription
    Genbank (Entrez)AF127918 AK092280 AK125220 AK290884 AK315207
    RefSeq transcript (Entrez)NM_001901
    RefSeq genomic (Entrez)AC_000138 NC_000006 NC_018917 NG_016131 NT_025741 NW_001838990 NW_004929328
    Consensus coding sequences : CCDS (NCBI)CTGF
    Cluster EST : UnigeneHs.410037 [ NCBI ]
    CGAP (NCI)Hs.410037
    Alternative Splicing : Fast-db (Paris)GSHG0026909
    Alternative Splicing GalleryENSG00000118523
    Gene ExpressionCTGF [ NCBI-GEO ]     CTGF [ SEEK ]   CTGF [ MEM ]
    Protein : pattern, domain, 3D structure
    UniProt/SwissProtP29279 (Uniprot)
    NextProtP29279  [Medical]
    With graphics : InterProP29279
    Splice isoforms : SwissVarP29279 (Swissvar)
    Domaine pattern : Prosite (Expaxy)CTCK_1 (PS01185)    CTCK_2 (PS01225)    IGFBP_N_1 (PS00222)    IGFBP_N_2 (PS51323)    TSP1 (PS50092)    VWFC_1 (PS01208)    VWFC_2 (PS50184)   
    Domains : Interpro (EBI)Cys_knot_C [organisation]   Glyco_hormone_CN [organisation]   Growth_fac_rcpt_N_dom [organisation]   IGFBP-like [organisation]   IGFBP_CNN [organisation]   Insulin_GF-bd_Cys-rich_CS [organisation]   Thrombospondin_1_rpt [organisation]   VWF_C [organisation]  
    Related proteins : CluSTrP29279
    Domain families : Pfam (Sanger)Cys_knot (PF00007)    IGFBP (PF00219)    TSP_1 (PF00090)    VWC (PF00093)   
    Domain families : Pfam (NCBI)pfam00007    pfam00219    pfam00090    pfam00093   
    Domain families : Smart (EMBL)CT (SM00041)  IB (SM00121)  TSP1 (SM00209)  VWC (SM00214)  
    DMDM Disease mutations1490
    Blocks (Seattle)P29279
    Human Protein AtlasENSG00000118523 [gene] [tissue] [antibody] [cell] [cancer]
    Peptide AtlasP29279
    HPRD00412
    IPIIPI00020977   IPI00220647   
    Protein Interaction databases
    DIP (DOE-UCLA)P29279
    IntAct (EBI)P29279
    FunCoupENSG00000118523
    BioGRIDCTGF
    InParanoidP29279
    Interologous Interaction database P29279
    IntegromeDBCTGF
    STRING (EMBL)CTGF
    Ontologies - Pathways
    Ontology : AmiGOcartilage condensation  ossification  angiogenesis  regulation of cell growth  positive regulation of protein phosphorylation  fibronectin binding  integrin binding  protein binding  insulin-like growth factor binding  extracellular region  proteinaceous extracellular matrix  extracellular space  Golgi apparatus  cis-Golgi network  cytosol  plasma membrane  cell cortex  DNA replication  transcription initiation from RNA polymerase II promoter  cell-matrix adhesion  integrin-mediated signaling pathway  growth factor activity  heparin binding  positive regulation of cell proliferation  fibroblast growth factor receptor signaling pathway  epidermis development  response to wounding  response to glucose  organ senescence  gene expression  positive regulation of gene expression  negative regulation of gene expression  positive regulation of cell death  cell migration  cell differentiation  lung development  regulation of chondrocyte differentiation  response to estradiol  positive regulation of collagen biosynthetic process  response to anoxia  intracellular signal transduction  chondrocyte proliferation  response to amino acid  intracellular membrane-bounded organelle  positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  response to peptide hormone  cellular lipid metabolic process  small molecule metabolic process  positive regulation of cell differentiation  positive regulation of JNK cascade  perinuclear region of cytoplasm  positive regulation of cell activation  response to mineralocorticoid  positive regulation of stress fiber assembly  cytosolic calcium ion transport  positive regulation of cardiac muscle contraction  negative regulation of cell death  extracellular matrix constituent secretion  positive regulation of G0 to G1 transition  positive regulation of ERK1 and ERK2 cascade  response to fatty acid  reactive oxygen species metabolic process  
