Atlas of Genetics and Cytogenetics in Oncology and Haematology

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

E2F3 (E2F transcription factor 3)

Written2005-07Roderick AF MacLeod, Stefan Nagel
DSMZ-Deutsche Sammlung von, Mikroorganismen und Zellkulturen, Inhoffenstr. 7B, D-38124 Braunschweig, Germany

(Note : for Links provided by Atlas : click)


Other aliasE2F-3
HGNC (Hugo) E2F3
LocusID (NCBI) 1871
Atlas_Id 40384
Location 6p22.3  [Link to chromosome band 6p22]
Location_base_pair Starts at 20401906 and ends at 20493714 bp from pter ( according to hg19-Feb_2009)  [Mapping E2F3.png]
Local_order tel-OACT1-E2F3-CDKAL1-cen
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
E2F3 (6p22.3) / CDKAL1 (6p22.3)E2F3 (6p22.3) / FBXO9 (6p12.1)LHFPL6 (13q13.3) / E2F3 (6p22.3)
USP12 (13q12.13) / E2F3 (6p22.3)ZNF787 (19q13.43) / E2F3 (6p22.3)


  Schematic diagram of the E2F3 gene comprising 7 exons (in blue). Exons 1a or 1b are used alternatively to produce variants E2F3A or E2F3B, respectively. The sizes in base pairs (bp) of exons (above) and introns (below) are shown.
Description The gene has 7 exons (two alternative exons 1) and 6 introns comprising 91545 bp.
Transcription Transcription takes place in a centromeric -> telomeric orientation. The length of the processed mRNA is about 4744 bp. EMBL lists two alternativly spliced forms other than those concerning exons 1a/b.
Pseudogene 2q33-q35, 17q11-q12


  Schematic diagram of E2F3 protein structure. E2F3A is shown in the upper part, E2F3B below. The proteins differ in their N-terminal regions comprising 132 and 6 amino acid residues, respectively. N: nuclear localization sequence, LZ: leucine zipper (blue), RBD: pRB binding domain (light blue). DNA binding domain (yellow), dimerization domain (red), transactivation domain (green). The positions of amino acid residues are indicated.
Description E2F3A comprises 465 amino acid residues (49 kDa), E2F3B comprises 334 amino acid residues.
Expression ubiquitous
Localisation nuclear
Function E2F3 is a sequence-specific transcription factor implicated in cell cycle regulation (S-phase). It is a transcriptional activator for E2F-responsive genes. E2F proteins heterodimerize with DP proteins and are subject to inhibition by binding to the pocket domain of retinoblastoma protein (pRB). Phosphorylation of pRB sets E2F proteins free to regulate their target genes.
Homology E2F transcription factor family consists of E2F-proteins (E2F1-6) and DP-proteins (DP1, DP2).


Note Gene mutations have not been described hitherto.
Germinal Not known
Somatic Not known

