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DDIT3 (DNA damage inducible transcript 3)

Written2004-07Pedro A Pérez-Mancera, Isidro Sánchez-Garcìa
Laboratorio 13, Instituto de Biologia Molecular y Celular del Cancer (IBMCC), Centro de Investigacion del Cancer, Campus Unamuno, 37.007-Salamanca, Spain

(Note : for Links provided by Atlas : click)

Identity

Alias_namesDNA-damage-inducible transcript 3
Alias_symbol (synonym)CHOP10
GADD153
CHOP
HGNC (Hugo) DDIT3
LocusID (NCBI) 1649
Atlas_Id 80
Location 12q13.3  [Link to chromosome band 12q13]
Location_base_pair Starts at 57910371 and ends at 57914300 bp from pter ( according to hg19-Feb_2009)  [Mapping DDIT3.png]
Fusion genes
(updated 2016)
DDIT3 (12q13.3) / ATF2 (2q31.1)DDIT3 (12q13.3) / DDIT3 (12q13.3)DDIT3 (12q13.3) / EWSR1 (22q12.2)
DDIT3 (12q13.3) / FUS (16p11.2)DDIT3 (12q13.3) / GLI1 (12q13.3)EWSR1 (22q12.2) / DDIT3 (12q13.3)
FUS (16p11.2) / DDIT3 (12q13.3)

DNA/RNA

Description The gene has 4 exons (94 bp, 48 bp, 167 bp and 586 bp). The start codon is in the exon 3. The total genomic sequence spanning the DDIT3 gene is approx. 3 Kb.
Transcription Transcript lenght: 1,1 Kb.

Protein

 
Description 169 amino acids, 29 Kda. DDIT3 contains a carboxy-terminal region (bZIP) formed by a DNA-binding basic domain and a leucine zipper dimerization domain.
Expression DDIT3 is expressed ubiquitously. It is usually expressed at undetectable levels and its expression is induced by cellular stress.
Localisation Nuclear.
Function DDIT3 does not form homodimers and it functions as a dominant negative C/EBP forming heterodimers with other C/EBP members and preventing their binding to C/EBP sequences in the DNA. DDIT3 is implicated in adipogenesis, erythropoiesis, in the induction of growth arrest and in the endoplasmic reticulum stress response.
Homology DDIT3 belongs to the CCAAT/enhancer binding protein (C/EBP) family of transcription factors and it has been found to have high homology in hamster, rat and mouse.

Mutations

Germinal In the mouse, germine mutation in the ddit3 gene produces a decrease in the programmed cell death induced by perturbation in the endoplasmic reticulum function. On the other hand, while DDIT3 inhibits adipogenesis in 3T3-L1 preadipocytes, transgenic mice expressing DDIT3 from a housekeeping promoter display normal adipogenesis.

Implicated in

Note
Note The DDIT3 gene is implicated in two chromosomal translocations associated to the myxoid liposarcoma (MLS). These fusion proteins generated as a result of chromosomal rearragements are used to monitor diagnosis and treatment.
 
  
Entity t(12;16)(q13;p11) chromosomal translocation. It produces the fusion protein FUS/DDIT3.
Disease Myxoid liposarcoma (MLS).
Hybrid/Mutated Gene 9 different types of fusions between the genes FUS and DDIT3 have been reported. The most frequent rearragements join the exons 5, 7 or 8 of FUS with the exon 2 of DDIT3.
Oncogenesis The unequivocally relation between FUS/DDIT3 and the MLS was shown by the generation of a transgenic mouse model expressing FUS/DDIT3 from a housekeeping promoter.
  
Entity t(12;22)(q13;q12) chromosomal translocation. It produces the fusion protein EWS/DDIT3.
Disease Myxoid liposarcoma (MLS).
Hybrid/Mutated Gene 2 different types of fusions between the genes EWS and DDIT3 have been reported. The first one joins the exon 7 of EWS with the exon 2 of DDIT3, while the second one joins the exon 10 of EWS with the exon 2 of DDIT3.
  