    Ontology : EGO-EBIcartilage condensation  ossification  angiogenesis  regulation of cell growth  positive regulation of protein phosphorylation  fibronectin binding  integrin binding  protein binding  insulin-like growth factor binding  extracellular region  proteinaceous extracellular matrix  extracellular space  Golgi apparatus  cis-Golgi network  cytosol  plasma membrane  cell cortex  DNA replication  transcription initiation from RNA polymerase II promoter  cell-matrix adhesion  integrin-mediated signaling pathway  growth factor activity  heparin binding  positive regulation of cell proliferation  fibroblast growth factor receptor signaling pathway  epidermis development  response to wounding  response to glucose  organ senescence  gene expression  positive regulation of gene expression  negative regulation of gene expression  positive regulation of cell death  cell migration  cell differentiation  lung development  regulation of chondrocyte differentiation  response to estradiol  positive regulation of collagen biosynthetic process  response to anoxia  intracellular signal transduction  chondrocyte proliferation  response to amino acid  intracellular membrane-bounded organelle  positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  response to peptide hormone  cellular lipid metabolic process  small molecule metabolic process  positive regulation of cell differentiation  positive regulation of JNK cascade  perinuclear region of cytoplasm  positive regulation of cell activation  response to mineralocorticoid  positive regulation of stress fiber assembly  cytosolic calcium ion transport  positive regulation of cardiac muscle contraction  negative regulation of cell death  extracellular matrix constituent secretion  positive regulation of G0 to G1 transition  positive regulation of ERK1 and ERK2 cascade  response to fatty acid  reactive oxygen species metabolic process  
    Pathways : KEGGHippo signaling pathway   
    Protein Interaction DatabaseCTGF
    Wikipedia pathwaysCTGF
    Gene fusion - rearrangments
    Polymorphisms : SNP, mutations, diseases
    SNP Single Nucleotide Polymorphism (NCBI)CTGF
    snp3D : Map Gene to Disease1490
    SNP (GeneSNP Utah)CTGF
    SNP : HGBaseCTGF
    Genetic variants : HAPMAPCTGF
    Exome VariantCTGF
    1000_GenomesCTGF 
    ICGC programENSG00000118523 
    Somatic Mutations in Cancer : COSMICCTGF 
    CONAN: Copy Number AnalysisCTGF 
    Mutations and Diseases : HGMDCTGF
    Genomic VariantsCTGF  CTGF [DGVbeta]
    dbVarCTGF
    ClinVarCTGF
    Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
    Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
    Diseases
    OMIM121009   
    MedgenCTGF
    GENETestsCTGF
    Disease Genetic AssociationCTGF
    Huge Navigator CTGF [HugePedia]  CTGF [HugeCancerGEM]
    General knowledge
    Homologs : HomoloGeneCTGF
    Homology/Alignments : Family Browser (UCSC)CTGF
    Phylogenetic Trees/Animal Genes : TreeFamCTGF
    Chemical/Protein Interactions : CTD1490
    Chemical/Pharm GKB GenePA27003
    Clinical trialCTGF
    Cancer Resource (Charite)ENSG00000118523
    Other databases
    Probes
    Litterature
    PubMed373 Pubmed reference(s) in Entrez
    CoreMineCTGF
    iHOPCTGF
    OncoSearchCTGF