Implicated in

Entity amp(6)(p22)
Note Medium-to-high-level genomic amplification sometimes resulting in HSR formation and believed to target E2F3 which lies within the common amplified region (see image below). Genomic amplification may not be required for over-expression.
Disease Notably, bladder and prostate cancers.
Prognosis Associated with invasiveness in bladder cancer, and with poor survival in prostate cancer. Circa 33% of primary transitional cell carcinomas of the bladder overexpress nuclear E2F3 protein.
Cytogenetics Presumptive target of genomic amplification at 6p22 in bladder cancer where it effects E2F3 overexpression (as exemplified by the bladder cancer cell lines 5637 and HT-1367). However, E2F3 may not be the only target gene inside the common amplified region.
Hybrid/Mutated Gene Not yet reported
Genomic amplification of E2F3: FISH image shows HT-1376 bladder cancer cell line (DSMZ acc 397) hybridized with a BAC clone (RPMI-99F1) covering the E2F3 locus at 6p22.3. (See breakpoint diagram below for map.) Note high level genomic amplification comprising multiple tandemly repeated copies of E2F3 via formation of an homogeneously staining region (HSR) in a marker chromosome - a hallmark of oncogene activity. Similar findings have been reported in both primary bladder and prostate cancers. Analysis of E2F3 protein has confirmed overexpression in cell lines evidencing genomic amplification, including HT-1376 as well as 5637 (DSMZ acc 35) and TCC-SUP (DSMZ acc 377).
Entity t(6;9)(p22;p13)
Note Observed in a DLBCL cell line: yet to be described clinically.
Disease Diffuse large B-cell lymphoma (DLBCL).
Prognosis Unknown
Cytogenetics Breakpoint lies upstream of E2F3 and juxtaposes upstream (regulatory) region of PAX5.
Hybrid/Mutated Gene Not yet reported
See below
Oncogenesis E2F3 behaves like a classical oncogene and is subject to upregulation via genomic amplification in bladder and prostate cancers. Upregulated E2F3 stimulates cycle progression and proliferation. E2F3 transcription is induced by MYC and these together conspire to promote G1/S-phase transition. This activity is negatively regulated by binding of the E2F transactivation domain to RB1 or p107. In prostate cancer, oncogenesis directed by E2F3 may be mediated by the polycomb group protein Enhancer of Zeste Homolog gene 2 (EZH2). E2F3 may also activate survivin transcription.
In Hodgkin lymphoma which, though lacking recurrent chromosomal rearrangements at 6p22, shows a pattern of gene dysregulation reminiscent of prostate cancer, E2F3 regulates HLXB9 expression which in turn drives IL-6 expression thought to play a central role in this enigmatic tumor.
E2F3 may also act as a tumor suppressor though the supporting evidence is tentative. Thus, while E2F3 loss results in centrosome defects associated with aneuploidy and promotes metastasis of medullary thyroid carcinoma, E2F3 -/- mice show no excess tumor incidence. Furthermore, loss of E2F3 has been associated with suppression of pituitary tumors.


  Figure depicts location of sole E2F3 breakpoint described hitherto, lying approximately 50-150 Kbp upstream of the transcription unit as detected in a complex t(6;9)(p22;p13) in a DLBCL cell line. The upstream region of E2F3 is thus juxtaposed with the upstream regulatory region of PAX5. Figure shows genes flanking E2F3 together with RPCI-11 library clones.


