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DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10

Identity

Other namesHRH-J8
HGNC (Hugo) DDX10
LocusID (NCBI) 1662
Location 11q22
Location_base_pair Starts at 108535816 and ends at 108811648 bp from pter ( according to hg19-Feb_2009)  [Mapping]
Local_order telomeric to ATM.
 
  DDX10 (11q22) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics. Laboratories willing to validate the probes are welcome : contact rocchi@biologia.uniba.it

DNA/RNA

Description at least 12 exons; spans more than a 200-kb region
Transcription alternative splicing; 3.2 and 5.0 kb mRNA

Protein

Description contains 2 nuclear localization signals (NLS), a DEAD box (DEAD for: ASP-GLU_ALA-ASP)
Expression wide
Localisation nucleolus (probable)
Function putative ATP-dependent DEAD box RNA helicase; possible role in ribosome assembly through rRNA processing
Homology SPB4 and DRS1 (yeast)

Implicated in

Entity inv (11)(p15q22)/MDS or ANLL --> NUP98-DDX10
Disease therapy related MDS and ANLL; de novo ANLL
Hybrid/Mutated Gene 5' NUP98 - 3' DDX10
Abnormal Protein fuses the GLFG repeat domains of NUP98 to the charged amino acids domain of DDX11
  

External links

Nomenclature
HGNC (Hugo)DDX10   2735
Entrez_Gene (NCBI)DDX10  1662  DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
Cards
AtlasDDX10
GeneCards (Weizmann)DDX10
Ensembl (Hinxton)ENSG00000178105 [Gene_View]  chr11:108535816-108811648 [Contig_View]  DDX10 [Vega]
AceView (NCBI)DDX10
Genatlas (Paris)DDX10
euGene (Indiana)1662
SOURCE (Stanford)NM_004398
Genomic and cartography
GoldenPath (UCSC)DDX10  -  11q22   chr11:108535816-108811648 +  11q22-q23   [Description]    (hg19-Feb_2009)
EnsemblDDX10 - 11q22-q23 [CytoView]
Mapping of homologs : NCBIDDX10 [Mapview]
OMIM601235   
Gene and transcription
Genbank (Entrez)AB001343 AB040537 AB209884 AK296752 AK315216
RefSeq transcript (SRS)NM_004398
RefSeq transcript (Entrez)NM_004398
RefSeq genomic (SRS)AC_000143 NC_000011 NT_033899 NW_001838042
RefSeq genomic (Entrez)AC_000143 NC_000011 NT_033899 NW_001838042
Consensus coding sequences : CCDS (NCBI)DDX10
Cluster EST : UnigeneHs.591931 [ SRS ] Hs.591931 [ NCBI ]
Alternative Splicing : Fast-db (Paris)13672
Alternative Splicing GalleryENSG00000178105
Gene ExpressionDDX10 [ NCBI-GEO ]   DDX10 [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13206 (SRS) Q13206 (Uniprot)
With graphics : InterProQ13206
Splice isoforms : SwissVarQ13206(Swissvar)
Domaine pattern : Prosite (SRS)DEAD_ATP_HELICASE (PS00039)    HELICASE_ATP_BIND_1 (PS51192)    HELICASE_CTER (PS51194)    Q_MOTIF (PS51195)   
Domaine pattern : Prosite (Expaxy)DEAD_ATP_HELICASE (PS00039)    HELICASE_ATP_BIND_1 (PS51192)    HELICASE_CTER (PS51194)    Q_MOTIF (PS51195)   
Domains : Interpro (SRS)DNA/RNA_helicase_DEAD/DEAH_N    Helicase_ATP-bd    Helicase_C    RNA-helicase_DEAD-box_CS    RNA_helicase_DEAD_Q_motif   
Domains : Interpro (EBI)DNA/RNA_helicase_DEAD/DEAH_N    Helicase_ATP-bd    Helicase_C    RNA-helicase_DEAD-box_CS    RNA_helicase_DEAD_Q_motif   
Related proteins : CluSTrQ13206
Domain families : Pfam (SRS)DEAD (PF00270)    Helicase_C (PF00271)   
Domain families : Pfam (Sanger)DEAD (PF00270)    Helicase_C (PF00271)   
Domain families : Pfam (NCBI)pfam00270    pfam00271   
Domain families : Smart (EMBL)DEXDc (SM00487)  HELICc (SM00490)  
Blocks (Seattle)Q13206
PDB (SRS)2PL3   
PDB (PDBSum)2PL3   
PDB (IMB)2PL3   
PDB (RSDB)2PL3   
Human Protein AtlasENSG00000178105
HPRD03138
IPIIPI00297900   IPI00908600   IPI00982941   
Protein Interaction databases
DIP (DOE-UCLA)Q13206
IntAct (EBI)Q13206
FunCoupENSG00000178105
REACTOMEDDX10
BioGRIDDDX10
InParanoidQ13206
Interologous Interaction database Q13206
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)DDX10
SNP (GeneSNP Utah)DDX10
SNP : HGBaseDDX10
Genetic variants : HAPMAPDDX10
Cancer Gene: CensusDDX10 
Somatic Mutations in Cancer : COSMICDDX10 
CONAN: Copy Number AnalysisDDX10 
Translocation Breakpoints in Cancer : TICdbDDX10 
Mutations and Diseases : HGMDDDX10
OMIM601235   
GENETests601235   
Disease Genetic AssociationDDX10
Huge Navigator DDX10 [HugePedia]  DDX10 [HugeCancerGEM]
Genomic VariantsDDX10
snp3D : Map Gene to Disease1662
General knowledge
Homologs : HomoloGeneDDX10
Homology/Alignments : Family Browser (UCSC)DDX10
Phylogenetic Trees/Animal Genes : TreeFamDDX10
Catalytic activity : Enzyme3.6.4.13 [ Enzyme-Expasy ]   3.6.4.13 [ Enzyme-SRS ]   3.6.4.13 [ IntEnz-EBI ]   3.6.4.13 [ BRENDA ]   3.6.4.13 [ KEGG ]   
Chemical/Protein Interactions : CTD1662
Chemical/Pharm GKB GenePA27200
Clinical trialDDX10
Cancer Resource (Charite)ENSG00000178105
Ontology : AmiGOnucleotide binding  RNA binding  RNA helicase activity  ATP binding  ATP-dependent helicase activity  hydrolase activity  
Ontology : EGO-EBInucleotide binding  RNA binding  RNA helicase activity  ATP binding  ATP-dependent helicase activity  hydrolase activity  
Other databases
Probes
ProbeCancer Cytogenetics (Bari)
Probes : ImagenesDDX10 Related clones (RZPD - Berlin)
Litterature
PubMed18 Pubmed reference(s) in Entrez
PubGeneDDX10
iHOPDDX10