    Bibliography

    Connective tissue growth factor: a cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10.
    Bradham DM, Igarashi A, Potter RL, Grotendorst GR
    The Journal of cell biology. 1991 ; 114 (6) : 1285-1294.
    PMID 1654338
     
    A novel transforming growth factor beta response element controls the expression of the connective tissue growth factor gene.
    Grotendorst GR, Okochi H, Hayashi N
    Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research. 1996 ; 7 (4) : 469-480.
    PMID 9052988
     
    Connective tissue growth factor gene expression in tissue sections from localized scleroderma, keloid, and other fibrotic skin disorders.
    Igarashi A, Nashiro K, Kikuchi K, Sato S, Ihn H, Fujimoto M, Grotendorst GR, Takehara K
    The Journal of investigative dermatology. 1996 ; 106 (4) : 729-733.
    PMID 8618012
     
    Cloning of a mRNA preferentially expressed in chondrocytes by differential display-PCR from a human chondrocytic cell line that is identical with connective tissue growth factor (CTGF) mRNA.
    Nakanishi T, Kimura Y, Tamura T, Ichikawa H, Yamaai Y, Sugimoto T, Takigawa M
    Biochemical and biophysical research communications. 1997 ; 234 (1) : 206-210.
    PMID 9168990
     
    Expression of connective tissue growth factor in human renal fibrosis.
    Ito Y, Aten J, Bende RJ, Oemar BS, Rabelink TJ, Weening JJ, Goldschmeding R
    Kidney international. 1998 ; 53 (4) : 853-861.
    PMID 9551391
     
    Establishment of the enzyme-linked immunosorbent assay for connective tissue growth factor (CTGF) and its detection in the sera of biliary atresia.
    Tamatani T, Kobayashi H, Tezuka K, Sakamoto S, Suzuki K, Nakanishi T, Takigawa M, Miyano T
    Biochemical and biophysical research communications. 1998 ; 251 (3) : 748-752.
    PMID 9790981
     
    Fisp12/mouse connective tissue growth factor mediates endothelial cell adhesion and migration through integrin alphavbeta3, promotes endothelial cell survival, and induces angiogenesis in vivo.
    Babic AM, Chen CC, Lau LF
    Molecular and cellular biology. 1999 ; 19 (4) : 2958-2966.
    PMID 10082563
     
    Connective tissue growth factor is a regulator for fibrosis in human chronic pancreatitis.
    di Mola FF, Friess H, Martignoni ME, Di Sebastiano P, Zimmermann A, Innocenti P, Graber H, Gold LI, Korc M, Bˆºchler MW
    Annals of surgery. 1999 ; 230 (1) : 63-71.
    PMID 10400038
     
    Connective tissue growth factor induces apoptosis in human breast cancer cell line MCF-7.
    Hishikawa K, Oemar BS, Tanner FC, Nakaki T, Lˆºscher TF, Fujii T
    The Journal of biological chemistry. 1999 ; 274 (52) : 37461-37466.
    PMID 10601320
     
    Connective tissue growth factor induces the proliferation, migration, and tube formation of vascular endothelial cells in vitro, and angiogenesis in vivo.
    Shimo T, Nakanishi T, Nishida T, Asano M, Kanyama M, Kuboki T, Tamatani T, Tezuka K, Takemura M, Matsumura T, Takigawa M
    Journal of biochemistry. 1999 ; 126 (1) : 137-145.
    PMID 10393331
     
    Novel intracellular effects of human connective tissue growth factor expressed in Cos-7 cells.
    Kubota S, Hattori T, Shimo T, Nakanishi T, Takigawa M
    FEBS letters. 2000 ; 474 (1) : 58-62.
    PMID 10828451
     
    Identification of an RNA element that confers post-transcriptional repression of connective tissue growth factor/hypertrophic chondrocyte specific 24 (ctgf/hcs24) gene: similarities to retroviral RNA-protein interactions.
    Kubota S, Kondo S, Eguchi T, Hattori T, Nakanishi T, Pomerantz RJ, Takigawa M
    Oncogene. 2000 ; 19 (41) : 4773-4786.
    PMID 11032028
     