Complex transcriptional regulatory mechanisms control expression of the E2F3 locus.
Adams MR, Sears R, Nuckolls F, Leone G, Nevins JR
Molecular and cellular biology. 2000 ; 20 (10) : 3633-3639.
PMID 10779353
Repression of the Arf tumor suppressor by E2F3 is required for normal cell cycle kinetics.
Aslanian A, Iaquinta PJ, Verona R, Lees JA
Genes & development. 2004 ; 18 (12) : 1413-1422.
PMID 15175242
Upregulation of E2F transcription factors in chemically induced mouse skin tumors.
Balasubramanian S, Ahmad N, Mukhtar H
International journal of oncology. 1999 ; 15 (2) : 387-390.
PMID 10402252
A genetic screen to identify genes that rescue the slow growth phenotype of c-myc null fibroblasts.
Berns K, Hijmans EM, Koh E, Daley GQ, Bernards R
Oncogene. 2000 ; 19 (29) : 3330-3334.
PMID 10918589
Neural precursor cells differentiating in the absence of Rb exhibit delayed terminal mitosis and deregulated E2F 1 and 3 activity.
Callaghan DA, Dong L, Callaghan SM, Hou YX, Dagnino L, Slack RS
Developmental biology. 1999 ; 207 (2) : 257-270.
PMID 10068462
CpG methylation as a mechanism for the regulation of E2F activity.
Campanero MR, Armstrong MI, Flemington EK
Proceedings of the National Academy of Sciences of the United States of America. 2000 ; 97 (12) : 6481-6486.
PMID 10823896
Mutant mouse models reveal the relative roles of E2F1 and E2F3 in vivo.
Cloud JE, Rogers C, Reza TL, Ziebold U, Stone JR, Picard MH, Caron AM, Bronson RT, Lees JA
Molecular and cellular biology. 2002 ; 22 (8) : 2663-2672.
PMID 11909960
Expression patterns of the E2F family of transcription factors during mouse nervous system development.
Dagnino L, Fry CJ, Bartley SM, Farnham P, Gallie BL, Phillips RA
Mechanisms of development. 1997 ; 66 (1-2) : 13-25.
PMID 9376316
The genetics of the E2F family of transcription factors: shared functions and unique roles.
DeGregori J
Biochimica et biophysica acta. 2002 ; 1602 (2) : 131-150.
PMID 12020800
Distinct roles for E2F proteins in cell growth control and apoptosis.
DeGregori J, Leone G, Miron A, Jakoi L, Nevins JR
Proceedings of the National Academy of Sciences of the United States of America. 1997 ; 94 (14) : 7245-7250.
PMID 9207076
Divergent siblings: E2F2 and E2F4 but not E2F1 and E2F3 induce DNA synthesis in cardiomyocytes without activation of apoptosis.
Ebelt H, Hufnagel N, Neuhaus P, Neuhaus H, Gajawada P, Simm A, Müller-Werdan U, Werdan K, Braun T
Circulation research. 2005 ; 96 (5) : 509-517.
PMID 15718499
Amplification and overexpression of E2F3 in human bladder cancer.
Feber A, Clark J, Goodwin G, Dodson AR, Smith PH, Fletcher A, Edwards S, Flohr P, Falconer A, Roe T, Kovacs G, Dennis N, Fisher C, Wooster R, Huddart R, Foster CS, Cooper CS
Oncogene. 2004 ; 23 (8) : 1627-1630.
PMID 14716298
E2F-3 accumulation is regulated by polypeptide stability.
Flores AM, Kassatly RF, Cress WD
Oncogene. 1998 ; 16 (10) : 1289-1298.
PMID 9546430
