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DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10

Written1998-01Jean-Loup Huret
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

(Note : for Links provided by Atlas : click)

Identity

Alias (NCBI)HRH-J8
HGNC (Hugo) DDX10
HGNC Alias symbHRH-J8
Dbp4
HGNC Previous nameDEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 10 (RNA helicase)
 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
LocusID (NCBI) 1662
Atlas_Id 35
Location 11q22.3  [Link to chromosome band 11q22]
Location_base_pair Starts at 108665069 and ends at 108940926 bp from pter ( according to GRCh38/hg38-Dec_2013)  [Mapping DDX10.png]
Local_order telomeric to ATM.
 
  DDX10 (11q22) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics.
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
C2CD2L (11q23.3)::DDX10 (11q22.3)DDX10 (11q22.3)::CUL5 (11q22.3)DDX10 (11q22.3)::DDX10 (11q22.3)
DDX10 (11q22.3)::NUP98 (11p15.4)DDX10 (11q22.3)::SKA3 (13q12.11)DDX10 (11q22.3)::YAP1 (11q22.1)
DECR2 (16p13.3)::DDX10 (11q22.3)NUP98 (11p15.4)::DDX10 (11q22.3)

DNA/RNA

Description at least 12 exons; spans more than a 200-kb region
Transcription alternative splicing; 3.2 and 5.0 kb mRNA

Protein

Description contains 2 nuclear localization signals (NLS), a DEAD box (DEAD for: ASP-GLU_ALA-ASP)
Expression wide
Localisation nucleolus (probable)
Function putative ATP-dependent DEAD box RNA helicase; possible role in ribosome assembly through rRNA processing
Homology SPB4 and DRS1 (yeast)

Implicated in

Note
  
Entity inv /MDS or AML --> NUP98- DDX10
Disease therapy related MDS and AML; de novo AML
Hybrid/Mutated Gene 5' NUP98 - 3' DDX10
Abnormal Protein fuses the GLFG repeat domains of NUP98 to the charged amino acids domain of DDX11
  

Bibliography

The inv(11)(p15q22) chromosome translocation of de novo and therapy-related myeloid malignancies results in fusion of the nucleoporin gene, NUP98, with the putative RNA helicase gene, DDX10.
Arai Y, Hosoda F, Kobayashi H, Arai K, Hayashi Y, Kamada N, Kaneko Y, Ohki M
Blood. 1997 ; 89 (11) : 3936-3944.
PMID 9166830
 
A human gene (DDX10) encoding a putative DEAD-box RNA helicase at 11q22-q23.
Savitsky K, Ziv Y, Bar-Shira A, Gilad S, Tagle DA, Smith S, Uziel T, Sfez S, Nahmias J, Sartiel A, Eddy RL, Shows TB, Collins FS, Shiloh Y, Rotman G
Genomics. 1996 ; 33 (2) : 199-206.
PMID 8660968
 

Citation

This paper should be referenced as such :
Jean-Loup Huret
DDX10 (DEAD (Asp-Glu-Ala-Asp) box polypeptide 10)
Atlas Genet Cytogenet Oncol Haematol. 1998;2(1):3-4.
Free journal version : [ pdf ]   [ DOI ]


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 4 ]
  inv(11)(p15q22) NUP98::DDX10::t(11;11)(p15;q22) NUP98/DDX10
t(4;11)(q21;p15) NUP98::RAP1GDS1
Therapy-Related Hematopoietic Neoplasia
t(11;11)(q22;q23) C2CD2L::DDX10


External links

 