    Effects of CTGF/Hcs24, a product of a hypertrophic chondrocyte-specific gene, on the proliferation and differentiation of chondrocytes in culture.
    Nakanishi T, Nishida T, Shimo T, Kobayashi K, Kubo T, Tamatani T, Tezuka K, Takigawa M
    Endocrinology. 2000 ; 141 (1) : 264-273.
    PMID 10614647
     
    Expression of connective tissue growth factor in cartilaginous tumors.
    Shakunaga T, Ozaki T, Ohara N, Asaumi K, Doi T, Nishida K, Kawai A, Nakanishi T, Takigawa M, Inoue H
    Cancer. 2000 ; 89 (7) : 1466-1473.
    PMID 11013359
     
    Elevated levels of connective tissue growth factor, WISP-1, and CYR61 in primary breast cancers associated with more advanced features.
    Xie D, Nakachi K, Wang H, Elashoff R, Koeffler HP
    Cancer research. 2001 ; 61 (24) : 8917-8923.
    PMID 11751417
     
    Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-beta.
    Abreu JG, Ketpura NI, Reversade B, De Robertis EM
    Nature cell biology. 2002 ; 4 (8) : 599-604.
    PMID 12134160
     
    A novel cis-element that enhances connective tissue growth factor gene expression in chondrocytic cells.
    Eguchi T, Kubota S, Kondo S, Kuboki T, Yatani H, Takigawa M
    Biochemical and biophysical research communications. 2002 ; 295 (2) : 445-451.
    PMID 12150969
     
    Connective tissue growth factor is directly related to liver fibrosis.
    Hayashi N, Kakimuma T, Soma Y, Grotendorst GR, Tamaki K, Harada M, Igarashi A
    Hepato-gastroenterology. 2002 ; 49 (43) : 133-135.
    PMID 11941937
     
    Connective tissue growth factor binds vascular endothelial growth factor (VEGF) and inhibits VEGF-induced angiogenesis.
    Inoki I, Shiomi T, Hashimoto G, Enomoto H, Nakamura H, Makino K, Ikeda E, Takata S, Kobayashi K, Okada Y
    The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2002 ; 16 (2) : 219-221.
    PMID 11744618
     
    CTGF/Hcs24, a hypertrophic chondrocyte-specific gene product, stimulates proliferation and differentiation, but not hypertrophy of cultured articular chondrocytes.
    Nishida T, Kubota S, Nakanishi T, Kuboki T, Yosimichi G, Kondo S, Takigawa M
    Journal of cellular physiology. 2002 ; 192 (1) : 55-63.
    PMID 12115736
     
    Connective tissue growth factor coordinates chondrogenesis and angiogenesis during skeletal development.
    Ivkovic S, Yoon BS, Popoff SN, Safadi FF, Libuda DE, Stephenson RC, Daluiski A, Lyons KM
    Development (Cambridge, England). 2003 ; 130 (12) : 2779-2791.
    PMID 12736220
     
    Connective tissue growth factor gene regulation. Requirements for its induction by transforming growth factor-beta 2 in fibroblasts.
    Leask A, Holmes A, Black CM, Abraham DJ
    The Journal of biological chemistry. 2003 ; 278 (15) : 13008-13015.
    PMID 12571253
     
    Suppressive effect of overexpressed connective tissue growth factor on tumor cell growth in a human oral squamous cell carcinoma-derived cell line.
    Moritani NH, Kubota S, Nishida T, Kawaki H, Kondo S, Sugahara T, Takigawa M
    Cancer letters. 2003 ; 192 (2) : 205-214.
    PMID 12668285
     
    CTGF/Hcs24 as a multifunctional growth factor for fibroblasts, chondrocytes and vascular endothelial cells.
    Takigawa M
    Drug news & perspectives. 2003 ; 16 (1) : 11-21.
    PMID 12682668
     