Transcription factor E2F3 overexpressed in prostate cancer independently predicts clinical outcome.
Foster CS, Falconer A, Dodson AR, Norman AR, Dennis N, Fletcher A, Southgate C, Dowe A, Dearnaley D, Jhavar S, Eeles R, Feber A, Cooper CS
Oncogene. 2004 ; 23 (35) : 5871-5879.
PMID 15184867
Combinatorial gene control involving E2F and E Box family members.
Giangrande PH, Zhu W, Rempel RE, Laakso N, Nevins JR
The EMBO journal. 2004 ; 23 (6) : 1336-1347.
PMID 15014447
E2F3-a novel repressor of the ARF/p53 pathway.
Ginsberg D
Developmental cell. 2004 ; 6 (6) : 742-743.
PMID 15177020
Deregulated E2F transcriptional activity in autonomously growing melanoma cells.
Halaban R, Cheng E, Smicun Y, Germino J
The Journal of experimental medicine. 2000 ; 191 (6) : 1005-1016.
PMID 10727462
Specificity in the activation and control of transcription factor E2F-dependent apoptosis.
Hallstrom TC, Nevins JR
Proceedings of the National Academy of Sciences of the United States of America. 2003 ; 100 (19) : 10848-10853.
PMID 12954980
Identification of E2F-3B, an alternative form of E2F-3 lacking a conserved N-terminal region.
He Y, Armanious MK, Thomas MJ, Cress WD
Oncogene. 2000 ; 19 (30) : 3422-3433.
PMID 10918599
Differential effects of cdk2 and cdk3 on the control of pRb and E2F function during G1 exit.
Hofmann F, Livingston DM
Genes & development. 1996 ; 10 (7) : 851-861.
PMID 8846921
Gene expression phenotypic models that predict the activity of oncogenic pathways.
Huang E, Ishida S, Pittman J, Dressman H, Bild A, Kloos M, D'Amico M, Pestell RG, West M, Nevins JR
Nature genetics. 2003 ; 34 (2) : 226-230.
PMID 12754511
E2f3 is critical for normal cellular proliferation.
Humbert PO, Verona R, Trimarchi JM, Rogers C, Dandapani S, Lees JA
Genes & development. 2000 ; 14 (6) : 690-703.
PMID 10733529
Aberrant regulation of survivin by the RB/E2F family of proteins.
Jiang Y, Saavedra HI, Holloway MP, Leone G, Altura RA
The Journal of biological chemistry. 2004 ; 279 (39) : 40511-40520.
PMID 15271987
E2F as a regulator of keratinocyte proliferation: implications for skin tumor development.
Jones SJ, Dicker AJ, Dahler AL, Saunders NA
The Journal of investigative dermatology. 1997 ; 109 (2) : 187-193.
PMID 9242506
E2F1 is crucial for E2F-dependent apoptosis.
Lazzerini Denchi E, Helin K
EMBO reports. 2005 ; 6 (7) : 661-668.
PMID 15976820
The retinoblastoma protein binds to a family of E2F transcription factors.
Lees JA, Saito M, Vidal M, Valentine M, Look T, Harlow E, Dyson N, Helin K
Molecular and cellular biology. 1993 ; 13 (12) : 7813-7825.
PMID 8246996
E2F3 activity is regulated during the cell cycle and is required for the induction of S phase.
Leone G, DeGregori J, Yan Z, Jakoi L, Ishida S, Williams RS, Nevins JR
Genes & development. 1998 ; 12 (14) : 2120-2130.
PMID 9679057
Identification of a novel E2F3 product suggests a mechanism for determining specificity of repression by Rb proteins.
Leone G, Nuckolls F, Ishida S, Adams M, Sears R, Jakoi L, Miron A, Nevins JR
