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EEF1A2 (eukaryotic translation elongation factor 1 alpha 2)

Written2008-04Sanna Noubir, Jonathan M Lee
Department of Biochemistry, Microbiology, Immunology, University of Ottawa, 451 Smyth Road, Ottawa, Ontario, Canada K1H 8M5.

(Note : for Links provided by Atlas : click)


HGNC (Hugo) EEF1A2
HGNC Alias symbEEF1AL
HGNC Previous nameSTNL
HGNC Previous namestatin-like
LocusID (NCBI) 1917
Atlas_Id 40408
Location 20q13.33  [Link to chromosome band 20q13]
Location_base_pair Starts at 63488014 and ends at 63499083 bp from pter ( according to hg19-Feb_2009)  [Mapping EEF1A2.png]
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
EEF1A2 (20q13.33) / DKKL1 (19q13.33)EEF1A2 (20q13.33) / EEF1A2 (20q13.33)


Description 8 exons and 7 introns.
Transcription 5 alternatives for transcript splicing.


Description 50kDa; 463 amino acids contains tRNA binding sites, GTP binding and hydrolysis sites and putative actin binding sites (see figure above).
Expression In mice and humans, eEF1A2 is expressed only in normal tissues of the brain, heart and skeletal muscle. Expression is found in tumours of the breast, lung and ovary.
Localisation Diffusely cytoplasmic and nuclear.
Function This protein is an isoform of the alpha subunit of the elongation factor-1 complex. There are two known isoforms of protein elongation factor eEF1A (eEF1A1 and eEF1A2). eEF1A proteins are GTP-binding proteins that interact with amino-acylated tRNA and recruit them to the ribosome during the elongation phase of protein translation. In addition, eEF1A2 binds to and stimulates the lipid kinase activity of phosphatidylinositol 4-kinase beta, the enzyme that catalyzes the generation of phosphatidylinositol 4-phosphate from phosphatidylinositol. eEF1A2 also activates the Akt serine/threonine kinase and can stimulate actin remodeling and increase the rate of cell invasion and migration in vitro.
Homology EEF1A2 is highly homologous to the EEF1A1. EEF1A2 and EEF1A1 share greater than 90% DNA sequence and amino acid identity. The GTP binding and hydrolysis domains also have homology to the Ras GTPase.


Note Inactivation of mouse EEF1A2 leads to immunodeficiency, neuromuscular abnormalities and death by 30 days of age.

Implicated in

Entity Tumorigenesis
Disease Breast, lung and ovarian cancer. EEF1A2 overexpression is found in approximatively 60% of breast, 30% of ovary and 40% of lung tumours.
Prognosis High eEF1A2 protein expression is associated with good prognosis in both breast and ovarian cancer. High eEF1A2 protein expression predicts poor prognosis in lung cancer.
Cytogenetics Fluorescence in situ hybridization (FISH), showed high copy numbers of EEF1A2 in 25% ovarian tumors.
Oncogenesis The eEF1A2 gene is transforming and increases the in-vitro growth rate of mouse and human cells grown in-vitro and also enhances their tumorigenicity in mouse xenograft models.


eEF1A2 activates Akt and stimulates Akt-dependent actin remodeling, invasion and migration.
Amiri A, Noei F, Jeganathan S, Kulkarni G, Pinke DE, Lee JM.
Oncogene. 2007 May 10;26(21):3027-40. Epub 2006 Nov 20.
PMID 17130842
Protein elongation factor EEF1A2 is a putative oncogene in ovarian cancer.
Anand N, Murthy S, Amann G, Wernick M, Porter LA, Cukier IH, Collins C, Gray JW, Diebold J, Demetrick DJ, Lee JM.
Nat Genet. 2002 Jul;31(3):301-5. Epub 2002 Jun 10.
PMID 12053177
Binding of elongation factor eEF1A2 to phosphatidylinositol 4-kinase beta stimulates lipid kinase activity and phosphatidylinositol 4-phosphate generation.
Jeganathan S, Lee JM.
J Biol Chem. 2007 Jan 5;282(1):372-80. Epub 2006 Nov 6.
PMID 17088255
Expression of protein elongation factor eEF1A2 predicts favorable outcome in breast cancer.
Kulkarni G, Turbin DA, Amiri A, Jeganathan S, Andrade-Navarro MA, Wu TD, Huntsman DG, Lee JM.
Breast Cancer Res Treat. 2007 Mar;102(1):31-41. Epub 2006 Aug 9.
PMID 16897428
The prognostic significance of elongation factor eEF1A2 in ovarian cancer.
Pinke DE, Kalloger SE, Francetic T, Huntsman DG, Lee JM.
Gynecol Oncol. 2008 Mar;108(3):561-8. Epub 2007 Dec 31.
PMID 18164751
Expression of eEF1A2 is associated with clear cell histology in ovarian carcinomas: overexpression of the gene is not dependent on modifications at the EEF1A2 locus.
Tomlinson VA, Newbery HJ, Bergmann JH, Boyd J, Scott D, Wray NR, Sellar GC, Gabra H, Graham A, Williams AR, Abbott CM.
Br J Cancer. 2007 May 21;96(10):1613-20. Epub 2007 Apr 17.
PMID 17437010