Breakpoints

 

Bibliography

-
 
Rearrangement of the transcription factor gene CHOP in myxoid liposarcomas with t(12;16)(q13;p11).
Aman P, Ron D, Mandahl N, Fioretos T, Heim S, Arheden K, Willén H, Rydholm A, Mitelman F
Genes, chromosomes & cancer. 1992 ; 5 (4) : 278-285.
PMID 1283316
 
CHOP (GADD153) and its oncogenic variant, TLS-CHOP, have opposing effects on the induction of G1/S arrest.
Barone MV, Crozat A, Tabaee A, Philipson L, Ron D
Genes & development. 1994 ; 8 (4) : 453-464.
PMID 8125258
 
Inhibition of adipogenesis by the stress-induced protein CHOP (Gadd153).
Batchvarova N, Wang XZ, Ron D
The EMBO journal. 1995 ; 14 (19) : 4654-4661.
PMID 7588595
 
Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells.
Cao Z, Umek RM, McKnight SL
Genes & development. 1991 ; 5 (9) : 1538-1552.
PMID 1840554
 
Regulation of the C/EBP-related gene gadd153 by glucose deprivation.
Carlson SG, Fawcett TW, Bartlett JD, Bernier M, Holbrook NJ
Molecular and cellular biology. 1993 ; 13 (8) : 4736-4744.
PMID 8336711
 
Regulated expression and functional role of the transcription factor CHOP (GADD153) in erythroid growth and differentiation.
Coutts M, Cui K, Davis KL, Keutzer JC, Sytkowski AJ
Blood. 1999 ; 93 (10) : 3369-3378.
PMID 10233889
 
Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma.
Crozat A, Aman P, Mandahl N, Ron D
Nature. 1993 ; 363 (6430) : 640-644.
PMID 8510758
 
Novel interaction between the transcription factor CHOP (GADD153) and the ribosomal protein FTE/S3a modulates erythropoiesis.
Cui K, Coutts M, Stahl J, Sytkowski AJ
The Journal of biological chemistry. 2000 ; 275 (11) : 7591-7596.
PMID 10713066
 
The role of C/EBP genes in adipocyte differentiation.
Darlington GJ, Ross SE, MacDougald OA
The Journal of biological chemistry. 1998 ; 273 (46) : 30057-30060.
PMID 9804754
 
Mammalian genes coordinately regulated by growth arrest signals and DNA-damaging agents.
Fornace AJ Jr, Nebert DW, Hollander MC, Luethy JD, Papathanasiou M, Fargnoli J, Holbrook NJ
Molecular and cellular biology. 1989 ; 9 (10) : 4196-4203.
PMID 2573827
 
A novel type of EWS-CHOP fusion gene in two cases of myxoid liposarcoma.
Hosaka T, Nakashima Y, Kusuzaki K, Murata H, Nakayama T, Nakamata T, Aoyama T, Okamoto T, Nishijo K, Araki N, Tsuboyama T, Nakamura T, Toguchida J
The Journal of molecular diagnostics : JMD. 2002 ; 4 (3) : 164-171.
PMID 12169678
 
Translocation t(12;16)(q13;p11) in myxoid liposarcoma and round cell liposarcoma: molecular and cytogenetic analysis.
Knight JC, Renwick PJ, Cin PD, Van den Berghe H, Fletcher CD
Cancer research. 1995 ; 55 (1) : 24-27.
PMID 7805034
 
Biological role of the CCAAT/enhancer-binding protein family of transcription factors.
Lekstrom-Himes J, Xanthopoulos KG
The Journal of biological chemistry. 1998 ; 273 (44) : 28545-28548.
PMID 9786841
 
Expression of the FUS domain restores liposarcoma development in CHOP transgenic mice.
Pérez-Mancera PA, Pérez-Losada J, Sánchez-Martín M, Rodríguez-García MA, Flores T, Battaner E, Gutiérrez-Adán A, Pintado B, Sánchez-García I
Oncogene. 2002 ; 21 (11) : 1679-1684.
PMID 11896599
 