Molecular and cellular biology. 2000 ; 20 (10) : 3626-3632.
PMID 10779352
Myc requires distinct E2F activities to induce S phase and apoptosis.
Leone G, Sears R, Huang E, Rempel R, Nuckolls F, Park CH, Giangrande P, Wu L, Saavedra HI, Field SJ, Thompson MA, Yang H, Fujiwara Y, Greenberg ME, Orkin S, Smith C, Nevins JR
Molecular cell. 2001 ; 8 (1) : 105-113.
PMID 11511364
Deregulated expression of E2F family members induces S-phase entry and overcomes p16INK4A-mediated growth suppression.
Lukas J, Petersen BO, Holm K, Bartek J, Helin K
Molecular and cellular biology. 1996 ; 16 (3) : 1047-1057.
PMID 8622649
E2Fs regulate the expression of genes involved in differentiation, development, proliferation, and apoptosis.
Müller H, Bracken AP, Vernell R, Moroni MC, Christians F, Grassilli E, Prosperini E, Vigo E, Oliner JD, Helin K
Genes & development. 2001 ; 15 (3) : 267-285.
PMID 11159908
Inhibition of cell proliferation and induction of apoptosis by novel tetravalent peptides inhibiting DNA binding of E2F.
Montigiani S, Müller R, Kontermann RE
Oncogene. 2003 ; 22 (32) : 4943-4952.
PMID 12902977
HLXB9 activates IL6 in Hodgkin lymphoma cell lines and is regulated by PI3K signalling involving E2F3.
Nagel S, Scherr M, Quentmeier H, Kaufmann M, Zaborski M, Drexler HG, MacLeod RA
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 2005 ; 19 (5) : 841-846.
PMID 15772702
E2F3 amplification and overexpression is associated with invasive tumor growth and rapid tumor cell proliferation in urinary bladder cancer.
Oeggerli M, Tomovska S, Schraml P, Calvano-Forte D, Schafroth S, Simon R, Gasser T, Mihatsch MJ, Sauter G
Oncogene. 2004 ; 23 (33) : 5616-5623.
PMID 15122326
Mitoinhibitory effects of the tumor promoter 2-acetylaminofluorene in rat liver: loss of E2F-1 and E2F-3 expression and cdk 2 kinase activity in late G1.
Ohlson LC, Koroxenidou L, Porsch-Hä I
Journal of hepatology. 2004 ; 40 (6) : 957-962.
PMID 15158336
Transcriptional regulation of the human tumor suppressor p14(ARF) by E2F1, E2F2, E2F3, and Sp1-like factors.
Parisi T, Pollice A, Di Cristofano A, Calabrò V, La Mantia G
Biochemical and biophysical research communications. 2002 ; 291 (5) : 1138-1145.
PMID 11883935
E2Fs up-regulate expression of genes involved in DNA replication, DNA repair and mitosis.
Polager S, Kalma Y, Berkovich E, Ginsberg D
Oncogene. 2002 ; 21 (3) : 437-446.
PMID 11821956
Inactivation of E2F3 results in centrosome amplification.
Saavedra HI, Maiti B, Timmers C, Altura R, Tokuyama Y, Fukasawa K, Leone G
Cancer cell. 2003 ; 3 (4) : 333-346.
PMID 12726860
Interaction of YY1 with E2Fs, mediated by RYBP, provides a mechanism for specificity of E2F function.
Schlisio S, Halperin T, Vidal M, Nevins JR
The EMBO journal. 2002 ; 21 (21) : 5775-5786.
PMID 12411495
E2F-1 and E2F-3 are functionally distinct in their ability to promote myeloid cell cycle progression and block granulocyte differentiation.
Strom DK, Cleveland JL, Chellappan S, Nip J, Hiebert SW
