Atlas of Genetics and Cytogenetics in Oncology and Haematology


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DAXX (death-associated protein 6)

Identity

Other namesBING2
DAP6
EAP1
MGC126245
MGC126246
OTTHUMP00000029289
OTTHUMP00000029290
HGNC (Hugo) DAXX
LocusID (NCBI) 1616
Location 6p21.32
Location_base_pair Starts at 33286335 and ends at 33290793 bp from pter ( according to hg19-Feb_2009)  [Mapping]
 

DNA/RNA

 
Description Daxx gene has 8 exons on chromosome 6. The sizes of the exons are 66, 256, 832, 212, 214, 475, 223 and 191 bps.
Transcription 2,477 bp mRNA.
Two alternative transcripts:
1. Isoform 1 has been chosen as the canonical sequence
2. Isoform 2 differs from the canonical sequence as follows:
696-740: SSLCIPSPARLSQTPHSQPPRPGTCKTSVATQCDPEEIIVLSDSDPAKNLGRRRSKQDQG

Protein

 
Description 740 amino acids, 82.2 kDa; contains in 3 coiled coils (residues 180-217, 358-399 and 430-489), and 2 nuclear localisation signals (residues 391-395 and 628-634).
Expression Ubiquitous.
Localisation Nucleus and cytoplasm.
Note: Dispersed throughout the nucleoplasm, in PML/POD/ND10 nuclear bodies, and in nucleoli.
Colocalizes with a subset of interphase centromeres, but is absent from mitotic centromeres.
Detected in the cytoplasmic punctate structures.
Translocated from the nucleus to the cytoplasm upon glucose deprivation or ischemic stress.
Function
  • Interaction with Fas death domain and induces Fas-mediated cell death.
  • Establishes Fas-Daxx-ASK1-JNK axis.
  • Implicated in ischemic cell death. Daxx translocates from the nucleus to the cytoplasm upon ischemic stress. Cytoplasmic Daxx interacts with NHE1 and stimulates the NHE1 transporter activity and suppresses the NHE1-ezrin-AKT1 pathway.
  • Associated with the PML body in the nucleus.
  • Interacts with SUMO1 and UBC9 and is sumorylated at K630 and 631. However, the sumoylation status does not determine its localization onto the PML body.
  • Mediates SUMO-dependent transcriptional control and subnuclear compartmentalization.
  • Suppresses cell death in the early embryo.
  • Daxx silencing sensitizes cells to Fas- and stress-induced cell death through caspase activation, cytochrome C release and JNK activation.
  • Homology Holomogy with Pan troglodytes (99%); Canis lupus familiaris (89%); Bos taurus (83%); Mus musculus (70%), Rattus norvegicus (73%).

    Mutations

    Note Substitutions (see the external links).

    Implicated in

    Entity Promyelocytic leukemia
    Disease Daxx is a component of the promyelocytic leukemia protein (PML) nuclear bodies (NBs).
      
    Entity Alpha-thalassemia
    Disease Daxx complex is a novel ATP-dependent chromatin-remodeling complex, with alpha-thalassaemia syndrome protein (ATRX) being the core ATPase subunit and Daxx being the targeting subunit.
      
    Entity Leukemia
    Disease Daxx protein was expressed in 38.0% of 50 children with acute leukemia, which was significantly higher than that of the control group (5.0%) (P < 0.05). Daxx expression is abnormal in children with acute leukemia and associated with some clinical features of acute leukemia, suggesting that it may play an important role in the genesis and development of acute leukemia.
      

