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DAXX (death-associated protein 6)

Written2009-01Eunhee Kim
School of Bioscience & Biotechnology, Chungnam National University, 220 Goong-dong, Yusung-gu, Daejeon, 305-764, Korea (South)

(Note : for Links provided by Atlas : click)


HGNC Alias symbDAP6
HGNC Previous namedeath-associated protein 6
LocusID (NCBI) 1616
Atlas_Id 40265
Location 6p21.32  [Link to chromosome band 6p21]
Location_base_pair Starts at 33318558 and ends at 33322959 bp from pter ( according to GRCh38/hg38-Dec_2013)  [Mapping DAXX.png]
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DAXX (6p21.32)::VAPB (20q13.32)EGR1 (5q31.2)::DAXX (6p21.32)OXSR1 (3p22.2)::DAXX (6p21.32)
TAPBP (6p21.32)::DAXX (6p21.32)


Description Daxx gene has 8 exons on chromosome 6. The sizes of the exons are 66, 256, 832, 212, 214, 475, 223 and 191 bps.
Transcription 2,477 bp mRNA.
Two alternative transcripts:
1. Isoform 1 has been chosen as the canonical sequence
2. Isoform 2 differs from the canonical sequence as follows:


Description 740 amino acids, 82.2 kDa; contains in 3 coiled coils (residues 180-217, 358-399 and 430-489), and 2 nuclear localisation signals (residues 391-395 and 628-634).
Expression Ubiquitous.
Localisation Nucleus and cytoplasm.
Note: Dispersed throughout the nucleoplasm, in PML/POD/ND10 nuclear bodies, and in nucleoli.
Colocalizes with a subset of interphase centromeres, but is absent from mitotic centromeres.
Detected in the cytoplasmic punctate structures.
Translocated from the nucleus to the cytoplasm upon glucose deprivation or ischemic stress.
  • Interaction with Fas death domain and induces Fas-mediated cell death.
  • Establishes Fas-Daxx-ASK1-JNK axis.
  • Implicated in ischemic cell death. Daxx translocates from the nucleus to the cytoplasm upon ischemic stress. Cytoplasmic Daxx interacts with NHE1 and stimulates the NHE1 transporter activity and suppresses the NHE1-ezrin-AKT1 pathway.
  • Associated with the PML body in the nucleus.
  • Interacts with SUMO1 and UBC9 and is sumorylated at K630 and 631. However, the sumoylation status does not determine its localization onto the PML body.
  • Mediates SUMO-dependent transcriptional control and subnuclear compartmentalization.
  • Suppresses cell death in the early embryo.
  • Daxx silencing sensitizes cells to Fas- and stress-induced cell death through caspase activation, cytochrome C release and JNK activation.
  • Homology Holomogy with Pan troglodytes (99%); Canis lupus familiaris (89%); Bos taurus (83%); Mus musculus (70%), Rattus norvegicus (73%).


    Note Substitutions (see the external links).

    Implicated in

    Entity Promyelocytic leukemia
    Disease Daxx is a component of the promyelocytic leukemia protein (PML) nuclear bodies (NBs).
    Entity Alpha-thalassemia
    Disease Daxx complex is a novel ATP-dependent chromatin-remodeling complex, with alpha-thalassaemia syndrome protein (ATRX) being the core ATPase subunit and Daxx being the targeting subunit.
    Entity Leukemia
    Disease Daxx protein was expressed in 38.0% of 50 children with acute leukemia, which was significantly higher than that of the control group (5.0%) (P < 0.05). Daxx expression is abnormal in children with acute leukemia and associated with some clinical features of acute leukemia, suggesting that it may play an important role in the genesis and development of acute leukemia.


