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CXCR1 (chemokine (C-X-C motif) receptor 1)

Written2013-06Sivan Sapoznik, Stav Kozlovski, Gal Markel
The Ella Institute for Melanoma Research, Treatment, Cancer Research Center, Sheba Medical Center, Israel (SS, SK, GM); Clinical Microbiology, Immunology, The Sackler School of Medicine of the Tel Aviv University, Israel (SK, GM); Talpiot Medical Leadership Program, Sheba Medical Center, Israel (GM)

(Note : for Links provided by Atlas : click)


Alias (NCBI)C-C
HGNC Alias symbCKR-1
HGNC Previous nameCMKAR1
HGNC Previous name"interleukin 8 receptor, alpha
 chemokine (C-X-C motif) receptor 1"
LocusID (NCBI) 3577
Atlas_Id 40966
Location 2q35  [Link to chromosome band 2q35]
Location_base_pair Starts at 218162841 and ends at 218166962 bp from pter ( according to GRCh38/hg38-Dec_2013)  [Mapping CXCR1.png]
Local_order Orientation: minus strand.
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PLPP4 (10q26.12) / CXCR1 (2q35)
Note CXCR1 together with IL8RB, another high affinity IL-8 receptor, and its pseudogene (IL8RBP), form a gene cluster in chromosome 2q33-q36 (provided by RefSeq, Jul 2008).


Description The CXCR1 gene (il8ra) is 4149 bp long and is composed of two exons, one of them included in the coding region (1053 bp) CXCR1 has 165 known SNPs; many of them correlate with disease states.
Genetic locus: CXCR1, together with its homolog CXCR2 (76% amino acids identity) and its pseudogene (il8rp), reside in chromosome 2q34-35. The high homology and close chromosomal localization between the three genes suggest gene duplications.
Transcription Transcripts: primer extension analysis revealed two start sites for CXCR1 (Sprenger et al., 1995). In addition, neutrophils contain two transcripts of CXCR1 (2.0 and 4.0 kb) which result from the usage of alternative poly adenylation signals.
Transcription regulators: PU.1, which belongs to the ets family of transcription factors, is a major activator of CXCR1 expression (Wilkinson and Navarro, 1999). HIF1 and NF-kappaB mediate the transcription of CXCR1 under hypoxia in prostate cancer cells (Maxwell et al., 2007). CXCR1 mRNA expression is also regulated by G-CSF (Lloyd et al., 1995).
Pseudogene Conservation during evolution: the CXCR1 gene was present in the common ancestor of chordates and has orthologs in diverse species, from lizards and Xenopus to primates. There is a high level of homology between CXCR1 from human, rabbit, rat, and mouse. The sequencing of the coding region of CXCR1 in worldwide human populations and 5 representative nonhuman primate species revealed accelerated protein evolution in the human lineage, mainly at the N-terminal ligand/receptor recognition domain (Liu et al., 2005).


Description 350 amino acids, 39791 Da.
CXCR1 is a G protein coupled receptor (GPCR), composed of seven transmembrane (TM) helices, an N-terminal ligand binding domain and a signaling cytoplasmic tail.
Expression Expression in tissues: according to SAGE (serial analysis of gene expression), CXCR1 is mainly expressed in the bone marrow, retina, heart, lungs and in the placenta.
Expression in cell types: CXCR1 is expressed on a wide variety of cell types, including neutrophils, monocytes, CD8 T cells, mast cells, basophils, natural killer cells, keratinocytes, fibroblasts, neurons, endothelial cells, and melanocytes.
Expression regulators: CXCR1 was found to be up-regulated by IL6, by a yet-unknown mechanism (Eikawa et al., 2010).
Localisation CXCR1 resides in the plasma membrane and transduces signals into the cell (figure 1).
  Figure 1.
Function Upon binding to its ligands, CXCR1 transduces signals via the phosphatidylinositol-calcium second messenger system and plays an important role in acute inflammation. IL-8 (CXCL8), the main ligand of CXCR1, is a powerful neutrophil chemotactic factor and its binding to CXCR1 induces activation and migration of neutrophils (Holmes et al., 1991; Liu et al., 2005). In neutrophils, receptor activation also stimulates the release of granule enzymes and the generation of superoxide in respiratory burst (Jones et al., 1996). In addition to its effect on immune cells, CXCR1 may be important in regulating vasculogenesis and consequent tumor growth (Strieter et al., 1995). The signaling pathway of CXCR1 as a G protein coupled receptor is presented in figure 1. Noteworthy, CXCR1 signaling also activates monomeric, low molecular weight G proteins of the Ras and Rho families (Laudanna et al., 1996).
Ligand selectivity: CXCR1 displays a relatively narrow selectivity and high preference for IL-8. At low affinity it also binds MGSA/GRO.