A novel FUS/CHOP chimera in myxoid liposarcoma.
Panagopoulos I, Mertens F, Isaksson M, Mandahl N
Biochemical and biophysical research communications. 2000 ; 279 (3) : 838-845.
PMID 11162437
 
Isolation, characterization and chromosomal localization of the human GADD153 gene.
Park JS, Luethy JD, Wang MG, Fargnoli J, Fornace AJ Jr, McBride OW, Holbrook NJ
Gene. 1992 ; 116 (2) : 259-267.
PMID 1339368
 
Gadd45 and Gadd153 messenger RNA levels are increased during hypoxia and after exposure of cells to agents which elevate the levels of the glucose-regulated proteins.
Price BD, Calderwood SK
Cancer research. 1992 ; 52 (13) : 3814-3817.
PMID 1617653
 
Fusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation t(12;16) in malignant liposarcoma.
Rabbitts TH, Forster A, Larson R, Nathan P
Nature genetics. 1993 ; 4 (2) : 175-180.
PMID 7503811
 
CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription.
Ron D, Habener JF
Genes & development. 1992 ; 6 (3) : 439-453.
PMID 1547942
 
Stress-induced binding of the transcriptional factor CHOP to a novel DNA control element.
Ubeda M, Wang XZ, Zinszner H, Wu I, Habener JF, Ron D
Molecular and cellular biology. 1996 ; 16 (4) : 1479-1489.
PMID 8657121
 
Identification of novel stress-induced genes downstream of chop.
Wang XZ, Kuroda M, Sok J, Batchvarova N, Kimmel R, Chung P, Zinszner H, Ron D
The EMBO journal. 1998 ; 17 (13) : 3619-3630.
PMID 9649432
 
Signals from the stressed endoplasmic reticulum induce C/EBP-homologous protein (CHOP/GADD153).
Wang XZ, Lawson B, Brewer JW, Zinszner H, Sanjay A, Mi LJ, Boorstein R, Kreibich G, Hendershot LM, Ron D
Molecular and cellular biology. 1996 ; 16 (8) : 4273-4280.
PMID 8754828
 
Cascade regulation of terminal adipocyte differentiation by three members of the C/EBP family of leucine zipper proteins.
Yeh WC, Cao Z, Classon M, McKnight SL
Genes & development. 1995 ; 9 (2) : 168-181.
PMID 7531665
 
CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum.
Zinszner H, Kuroda M, Wang X, Batchvarova N, Lightfoot RT, Remotti H, Stevens JL, Ron D
Genes & development. 1998 ; 12 (7) : 982-995.
PMID 9531536
 

Citation

This paper should be referenced as such :
Pérez-Mancera, PA ; Sanchez-Garcia, I
DDIT3 (DNA damage inducible transcript 3)
Atlas Genet Cytogenet Oncol Haematol. 2004;8(3):232-235.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Genes/DDIT3ID80.html


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 4 ]
  t(8;14)(q11;q32) IGH/CEBPD
t(14;14)(q11;q32) CEBPE/IGH::inv(14)(q11q32) CEBPE/IGH
t(14;19)(q32;q13) IGH/CEBPA
t(14;20)(q32;q13) IGH/CEBPB


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 6 ]
  Soft Tissues: Angiomatoid fibrous histiocytoma
Nervous System: Glioma: an overview
Soft Tissues: Liposarcoma / malignant lipomatous tumors
Soft Tissues: Low grade fibromyxoid sarcoma
Soft Tissues: Liposarcoma: Myxoid liposarcoma
Soft tissue tumors: an overview