    Survival role of protein kinase C (PKC) in chronic lymphocytic leukemia and determination of isoform expression pattern and genes altered by PKC inhibition.
    Alkan S, Huang Q, Ergin M, Denning MF, Nand S, Maududi T, Paner GP, Ozpuyan F, Izban KF.
    Am J Hematol. 2005 Jun;79(2):97-106.
    PMID 15929099
    Histone deacetylase inhibitors induce caspase-dependent apoptosis and downregulation of daxx in acute promyelocytic leukaemia with t(15;17).
    Amin HM, Saeed S, Alkan S.
    Br J Haematol. 2001 Nov;115(2):287-97.
    PMID 11703323
    Self-regulatory role of 4-hydroxynonenal in signaling for stress-induced programmed cell death.
    Awasthi YC, Sharma R, Sharma A, Yadav S, Singhal SS, Chaudhary P, Awasthi S.
    Free Radic Biol Med. 2008 Jul 15;45(2):111-8. Epub 2008 May 2.
    PMID 18456001
    Large-scale characterization of HeLa cell nuclear phosphoproteins.
    Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villen J, Li J, Cohn MA, Cantley LC, Gygi SP.
    Proc Natl Acad Sci U S A. 2004 Aug 17;101(33):12130-5. Epub 2004 Aug 9.
    PMID 15302935
    Nuclear localization but not PML protein is required for incorporation of the papillomavirus minor capsid protein L2 into virus-like particles.
    Becker KA, Florin L, Sapp C, Maul GG, Sapp M.
    J Virol. 2004 Feb;78(3):1121-8.
    PMID 14722267
    In the erythroleukemic cell line HEL Prostate-apoptosis-response-gene-4 (par-4) fails to down-regulate Bcl-2 and to promote apoptosis.
    Boehrer S, Brieger A, Schaaf S, Kukoc-Zivojnov N, Nowak D, Ruthardt M, Hoelzer D, Mitrou PS, Weidmann E, Chow KU.
    Leuk Lymphoma. 2004 Jul;45(7):1445-51.
    PMID 15359646
    Expression of Daxx sensitizes Jurkat T-cells to the apoptosis-inducing effect of chemotherapeutic agents.
    Boehrer S, Nowak D, Kukoc-Zivojnov N, Hochmuth S, Kim SZ, Hoelzer D, Mitrou PS, Weidmann E, Chow KU.
    Pharmacol Res. 2005 Apr;51(4):367-74.
    PMID 15683751
    In bcr-abl-positive myeloid cells resistant to conventional chemotherapeutic agents, expression of Par-4 increases sensitivity to imatinib (STI571) and histone deacetylase-inhibitors.
    Brieger A, Boehrer S, Schaaf S, Nowak D, Ruthardt M, Kim SZ, Atadja P, Hoelzer D, Mitrou PS, Weidmann E, Chow KU.
    Biochem Pharmacol. 2004 Jul 1;68(1):85-93.
    PMID 15183120
    Human cytomegalovirus (HCMV) UL82 gene product (pp71) relieves hDaxx-mediated repression of HCMV replication.
    Cantrell SR, Bresnahan WA.
    J Virol. 2006 Jun;80(12):6188-91.
    PMID 16731959
    Molecular mechanisms involved in CD43-mediated apoptosis of TF-1 cells. Roles of transcription Daxx expression, and adhesion molecules.
    Cermak L, Simova S, Pintzas A, Horejsi V, Andera L.
    J Biol Chem. 2002 Mar 8;277(10):7955-61. Epub 2001 Dec 31.
    PMID 11773067
    Daxx mediates the small ubiquitin-like modifier-dependent transcriptional repression of Smad4.
    Chang CC, Lin DY, Fang HI, Chen RH, Shih HM.
    J Biol Chem. 2005 Mar 18;280(11):10164-73. Epub 2005 Jan 6.
    PMID 15637079
    Activation of apoptosis signal-regulating kinase 1 (ASK1) by the adapter protein Daxx.
    Chang HY, Nishitoh H, Yang X, Ichijo H, Baltimore D.
    Science. 1998 Sep 18;281(5384):1860-3.
    PMID 9743501
    Dissecting Fas signaling with an altered-specificity death-domain mutant: requirement of FADD binding for apoptosis but not Jun N-terminal kinase activation.
    Chang HY, Yang X, Baltimore D.
    Proc Natl Acad Sci U S A. 1999 Feb 16;96(4):1252-6.
    PMID 9990010
    A kinase-independent function of Ask1 in caspase-independent cell death.
    Charette SJ, Lambert H, Landry J.
    J Biol Chem. 2001 Sep 28;276(39):36071-4. Epub 2001 Aug 7.
    PMID 11493600
    SUMO regulates the cytoplasmonuclear transport of its target protein Daxx.
    Chen A, Wang PY, Yang YC, Huang YH, Yeh JJ, Chou YH, Cheng JT, Hong YR, Li SS.
    J Cell Biochem. 2006 Jul 1;98(4):895-911.
    PMID 16475184
    DAXX interacts with phage PhiC31 integrase and inhibits recombination.
    Chen JZ, Ji CN, Xu GL, Pang RY, Yao JH, Zhu HZ, Xue JL, Jia W.
    Nucleic Acids Res. 2006;34(21):6298-304. Epub 2006 Nov 10.
    PMID 17098929
    Daxx silencing sensitizes cells to multiple apoptotic pathways.
    Chen LY, Chen JD.
    Mol Cell Biol. 2003 Oct;23(20):7108-21.
    PMID 14517282
    [Expression of apoptosis-related proteins in the human bone marrow hematopoietic cells treated by Panax Notoginosides]
    Chen XH, Gao RL, Zhen ZY, Qian XD, Xu WH.
    Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2006 Apr;14(2):343-6.
    PMID 16638211
    Live cell dynamics of promyelocytic leukemia nuclear bodies upon entry into and exit from mitosis.
    Chen YC, Kappel C, Beaudouin J, Eils R, Spector DL.
    Mol Biol Cell. 2008 Jul;19(7):3147-62. Epub 2008 May 14.
    PMID 18480407
    Positive regulation of apoptosis signal-regulating kinase 1 by hD53L1.
    Cho S, Ko HM, Kim JM, Lee JA, Park JE, Jang MS, Park SG, Lee DH, Ryu SE, Park BC.
    J Biol Chem. 2004 Apr 16;279(16):16050-6. Epub 2004 Feb 4.
    PMID 14761963
    Synergistic effects of chemotherapeutic drugs in lymphoma cells are associated with down-regulation of inhibitor of apoptosis proteins (IAPs), prostate-apoptosis-response-gene 4 (Par-4), death-associated protein (Daxx) and with enforced caspase activation.
    Chow KU, Nowak D, Boehrer S, Ruthardt M, Knau A, Hoelzer D, Mitrou PS, Weidmann E.
    Biochem Pharmacol. 2003 Sep 1;66(5):711-24.