    External links

    Nomenclature
    HGNC (Hugo)DAXX   2681
    Cards
    AtlasDAXXID40265ch6p21
    Entrez_Gene (NCBI)DAXX  1616  death-domain associated protein
    GeneCards (Weizmann)DAXX
    Ensembl (Hinxton)ENSG00000204209 [Gene_View]  chr6:33286335-33290793 [Contig_View]  DAXX [Vega]
    AceView (NCBI)DAXX
    Genatlas (Paris)DAXX
    WikiGenes1616
    SOURCE (Princeton)NM_001141969 NM_001141970 NM_001254717 NM_001350
    Genomic and cartography
    GoldenPath (UCSC)DAXX  -  6p21.32   chr6:33286335-33290793 -  6p21.3   [Description]    (hg19-Feb_2009)
    EnsemblDAXX - 6p21.3 [CytoView]
    Mapping of homologs : NCBIDAXX [Mapview]
    OMIM603186   
    Gene and transcription
    Genbank (Entrez)AA533586 AB209493 AF006041 AF015956 AF039136
    RefSeq transcript (Entrez)NM_001141969 NM_001141970 NM_001254717 NM_001350
    RefSeq genomic (Entrez)AC_000138 NC_000006 NC_018917 NT_007592 NT_113891 NT_167245 NT_167247 NT_167248 NW_001838980 NW_004929326
    Consensus coding sequences : CCDS (NCBI)DAXX
    Cluster EST : UnigeneHs.336916 [ NCBI ]
    CGAP (NCI)Hs.336916
    Alternative Splicing : Fast-db (Paris)GSHG0026520
    Alternative Splicing GalleryENSG00000204209
    Gene ExpressionDAXX [ NCBI-GEO ]     DAXX [ SEEK ]   DAXX [ MEM ]
    Protein : pattern, domain, 3D structure
    UniProt/SwissProtQ9UER7 (Uniprot)
    NextProtQ9UER7  [Medical]
    With graphics : InterProQ9UER7
    Splice isoforms : SwissVarQ9UER7 (Swissvar)
    Domains : Interpro (EBI)Daxx   
    Related proteins : CluSTrQ9UER7
    Domain families : Pfam (Sanger)Daxx (PF03344)   
    Domain families : Pfam (NCBI)pfam03344   
    DMDM Disease mutations1616
    Blocks (Seattle)Q9UER7
    PDB (SRS)2KQS    2KZS    2KZU    4H9N    4H9O    4H9P    4H9Q    4H9R    4H9S    4HGA   
    PDB (PDBSum)2KQS    2KZS    2KZU    4H9N    4H9O    4H9P    4H9Q    4H9R    4H9S    4HGA   
    PDB (IMB)2KQS    2KZS    2KZU    4H9N    4H9O    4H9P    4H9Q    4H9R    4H9S    4HGA   
    PDB (RSDB)2KQS    2KZS    2KZU    4H9N    4H9O    4H9P    4H9Q    4H9R    4H9S    4HGA   
    Human Protein AtlasENSG00000204209
    Peptide AtlasQ9UER7
    HPRD04424
    IPIIPI00170867   IPI00220885   IPI00642750   IPI01009417   IPI00915456   IPI00640563   IPI00644413   
    Protein Interaction databases
    DIP (DOE-UCLA)Q9UER7
    IntAct (EBI)Q9UER7
    FunCoupENSG00000204209
    BioGRIDDAXX
    InParanoidQ9UER7
    Interologous Interaction database Q9UER7
    IntegromeDBDAXX
    STRING (EMBL)DAXX
    Ontologies - Pathways
    Ontology : AmiGOmitotic cytokinesis  chromosome, centromeric region  heterochromatin  p53 binding  receptor signaling protein activity  protein binding  nucleus  nucleus  nucleolus  cytoplasm  cytosol  transcription, DNA-templated  regulation of transcription, DNA-dependent  apoptotic process  activation of JUN kinase activity  transcription factor binding  extrinsic apoptotic signaling pathway via death domain receptors  PML body  PML body  modulation by virus of host morphology or physiology  enzyme binding  androgen receptor signaling pathway  heat shock protein binding  regulation of protein ubiquitination  ubiquitin protein ligase binding  protein homodimerization activity  negative regulation of transcription, DNA-dependent  protein N-terminus binding  androgen receptor binding  
    Ontology : EGO-EBImitotic cytokinesis  chromosome, centromeric region  heterochromatin  p53 binding  receptor signaling protein activity  protein binding  nucleus  nucleus  nucleolus  cytoplasm  cytosol  transcription, DNA-templated  regulation of transcription, DNA-dependent  apoptotic process  activation of JUN kinase activity  transcription factor binding  extrinsic apoptotic signaling pathway via death domain receptors  PML body  PML body  modulation by virus of host morphology or physiology  enzyme binding  androgen receptor signaling pathway  heat shock protein binding  regulation of protein ubiquitination  ubiquitin protein ligase binding  protein homodimerization activity  negative regulation of transcription, DNA-dependent  protein N-terminus binding  androgen receptor binding  
    Pathways : BIOCARTAFAS signaling pathway ( CD95 ) [Genes]    Keratinocyte Differentiation [Genes]    MAPKinase Signaling Pathway [Genes]    Stress Induction of HSP Regulation [Genes]    Regulation of transcriptional activity by PML [Genes]    HIV-I Nef: negative effector of Fas and TNF [Genes]    p38 MAPK Signaling Pathway [Genes]   
    Pathways : KEGGMAPK signaling pathway    Amyotrophic lateral sclerosis (ALS)    Herpes simplex infection   
    REACTOMEDAXX
    Protein Interaction DatabaseDAXX
    Wikipedia pathwaysDAXX
    Gene fusion - rearrangments
    Polymorphisms : SNP, mutations, diseases
    SNP Single Nucleotide Polymorphism (NCBI)DAXX
    SNP (GeneSNP Utah)DAXX
    SNP : HGBaseDAXX
    Genetic variants : HAPMAPDAXX
    1000_GenomesDAXX 
    ICGC programENSG00000204209 
    Cancer Gene: CensusDAXX 
    Somatic Mutations in Cancer : COSMICDAXX 
    CONAN: Copy Number AnalysisDAXX 
    Mutations and Diseases : HGMDDAXX
    OMIM603186   
    GENETestsDAXX
    Disease Genetic AssociationDAXX
    Huge Navigator DAXX [HugePedia]  DAXX [HugeCancerGEM]
    Genomic VariantsDAXX  DAXX [DGVbeta]
    Exome VariantDAXX
    dbVarDAXX
    ClinVarDAXX
    snp3D : Map Gene to Disease1616
    General knowledge
    Homologs : HomoloGeneDAXX
    Homology/Alignments : Family Browser (UCSC)DAXX
    Phylogenetic Trees/Animal Genes : TreeFamDAXX
    Chemical/Protein Interactions : CTD1616
    Chemical/Pharm GKB GenePA27148
    Clinical trialDAXX
    Cancer Resource (Charite)ENSG00000204209
    Other databases
    Probes
    Litterature
    PubMed201 Pubmed reference(s) in Entrez
    CoreMineDAXX
    iHOPDAXX