    Role of CTGF/HCS24/ecogenin in skeletal growth control.
    Takigawa M, Nakanishi T, Kubota S, Nishida T
    Journal of cellular physiology. 2003 ; 194 (3) : 256-266.
    PMID 12548546
     
    Activated human platelets release connective tissue growth factor.
    Cicha I, Garlichs CD, Daniel WG, Goppelt-Struebe M
    Thrombosis and haemostasis. 2004 ; 91 (4) : 755-760.
    PMID 15045137
     
    Connective tissue growth factor (CCN2) induces adhesion of rat activated hepatic stellate cells by binding of its C-terminal domain to integrin alpha(v)beta(3) and heparan sulfate proteoglycan.
    Gao R, Brigstock DR
    The Journal of biological chemistry. 2004 ; 279 (10) : 8848-8855.
    PMID 14684735
     
    Abundant retention and release of connective tissue growth factor (CTGF/CCN2) by platelets.
    Kubota S, Kawata K, Yanagita T, Doi H, Kitoh T, Takigawa M
    Journal of biochemistry. 2004 ; 136 (3) : 279-282.
    PMID 15598883
     
    CCN proteins: multifunctional signalling regulators.
    Perbal B
    Lancet. 2004 ; 363 (9402) : 62-64.
    PMID 14723997
     
    Effect of connective tissue growth factor (CCN2/CTGF) on proliferation and differentiation of mouse periodontal ligament-derived cells.
    Asano M, Kubota S, Nakanishi T, Nishida T, Yamaai T, Yosimichi G, Ohyama K, Sugimoto T, Murayama Y, Takigawa M
    Cell communication and signaling : CCS. 2005 ; 3 : page 11.
    PMID 16207372
     
    Connective tissue growth factor CCN2 interacts with and activates the tyrosine kinase receptor TrkA.
    Wahab NA, Weston BS, Mason RM
    Journal of the American Society of Nephrology : JASN. 2005 ; 16 (2) : 340-351.
    PMID 15601748
     
    CT domain of CCN2/CTGF directly interacts with fibronectin and enhances cell adhesion of chondrocytes through integrin alpha5beta1.
    Hoshijima M, Hattori T, Inoue M, Araki D, Hanagata H, Miyauchi A, Takigawa M
    FEBS letters. 2006 ; 580 (5) : 1376-1382.
    PMID 16457822
     
    Pathogenic role of connective tissue growth factor (CTGF/CCN2) in osteolytic metastasis of breast cancer.
    Shimo T, Kubota S, Yoshioka N, Ibaragi S, Isowa S, Eguchi T, Sasaki A, Takigawa M
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2006 ; 21 (7) : 1045-1059.
    PMID 16813525
     
    Role of CCN2/CTGF/Hcs24 in bone growth.
    Kubota S, Takigawa M
    International review of cytology. 2007 ; 257 : 1-41.
    PMID 17280894
     
    REVIEW articlesautomatic search in PubMed
    Last year publicationsautomatic search in PubMed

    Search in all EBI   NCBI

    Contributor(s)

    Written07-2007Satoshi Kubota, Masaharu Takigawa
    Department of Biochemistry and Molecular Dentistry Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Dean, Okayama University Dental School 2-5-1, Shikata-cho, Okayama, 700-8525, Japan

    Citation

    This paper should be referenced as such :
    Kubota, S ; Takigawa, M
    CTGF (connective tissue growth factor)
    Atlas Genet Cytogenet Oncol Haematol. 2008;12(1):35-38.
    Free online version   Free pdf version   [Bibliographic record ]
    URL : http://AtlasGeneticsOncology.org/Genes/CTGFID40192ch6q23.html

    © Atlas of Genetics and Cytogenetics in Oncology and Haematology
    indexed on : Wed Jul 30 16:39:35 CEST 2014

    Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

    For comments and suggestions or contributions, please contact us

    jlhuret@AtlasGeneticsOncology.org.