    PMID 12948851
    Daxx represses expression of a subset of antiapoptotic genes regulated by nuclear factor-kappaB.
    Croxton R, Puto LA, de Belle I, Thomas M, Torii S, Hanaii F, Cuddy M, Reed JC.
    Cancer Res. 2006 Sep 15;66(18):9026-35.
    PMID 16982744
    Homeodomain-interacting protein kinase 1 modulates Daxx localization, phosphorylation, and transcriptional activity.
    Ecsedy JA, Michaelson JS, Leder P.
    Mol Cell Biol. 2003 Feb;23(3):950-60.
    PMID 12529400
    The interaction of Pax5 (BSAP) with Daxx can result in transcriptional activation in B cells.
    Emelyanov AV, Kovac CR, Sepulveda MA, Birshtein BK.
    J Biol Chem. 2002 Mar 29;277(13):11156-64. Epub 2002 Jan 17.
    PMID 11799127
    Interferon-induced antiviral Mx1 GTPase is associated with components of the SUMO-1 system and promyelocytic leukemia protein nuclear bodies.
    Engelhardt OG, Ullrich E, Kochs G, Haller O.
    Exp Cell Res. 2001 Dec 10;271(2):286-95.
    PMID 11716541
    Herpes simplex virus type 1 genomes are associated with ND10 nuclear substructures in quiescently infected human fibroblasts.
    Everett RD, Murray J, Orr A, Preston CM.
    J Virol. 2007 Oct;81(20):10991-1004. Epub 2007 Aug 1.
    PMID 17670833
    Reorganization of nuclear domain 10 induced by papillomavirus capsid protein l2.
    Florin L, Schafer F, Sotlar K, Streeck RE, Sapp M.
    Virology. 2002 Mar 30;295(1):97-107.
    PMID 12033769
    HIV induces lymphocyte apoptosis by a p53-initiated, mitochondrial-mediated mechanism.
    Genini D, Sheeter D, Rought S, Zaunders JJ, Susin SA, Kroemer G, Richman DD, Carson DA, Corbeil J, Leoni LM.
    FASEB J. 2001 Jan;15(1):5-6. Epub 2000 Nov 9.
    PMID 11099484
    The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
    Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J; MGC Project Team.
    Genome Res. 2004 Oct;14(10B):2121-7.
    PMID 15489334
    An essential role for Daxx in the inhibition of B lymphopoiesis by type I interferons.
    Gongora R, Stephan RP, Zhang Z, Cooper MD.
    Immunity. 2001 Jun;14(6):727-37.
    PMID 11420043
    The transcriptional repressor hDaxx potentiates p53-dependent apoptosis.
    Gostissa M, Morelli M, Mantovani F, Guida E, Piazza S, Collavin L, Brancolini C, Schneider C, Del Sal G.
    J Biol Chem. 2004 Nov 12;279(46):48013-23. Epub 2004 Aug 31.
    PMID 15339933
    The cellular protein daxx interacts with avian sarcoma virus integrase and viral DNA to repress viral transcription.
    Greger JG, Katz RA, Ishov AM, Maul GG, Skalka AM.
    J Virol. 2005 Apr;79(8):4610-8.
    PMID 15795247
    Knockdown of hDaxx in normally non-permissive undifferentiated cells does not permit human cytomegalovirus immediate-early gene expression.
    Groves IJ, Sinclair JH.
    J Gen Virol. 2007 Nov;88(Pt 11):2935-40.
    PMID 17947514
    Gene expression profiling of human synovial sarcoma cell line (Hs701.T) in response to IL-1beta stimulation.
    Ha WY, Li XJ, Yue PY, Wong DY, Yue KK, Chung WS, Zhao L, Leung PY, Liu L, Wong RN.
    Inflamm Res. 2006 Jul;55(7):293-9.
    PMID 16955392
    Genomic analysis of the Tapasin gene, located close to the TAP loci in the MHC.
    Herberg JA, Sgouros J, Jones T, Copeman J, Humphray SJ, Sheer D, Cresswell P, Beck S, Trowsdale J.
    Eur J Immunol. 1998 Feb;28(2):459-67.
    PMID 9521053
    Functional interaction between the pp71 protein of human cytomegalovirus and the PML-interacting protein human Daxx.
    Hofmann H, Sindre H, Stamminger T.
    J Virol. 2002 Jun;76(11):5769-83.
    PMID 11992005
    HIPK2 regulates transforming growth factor-beta-induced c-Jun NH(2)-terminal kinase activation and apoptosis in human hepatoma cells.
    Hofmann TG, Stollberg N, Schmitz ML, Will H.
    Cancer Res. 2003 Dec 1;63(23):8271-7.
    PMID 14678985
    Daxx and histone deacetylase II associate with chromatin through an interaction with core histones and the chromatin-associated protein Dek.
    Hollenbach AD, McPherson CJ, Mientjes EJ, Iyengar R, Grosveld G.
    J Cell Sci. 2002 Aug 15;115(Pt 16):3319-30.
    PMID 12140263
    Proteasome-dependent, ubiquitin-independent degradation of Daxx by the viral pp71 protein in human cytomegalovirus-infected cells.
    Hwang J, Kalejta RF.
    Virology. 2007 Oct 25;367(2):334-8. Epub 2007 Jun 27.
    PMID 17590404
    C-terminus of heat shock protein 70-interacting protein facilitates degradation of apoptosis signal-regulating kinase 1 and inhibits apoptosis signal-regulating kinase 1-dependent apoptosis.
    Hwang JR, Zhang C, Patterson C.
    Cell Stress Chaperones. 2005 Summer;10(2):147-56.
    PMID 16038411
    Differential effects of a novel IFN-zeta/limitin and IFN-alpha on signals for Daxx induction and Crk phosphorylation that couple with growth control of megakaryocytes.
    Ishida N, Oritani K, Shiraga M, Yoshida H, Kawamoto S, Ujiie H, Masaie H, Ichii M, Tomiyama Y, Kanakura Y.
    Exp Hematol. 2005 Apr;33(4):495-503.
    PMID 15781341
    PML is critical for ND10 formation and recruits the PML-interacting protein daxx to this nuclear structure when modified by SUMO-1.
    Ishov AM, Sotnikov AG, Negorev D, Vladimirova OV, Neff N, Kamitani T, Yeh ET, Strauss JF 3rd, Maul GG.
    J Cell Biol. 1999 Oct 18;147(2):221-34.
    PMID 10525530
    Heterochromatin and ND10 are cell-cycle regulated and phosphorylation-dependent alternate nuclear sites of the transcription repressor Daxx and SWI/SNF protein ATRX.