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    EAP1/Daxx interacts with ETS1 and represses transcriptional activation of ETS1 target genes.
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    FIST/HIPK3: a Fas/FADD-interacting serine/threonine kinase that induces FADD phosphorylation and inhibits fas-mediated Jun NH(2)-terminal kinase activation.
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    J Exp Med. 2000 Oct 16;192(8):1165-74.
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    Interaction of Daxx, a Fas binding protein, with sentrin and Ubc9.
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    Fas ligand-induced c-Jun kinase activation in lymphoid cells requires extensive receptor aggregation but is independent of DAXX, and Fas-mediated cell death does not involve DAXX, RIP, or RAIDD.
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    TGF-beta-induced apoptosis is mediated by the adapter protein Daxx that facilitates JNK activation.
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    Daxx and histone deacetylase II associate with chromatin through an interaction with core histones and the chromatin-associated protein Dek.
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    The insulin-sensitive glucose transporter, GLUT4, interacts physically with Daxx. Two proteins with capacity to bind Ubc9 and conjugated to SUMO1.
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    Ultraviolet radiation-induced apoptosis is mediated by Daxx.
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    Daxx silencing sensitizes cells to multiple apoptotic pathways.
    Chen LY, Chen JD.
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    PMID 14517282
     
    Synergistic effects of chemotherapeutic drugs in lymphoma cells are associated with down-regulation of inhibitor of apoptosis proteins (IAPs), prostate-apoptosis-response-gene 4 (Par-4), death-associated protein (Daxx) and with enforced caspase activation.
    Chow KU, Nowak D, Boehrer S, Ruthardt M, Knau A, Hoelzer D, Mitrou PS, Weidmann E.
    Biochem Pharmacol. 2003 Sep 1;66(5):711-24.
    PMID 12948851
     
    Homeodomain-interacting protein kinase 1 modulates Daxx localization, phosphorylation, and transcriptional activity.
    Ecsedy JA, Michaelson JS, Leder P.
    Mol Cell Biol. 2003 Feb;23(3):950-60.
    PMID 12529400
     
    HIPK2 regulates transforming growth factor-beta-induced c-Jun NH(2)-terminal kinase activation and apoptosis in human hepatoma cells.
    Hofmann TG, Stollberg N, Schmitz ML, Will H.
    Cancer Res. 2003 Dec 1;63(23):8271-7.
    PMID 14678985
     