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research. 1998 ; 9 (1) : 59-69.
PMID 9438389
Expression of the E2F family in human gastrointestinal carcinomas.
Suzuki T, Yasui W, Yokozaki H, Naka K, Ishikawa T, Tahara E
International journal of cancer. Journal international du cancer. 1999 ; 81 (4) : 535-538.
PMID 10225440
Analysis of promoter binding by the E2F and pRB families in vivo: distinct E2F proteins mediate activation and repression.
Takahashi Y, Rayman JB, Dynlacht BD
Genes & development. 2000 ; 14 (7) : 804-816.
PMID 10766737
Inhibition of retinoblastoma protein (Rb) phosphorylation at serine sites and an increase in Rb-E2F complex formation by silibinin in androgen-dependent human prostate carcinoma LNCaP cells: role in prostate cancer prevention.
Tyagi A, Agarwal C, Agarwal R
Molecular cancer therapeutics. 2002 ; 1 (7) : 525-532.
PMID 12479270
Differential regulation of E2F transcription factors by p53 tumor suppressor protein.
Vaishnav YN, Pant V
DNA and cell biology. 1999 ; 18 (12) : 911-922.
PMID 10619603
Array-based comparative genomic hybridization for genome-wide screening of DNA copy number in bladder tumors.
Veltman JA, Fridlyand J, Pejavar S, Olshen AB, Korkola JE, DeVries S, Carroll P, Kuo WL, Pinkel D, Albertson D, Cordon-Cardo C, Jain AN, Waldman FM
Cancer research. 2003 ; 63 (11) : 2872-2880.
PMID 12782593
The E2F1-3 transcription factors are essential for cellular proliferation.
Wu L, Timmers C, Maiti B, Saavedra HI, Sang L, Chong GT, Nuckolls F, Giangrande P, Wright FA, Field SJ, Greenberg ME, Orkin S, Nevins JR, Robinson ML, Leone G
Nature. 2001 ; 414 (6862) : 457-462.
PMID 11719808
Amplification and overexpression of the ID4 gene at 6p22.3 in bladder cancer.
Wu Q, Hoffmann MJ, Hartmann FH, Schulz WA
Molecular cancer. 2005 ; 4 (1) : page 16.
PMID 15876350
Multiple members of the E2F transcription factor family are the products of oncogenes.
Xu G, Livingston DM, Krek W
Proceedings of the National Academy of Sciences of the United States of America. 1995 ; 92 (5) : 1357-1361.
PMID 7877982
E2Fs link the control of G1/S and G2/M transcription.
Zhu W, Giangrande PH, Nevins JR
The EMBO journal. 2004 ; 23 (23) : 4615-4626.
PMID 15510213
Vascular endothelial growth factor promotes proliferation of cortical neuron precursors by regulating E2F expression.
Zhu Y, Jin K, Mao XO, Greenberg DA
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2003 ; 17 (2) : 186-193.
PMID 12554697
E2F3 loss has opposing effects on different pRB-deficient tumors, resulting in suppression of pituitary tumors but metastasis of medullary thyroid carcinomas.
Ziebold U, Lee EY, Bronson RT, Lees JA
Molecular and cellular biology. 2003 ; 23 (18) : 6542-6552.
PMID 12944480
E2F3 contributes both to the inappropriate proliferation and to the apoptosis arising in Rb mutant embryos.
Ziebold U, Reza T, Caron A, Lees JA
Genes & development. 2001 ; 15 (4) : 386-391.
PMID 11230146