    Ishov AM, Vladimirova OV, Maul GG.
    J Cell Sci. 2004 Aug 1;117(Pt 17):3807-20. Epub 2004 Jul 13.
    PMID 15252119
    Modification of Daxx by small ubiquitin-related modifier-1.
    Jang MS, Ryu SW, Kim E.
    Biochem Biophys Res Commun. 2002 Jul 12;295(2):495-500.
    PMID 12150977
    Critical roles for JNK, c-Jun, and Fas/FasL-Signaling in vitamin E analog-induced apoptosis in human prostate cancer cells.
    Jia L, Yu W, Wang P, Li J, Sanders BG, Kline K.
    Prostate. 2008 Mar 1;68(4):427-41.
    PMID 18196534
    Physical interactions and functional coupling between Daxx and sodium hydrogen exchanger 1 in ischemic cell death.
    Jung YS, Kim HY, Kim J, Lee MG, Pouyssegur J, Kim E.
    J Biol Chem. 2008 Jan 11;283(2):1018-25. Epub 2007 Nov 14.
    PMID 18003619
    Interaction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell death.
    Junn E, Taniguchi H, Jeong BS, Zhao X, Ichijo H, Mouradian MM.
    Proc Natl Acad Sci U S A. 2005 Jul 5;102(27):9691-6. Epub 2005 Jun 27.
    PMID 15983381
    Essential requirement for caspase-8/FLICE in the initiation of the Fas-induced apoptotic cascade.
    Juo P, Kuo CJ, Yuan J, Blenis J.
    Curr Biol. 1998 Sep 10;8(18):1001-8.
    PMID 9740801
    Proteasome inhibitor MG132 blocks viral DNA replication and assembly of human cytomegalovirus.
    Kaspari M, Tavalai N, Stamminger T, Zimmermann A, Schilf R, Bogner E.
    FEBS Lett. 2008 Mar 5;582(5):666-72. Epub 2008 Jan 31.
    PMID 18242185
    ZIP kinase triggers apoptosis from nuclear PML oncogenic domains.
    Kawai T, Akira S, Reed JC.
    Mol Cell Biol. 2003 Sep;23(17):6174-86.
    PMID 12917339
    Daxx is required for stress-induced cell death and JNK activation.
    Khelifi AF, D'Alcontres MS, Salomoni P.
    Cell Death Differ. 2005 Jul;12(7):724-33.
    PMID 15861194
    Identification of Daxx interacting with p73, one of the p53 family, and its regulation of p53 activity by competitive interaction with PML.
    Kim EJ, Park JS, Um SJ.
    Nucleic Acids Res. 2003 Sep 15;31(18):5356-67.
    PMID 12954772
    Upregulation of Daxx mediates apoptosis in response to oxidative stress.
    Kim KS, Hwang HA, Chae SK, Ha H, Kwon KS.
    J Cell Biochem. 2005 Oct 1;96(2):330-8.
    PMID 16088932
    Long form of cellular FLICE-inhibitory protein interacts with Daxx and prevents Fas-induced JNK activation.
    Kim YY, Park BJ, Seo GJ, Lim JY, Lee SM, Kimm KC, Park C, Kim J, Park SI.
    Biochem Biophys Res Commun. 2003 Dec 12;312(2):426-33.
    PMID 14637155
    Cloning and expression of primate Daxx cDNAs and mapping of the human gene to chromosome 6p21.3 in the MHC region.
    Kiriakidou M, Driscoll DA, Lopez-Guisa JM, Strauss JF 3rd.
    DNA Cell Biol. 1997 Nov;16(11):1289-98.
    PMID 9407001
    Release of RASSF1C from the nucleus by Daxx degradation links DNA damage and SAPK/JNK activation.
    Kitagawa D, Kajiho H, Negishi T, Ura S, Watanabe T, Wada T, Ichijo H, Katada T, Nishina H.
    EMBO J. 2006 Jul 26;25(14):3286-97. Epub 2006 Jun 29.
    PMID 16810318
    Apoptosis signal-regulating kinase 1 controls the proapoptotic function of death-associated protein (Daxx) in the cytoplasm.
    Ko YG, Kang YS, Park H, Seol W, Kim J, Kim T, Park HS, Choi EJ, Kim S.
    J Biol Chem. 2001 Oct 19;276(42):39103-6. Epub 2001 Aug 8.
    PMID 11495919
    SUMO modification negatively modulates the transcriptional activity of CREB-binding protein via the recruitment of Daxx.
    Kuo HY, Chang CC, Jeng JC, Hu HM, Lin DY, Maul GG, Kwok RP, Shih HM.
    Proc Natl Acad Sci U S A. 2005 Nov 22;102(47):16973-8. Epub 2005 Nov 15.
    PMID 16287980
    BTB domain-containing speckle-type POZ protein (SPOP) serves as an adaptor of Daxx for ubiquitination by Cul3-based ubiquitin ligase.
    Kwon JE, La M, Oh KH, Oh YM, Kim GR, Seol JH, Baek SH, Chiba T, Tanaka K, Bang OS, Joe CO, Chung CH.
    J Biol Chem. 2006 May 5;281(18):12664-72. Epub 2006 Mar 8.
    PMID 16524876
    Daxx-mediated transcriptional repression of MMP1 gene is reversed by SPOP.
    La M, Kim K, Park J, Won J, Lee JH, Fu YM, Meadows GG, Joe CO.
    Biochem Biophys Res Commun. 2004 Jul 30;320(3):760-5.
    PMID 15240113
    The insulin-sensitive glucose transporter, GLUT4, interacts physically with Daxx. Two proteins with capacity to bind Ubc9 and conjugated to SUMO1.
    Lalioti VS, Vergarajauregui S, Pulido D, Sandoval IV.
    J Biol Chem. 2002 May 31;277(22):19783-91. Epub 2002 Feb 12.
    PMID 11842083
    Regulation of Pax3 transcriptional activity by SUMO-1-modified PML.
    Lehembre F, Muller S, Pandolfi PP, Dejean A.
    Oncogene. 2001 Jan 4;20(1):1-9.
    PMID 11244500
    CGI-55 interacts with nuclear proteins and co-localizes to p80-coilin positive-coiled bodies in the nucleus.
    Lemos TA, Kobarg J.
    Cell Biochem Biophys. 2006;44(3):463-74.
    PMID 16679534
    HGF/SF regulates expression of apoptotic genes in MCF-10A human mammary epithelial cells.
    Leroy C, Deheuninck J, Reveneau S, Foveau B, Ji Z, Villenet C, Quief S, Tulasne D, Kerckaert JP, Fafeur V.
    Ann N Y Acad Sci. 2006 Dec;1090:188-202.
    PMID 17384262
    Sequestration and inhibition of Daxx-mediated transcriptional repression by PML.
    Li H, Leo C, Zhu J, Wu X, O'Neil J, Park EJ, Chen JD.
    Mol Cell Biol. 2000 Mar;20(5):1784-96.
    PMID 10669754
    EAP1/Daxx interacts with ETS1 and represses transcriptional activation of ETS1 target genes.