    ZIP kinase triggers apoptosis from nuclear PML oncogenic domains.
    Kawai T, Akira S, Reed JC.
    Mol Cell Biol. 2003 Sep;23(17):6174-86.
    PMID 12917339
     
    Identification of Daxx interacting with p73, one of the p53 family, and its regulation of p53 activity by competitive interaction with PML.
    Kim EJ, Park JS, Um SJ.
    Nucleic Acids Res. 2003 Sep 15;31(18):5356-67.
    PMID 12954772
     
    Long form of cellular FLICE-inhibitory protein interacts with Daxx and prevents Fas-induced JNK activation.
    Kim YY, Park BJ, Seo GJ, Lim JY, Lee SM, Kimm KC, Park C, Kim J, Park SI.
    Biochem Biophys Res Commun. 2003 Dec 12;312(2):426-33.
    PMID 14637155
     
    Promyelocytic leukemia protein (PML) functions as a glucocorticoid receptor co-activator by sequestering Daxx to the PML oncogenic domains (PODs) to enhance its transactivation potential.
    Lin DY, Lai MZ, Ann DK, Shih HM.
    J Biol Chem. 2003 May 2;278(18):15958-65. Epub 2003 Feb 20.
    PMID 12595526
     
    The DNA sequence and analysis of human chromosome 6.
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    RNAi reveals anti-apoptotic and transcriptionally repressive activities of DAXX.
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    Inhibition of stress-inducible kinase pathways by tumorigenic mutant p53.
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    Mol Cell Biol. 2003 Jan;23(1):322-34.
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    Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport.
    Reuter TY, Medhurst AL, Waisfisz Q, Zhi Y, Herterich S, Hoehn H, Gross HJ, Joenje H, Hoatlin ME, Mathew CG, Huber PA.
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    Effect of glucose concentration on activation of the ASK1-SEK1-JNK1 signal transduction pathway.
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    Role of the ASK1-SEK1-JNK1-HIPK1 signal in Daxx trafficking and ASK1 oligomerization.
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    Catalase, but not MnSOD, inhibits glucose deprivation-activated ASK1-MEK-MAPK signal transduction pathway and prevents relocalization of Daxx: hydrogen peroxide as a major second messenger of metabolic oxidative stress.
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    J Cell Biochem. 2003 Oct 1;90(2):304-14.
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    The ATRX syndrome protein forms a chromatin-remodeling complex with Daxx and localizes in promyelocytic leukemia nuclear bodies.
    Xue Y, Gibbons R, Yan Z, Yang D, McDowell TL, Sechi S, Qin J, Zhou S, Higgs D, Wang W.
    Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):10635-40. Epub 2003 Sep 2.
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    Adenovirus E1B 55-kilodalton oncoprotein binds to Daxx and eliminates enhancement of p53-dependent transcription by Daxx.
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    Large-scale characterization of HeLa cell nuclear phosphoproteins.
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    Proc Natl Acad Sci U S A. 2004 Aug 17;101(33):12130-5. Epub 2004 Aug 9.
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    Nuclear localization but not PML protein is required for incorporation of the papillomavirus minor capsid protein L2 into virus-like particles.
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    J Virol. 2004 Feb;78(3):1121-8.
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    In the erythroleukemic cell line HEL Prostate-apoptosis-response-gene-4 (par-4) fails to down-regulate Bcl-2 and to promote apoptosis.
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    Leuk Lymphoma. 2004 Jul;45(7):1445-51.
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    In malignant myeloid cells expression of Daxx downregulates expression of p53 and of the inhibitors of apoptosis proteins.
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    Hematol J. 2004;5(6):513-8.
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    In bcr-abl-positive myeloid cells resistant to conventional chemotherapeutic agents, expression of Par-4 increases sensitivity to imatinib (STI571) and histone deacetylase-inhibitors.
    Brieger A, Boehrer S, Schaaf S, Nowak D, Ruthardt M, Kim SZ, Atadja P, Hoelzer D, Mitrou PS, Weidmann E, Chow KU.
    Biochem Pharmacol. 2004 Jul 1;68(1):85-93.
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    Positive regulation of apoptosis signal-regulating kinase 1 by hD53L1.
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    J Biol Chem. 2004 Apr 16;279(16):16050-6. Epub 2004 Feb 4.
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    The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
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    Genome Res. 2004 Oct;14(10B):2121-7.
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    The transcriptional repressor hDaxx potentiates p53-dependent apoptosis.
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    J Biol Chem. 2004 Nov 12;279(46):48013-23. Epub 2004 Aug 31.
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    Heterochromatin and ND10 are cell-cycle regulated and phosphorylation-dependent alternate nuclear sites of the transcription repressor Daxx and SWI/SNF protein ATRX.
    Ishov AM, Vladimirova OV, Maul GG.
    J Cell Sci. 2004 Aug 1;117(Pt 17):3807-20. Epub 2004 Jul 13.
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    Daxx-mediated transcriptional repression of MMP1 gene is reversed by SPOP.
    La M, Kim K, Park J, Won J, Lee JH, Fu YM, Meadows GG, Joe CO.
    Biochem Biophys Res Commun. 2004 Jul 30;320(3):760-5.
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    Negative modulation of androgen receptor transcriptional activity by Daxx.
    Lin DY, Fang HI, Ma AH, Huang YS, Pu YS, Jenster G, Kung HJ, Shih HM.
    Mol Cell Biol. 2004 Dec;24(24):10529-41.
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    Overexpression of a dominant-negative mutant Ubc9 is associated with increased sensitivity to anticancer drugs.
    Mo YY, Yu Y, Ee PL, Beck WT.
    Cancer Res. 2004 Apr 15;64(8):2793-8.
    PMID 15087395
     