Implicated in

Entity Melanoma
Note Highly expressed by melanoma cells and and mediates their proliferation and invasiveness in vitro and tumor growth in mice experiments (Singh et al., 2009). Recently, it was shown as a potential target for T cell engineering, a finding which highly impacts on adoptive cell immune-therapy for melanoma patients (Sapoznik et al., 2012).
Entity Breast cancer
Note CXCR1 is over-expressed in tumor and cascular endothelial cells, as shown by immunohistochemistry studies on a cohort of 50 breast cancer patients performed by Miller et al. (Miller et al., 1998). Recently, Singh and his colleagues showed that CXCR1 as well as CXCR2 are important mediators of breast cancer stem-like cells activity. Furthermore, blockade of CXCR1 and CXCR2 adds to the inhibitory effect of HER2-targeted therapy on these cells and may potentially serve as a novel therapeutic strategy for breast cancer (Singh et al., 2013).
Entity Colorectal cancer
Note CXCR1 is over-expressed in colorectal cancer cells (Abolhassani et al., 2008) and antagonists of CXCR1 and CXCR2 inhibit liver metastases of human colon cancer in a murine model (Varney et al., 2011). Interestingly, based on two large cohorts of population incident studies, Bondurant and his colleagues were recently able to show that SNPs in genes connected with the IL8 pathway (including CXCR1 and CXCR2) are associated with higher risk of both colon and rectal cancers (Bondurant et al., 2013).
Entity Prostate cancer
Note CXCR1 is over-expressed in tumor cells from human prostate biopsies (Murphy et al., 2005). Depletion of CXCR1 by RNA interference in androgen-independent human prostate cancer cells induces cell death and reduced proliferation in vitro (Shamaladevi et al., 2009). In consistence with that, down- regulation of CXCR1 by shRNA or by a specific antagonist lead to inhibition of human xenograft growth in immune-deficient mice (Shamaladevi et al., 2009; Liu et al., 2012).
Entity Nasopharyngeal carcinoma
Note Immune-histochemical analysis of 30 patients with nasopharyngeal carcinoma proved that its expression in tumor tissue significantly correlates with a shorter overall survival rate. Thus it is an indicator of poor prognosis in nasopharyngeal carcinoma (Horikawa et al., 2005).
Entity Chronic obstractive pulmonary disease (COPD)
Note CXCR1 polymorphisms are identified polymorphisms associated with COPD and asthma, as shown by Stemmler et al. by screening 50 COPD patients (Stemmler et al., 2005). Pignatti and colleagues found that neutrophilic asthma patients have similar expression levels of CXCR1 as COPD patients and that CXCR1 expression is negatively correlated with the inflammatory infiltrate in the airways (Pignatti et al., 2005).
Entity Urinary tract infection recurrent
Note CXCR1 was first identified as a candidate gene for urinary tract infections when Godaly et al showed that mIL-8Rh mutant mice developed acute pyelonephiritis with severe renal scattering (Godaly et al., 2001). Lundstedt et al. have afterwards identified two sequence variants which were shown to impair transcription of CXCR1 and led to reduced levels of the CXCR1 protein in children prone to urinary tract infections (Lundstedt et al., 2007).
Entity Psoriasis
Note A single study by Arenberger et al showed in a small cohort of psoriasis patients that CXCR1 is slightly though significantly over-expressed in polymorphonuclear leukocyte infiltration in the epidermis as compared to normal volunteers (Arenberger et al., 1992).