    Li R, Pei H, Watson DK, Papas TS.
    Oncogene. 2000 Feb 10;19(6):745-53.
    PMID 10698492
    Hantavirus nucleocapsid protein interacts with the Fas-mediated apoptosis enhancer Daxx.
    Li XD, Makela TP, Guo D, Soliymani R, Koistinen V, Vapalahti O, Vaheri A, Lankinen H.
    J Gen Virol. 2002 Apr;83(Pt 4):759-66.
    PMID 11907324
    Effect of sinomenine on gene expression of the IL-1 beta-activated human synovial sarcoma.
    Li XJ, Yue PY, Ha WY, Wong DY, Tin MM, Wang PX, Wong RN, Liu L.
    Life Sci. 2006 Jul 10;79(7):665-73. Epub 2006 Mar 6.
    PMID 16566946
    Sensitization to Fas-mediated apoptosis by dengue virus capsid protein.
    Limjindaporn T, Netsawang J, Noisakran S, Thiemmeca S, Wongwiwat W, Sudsaward S, Avirutnan P, Puttikhunt C, Kasinrerk W, Sriburi R, Sittisombut N, Yenchitsomanus PT, Malasit P.
    Biochem Biophys Res Commun. 2007 Oct 19;362(2):334-9. Epub 2007 Aug 13.
    PMID 17707345
    Negative modulation of androgen receptor transcriptional activity by Daxx.
    Lin DY, Fang HI, Ma AH, Huang YS, Pu YS, Jenster G, Kung HJ, Shih HM.
    Mol Cell Biol. 2004 Dec;24(24):10529-41.
    PMID 15572661
    Role of SUMO-interacting motif in Daxx SUMO modification, subnuclear localization, and repression of sumoylated transcription factors.
    Lin DY, Huang YS, Jeng JC, Kuo HY, Chang CC, Chao TT, Ho CC, Chen YC, Lin TP, Fang HI, Hung CC, Suen CS, Hwang MJ, Chang KS, Maul GG, Shih HM.
    Mol Cell. 2006 Nov 3;24(3):341-54.
    PMID 17081986
    Promyelocytic leukemia protein (PML) functions as a glucocorticoid receptor co-activator by sequestering Daxx to the PML oncogenic domains (PODs) to enhance its transactivation potential.
    Lin DY, Lai MZ, Ann DK, Shih HM.
    J Biol Chem. 2003 May 2;278(18):15958-65. Epub 2003 Feb 20.
    PMID 12595526
    Essential role of the 58-kDa microspherule protein in the modulation of Daxx-dependent transcriptional repression as revealed by nucleolar sequestration.
    Lin DY, Shih HM.
    J Biol Chem. 2002 Jul 12;277(28):25446-56. Epub 2002 Apr 10.
    PMID 11948183
    Axin bridges Daxx to p53.
    Lin SC, Li Q.
    Cell Res. 2007 Apr;17(4):301-2. Review
    PMID 17404597
    Daxx shortens mitotic arrest caused by paclitaxel.
    Lindsay CR, Scholz A, Morozov VM, Ishov AM.
    Cell Cycle. 2007 May 15;6(10):1200-4. Epub 2007 May 5.
    PMID 17471023
    [Expression of Daxx in children with acute leukemia]
    Liu J, Zhang LQ, Hu Q, Lin HH, Liu AG, Tao HF, Song YQ, Zhang XL.
    Zhongguo Dang Dai Er Ke Za Zhi. 2007 Feb;9(1):33-6.
    PMID 17306074
    Overexpression of promyelocytic leukemia protein precludes the dispersal of ND10 structures and has no effect on accumulation of infectious herpes simplex virus 1 or its proteins.
    Lopez P, Jacob RJ, Roizman B.
    J Virol. 2002 Sep;76(18):9355-67.
    PMID 12186918
    Gene control in germinal differentiation: RNF6, a transcription regulatory protein in the mouse sertoli cell.
    Lopez P, Vidal F, Martin L, Lopez-Fernandez LA, Rual JF, Rosen BS, Cuzin F, Rassoulzadegan M.
    Mol Cell Biol. 2002 May;22(10):3488-96.
    PMID 11971979
    Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.
    Maruyama K, Sugano S.
    Gene. 1994 Jan 28;138(1-2):171-4.
    PMID 8125298
    Differences between mouse and human cytomegalovirus interactions with their respective hosts at immediate early times of the replication cycle.
    Maul GG, Negorev D.
    Med Microbiol Immunol. 2008 Jun;197(2):241-9. Epub 2008 Feb 9. Review
    PMID 18264718
    Modification of nuclear PML protein by SUMO-1 regulates Fas-induced apoptosis in rheumatoid arthritis synovial fibroblasts.
    Meinecke I, Cinski A, Baier A, Peters MA, Dankbar B, Wille A, Drynda A, Mendoza H, Gay RE, Hay RT, Ink B, Gay S, Pap T.
    Proc Natl Acad Sci U S A. 2007 Mar 20;104(12):5073-8. Epub 2007 Mar 14.
    PMID 17360386
    RNAi reveals anti-apoptotic and transcriptionally repressive activities of DAXX.
    Michaelson JS, Leder P.
    J Cell Sci. 2003 Jan 15;116(Pt 2):345-52.
    PMID 12482920
    Overexpression of a dominant-negative mutant Ubc9 is associated with increased sensitivity to anticancer drugs.
    Mo YY, Yu Y, Ee PL, Beck WT.
    Cancer Res. 2004 Apr 15;64(8):2793-8.
    PMID 15087395
    The DNA sequence and analysis of human chromosome 6.
    Mungall AJ, Palmer SA, Sims SK, Edwards CA, Ashurst JL, Wilming L, Jones MC, Horton R, Hunt SE, Scott CE, Gilbert JG, Clamp ME, Bethel G, Milne S, Ainscough R, Almeida JP, Ambrose KD, Andrews TD, Ashwell RI, Babbage AK, Bagguley CL, Bailey J, Banerjee R, Barker DJ, Barlow KF, Bates K, Beare DM, Beasley H, Beasley O, Bird CP, Blakey S, Bray-Allen S, Brook J, Brown AJ, Brown JY, Burford DC, Burrill W, Burton J, Carder C, Carter NP, Chapman JC, Clark SY, Clark G, Clee CM, Clegg S, Cobley V, Collier RE, Collins JE, Colman LK, Corby NR, Coville GJ, Culley KM, Dhami P, Davies J, Dunn M, Earthrowl ME, Ellington AE, Evans KA, Faulkner L, Francis MD, Frankish A, Frankland J, French L, Garner P, Garnett J, Ghori MJ, Gilby LM, Gillson CJ, Glithero RJ, Grafham DV, Grant M, Gribble S, Griffiths C, Griffiths M, Hall R, Halls KS, Hammond S, Harley JL, Hart EA, Heath PD, Heathcott R, Holmes SJ, Howden PJ, Howe KL, Howell GR, Huckle E, Humphray SJ, Humphries MD, Hunt AR, Johnson CM, Joy AA, Kay M, Keenan SJ, Kimberley AM, King A, Laird GK, Langford C, Lawlor S, Leongamornlert DA, Leversha M, Lloyd CR, Lloyd DM, Loveland JE, Lovell J, Martin S, Mashreghi-Mohammadi M, Maslen GL, Matthews L, McCann OT, McLaren SJ, McLay K, McMurray A, Moore MJ, Mullikin JC, Niblett D, Nickerson T, Novik KL, Oliver K, Overton-Larty EK, Parker A, Patel R, Pearce AV, Peck AI, Phillimore B, Phillips S, Plumb RW, Porter KM, Ramsey Y, Ranby SA, Rice CM, Ross MT, Searle SM, Sehra HK, Sheridan E, Skuce CD, Smith S, Smith M, Spraggon L, Squares SL, Steward CA, Sycamore N, Tamlyn-Hall G, Tester J, Theaker AJ, Thomas DW, Thorpe A, Tracey A, Tromans A, Tubby B, Wall M, Wallis JM, West AP, White SS, Whitehead SL, Whittaker H, Wild A, Willey DJ, Wilmer TE, Wood JM, Wray PW, Wyatt JC, Young L, Younger RM, Bentley DR, Coulson A, Durbin R, Hubbard T, Sulston JE, Dunham I, Rogers J, Beck S.