    Physical and functional interactions between Daxx and DNA methyltransferase 1-associated protein, DMAP1.
    Muromoto R, Sugiyama K, Takachi A, Imoto S, Sato N, Yamamoto T, Oritani K, Shimoda K, Matsuda T.
    J Immunol. 2004 Mar 1;172(5):2985-93.
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    Physical and functional interactions between Daxx and TSG101.
    Muromoto R, Sugiyama K, Yamamoto T, Oritani K, Shimoda K, Matsuda T.
    Biochem Biophys Res Commun. 2004 Apr 9;316(3):827-33.
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    Tryptophan 621 and serine 667 residues of Daxx regulate its nuclear export during glucose deprivation.
    Song JJ, Lee YJ.
    J Biol Chem. 2004 Jul 16;279(29):30573-8. Epub 2004 May 5.
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    Daxx deletion mutant (amino acids 501-625)-induced apoptosis occurs through the JNK/p38-Bax-dependent mitochondrial pathway.
    Song JJ, Lee YJ.
    J Cell Biochem. 2004 Aug 15;92(6):1257-70.
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    PML nuclear bodies and apoptosis.
    Takahashi Y, Lallemand-Breitenbach V, Zhu J, de The H.
    Oncogene. 2004 Apr 12;23(16):2819-24. Review
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    A novel transcription regulatory complex containing death domain-associated protein and the ATR-X syndrome protein.
    Tang J, Wu S, Liu H, Stratt R, Barak OG, Shiekhattar R, Picketts DJ, Yang X.
    J Biol Chem. 2004 May 7;279(19):20369-77. Epub 2004 Feb 27.
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    Survival role of protein kinase C (PKC) in chronic lymphocytic leukemia and determination of isoform expression pattern and genes altered by PKC inhibition.
    Alkan S, Huang Q, Ergin M, Denning MF, Nand S, Maududi T, Paner GP, Ozpuyan F, Izban KF.
    Am J Hematol. 2005 Jun;79(2):97-106.
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    Daxx overexpression in T-lymphoblastic Jurkat cells enhances caspase-dependent death receptor- and drug-induced apoptosis in distinct ways.
    Boehrer S, Nowak D, Hochmuth S, Kim SZ, Trepohl B, Afkir A, Hoelzer D, Mitrou PS, Weidmann E, Chow KU.
    Cell Signal. 2005 May;17(5):581-95.
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    Expression of Daxx sensitizes Jurkat T-cells to the apoptosis-inducing effect of chemotherapeutic agents.
    Boehrer S, Nowak D, Kukoc-Zivojnov N, Hochmuth S, Kim SZ, Hoelzer D, Mitrou PS, Weidmann E, Chow KU.
    Pharmacol Res. 2005 Apr;51(4):367-74.
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    Interaction between the human cytomegalovirus UL82 gene product (pp71) and hDaxx regulates immediate-early gene expression and viral replication.
    Cantrell SR, Bresnahan WA.
    J Virol. 2005 Jun;79(12):7792-802.
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    Daxx mediates the small ubiquitin-like modifier-dependent transcriptional repression of Smad4.
    Chang CC, Lin DY, Fang HI, Chen RH, Shih HM.
    J Biol Chem. 2005 Mar 18;280(11):10164-73. Epub 2005 Jan 6.
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    The cellular protein daxx interacts with avian sarcoma virus integrase and viral DNA to repress viral transcription.
    Greger JG, Katz RA, Ishov AM, Maul GG, Skalka AM.
    J Virol. 2005 Apr;79(8):4610-8.
    PMID 15795247
     
