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DEK DEK oncogene)

Identity

HGNC (Hugo) DEK
LocusID (NCBI) 7913
Location 6p23
Location_base_pair Starts at 18224400 and ends at 18264799 bp from pter ( according to hg19-Feb_2009)  [Mapping]
 
  DEK (6p23) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics. Laboratories willing to validate the probes are welcome : contact rocchi@biologia.uniba.it

DNA/RNA

Description spans on a 40 kb genomic segment
Transcription 2.7 kb mRNA; coding sequence: 1.1 kb

Protein

Description 375 amino acids; 43 kDa; contains numerous acidic domains (Asp/Glu rich) and a nuclear localisation signal
Expression wide
Localisation potentially nuclear
Function site specific DNA binding protein involved in transcriptional regulation and signal transduction

Implicated in

Entity t(6;9)(p23;q34)/ANLL or MDS -->DEK-CAN
Disease M2, M4 ANLL or MDS
Prognosis remission difficult to obtain
Cytogenetics this chromosome anomaly may be over loocked
Hybrid/Mutated Gene 5' DEK - 3' CAN; chromosome 6 breakpoint clusters in a single intron
Abnormal Protein head to tail DEK/CAN fusion protein (the alternative SET/CAN is exceptional); almost the entire DEK protein fused to the C-terminal two-thirds of the CAN protein; nuclear localization
  

External links

Nomenclature
HGNC (Hugo)DEK   2768
Entrez_Gene (NCBI)DEK  7913  DEK oncogene
Cards
AtlasDEK_23
GeneCards (Weizmann)DEK
Ensembl (Hinxton)ENSG00000124795 [Gene_View]  chr6:18224400-18264799 [Contig_View]  DEK [Vega]
AceView (NCBI)DEK
Genatlas (Paris)DEK
euGene (Indiana)7913
SOURCE (Stanford)NM_001134709 NM_003472
Genomic and cartography
GoldenPath (UCSC)DEK  -  6p23   chr6:18224400-18264799 -  6p22.3   [Description]    (hg19-Feb_2009)
EnsemblDEK - 6p22.3 [CytoView]
Mapping of homologs : NCBIDEK [Mapview]
OMIM125264   
Gene and transcription
Genbank (Entrez)AJ270688 AJ420539 AK294079 AK297749 AK298089
RefSeq transcript (SRS)NM_001134709 NM_003472
RefSeq transcript (Entrez)NM_001134709 NM_003472
RefSeq genomic (SRS)AC_000138 NC_000006 NT_007592 NW_001838973
RefSeq genomic (Entrez)AC_000138 NC_000006 NT_007592 NW_001838973
Consensus coding sequences : CCDS (NCBI)DEK
Cluster EST : UnigeneHs.484813 [ SRS ] Hs.484813 [ NCBI ]
Alternative Splicing : Fast-db (Paris)3147
Alternative Splicing GalleryENSG00000124795
Gene ExpressionDEK [ NCBI-GEO ]   DEK [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP35659 (SRS) P35659 (Uniprot)
With graphics : InterProP35659
Splice isoforms : SwissVarP35659(Swissvar)
Domaine pattern : Prosite (SRS)SAP (PS50800)   
Domaine pattern : Prosite (Expaxy)SAP (PS50800)   
Domains : Interpro (SRS)DEK_C    SAP_DNA-bd   
Domains : Interpro (EBI)DEK_C    SAP_DNA-bd   
Related proteins : CluSTrP35659
Domain families : Pfam (SRS)DEK_C (PF08766)    SAP (PF02037)   
Domain families : Pfam (Sanger)DEK_C (PF08766)    SAP (PF02037)   
Domain families : Pfam (NCBI)pfam08766    pfam02037   
Domain families : Smart (EMBL)SAP (SM00513)  
Blocks (Seattle)P35659
PDB (SRS)1Q1V    2JX3   
PDB (PDBSum)1Q1V    2JX3   
PDB (IMB)1Q1V    2JX3   
PDB (RSDB)1Q1V    2JX3   
Human Protein AtlasENSG00000124795
HPRD00503
IPIIPI00020021   IPI00425937   IPI00942944   IPI00909779   IPI00967473   IPI00968273   IPI00966422   
Protein Interaction databases
DIP (DOE-UCLA)P35659
IntAct (EBI)P35659
FunCoupENSG00000124795
REACTOMEDEK
BioGRIDDEK
InParanoidP35659
Interologous Interaction database P35659
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)DEK
SNP (GeneSNP Utah)DEK
SNP : HGBaseDEK
Genetic variants : HAPMAPDEK
Cancer Gene: CensusDEK 
Somatic Mutations in Cancer : COSMICDEK 
CONAN: Copy Number AnalysisDEK 
Translocation Breakpoints in Cancer : TICdbDEK 
Mutations and Diseases : HGMDDEK
OMIM125264   
GENETests125264   
Disease Genetic AssociationDEK
Huge Navigator DEK [HugePedia]  DEK [HugeCancerGEM]
Genomic VariantsDEK
snp3D : Map Gene to Disease7913
General knowledge
Homologs : HomoloGeneDEK
Homology/Alignments : Family Browser (UCSC)DEK
Phylogenetic Trees/Animal Genes : TreeFamDEK
Chemical/Protein Interactions : CTD7913
Chemical/Pharm GKB GenePA27251
Clinical trialDEK
Cancer Resource (Charite)ENSG00000124795
Ontology : AmiGODNA binding  nucleus  regulation of transcription from RNA polymerase II promoter  transcription from RNA polymerase II promoter  signal transduction  chromatin modification  viral genome replication  histone binding  
Ontology : EGO-EBIDNA binding  nucleus  regulation of transcription from RNA polymerase II promoter  transcription from RNA polymerase II promoter  signal transduction  chromatin modification  viral genome replication  histone binding  
Other databases
Probes
ProbeCancer Cytogenetics (Bari)
Probes : ImagenesDEK Related clones (RZPD - Berlin)
Litterature
PubMed76 Pubmed reference(s) in Entrez
PubGeneDEK
iHOPDEK