External links

Nomenclature
HGNC (Hugo)DDIT3   2726
Cards
AtlasDDIT3ID80
Entrez_Gene (NCBI)DDIT3  1649  DNA damage inducible transcript 3
AliasesCEBPZ; CHOP; CHOP-10; CHOP10; 
GADD153
GeneCards (Weizmann)DDIT3
Ensembl hg19 (Hinxton)ENSG00000175197 [Gene_View]  chr12:57910371-57914300 [Contig_View]  DDIT3 [Vega]
Ensembl hg38 (Hinxton)ENSG00000175197 [Gene_View]  chr12:57910371-57914300 [Contig_View]  DDIT3 [Vega]
ICGC DataPortalENSG00000175197
TCGA cBioPortalDDIT3
AceView (NCBI)DDIT3
Genatlas (Paris)DDIT3
WikiGenes1649
SOURCE (Princeton)DDIT3
Genetics Home Reference (NIH)DDIT3
Genomic and cartography
GoldenPath hg19 (UCSC)DDIT3  -     chr12:57910371-57914300 -  12q13.1-q13.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)DDIT3  -     12q13.1-q13.2   [Description]    (hg38-Dec_2013)
EnsemblDDIT3 - 12q13.1-q13.2 [CytoView hg19]  DDIT3 - 12q13.1-q13.2 [CytoView hg38]
Mapping of homologs : NCBIDDIT3 [Mapview hg19]  DDIT3 [Mapview hg38]
OMIM126337   613488   
Gene and transcription
Genbank (Entrez)AA054097 AA476561 AI658803 AK316581 AV729744
RefSeq transcript (Entrez)NM_001195053 NM_001195054 NM_001195055 NM_001195056 NM_001195057 NM_004083
RefSeq genomic (Entrez)NC_000012 NC_018923 NG_027674 NT_029419 NW_004929384
Consensus coding sequences : CCDS (NCBI)DDIT3
Cluster EST : UnigeneHs.505777 [ NCBI ]
CGAP (NCI)Hs.505777
Alternative Splicing GalleryENSG00000175197
Gene ExpressionDDIT3 [ NCBI-GEO ]   DDIT3 [ EBI - ARRAY_EXPRESS ]   DDIT3 [ SEEK ]   DDIT3 [ MEM ]
Gene Expression Viewer (FireBrowse)DDIT3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1649
GTEX Portal (Tissue expression)DDIT3
Protein : pattern, domain, 3D structure
UniProt/SwissProtP35638   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP35638  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP35638
Splice isoforms : SwissVarP35638
PhosPhoSitePlusP35638
Domaine pattern : Prosite (Expaxy)BZIP (PS50217)   
Domains : Interpro (EBI)bZIP    DNA_damage_induc_transcript_3   
Domain families : Pfam (Sanger)bZIP_2 (PF07716)   
Domain families : Pfam (NCBI)pfam07716   
Domain families : Smart (EMBL)BRLZ (SM00338)  
Conserved Domain (NCBI)DDIT3
DMDM Disease mutations1649
Blocks (Seattle)DDIT3
SuperfamilyP35638
Human Protein AtlasENSG00000175197
Peptide AtlasP35638
HPRD00529
IPIIPI00019956   IPI01021592   IPI00798213   
Protein Interaction databases
DIP (DOE-UCLA)P35638
IntAct (EBI)P35638
FunCoupENSG00000175197
BioGRIDDDIT3
STRING (EMBL)DDIT3
ZODIACDDIT3
Ontologies - Pathways
QuickGOP35638
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  negative regulation of transcription from RNA polymerase II promoter  transcription regulatory region sequence-specific DNA binding  RNA polymerase II core promoter proximal region sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  blood vessel maturation  response to amphetamine  DNA binding  transcription factor activity, sequence-specific DNA binding  transcription factor activity, sequence-specific DNA binding  transcription corepressor activity  protein binding  nucleus  nucleoplasm  late endosome  cytosol  regulation of transcription, DNA-templated  cellular response to DNA damage stimulus  ER overload response  response to unfolded protein  cell cycle arrest  aging  response to nutrient  transcription factor binding  cAMP response element binding protein binding  Wnt signaling pathway  positive regulation of interleukin-8 production  negative regulation of CREB transcription factor activity  negative regulation of CREB transcription factor activity  protein-DNA complex  response to endoplasmic reticulum stress  AP1 complex  CHOP-C/EBP complex  CHOP-C/EBP complex  PERK-mediated unfolded protein response  ATF6-mediated unfolded protein response  response to drug  response to hydrogen peroxide  response to starvation  mRNA transcription from RNA polymerase