    C-terminus of heat shock protein 70-interacting protein facilitates degradation of apoptosis signal-regulating kinase 1 and inhibits apoptosis signal-regulating kinase 1-dependent apoptosis.
    Hwang JR, Zhang C, Patterson C.
    Cell Stress Chaperones. 2005 Summer;10(2):147-56.
    PMID 16038411
     
    Differential effects of a novel IFN-zeta/limitin and IFN-alpha on signals for Daxx induction and Crk phosphorylation that couple with growth control of megakaryocytes.
    Ishida N, Oritani K, Shiraga M, Yoshida H, Kawamoto S, Ujiie H, Masaie H, Ichii M, Tomiyama Y, Kanakura Y.
    Exp Hematol. 2005 Apr;33(4):495-503.
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    Interaction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell death.
    Junn E, Taniguchi H, Jeong BS, Zhao X, Ichijo H, Mouradian MM.
    Proc Natl Acad Sci U S A. 2005 Jul 5;102(27):9691-6. Epub 2005 Jun 27.
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    Daxx is required for stress-induced cell death and JNK activation.
    Khelifi AF, D'Alcontres MS, Salomoni P.
    Cell Death Differ. 2005 Jul;12(7):724-33.
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    Upregulation of Daxx mediates apoptosis in response to oxidative stress.
    Kim KS, Hwang HA, Chae SK, Ha H, Kwon KS.
    J Cell Biochem. 2005 Oct 1;96(2):330-8.
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    SUMO modification negatively modulates the transcriptional activity of CREB-binding protein via the recruitment of Daxx.
    Kuo HY, Chang CC, Jeng JC, Hu HM, Lin DY, Maul GG, Kwok RP, Shih HM.
    Proc Natl Acad Sci U S A. 2005 Nov 22;102(47):16973-8. Epub 2005 Nov 15.
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    Dissociation of Akt1 from its negative regulator JIP1 is mediated through the ASK1-MEK-JNK signal transduction pathway during metabolic oxidative stress: a negative feedback loop.
    Song JJ, Lee YJ.
    J Cell Biol. 2005 Jul 4;170(1):61-72.
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    The death domain-associated protein modulates activity of the transcription co-factor Skip/NcoA62.
    Tang J, Chang HY, Yang X.
    FEBS Lett. 2005 May 23;579(13):2883-90.
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    Human cytomegalovirus (HCMV) UL82 gene product (pp71) relieves hDaxx-mediated repression of HCMV replication.
    Cantrell SR, Bresnahan WA.
    J Virol. 2006 Jun;80(12):6188-91.
    PMID 16731959
     