Leptin receptor-related immune response in colorectal tumors: the role of colonocytes and interleukin-8.
Abolhassani M, Aloulou N, Chaumette MT, Aparicio T, Martin-Garcia N, Mansour H, Le Gouvello S, Delchier JC, Sobhani I.
Cancer Res. 2008 Nov 15;68(22):9423-32. doi: 10.1158/0008-5472.CAN-08-1017.
PMID 19010917
Interleukin-8 receptors in normal and psoriatic polymorphonuclear leukocytes.
Arenberger P, Kemeny L, Suss R, Michel G, Peter RU, Ruzicka T.
Acta Derm Venereol. 1992 Sep;72(5):334-6.
PMID 1361277
Interleukin genes and associations with colon and rectal cancer risk and overall survival.
Bondurant KL, Lundgreen A, Herrick JS, Kadlubar S, Wolff RK, Slattery ML.
Int J Cancer. 2013 Feb 15;132(4):905-15. doi: 10.1002/ijc.27660. Epub 2012 Jun 26.
PMID 22674296
Enrichment of Foxp3+ CD4 regulatory T cells in migrated T cells to IL-6- and IL-8-expressing tumors through predominant induction of CXCR1 by IL-6.
Eikawa S, Ohue Y, Kitaoka K, Aji T, Uenaka A, Oka M, Nakayama E.
J Immunol. 2010 Dec 1;185(11):6734-40. doi: 10.4049/jimmunol.1000225. Epub 2010 Nov 3.
PMID 21048114
Neutrophil recruitment, chemokine receptors, and resistance to mucosal infection.
Godaly G, Bergsten G, Hang L, Fischer H, Frendeus B, Lundstedt AC, Samuelsson M, Samuelsson P, Svanborg C.
J Leukoc Biol. 2001 Jun;69(6):899-906.
PMID 11404374
Structure and functional expression of a human interleukin-8 receptor.
Holmes WE, Lee J, Kuang WJ, Rice GC, Wood WI.
Science. 1991 Sep 13;253(5025):1278-80.
PMID 1840701
Expression of interleukin-8 receptor A predicts poor outcome in patients with nasopharyngeal carcinoma.
Horikawa T, Kaizaki Y, Kato H, Furukawa M, Yoshizaki T.
Laryngoscope. 2005 Jan;115(1):62-7.
PMID 15630368
Different functions for the interleukin 8 receptors (IL-8R) of human neutrophil leukocytes: NADPH oxidase and phospholipase D are activated through IL-8R1 but not IL-8R2.
Jones SA, Wolf M, Qin S, Mackay CR, Baggiolini M.
Proc Natl Acad Sci U S A. 1996 Jun 25;93(13):6682-6.
PMID 8692878
Role of Rho in chemoattractant-activated leukocyte adhesion through integrins.
Laudanna C, Campbell JJ, Butcher EC.
Science. 1996 Feb 16;271(5251):981-3.
PMID 8584934
G31P, an antagonist against CXC chemokine receptors 1 and 2, inhibits growth of human prostate cancer cells in nude mice.
Liu X, Peng J, Sun W, Yang S, Deng G, Li F, Cheng JW, Gordon JR.
Tohoku J Exp Med. 2012;228(2):147-56.
PMID 23019013
Molecular evolution of CXCR1, a G protein-coupled receptor involved in signal transduction of neutrophils.
Liu Y, Yang S, Lin AA, Cavalli-Sforza LL, Su B.
J Mol Evol. 2005 Nov;61(5):691-6. Epub 2005 Oct 4.
PMID 16205979
Granulocyte-colony stimulating factor and lipopolysaccharide regulate the expression of interleukin 8 receptors on polymorphonuclear leukocytes.
Lloyd AR, Biragyn A, Johnston JA, Taub DD, Xu L, Michiel D, Sprenger H, Oppenheim JJ, Kelvin DJ.
J Biol Chem. 1995 Nov 24;270(47):28188-92.
PMID 7499311
A genetic basis of susceptibility to acute pyelonephritis.
Lundstedt AC, McCarthy S, Gustafsson MC, Godaly G, Jodal U, Karpman D, Leijonhufvud I, Linden C, Martinell J, Ragnarsdottir B, Samuelsson M, Truedsson L, Andersson B, Svanborg C.
PLoS One. 2007 Sep 5;2(9):e825.
PMID 17786197