II promoter  protein homodimerization activity  proteasome-mediated ubiquitin-dependent protein catabolic process  negative regulation of sequence-specific DNA binding transcription factor activity  leucine zipper domain binding  positive regulation of neuron apoptotic process  regulation of DNA-templated transcription in response to stress  transcription regulatory region DNA binding  transcription regulatory region DNA binding  regulation of transcription involved in anterior/posterior axis specification  cell redox homeostasis  negative regulation of fat cell differentiation  negative regulation of myoblast differentiation  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  protein heterodimerization activity  protein heterodimerization activity  protein heterodimerization activity  embryonic organ development  release of sequestered calcium ion into cytosol  negative regulation of protein kinase B signaling  intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  negative regulation of canonical Wnt signaling pathway  positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding  positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress  positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress  positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress  positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress  CHOP-ATF4 complex  CHOP-ATF4 complex  CHOP-ATF3 complex  negative regulation of determination of dorsal identity  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  negative regulation of transcription from RNA polymerase II promoter  transcription regulatory region sequence-specific DNA binding  RNA polymerase II core promoter proximal region sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  blood vessel maturation  response to amphetamine  DNA binding  transcription factor activity, sequence-specific DNA binding  transcription factor activity, sequence-specific DNA binding  transcription corepressor activity  protein binding  nucleus  nucleoplasm  late endosome  cytosol  regulation of transcription, DNA-templated  cellular response to DNA damage stimulus  ER overload response  response to unfolded protein  cell cycle arrest  aging  response to nutrient  transcription factor binding  cAMP response element binding protein binding  Wnt signaling pathway  positive regulation of interleukin-8 production  negative regulation of CREB transcription factor activity  negative regulation of CREB transcription factor activity  protein-DNA complex  response to endoplasmic reticulum stress  AP1 complex  CHOP-C/EBP complex  CHOP-C/EBP complex  PERK-mediated unfolded protein response  ATF6-mediated unfolded protein response  response to drug  response to hydrogen peroxide  response to starvation  mRNA transcription from RNA polymerase II promoter  protein homodimerization activity  proteasome-mediated ubiquitin-dependent protein catabolic process  negative regulation of sequence-specific DNA binding transcription factor activity  leucine zipper domain binding  positive regulation of neuron apoptotic process  regulation of DNA-templated transcription in response to stress  transcription regulatory region DNA binding  transcription regulatory region DNA binding  regulation of transcription involved in anterior/posterior axis specification  cell redox homeostasis  negative regulation of fat cell differentiation  negative regulation of myoblast differentiation  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  protein heterodimerization activity  protein heterodimerization activity  protein heterodimerization activity  embryonic organ development  release of sequestered calcium ion into cytosol  negative regulation of protein kinase B signaling  intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  negative regulation of canonical Wnt signaling pathway  positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding  positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress  positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress  positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress  positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress  CHOP-ATF4 complex  CHOP-ATF4 complex  CHOP-ATF3 complex  negative regulation of determination of dorsal identity  