    [Expression of apoptosis-related proteins in the human bone marrow hematopoietic cells treated by Panax Notoginosides]
    Chen XH, Gao RL, Zhen ZY, Qian XD, Xu WH.
    Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2006 Apr;14(2):343-6.
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    DAXX interacts with phage PhiC31 integrase and inhibits recombination.
    Chen JZ, Ji CN, Xu GL, Pang RY, Yao JH, Zhu HZ, Xue JL, Jia W.
    Nucleic Acids Res. 2006;34(21):6298-304. Epub 2006 Nov 10.
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    SUMO regulates the cytoplasmonuclear transport of its target protein Daxx.
    Chen A, Wang PY, Yang YC, Huang YH, Yeh JJ, Chou YH, Cheng JT, Hong YR, Li SS.
    J Cell Biochem. 2006 Jul 1;98(4):895-911.
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    Daxx represses expression of a subset of antiapoptotic genes regulated by nuclear factor-kappaB.
    Croxton R, Puto LA, de Belle I, Thomas M, Torii S, Hanaii F, Cuddy M, Reed JC.
    Cancer Res. 2006 Sep 15;66(18):9026-35.
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    Gene expression profiling of human synovial sarcoma cell line (Hs701.T) in response to IL-1beta stimulation.
    Ha WY, Li XJ, Yue PY, Wong DY, Yue KK, Chung WS, Zhao L, Leung PY, Liu L, Wong RN.
    Inflamm Res. 2006 Jul;55(7):293-9.
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    Release of RASSF1C from the nucleus by Daxx degradation links DNA damage and SAPK/JNK activation.
    Kitagawa D, Kajiho H, Negishi T, Ura S, Watanabe T, Wada T, Ichijo H, Katada T, Nishina H.
    EMBO J. 2006 Jul 26;25(14):3286-97. Epub 2006 Jun 29.
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    BTB domain-containing speckle-type POZ protein (SPOP) serves as an adaptor of Daxx for ubiquitination by Cul3-based ubiquitin ligase.
    Kwon JE, La M, Oh KH, Oh YM, Kim GR, Seol JH, Baek SH, Chiba T, Tanaka K, Bang OS, Joe CO, Chung CH.
    J Biol Chem. 2006 May 5;281(18):12664-72. Epub 2006 Mar 8.
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    CGI-55 interacts with nuclear proteins and co-localizes to p80-coilin positive-coiled bodies in the nucleus.
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    Cell Biochem Biophys. 2006;44(3):463-74.
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    HGF/SF regulates expression of apoptotic genes in MCF-10A human mammary epithelial cells.
    Leroy C, Deheuninck J, Reveneau S, Foveau B, Ji Z, Villenet C, Quief S, Tulasne D, Kerckaert JP, Fafeur V.
    Ann N Y Acad Sci. 2006 Dec;1090:188-202.
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    Effect of sinomenine on gene expression of the IL-1 beta-activated human synovial sarcoma.
    Li XJ, Yue PY, Ha WY, Wong DY, Tin MM, Wang PX, Wong RN, Liu L.
    Life Sci. 2006 Jul 10;79(7):665-73. Epub 2006 Mar 6.
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    Role of SUMO-interacting motif in Daxx SUMO modification, subnuclear localization, and repression of sumoylated transcription factors.
    Lin DY, Huang YS, Jeng JC, Kuo HY, Chang CC, Chao TT, Ho CC, Chen YC, Lin TP, Fang HI, Hung CC, Suen CS, Hwang MJ, Chang KS, Maul GG, Shih HM.
    Mol Cell. 2006 Nov 3;24(3):341-54.
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    Ets-1-dependent expression of vascular endothelial growth factor receptors is activated by latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus through interaction with Daxx.
    Murakami Y, Yamagoe S, Noguchi K, Takebe Y, Takahashi N, Uehara Y, Fukazawa H.
    J Biol Chem. 2006 Sep 22;281(38):28113-21. Epub 2006 Jul 20.
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    Sumoylation of Daxx regulates IFN-induced growth suppression of B lymphocytes and the hormone receptor-mediated transactivation.
    Muromoto R, Ishida M, Sugiyama K, Sekine Y, Oritani K, Shimoda K, Matsuda T.
    J Immunol. 2006 Jul 15;177(2):1160-70.
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    Physical and functional interactions between Daxx and STAT3.
    Muromoto R, Nakao K, Watanabe T, Sato N, Sekine Y, Sugiyama K, Oritani K, Shimoda K, Matsuda T.
    Oncogene. 2006 Mar 30;25(14):2131-6.
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    Evidence for the interaction of the regulatory protein Ki-1/57 with p53 and its interacting proteins.
    Nery FC, Rui E, Kuniyoshi TM, Kobarg J.
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    Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
    Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M.
    Cell. 2006 Nov 3;127(3):635-48.
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    Role of the cellular protein hDaxx in human cytomegalovirus immediate-early gene expression.
    Preston CM, Nicholl MJ.
    J Gen Virol. 2006 May;87(Pt 5):1113-21.
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    Inactivating a cellular intrinsic immune defense mediated by Daxx is the mechanism through which the human cytomegalovirus pp71 protein stimulates viral immediate-early gene expression.