HIF-1 and NF-kappaB-mediated upregulation of CXCR1 and CXCR2 expression promotes cell survival in hypoxic prostate cancer cells.
Maxwell PJ, Gallagher R, Seaton A, Wilson C, Scullin P, Pettigrew J, Stratford IJ, Williams KJ, Johnston PG, Waugh DJ.
Oncogene. 2007 Nov 15;26(52):7333-45. Epub 2007 May 28.
PMID 17533374
Expression of interleukin-8 receptors on tumor cells and vascular endothelial cells in human breast cancer tissue.
Miller LJ, Kurtzman SH, Wang Y, Anderson KH, Lindquist RR, Kreutzer DL.
Anticancer Res. 1998 Jan-Feb;18(1A):77-81.
PMID 9568059
Nonapical and cytoplasmic expression of interleukin-8, CXCR1, and CXCR2 correlates with cell proliferation and microvessel density in prostate cancer.
Murphy C, McGurk M, Pettigrew J, Santinelli A, Mazzucchelli R, Johnston PG, Montironi R, Waugh DJ.
Clin Cancer Res. 2005 Jun 1;11(11):4117-27.
PMID 15930347
Downmodulation of CXCL8/IL-8 receptors on neutrophils after recruitment in the airways.
Pignatti P, Moscato G, Casarini S, Delmastro M, Poppa M, Brunetti G, Pisati P, Balbi B.
J Allergy Clin Immunol. 2005 Jan;115(1):88-94.
PMID 15637552
CXCR1 as a novel target for directing reactive T cells toward melanoma: implications for adoptive cell transfer immunotherapy.
Sapoznik S, Ortenberg R, Galore-Haskel G, Kozlovski S, Levy D, Avivi C, Barshack I, Cohen CJ, Besser MJ, Schachter J, Markel G.
Cancer Immunol Immunother. 2012 Oct;61(10):1833-47. Epub 2012 Mar 24.
PMID 22441657
CXC receptor-1 silencing inhibits androgen-independent prostate cancer.
Shamaladevi N, Lyn DA, Escudero DO, Lokeshwar BL.
Cancer Res. 2009 Nov 1;69(21):8265-74. doi: 10.1158/0008-5472.CAN-09-0374. Epub 2009 Oct 27.
PMID 19861539
Targeting CXCR1/2 significantly reduces breast cancer stem cell activity and increases the efficacy of inhibiting HER2 via HER2-dependent and -independent mechanisms.
Singh JK, Farnie G, Bundred NJ, Simoes BM, Shergill A, Landberg G, Howell SJ, Clarke RB.
Clin Cancer Res. 2013 Feb 1;19(3):643-56. doi: 10.1158/1078-0432.CCR-12-1063. Epub 2012 Nov 13.
PMID 23149820
CXCR1 and CXCR2 enhances human melanoma tumourigenesis, growth and invasion.
Singh S, Nannuru KC, Sadanandam A, Varney ML, Singh RK.
Br J Cancer. 2009 May 19;100(10):1638-46. doi: 10.1038/sj.bjc.6605055. Epub 2009 Apr 28.
PMID 19401689
Promoter analysis of the human interleukin-8 receptor genes, IL-8RA and IL-8RB.
Sprenger H, Lloyd AR, Kelvin DJ.
Immunobiology. 1995 Jul;193(2-4):334-40.
PMID 8530163
Association of interleukin-8 receptor alpha polymorphisms with chronic obstructive pulmonary disease and asthma.
Stemmler S, Arinir U, Klein W, Rohde G, Hoffjan S, Wirkus N, Reinitz-Rademacher K, Bufe A, Schultze-Werninghaus G, Epplen JT.
Genes Immun. 2005 May;6(3):225-30.
PMID 15772681
Role of C-X-C chemokines as regulators of angiogenesis in lung cancer.
Strieter RM, Polverini PJ, Arenberg DA, Walz A, Opdenakker G, Van Damme J, Kunkel SL.
J Leukoc Biol. 1995 May;57(5):752-62. (REVIEW)
PMID 7539029
Small molecule antagonists for CXCR2 and CXCR1 inhibit human colon cancer liver metastases.
Varney ML, Singh S, Li A, Mayer-Ezell R, Bond R, Singh RK.
Cancer Lett. 2011 Jan 28;300(2):180-8. doi: 10.1016/j.canlet.2010.10.004. Epub 2010 Oct 29.
PMID 21035946
PU.1 regulates the CXCR1 promoter.
Wilkinson NC, Navarro J.
J Biol Chem. 1999 Jan 1;274(1):438-43.
PMID 9867862