    Nature. 2003 Oct 23;425(6960):805-11.
    PMID 14574404
    Ets-1-dependent expression of vascular endothelial growth factor receptors is activated by latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus through interaction with Daxx.
    Murakami Y, Yamagoe S, Noguchi K, Takebe Y, Takahashi N, Uehara Y, Fukazawa H.
    J Biol Chem. 2006 Sep 22;281(38):28113-21. Epub 2006 Jul 20.
    PMID 16861237
    Physical and functional interactions between Daxx and STAT3.
    Muromoto R, Nakao K, Watanabe T, Sato N, Sekine Y, Sugiyama K, Oritani K, Shimoda K, Matsuda T.
    Oncogene. 2006 Mar 30;25(14):2131-6.
    PMID 16331268
    Evidence for the interaction of the regulatory protein Ki-1/57 with p53 and its interacting proteins.
    Nery FC, Rui E, Kuniyoshi TM, Kobarg J.
    Biochem Biophys Res Commun. 2006 Mar 17;341(3):847-55. Epub 2006 Jan 23.
    PMID 16455055
    Proapoptotic role of Hsp90 by its interaction with c-Jun N-terminal kinase in lipid rafts in edelfosine-mediated antileukemic therapy.
    Nieto-Miguel T, Gajate C, Gonzalez-Camacho F, Mollinedo F.
    Oncogene. 2008 Mar 13;27(12):1779-87. Epub 2007 Sep 24.
    PMID 17891170
    Inhibition of stress-inducible kinase pathways by tumorigenic mutant p53.
    Ohiro Y, Usheva A, Kobayashi S, Duffy SL, Nantz R, Gius D, Horikoshi N.
    Mol Cell Biol. 2003 Jan;23(1):322-34.
    PMID 12482984
    Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
    Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M.
    Cell. 2006 Nov 3;127(3):635-48.
    PMID 17081983
    Inhibition of NF-kappaB acetylation and its transcriptional activity by Daxx.
    Park J, Lee JH, La M, Jang MJ, Chae GW, Kim SB, Tak H, Jung Y, Byun B, Ahn JK, Joe CO.
    J Mol Biol. 2007 Apr 27;368(2):388-97. Epub 2007 Feb 22.
    PMID 17362989
    TGF-beta-induced apoptosis is mediated by the adapter protein Daxx that facilitates JNK activation.
    Perlman R, Schiemann WP, Brooks MW, Lodish HF, Weinberg RA.
    Nat Cell Biol. 2001 Aug;3(8):708-14.
    PMID 11483955
    Interphase-specific association of intrinsic centromere protein CENP-C with HDaxx, a death domain-binding protein implicated in Fas-mediated cell death.
    Pluta AF, Earnshaw WC, Goldberg IG.
    J Cell Sci. 1998 Jul 30;111 ( Pt 14):2029-41.
    PMID 9645950
    Identification of cellular proteins that maintain retroviral epigenetic silencing: evidence for an antiviral response.
    Poleshko A, Palagin I, Zhang R, Boimel P, Castagna C, Adams PD, Skalka AM, Katz RA.
    J Virol. 2008 Mar;82(5):2313-23. Epub 2007 Dec 19.
    PMID 18094192
    Role of the cellular protein hDaxx in human cytomegalovirus immediate-early gene expression.
    Preston CM, Nicholl MJ.
    J Gen Virol. 2006 May;87(Pt 5):1113-21.
    PMID 16603511
    Daxx represses RelB target promoters via DNA methyltransferase recruitment and DNA hypermethylation.
    Puto LA, Reed JC.
    Genes Dev. 2008 Apr 15;22(8):998-1010.
    PMID 18413714
    Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport.
    Reuter TY, Medhurst AL, Waisfisz Q, Zhi Y, Herterich S, Hoehn H, Gross HJ, Joenje H, Hoatlin ME, Mathew CG, Huber PA.
    Exp Cell Res. 2003 Oct 1;289(2):211-21.
    PMID 14499622
    FIST/HIPK3: a Fas/FADD-interacting serine/threonine kinase that induces FADD phosphorylation and inhibits fas-mediated Jun NH(2)-terminal kinase activation.
    Rochat-Steiner V, Becker K, Micheau O, Schneider P, Burns K, Tschopp J.
    J Exp Med. 2000 Oct 16;192(8):1165-74.
    PMID 11034606
    A suppressive role of the prolyl isomerase Pin1 in cellular apoptosis mediated by the death-associated protein Daxx.
    Ryo A, Hirai A, Nishi M, Liou YC, Perrem K, Lin SC, Hirano H, Lee SW, Aoki I.
    J Biol Chem. 2007 Dec 14;282(50):36671-81. Epub 2007 Oct 15.
    PMID 17938171
    Interaction of Daxx, a Fas binding protein, with sentrin and Ubc9.
    Ryu SW, Chae SK, Kim E.
    Biochem Biophys Res Commun. 2000 Dec 9;279(1):6-10.
    PMID 11112409
    Human cytomegalovirus gene expression is silenced by Daxx-mediated intrinsic immune defense in model latent infections established in vitro.
    Saffert RT, Kalejta RF.
    J Virol. 2007 Sep;81(17):9109-20. Epub 2007 Jun 27.
    PMID 17596307
    Daxx: death or survival protein?
    Salomoni P, Khelifi AF.
    Trends Cell Biol. 2006 Feb;16(2):97-104. Epub 2006 Jan 10.
    PMID 16406523
    4-Hydroxynonenal self-limits fas-mediated DISC-independent apoptosis by promoting export of Daxx from the nucleus to the cytosol and its binding to Fas.
    Sharma R, Sharma A, Dwivedi S, Zimniak P, Awasthi S, Awasthi YC.
    Biochemistry. 2008 Jan 8;47(1):143-56. Epub 2007 Dec 11.
    PMID 18069800