    Saffert RT, Kalejta RF.
    J Virol. 2006 Apr;80(8):3863-71.
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    Daxx: death or survival protein?
    Salomoni P, Khelifi AF.
    Trends Cell Biol. 2006 Feb;16(2):97-104. Epub 2006 Jan 10.
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    Physiological and functional interactions between Tcf4 and Daxx in colon cancer cells.
    Tzeng SL, Cheng YW, Li CH, Lin YS, Hsu HC, Kang JJ.
    J Biol Chem. 2006 Jun 2;281(22):15405-11. Epub 2006 Mar 28.
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    Human Daxx-mediated repression of human cytomegalovirus gene expression correlates with a repressive chromatin structure around the major immediate early promoter.
    Woodhall DL, Groves IJ, Reeves MB, Wilkinson G, Sinclair JH.
    J Biol Chem. 2006 Dec 8;281(49):37652-60. Epub 2006 Oct 11.
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    Herpes simplex virus type 1 genomes are associated with ND10 nuclear substructures in quiescently infected human fibroblasts.
    Everett RD, Murray J, Orr A, Preston CM.
    J Virol. 2007 Oct;81(20):10991-1004. Epub 2007 Aug 1.
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    Knockdown of hDaxx in normally non-permissive undifferentiated cells does not permit human cytomegalovirus immediate-early gene expression.
    Groves IJ, Sinclair JH.
    J Gen Virol. 2007 Nov;88(Pt 11):2935-40.
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    Proteasome-dependent, ubiquitin-independent degradation of Daxx by the viral pp71 protein in human cytomegalovirus-infected cells.
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    Subcellular localization of Daxx determines its opposing functions in ischemic cell death.
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    Sensitization to Fas-mediated apoptosis by dengue virus capsid protein.
    Limjindaporn T, Netsawang J, Noisakran S, Thiemmeca S, Wongwiwat W, Sudsaward S, Avirutnan P, Puttikhunt C, Kasinrerk W, Sriburi R, Sittisombut N, Yenchitsomanus PT, Malasit P.
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    Axin bridges Daxx to p53.
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    Daxx shortens mitotic arrest caused by paclitaxel.
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    Cell Cycle. 2007 May 15;6(10):1200-4. Epub 2007 May 5.
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    Zhongguo Dang Dai Er Ke Za Zhi. 2007 Feb;9(1):33-6.
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    Modification of nuclear PML protein by SUMO-1 regulates Fas-induced apoptosis in rheumatoid arthritis synovial fibroblasts.
    Meinecke I, Cinski A, Baier A, Peters MA, Dankbar B, Wille A, Drynda A, Mendoza H, Gay RE, Hay RT, Ink B, Gay S, Pap T.
    Proc Natl Acad Sci U S A. 2007 Mar 20;104(12):5073-8. Epub 2007 Mar 14.
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    Inhibition of NF-kappaB acetylation and its transcriptional activity by Daxx.
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    J Mol Biol. 2007 Apr 27;368(2):388-97. Epub 2007 Feb 22.
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    A suppressive role of the prolyl isomerase Pin1 in cellular apoptosis mediated by the death-associated protein Daxx.
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    Human cytomegalovirus gene expression is silenced by Daxx-mediated intrinsic immune defense in model latent infections established in vitro.
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    Daxx mediates SUMO-dependent transcriptional control and subnuclear compartmentalization.
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    Anti-apoptotic effects of probucol are associated with downregulation of Daxx expression in THP-1 macrophage.
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    Cardiovasc Drugs Ther. 2007 Feb;21(1):37-45. Epub 2007 Mar 17.
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    Sequence variation within the major histocompatibility complex subregion centromeric of HLA class II in type 1 diabetes.
    van der Slik AR, van den Eng I, Eerligh P, Doxiadis II, Koeleman BP, Roep BO, Giphart MJ.
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    Self-regulatory role of 4-hydroxynonenal in signaling for stress-induced programmed cell death.
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    Contributor(s)

    Written01-2009Eunhee Kim
    School of Bioscience & Biotechnology, Chungnam National University, 220 Goong-dong, Yusung-gu, Daejeon, 305-764, Korea (South)

    Citation

    This paper should be referenced as such :
    Kim E . DAXX (death-associated protein 6). Atlas Genet Cytogenet Oncol Haematol. January 2009 .
    URL : http://AtlasGeneticsOncology.org/Genes/DAXXID40265ch6p21.html

    The various updated versions of this paper are referenced and archived by INIST as such :
    http://documents.irevues.inist.fr/bitstream/2042/44633/1/01-2009-DAXXID40265ch6p21.pdf   [ Bibliographic record ]

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