This paper should be referenced as such :
Sapoznik, S ; Kozlovski, S ; Markel, G
CXCR1 (chemokine (C-X-C motif) receptor 1)
Atlas Genet Cytogenet Oncol Haematol. 2014;18(1):8-11.
Free journal version : [ pdf ]   [ DOI ]

External links

HGNC (Hugo)CXCR1   6026
Entrez_Gene (NCBI)CXCR1    C-X-C motif chemokine receptor 1
AliasesC-C; C-C-CKR-1; CD128; CD181; 
CDw128a; CKR-1; CMKAR1; IL8R1; IL8RA; IL8RBA
GeneCards (Weizmann)CXCR1
Ensembl hg19 (Hinxton)ENSG00000163464 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000163464 [Gene_View]  ENSG00000163464 [Sequence]  chr2:218162841-218166962 [Contig_View]  CXCR1 [Vega]
ICGC DataPortalENSG00000163464
TCGA cBioPortalCXCR1
Genatlas (Paris)CXCR1
SOURCE (Princeton)CXCR1
Genetics Home Reference (NIH)CXCR1
Genomic and cartography
GoldenPath hg38 (UCSC)CXCR1  -     chr2:218162841-218166962 -  2q35   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CXCR1  -     2q35   [Description]    (hg19-Feb_2009)
GoldenPathCXCR1 - 2q35 [CytoView hg19]  CXCR1 - 2q35 [CytoView hg38]
genome Data Viewer NCBICXCR1 [Mapview hg19]  
OMIM146929   609423   
Gene and transcription
Genbank (Entrez)AK298647 AK309632 AK312668 BC028221 BC072397
RefSeq transcript (Entrez)NM_000634
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CXCR1
Alternative Splicing GalleryENSG00000163464
Gene ExpressionCXCR1 [ NCBI-GEO ]   CXCR1 [ EBI - ARRAY_EXPRESS ]   CXCR1 [ SEEK ]   CXCR1 [ MEM ]
Gene Expression Viewer (FireBrowse)CXCR1 [ Firebrowse - Broad ]
GenevisibleExpression of CXCR1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3577
GTEX Portal (Tissue expression)CXCR1
Human Protein AtlasENSG00000163464-CXCR1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP25024   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP25024  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP25024
Splice isoforms : SwissVarP25024
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_1 (PS00237)    G_PROTEIN_RECEP_F1_2 (PS50262)   
Domains : Interpro (EBI)Chemokine_CXCR1    Chemokine_CXCR_1/2    GPCR_Rhodpsn    GPCR_Rhodpsn_7TM   
Domain families : Pfam (Sanger)7tm_1 (PF00001)   
Domain families : Pfam (NCBI)pfam00001   
Conserved Domain (NCBI)CXCR1
Blocks (Seattle)CXCR1
PDB (RSDB)1ILP    1ILQ    2LNL   
PDB Europe1ILP    1ILQ    2LNL   
PDB (PDBSum)1ILP    1ILQ    2LNL   
PDB (IMB)1ILP    1ILQ    2LNL   
Structural Biology KnowledgeBase1ILP    1ILQ    2LNL   
SCOP (Structural Classification of Proteins)1ILP    1ILQ    2LNL   
CATH (Classification of proteins structures)1ILP    1ILQ    2LNL   
Human Protein Atlas [tissue]ENSG00000163464-CXCR1 [tissue]
Peptide AtlasP25024
IPIIPI00296618   IPI00910914   
Protein Interaction databases
IntAct (EBI)P25024
Ontologies - Pathways