    Daxx mediates SUMO-dependent transcriptional control and subnuclear compartmentalization.
    Shih HM, Chang CC, Kuo HY, Lin DY.
    Biochem Soc Trans. 2007 Dec;35(Pt 6):1397-400.
    PMID 18031230
    Dissociation of Akt1 from its negative regulator JIP1 is mediated through the ASK1-MEK-JNK signal transduction pathway during metabolic oxidative stress: a negative feedback loop.
    Song JJ, Lee YJ.
    J Cell Biol. 2005 Jul 4;170(1):61-72.
    PMID 15998799
    [Monoclonal antibodies against protein Daxx and its localization in nuclear domains 10]
    Sotnikov AG, Negorev D, Ishov AM, Maul GG.
    Tsitologiia. 2001;43(12):1123-9.
    PMID 11881150
    Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
    Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA; Mammalian Gene Collection Program Team.
    Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
    PMID 12477932
    Anti-apoptotic effects of probucol are associated with downregulation of Daxx expression in THP-1 macrophage.
    Su B, Yang YB, Tuo QH, Zhu BY, Lei XY, Yin W, Liao DF.
    Cardiovasc Drugs Ther. 2007 Feb;21(1):37-45. Epub 2007 Mar 17.
    PMID 17370120
    Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.
    Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S.
    Gene. 1997 Oct 24;200(1-2):149-56.
    PMID 9373149
    PML nuclear bodies and apoptosis.
    Takahashi Y, Lallemand-Breitenbach V, Zhu J, de The H.
    Oncogene. 2004 Apr 12;23(16):2819-24. Review
    PMID 15077145
    The death domain-associated protein modulates activity of the transcription co-factor Skip/NcoA62.
    Tang J, Chang HY, Yang X.
    FEBS Lett. 2005 May 23;579(13):2883-90.
    PMID 15878163
    A novel transcription regulatory complex containing death domain-associated protein and the ATR-X syndrome protein.
    Tang J, Wu S, Liu H, Stratt R, Barak OG, Shiekhattar R, Picketts DJ, Yang X.
    J Biol Chem. 2004 May 7;279(19):20369-77. Epub 2004 Feb 27.
    PMID 14990586
    Nuclear domain 10 components promyelocytic leukemia protein and hDaxx independently contribute to an intrinsic antiviral defense against human cytomegalovirus infection.
    Tavalai N, Papior P, Rechter S, Stamminger T.
    J Virol. 2008 Jan;82(1):126-37. Epub 2007 Oct 17.
    PMID 17942542
    Human Daxx regulates Fas-induced apoptosis from nuclear PML oncogenic domains (PODs).
    Torii S, Egan DA, Evans RA, Reed JC.
    EMBO J. 1999 Nov 1;18(21):6037-49.
    PMID 10545115
    Effect of Daxx on cholesterol accumulation in hepatic cells.
    Tuo QH, Liang L, Zhu BY, Cao X, Liao DF.
    World J Gastroenterol. 2008 Jan 21;14(3):435-40.
    PMID 18200667
    Physiological and functional interactions between Tcf4 and Daxx in colon cancer cells.
    Tzeng SL, Cheng YW, Li CH, Lin YS, Hsu HC, Kang JJ.
    J Biol Chem. 2006 Jun 2;281(22):15405-11. Epub 2006 Mar 28.
    PMID 16569639
    Fas ligand-induced c-Jun kinase activation in lymphoid cells requires extensive receptor aggregation but is independent of DAXX, and Fas-mediated cell death does not involve DAXX, RIP, or RAIDD.
    Villunger A, Huang DC, Holler N, Tschopp J, Strasser A.
    J Immunol. 2000 Aug 1;165(3):1337-43.
    PMID 10903735
    Human Daxx-mediated repression of human cytomegalovirus gene expression correlates with a repressive chromatin structure around the major immediate early promoter.
    Woodhall DL, Groves IJ, Reeves MB, Wilkinson G, Sinclair JH.
    J Biol Chem. 2006 Dec 8;281(49):37652-60. Epub 2006 Oct 11.
    PMID 17035242
    Ultraviolet radiation-induced apoptosis is mediated by Daxx.
    Wu S, Loke HN, Rehemtulla A.
    Neoplasia. 2002 Nov-Dec;4(6):486-92.
    PMID 12407442
    The ATRX syndrome protein forms a chromatin-remodeling complex with Daxx and localizes in promyelocytic leukemia nuclear bodies.
    Xue Y, Gibbons R, Yan Z, Yang D, McDowell TL, Sechi S, Qin J, Zhou S, Higgs D, Wang W.
    Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):10635-40. Epub 2003 Sep 2.
    PMID 12953102
    Daxx, a novel Fas-binding protein that activates JNK and apoptosis.
    Yang X, Khosravi-Far R, Chang HY, Baltimore D.
    Cell. 1997 Jun 27;89(7):1067-76.
    PMID 9215629
    Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling.
    Yeoh EJ, Ross ME, Shurtleff SA, Williams WK, Patel D, Mahfouz R, Behm FG, Raimondi SC, Relling MV, Patel A, Cheng C, Campana D, Wilkins D, Zhou X, Li J, Liu H, Pui CH, Evans WE, Naeve C, Wong L, Downing JR.
    Cancer Cell. 2002 Mar;1(2):133-43.
    PMID 12086872
    Daxx contains two nuclear localization signals and interacts with importin alpha3.
    Yeung PL, Chen LY, Tsai SC, Zhang A, Chen JD.
    J Cell Biochem. 2008 Feb 1;103(2):456-70.
    PMID 17661348
    Adenovirus E1B 55-kilodalton oncoprotein binds to Daxx and eliminates enhancement of p53-dependent transcription by Daxx.
    Zhao LY, Colosimo AL, Liu Y, Wan Y, Liao D.
    J Virol. 2003 Nov;77(21):11809-21.
    PMID 14557665
    Promyelocytic leukemia protein (PML) and Daxx participate in a novel nuclear pathway for apoptosis.
    Zhong S, Salomoni P, Ronchetti S, Guo A, Ruggero D, Pandolfi PP.
    J Exp Med. 2000 Feb 21;191(4):631-40.
    PMID 10684855
    Sequence variation within the major histocompatibility complex subregion centromeric of HLA class II in type 1 diabetes.
    van der Slik AR, van den Eng I, Eerligh P, Doxiadis II, Koeleman BP, Roep BO, Giphart MJ.
    Tissue Antigens. 2007 Apr;69(4):348-53.
    PMID 17389020