This paper should be referenced as such :
MacLeod, RAF ; Nagel, S
E2F3 (E2F transcription factor 3)
Atlas Genet Cytogenet Oncol Haematol. 2005;9(4):286-290.
Free journal version : [ pdf ]   [ DOI ]
On line version :

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 5 ]
  Head and neck: Retinoblastoma
Eye: Retinoma
t(6;6)(p12;p22) E2F3/FBXO9
t(6;6)(p22;p22) E2F3/CDKAL1
t(6;13)(p22;q12) USP12/E2F3

External links

HGNC (Hugo)E2F3   3115
Entrez_Gene (NCBI)E2F3  1871  E2F transcription factor 3
GeneCards (Weizmann)E2F3
Ensembl hg19 (Hinxton)ENSG00000112242 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000112242 [Gene_View]  ENSG00000112242 [Sequence]  chr6:20401906-20493714 [Contig_View]  E2F3 [Vega]
ICGC DataPortalENSG00000112242
TCGA cBioPortalE2F3
AceView (NCBI)E2F3
Genatlas (Paris)E2F3
SOURCE (Princeton)E2F3
Genetics Home Reference (NIH)E2F3
Genomic and cartography
GoldenPath hg38 (UCSC)E2F3  -     chr6:20401906-20493714 +  6p22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)E2F3  -     6p22.3   [Description]    (hg19-Feb_2009)
EnsemblE2F3 - 6p22.3 [CytoView hg19]  E2F3 - 6p22.3 [CytoView hg38]
Mapping of homologs : NCBIE2F3 [Mapview hg19]  E2F3 [Mapview hg38]
Gene and transcription
Genbank (Entrez)BC016847 BC099908 BC114554 BU633769 CR749285
RefSeq transcript (Entrez)NM_001243076 NM_001949
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)E2F3
Cluster EST : UnigeneHs.703174 [ NCBI ]
CGAP (NCI)Hs.703174
Alternative Splicing GalleryENSG00000112242
Gene ExpressionE2F3 [ NCBI-GEO ]   E2F3 [ EBI - ARRAY_EXPRESS ]   E2F3 [ SEEK ]   E2F3 [ MEM ]
Gene Expression Viewer (FireBrowse)E2F3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1871
GTEX Portal (Tissue expression)E2F3
Human Protein AtlasENSG00000112242-E2F3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO00716   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO00716  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO00716
Splice isoforms : SwissVarO00716
Domains : Interpro (EBI)E2F    E2F_CC-MB    E2F_WHTH_DNA-bd_dom    WHTH_DNA-bd_dom   
Domain families : Pfam (Sanger)E2F_CC-MB (PF16421)    E2F_TDP (PF02319)   
Domain families : Pfam (NCBI)pfam16421    pfam02319   
Domain families : Smart (EMBL)E2F_TDP (SM01372)  
Conserved Domain (NCBI)E2F3
DMDM Disease mutations1871
Blocks (Seattle)E2F3
Human Protein Atlas [tissue]ENSG00000112242-E2F3 [tissue]
Peptide AtlasO00716
IPIIPI00743509   IPI00647428   IPI01011332   IPI00386286   
Protein Interaction databases
IntAct (EBI)O00716
Ontologies - Pathways
Ontology : AmiGORNA polymerase II regulatory region sequence-specific DNA binding  core promoter binding  transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding  DNA binding transcription factor activity  protein binding  nucleoplasm  transcription initiation from RNA polymerase II promoter  cell cycle  positive regulation of cell proliferation  sequence-specific DNA binding  positive regulation of transcription by RNA polymerase II  protein dimerization activity  negative regulation of fat cell proliferation  RNA polymerase II transcription factor complex  positive regulation of vascular associated smooth muscle cell apoptotic process  
Ontology : EGO-EBIRNA polymerase II regulatory region sequence-specific DNA binding  core promoter binding  transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding  DNA binding transcription factor activity  protein binding  nucleoplasm  transcription initiation from RNA polymerase II promoter  cell cycle  positive regulation of cell proliferation  sequence-specific DNA binding  positive regulation of transcription by RNA polymerase II  protein dimerization activity  negative regulation of fat cell proliferation  RNA polymerase II transcription factor complex  positive regulation of vascular associated smooth muscle cell apoptotic process  
REACTOMEO00716 [protein]
REACTOME PathwaysR-HSA-69298 [pathway]   
NDEx NetworkE2F3
Atlas of Cancer Signalling NetworkE2F3
Wikipedia pathwaysE2F3
Orthology - Evolution
GeneTree (enSembl)ENSG00000112242
Phylogenetic Trees/Animal Genes : TreeFamE2F3
Homologs : HomoloGeneE2F3
Homology/Alignments : Family Browser (UCSC)E2F3
Gene fusions - Rearrangements
Fusion : MitelmanE2F3/CDKAL1 [6p22.3/6p22.3]  
Fusion : MitelmanE2F3/FBXO9 [6p22.3/6p12.1]  [t(6;6)(p12;p22)]  
Fusion : MitelmanUSP12/E2F3 [13q12.13/6p22.3]  [t(6;13)(p22;q12)]  
Fusion PortalE2F3 6p22.3 FBXO9 6p12.1 BRCA
Fusion PortalUSP12 13q12.13 E2F3 6p22.3 BLCA
Fusion Cancer (Beijing)cytochrome_b [E2F3]  -  6p22.3 [FUSC003885]
Fusion : QuiverE2F3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerE2F3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)E2F3
Exome Variant ServerE2F3
ExAC (Exome Aggregation Consortium)ENSG00000112242
GNOMAD BrowserENSG00000112242
Genetic variants : HAPMAP1871
Genomic Variants (DGV)E2F3 [DGVbeta]
DECIPHERE2F3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisE2F3 
ICGC Data PortalE2F3 
TCGA Data PortalE2F3 
Broad Tumor PortalE2F3
OASIS PortalE2F3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICE2F3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDE2F3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch E2F3
DgiDB (Drug Gene Interaction Database)E2F3
DoCM (Curated mutations)E2F3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)E2F3 (select a term)
NCG5 (London)E2F3
Cancer3DE2F3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Genetic Testing Registry E2F3
NextProtO00716 [Medical]
Target ValidationE2F3
Huge Navigator E2F3 [HugePedia]
snp3D : Map Gene to Disease1871
BioCentury BCIQE2F3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1871
Chemical/Pharm GKB GenePA27573
Clinical trialE2F3
canSAR (ICR)E2F3 (select the gene name)
PubMed134 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Jul 16 09:46:30 CEST 2018

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us