Pathways : BIOCARTAp38 MAPK Signaling Pathway [Genes]   
Pathways : KEGGMAPK signaling pathway    Protein processing in endoplasmic reticulum    Non-alcoholic fatty liver disease (NAFLD)    Transcriptional misregulation in cancer   
REACTOMEP35638 [protein]
REACTOME PathwaysR-HSA-380994 ATF4 activates genes [pathway]
REACTOME PathwaysR-HSA-381183 ATF6-alpha activates chaperone genes [pathway]
NDEx NetworkDDIT3
Atlas of Cancer Signalling NetworkDDIT3
Wikipedia pathwaysDDIT3
Orthology - Evolution
OrthoDB1649
GeneTree (enSembl)ENSG00000175197
Phylogenetic Trees/Animal Genes : TreeFamDDIT3
HOVERGENP35638
HOGENOMP35638
Homologs : HomoloGeneDDIT3
Homology/Alignments : Family Browser (UCSC)DDIT3
Gene fusions - Rearrangements
Fusion : MitelmanDDIT3/GLI1 [12q13.3/12q13.3]  
Fusion : MitelmanEWSR1/DDIT3 [22q12.2/12q13.3]  [ins(22;12)(q12;q13q14)]  [t(12;16)(q13;p11)]  
[t(12;22)(q13;q12)]  [t(12;22;20)(q13;q12;q11)]  
Fusion : MitelmanFUS/DDIT3 [16p11.2/12q13.3]  [t(12;16)(q13;p11)]  [t(12;22)(q13;q12)]  
Fusion : COSMICDDIT3 [12q13.3]  -  FUS [16p11.2]  [fusion_831]  
Fusion : COSMICEWSR1 [22q12.2]  -  DDIT3 [12q13.3]  [fusion_269]  [fusion_270]  [fusion_271]  [fusion_272]  [fusion_273]  [fusion_274]  [fusion_281]  
[fusion_282]  [fusion_284]  [fusion_328]  [fusion_837]  
Fusion : COSMICFUS [16p11.2]  -  DDIT3 [12q13.3]  [fusion_1018]  [fusion_1019]  [fusion_291]  [fusion_292]  [fusion_293]  [fusion_294]  [fusion_297]  
[fusion_298]  [fusion_300]  [fusion_301]  [fusion_302]  [fusion_303]  [fusion_304]  [fusion_342]  [fusion_832]  [fusion_833]  [fusion_834]  
[fusion_835]  [fusion_836]  [fusion_867]  [fusion_868]  
Fusion: TCGADDIT3 12q13.3 GLI1 12q13.3 GBM
Fusion : TICdbEWSR1 [22q12.2]  -  DDIT3 [12q13.3]
Fusion : TICdbFUS [16p11.2]  -  DDIT3 [12q13.3]
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDDIT3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DDIT3
dbVarDDIT3
ClinVarDDIT3
1000_GenomesDDIT3 
Exome Variant ServerDDIT3
ExAC (Exome Aggregation Consortium)DDIT3 (select the gene name)
Genetic variants : HAPMAP1649
Genomic Variants (DGV)DDIT3 [DGVbeta]
DECIPHER (Syndromes)12:57910371-57914300  ENSG00000175197
CONAN: Copy Number AnalysisDDIT3 
Mutations
ICGC Data PortalDDIT3 
TCGA Data PortalDDIT3 
Broad Tumor PortalDDIT3
OASIS PortalDDIT3 [ Somatic mutations - Copy number]
Cancer Gene: CensusDDIT3 
Somatic Mutations in Cancer : COSMICDDIT3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDDIT3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DDIT3
DgiDB (Drug Gene Interaction Database)DDIT3
DoCM (Curated mutations)DDIT3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DDIT3 (select a term)
intoGenDDIT3
NCG5 (London)DDIT3
Cancer3DDDIT3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM126337    613488   
Orphanet14540   
MedgenDDIT3
Genetic Testing Registry DDIT3
NextProtP35638 [Medical]
TSGene1649
GENETestsDDIT3
Huge Navigator DDIT3 [HugePedia]
snp3D : Map Gene to Disease1649
BioCentury BCIQDDIT3
ClinGenDDIT3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1649
Chemical/Pharm GKB GenePA27193
Clinical trialDDIT3
Miscellaneous
canSAR (ICR)DDIT3 (select the gene name)
Probes
Litterature
PubMed193 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDDIT3
EVEXDDIT3
GoPubMedDDIT3
iHOPDDIT3
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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