Bibliography

The translocation (6;9), associated with a specific subtype of acute myeloid leukemia, results in the fusion of two genes, dek and can, and the expression of a chimeric, leukemia-specific dek-can mRNA.
von Lindern M, Fornerod M, van Baal S, Jaegle M, de Wit T, Buijs A, Grosveld G
Molecular and cellular biology. 1992 ; 12 (4) : 1687-1697.
PMID 1549122
 
Relocation of the carboxyterminal part of CAN from the nuclear envelope to the nucleus as a result of leukemia-specific chromosome rearrangements.
Fornerod M, Boer J, van Baal S, Jaeglˆ© M, von Lindern M, Murti KG, Davis D, Bonten J, Buijs A, Grosveld G
Oncogene. 1995 ; 10 (9) : 1739-1748.
PMID 7753551
 
Interaction of cellular proteins with the leukemia specific fusion proteins DEK-CAN and SET-CAN and their normal counterpart, the nucleoporin CAN.
Fornerod M, Boer J, van Baal S, Morreau H, Grosveld G
Oncogene. 1996 ; 13 (8) : 1801-1808.
PMID 8895527
 
DEK, an autoantigen involved in a chromosomal translocation in acute myelogenous leukemia, binds to the HIV-2 enhancer.
Fu GK, Grosveld G, Markovitz DM
Proceedings of the National Academy of Sciences of the United States of America. 1997 ; 94 (5) : 1811-1815.
PMID 9050861
 
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written01-1998Jean-Loup Huret

Citation

This paper should be referenced as such :
Huret JL . DEK DEK oncogene). Atlas Genet Cytogenet Oncol Haematol. January 1998 .
URL : http://AtlasGeneticsOncology.org/Genes/DEK_23.html

This paper is referenced by INIST as such :
http://documents.irevues.inist.fr/bitstream/handle/2042/32091/01-1998-DEK_23.pdf   [ Bibliographic record ]

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Apr 28 15:05:45 CEST 2012

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