    This paper should be referenced as such :
    Kim, E
    DAXX (death-associated protein 6)
    Atlas Genet Cytogenet Oncol Haematol. 2009;13(12):925-931.
    Free journal version : [ pdf ]   [ DOI ]

    Other Leukemias implicated (Data extracted from papers in the Atlas) [ 3 ]
      del(6p) (loss of JARID2 and DTNBP1) in myeloid malignances
    M3::M3v acute myeloid leukemia (AML M3::M3v)
    ::Acute promyelocytic leukemia (APL)
    ::Acute promyelocytic leukemia (APL) PML::RARA

    t(1;9)(p13;p12) PAX5::HIPK1

    External links

    HGNC (Hugo)DAXX   2681
    Atlas Explorer : (Salamanque)DAXX
    Entrez_Gene (NCBI)DAXX    death domain associated protein
    AliasesBING2; DAP6; EAP1; SMIM40
    GeneCards (Weizmann)DAXX
    Ensembl hg19 (Hinxton)ENSG00000204209 [Gene_View]
    Ensembl hg38 (Hinxton)ENSG00000204209 [Gene_View]  ENSG00000204209 [Sequence]  chr6:33318558-33322959 [Contig_View]  DAXX [Vega]
    ICGC DataPortalENSG00000204209
    TCGA cBioPortalDAXX
    AceView (NCBI)DAXX
    Genatlas (Paris)DAXX
    SOURCE (Princeton)DAXX
    Genetics Home Reference (NIH)DAXX
    Genomic and cartography
    GoldenPath hg38 (UCSC)DAXX  -     chr6:33318558-33322959 -  6p21.32   [Description]    (hg38-Dec_2013)
    GoldenPath hg19 (UCSC)DAXX  -     6p21.32   [Description]    (hg19-Feb_2009)
    GoldenPathDAXX - 6p21.32 [CytoView hg19]  DAXX - 6p21.32 [CytoView hg38]
    Genome Data Viewer NCBIDAXX [Mapview hg19]  
    Gene and transcription
    Genbank (Entrez)AA533586 AB209493 AF006041 AF015956 AF039136
    RefSeq transcript (Entrez)NM_001141969 NM_001141970 NM_001254717 NM_001350
    Consensus coding sequences : CCDS (NCBI)DAXX
    Gene ExpressionDAXX [ NCBI-GEO ]   DAXX [ EBI - ARRAY_EXPRESS ]   DAXX [ SEEK ]   DAXX [ MEM ]
    Gene Expression Viewer (FireBrowse)DAXX [ Firebrowse - Broad ]
    GenevisibleExpression of DAXX in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
    BioGPS (Tissue expression)1616
    GTEX Portal (Tissue expression)DAXX
    Human Protein AtlasENSG00000204209-DAXX [pathology]   [cell]   [tissue]
    Protein : pattern, domain, 3D structure
    Domain families : Pfam (Sanger)
    Domain families : Pfam (NCBI)
    Conserved Domain (NCBI)DAXX
    Human Protein Atlas [tissue]ENSG00000204209-DAXX [tissue]
    Protein Interaction databases
    Ontologies - Pathways
    PubMed324 Pubmed reference(s) in Entrez
    GeneRIFsGene References Into Functions (Entrez)
    REVIEW articlesautomatic search in PubMed
    Last year publicationsautomatic search in PubMed

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