Atlas of Genetics and Cytogenetics in Oncology and Haematology
DEK
| Identity |
| HGNC (Hugo) | DEK |
| Location | 6p23 |
| Location_base_pair | Starts at 18332381 and ends at 18372778 bp from pter ( according to hg18-Mar_2006) [Mapping] |
 | |
| DEK (6p23) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics. Laboratories willing to validate the probes are welcome : contact rocchi@biologia.uniba.it | |
| DNA/RNA |
| Description | spans on a 40 kb genomic segment |
| Transcription | 2.7 kb mRNA; coding sequence: 1.1 kb |
| Protein |
| Description | 375 amino acids; 43 kDa; contains numerous acidic domains (Asp/Glu rich) and a nuclear localisation signal |
| Expression | wide |
| Localisation | potentially nuclear |
| Function | site specific DNA binding protein involved in transcriptional regulation and signal transduction |
| Implicated in |
| Entity | t(6;9)(p23;q34)/ANLL or MDS -->DEK-CAN |
| Disease | M2, M4 ANLL or MDS |
| Prognosis | remission difficult to obtain |
| Cytogenetics | this chromosome anomaly may be over loocked |
| Hybrid/Mutated Gene | 5' DEK - 3' CAN; chromosome 6 breakpoint clusters in a single intron |
| Abnormal Protein | head to tail DEK/CAN fusion protein (the alternative SET/CAN is exceptional); almost the entire DEK protein fused to the C-terminal two-thirds of the CAN protein; nuclear localization |
| External links |
| Bibliography |
| The translocation (6;9), associated with a specific subtype of acute myeloid leukemia, results in the fusion of two genes, dek and can, and the expression of a chimeric, leukemia-specific dek-can mRNA. |
| von Lindern M, Fornerod M, van Baal S, Jaegle M, de Wit T, Buijs A, Grosveld G |
| Molecular and cellular biology. 1992 ; 12 (4) : 1687-1697. |
| PMID 1549122 |
| Relocation of the carboxyterminal part of CAN from the nuclear envelope to the nucleus as a result of leukemia-specific chromosome rearrangements. |
| Fornerod M, Boer J, van Baal S, Jaeglˆ© M, von Lindern M, Murti KG, Davis D, Bonten J, Buijs A, Grosveld G |
| Oncogene. 1995 ; 10 (9) : 1739-1748. |
| PMID 7753551 |
| Interaction of cellular proteins with the leukemia specific fusion proteins DEK-CAN and SET-CAN and their normal counterpart, the nucleoporin CAN. |
| Fornerod M, Boer J, van Baal S, Morreau H, Grosveld G |
| Oncogene. 1996 ; 13 (8) : 1801-1808. |
| PMID 8895527 |
| DEK, an autoantigen involved in a chromosomal translocation in acute myelogenous leukemia, binds to the HIV-2 enhancer. |
| Fu GK, Grosveld G, Markovitz DM |
| Proceedings of the National Academy of Sciences of the United States of America. 1997 ; 94 (5) : 1811-1815. |
| PMID 9050861 |
| REVIEW articles | automatic search in PubMed |
| Last year publications | automatic search in PubMed |
| Contributor(s) |
| Written | 01-1998 | Jean-Loup Huret |
| Citation |
| This paper should be referenced as such : |
| Huret JL . DEK. Atlas Genet Cytogenet Oncol Haematol. January 1998 . URL : http://AtlasGeneticsOncology.org/Genes/DEK_23.html |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Sat Jun 27 16:39:58 CEST 2009 |
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