Bibliography

A human gene (DDX10) encoding a putative DEAD-box RNA helicase at 11q22-q23.
Savitsky K, Ziv Y, Bar-Shira A, Gilad S, Tagle DA, Smith S, Uziel T, Sfez S, Nahmias J, Sartiel A, Eddy RL, Shows TB, Collins FS, Shiloh Y, Rotman G
Genomics. 1996 ; 33 (2) : 199-206.
PMID 8660968
 
The inv(11)(p15q22) chromosome translocation of de novo and therapy-related myeloid malignancies results in fusion of the nucleoporin gene, NUP98, with the putative RNA helicase gene, DDX10.
Arai Y, Hosoda F, Kobayashi H, Arai K, Hayashi Y, Kamada N, Kaneko Y, Ohki M
Blood. 1997 ; 89 (11) : 3936-3944.
PMID 9166830
 
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written01-1998Jean-Loup Huret

Citation

This paper should be referenced as such :
Huret JL . DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10. Atlas Genet Cytogenet Oncol Haematol. January 1998 .
URL : http://AtlasGeneticsOncology.org/Genes/DDX10.html

This paper is referenced by INIST as such :
http://documents.irevues.inist.fr/bitstream/handle/2042/32090/01-1998-DDX10.pdf   [ Bibliographic record ]

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indexed on : Sat Apr 28 15:05:32 CEST 2012
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