Nomenclature
HGNC (Hugo)DDX10   2735
Cards
AtlasDDX10ID35
Entrez_Gene (NCBI)DDX10    DEAD-box helicase 10
AliasesDbp4; HRH-J8
GeneCards (Weizmann)DDX10
Ensembl hg19 (Hinxton)ENSG00000178105 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000178105 [Gene_View]  ENSG00000178105 [Sequence]  chr11:108665069-108940926 [Contig_View]  DDX10 [Vega]
ICGC DataPortalENSG00000178105
TCGA cBioPortalDDX10
AceView (NCBI)DDX10
Genatlas (Paris)DDX10
SOURCE (Princeton)DDX10
Genetics Home Reference (NIH)DDX10
Genomic and cartography
GoldenPath hg38 (UCSC)DDX10  -     chr11:108665069-108940926 +  11q22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DDX10  -     11q22.3   [Description]    (hg19-Feb_2009)
GoldenPathDDX10 - 11q22.3 [CytoView hg19]  DDX10 - 11q22.3 [CytoView hg38]
ImmunoBaseENSG00000178105
Genome Data Viewer NCBIDDX10 [Mapview hg19]  
OMIM601235   
Gene and transcription
Genbank (Entrez)AB001343 AB040537 AB209884 AK296752 AK315216
RefSeq transcript (Entrez)NM_004398
Consensus coding sequences : CCDS (NCBI)DDX10
Gene ExpressionDDX10 [ NCBI-GEO ]   DDX10 [ EBI - ARRAY_EXPRESS ]   DDX10 [ SEEK ]   DDX10 [ MEM ]
Gene Expression Viewer (FireBrowse)DDX10 [ Firebrowse - Broad ]
GenevisibleExpression of DDX10 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1662
GTEX Portal (Tissue expression)DDX10
Human Protein AtlasENSG00000178105-DDX10 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13206   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13206  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13206
Catalytic activity : Enzyme3.6.4.13 [ Enzyme-Expasy ]   3.6.4.133.6.4.13 [ IntEnz-EBI ]   3.6.4.13 [ BRENDA ]   3.6.4.13 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ13206
Domaine pattern : Prosite (Expaxy)DEAD_ATP_HELICASE (PS00039)    HELICASE_ATP_BIND_1 (PS51192)    HELICASE_CTER (PS51194)    Q_MOTIF (PS51195)   
Domains : Interpro (EBI)DEAD/DEAH_box_helicase_dom    DUF4217    Helicase_ATP-bd    Helicase_C    P-loop_NTPase    RNA-helicase_DEAD-box_CS    RNA_helicase_DEAD_Q_motif   
Domain families : Pfam (Sanger)DEAD (PF00270)    DUF4217 (PF13959)    Helicase_C (PF00271)   
Domain families : Pfam (NCBI)pfam00270    pfam13959    pfam00271   
Domain families : Smart (EMBL)DEXDc (SM00487)  DUF4217 (SM01178)  HELICc (SM00490)  
Conserved Domain (NCBI)DDX10
PDB (RSDB)2PL3   
PDB Europe2PL3   
PDB (PDBSum)2PL3   
PDB (IMB)2PL3   
Structural Biology KnowledgeBase2PL3   
SCOP (Structural Classification of Proteins)2PL3   
CATH (Classification of proteins structures)2PL3   
SuperfamilyQ13206
AlphaFold pdb e-kbQ13206   
Human Protein Atlas [tissue]ENSG00000178105-DDX10 [tissue]
HPRD03138
Protein Interaction databases
DIP (DOE-UCLA)Q13206
IntAct (EBI)Q13206
BioGRIDDDX10
STRING (EMBL)DDX10
ZODIACDDX10
Ontologies - Pathways
QuickGOQ13206
Ontology : AmiGORNA binding  RNA helicase activity  ATP binding  nucleus  rRNA processing  hydrolase activity  anterior head development  
Ontology : EGO-EBIRNA binding  RNA helicase activity  ATP binding  nucleus  rRNA processing  hydrolase activity  anterior head development  
NDEx NetworkDDX10
Atlas of Cancer Signalling NetworkDDX10
Wikipedia pathwaysDDX10
Orthology - Evolution
OrthoDB1662
GeneTree (enSembl)ENSG00000178105
Phylogenetic Trees/Animal Genes : TreeFamDDX10
Homologs : HomoloGeneDDX10
Homology/Alignments : Family Browser (UCSC)DDX10
Gene fusions - Rearrangements
Fusion : MitelmanC2CD2L::DDX10 [11q23.3/11q22.3]  
Fusion : MitelmanDDX10::SKA3 [11q22.3/13q12.11]  
Fusion : MitelmanNUP98::DDX10 [11p15.4/11q22.3]  
Fusion : QuiverDDX10
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDDX10 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DDX10
dbVarDDX10
ClinVarDDX10
MonarchDDX10
1000_GenomesDDX10 
Exome Variant ServerDDX10
GNOMAD BrowserENSG00000178105
Varsome BrowserDDX10
ACMGDDX10 variants
VarityQ13206
Genomic Variants (DGV)DDX10 [DGVbeta]
DECIPHERDDX10 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDDX10 
Mutations
ICGC Data PortalDDX10 
TCGA Data PortalDDX10 
Broad Tumor PortalDDX10
OASIS PortalDDX10 [ Somatic mutations - Copy number]
Cancer Gene: CensusDDX10 
Somatic Mutations in Cancer : COSMICDDX10  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DDDX10
Mutations and Diseases : HGMDDDX10
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaDDX10
DgiDB (Drug Gene Interaction Database)DDX10
DoCM (Curated mutations)DDX10
CIViC (Clinical Interpretations of Variants in Cancer)DDX10
OncoKBDDX10
NCG (London)DDX10
Cancer3DDDX10
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601235   
Orphanet
DisGeNETDDX10
MedgenDDX10
Genetic Testing Registry DDX10
NextProtQ13206 [Medical]
GENETestsDDX10
Target ValidationDDX10
Huge Navigator DDX10 [HugePedia]
ClinGenDDX10
Clinical trials, drugs, therapy
MyCancerGenomeDDX10
Protein Interactions : CTDDDX10
Pharm GKB GenePA27200
PharosQ13206
Clinical trialDDX10
Miscellaneous
canSAR (ICR)DDX10
HarmonizomeDDX10
DataMed IndexDDX10
Probes
Litterature
PubMed65 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXDDX10
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Oct 8 21:16:01 CEST 2021

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jlhuret@AtlasGeneticsOncology.org.