Ontology : AmiGOdendritic cell chemotaxis  interleukin-8 receptor activity  G protein-coupled receptor activity  chemokine receptor activity  plasma membrane  chemotaxis  immune response  cell surface receptor signaling pathway  G protein-coupled receptor signaling pathway  positive regulation of cytosolic calcium ion concentration  external side of plasma membrane  integral component of membrane  C-C chemokine receptor activity  calcium-mediated signaling  chemokine binding  C-C chemokine binding  interleukin-8 binding  neutrophil chemotaxis  secretory granule membrane  receptor internalization  interleukin-8-mediated signaling pathway  neutrophil degranulation  cell chemotaxis  chemokine-mediated signaling pathway  
Ontology : EGO-EBIdendritic cell chemotaxis  interleukin-8 receptor activity  G protein-coupled receptor activity  chemokine receptor activity  plasma membrane  chemotaxis  immune response  cell surface receptor signaling pathway  G protein-coupled receptor signaling pathway  positive regulation of cytosolic calcium ion concentration  external side of plasma membrane  integral component of membrane  C-C chemokine receptor activity  calcium-mediated signaling  chemokine binding  C-C chemokine binding  interleukin-8 binding  neutrophil chemotaxis  secretory granule membrane  receptor internalization  interleukin-8-mediated signaling pathway  neutrophil degranulation  cell chemotaxis  chemokine-mediated signaling pathway  
Pathways : KEGGCytokine-cytokine receptor interaction    Chemokine signaling pathway    Endocytosis    Epithelial cell signaling in Helicobacter pylori infection   
REACTOMEP25024 [protein]
REACTOME PathwaysR-HSA-6798695 [pathway]   
NDEx NetworkCXCR1
Atlas of Cancer Signalling NetworkCXCR1
Wikipedia pathwaysCXCR1
Orthology - Evolution
GeneTree (enSembl)ENSG00000163464
Phylogenetic Trees/Animal Genes : TreeFamCXCR1
Homologs : HomoloGeneCXCR1
Homology/Alignments : Family Browser (UCSC)CXCR1
Gene fusions - Rearrangements
Fusion : Fusion_HubCXCR1--CXCR2    PPAPDC1A--CXCR1   
Fusion : QuiverCXCR1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCXCR1 [hg38]
Exome Variant ServerCXCR1
GNOMAD BrowserENSG00000163464
Varsome BrowserCXCR1
Genomic Variants (DGV)CXCR1 [DGVbeta]
DECIPHERCXCR1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCXCR1 
ICGC Data PortalCXCR1 
TCGA Data PortalCXCR1 
Broad Tumor PortalCXCR1
OASIS PortalCXCR1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCXCR1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCXCR1
Mutations and Diseases : HGMDCXCR1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CXCR1
DgiDB (Drug Gene Interaction Database)CXCR1
DoCM (Curated mutations)CXCR1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CXCR1 (select a term)
NCG6 (London) select CXCR1
Cancer3DCXCR1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
OMIM146929    609423   
Genetic Testing Registry CXCR1
NextProtP25024 [Medical]
Target ValidationCXCR1
Huge Navigator CXCR1 [HugePedia]
Clinical trials, drugs, therapy
Protein Interactions : CTD
Pharm GKB GenePA29842
Clinical trialCXCR1
canSAR (ICR)CXCR1 (select the gene name)
DataMed IndexCXCR1
PubMed217 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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