This paper should be referenced as such :
Noubir, S ; Lee, JM
EEF1A2 (eukaryotic translation elongation factor 1 alpha 2)
Atlas Genet Cytogenet Oncol Haematol. 2009;13(3):196-197.
Free journal version : [ pdf ]   [ DOI ]

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(19;20)(q13;q13) EEF1A2/DKKL1

External links

HGNC (Hugo)EEF1A2   3192
Entrez_Gene (NCBI)EEF1A2  1917  eukaryotic translation elongation factor 1 alpha 2
AliasesEEF1AL; EF-1-alpha-2; EF1A; EIEE33; 
GeneCards (Weizmann)EEF1A2
Ensembl hg19 (Hinxton)ENSG00000101210 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000101210 [Gene_View]  ENSG00000101210 [Sequence]  chr20:63488014-63499083 [Contig_View]  EEF1A2 [Vega]
ICGC DataPortalENSG00000101210
TCGA cBioPortalEEF1A2
AceView (NCBI)EEF1A2
Genatlas (Paris)EEF1A2
SOURCE (Princeton)EEF1A2
Genetics Home Reference (NIH)EEF1A2
Genomic and cartography
GoldenPath hg38 (UCSC)EEF1A2  -     chr20:63488014-63499083 -  20q13.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)EEF1A2  -     20q13.33   [Description]    (hg19-Feb_2009)
GoldenPathEEF1A2 - 20q13.33 [CytoView hg19]  EEF1A2 - 20q13.33 [CytoView hg38]
genome Data Viewer NCBIEEF1A2 [Mapview hg19]  
OMIM602959   616393   616409   
Gene and transcription
Genbank (Entrez)AB209064 AB451389 AK123690 AK307536 BC000432
RefSeq transcript (Entrez)NM_001958
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)EEF1A2
Alternative Splicing GalleryENSG00000101210
Gene ExpressionEEF1A2 [ NCBI-GEO ]   EEF1A2 [ EBI - ARRAY_EXPRESS ]   EEF1A2 [ SEEK ]   EEF1A2 [ MEM ]
Gene Expression Viewer (FireBrowse)EEF1A2 [ Firebrowse - Broad ]
GenevisibleExpression of EEF1A2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1917
GTEX Portal (Tissue expression)EEF1A2
Human Protein AtlasENSG00000101210-EEF1A2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ05639   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ05639  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ05639
Splice isoforms : SwissVarQ05639
Domaine pattern : Prosite (Expaxy)G_TR_1 (PS00301)    G_TR_2 (PS51722)   
Domains : Interpro (EBI)EFTu-like_2    G_TR_CS    P-loop_NTPase    TF_GTP-bd_dom    Transl_B-barrel_sf    Transl_elong_EF1A/Init_IF2_C    Transl_elong_EF1A_euk/arc    Transl_elong_EFTu/EF1A_C   
Domain families : Pfam (Sanger)GTP_EFTU (PF00009)    GTP_EFTU_D2 (PF03144)    GTP_EFTU_D3 (PF03143)   
Domain families : Pfam (NCBI)pfam00009    pfam03144    pfam03143   
Conserved Domain (NCBI)EEF1A2
DMDM Disease mutations1917
Blocks (Seattle)EEF1A2
PDB Europe3C5J   
PDB (PDBSum)3C5J   
PDB (IMB)3C5J   
Structural Biology KnowledgeBase3C5J   
SCOP (Structural Classification of Proteins)3C5J   
CATH (Classification of proteins structures)3C5J   
Human Protein Atlas [tissue]ENSG00000101210-EEF1A2 [tissue]
Peptide AtlasQ05639
IPIIPI00014424   IPI00556204   
Protein Interaction databases
IntAct (EBI)Q05639
Ontologies - Pathways
Ontology : AmiGOtranslation elongation factor activity  GTPase activity  protein binding  GTP binding  nucleus  cytoplasm  eukaryotic translation elongation factor 1 complex  translation  translational elongation  translation factor activity, RNA binding  response to inorganic substance  protein kinase binding  neuronal cell body  positive regulation of apoptotic process  synapse  response to electrical stimulus  positive regulation of lipid kinase activity  cytoplasmic side of lysosomal membrane  regulation of chaperone-mediated autophagy  
Ontology : EGO-EBItranslation elongation factor activity  GTPase activity  protein binding  GTP binding  nucleus  cytoplasm  eukaryotic translation elongation factor 1 complex  translation  translational elongation  translation factor activity, RNA binding  response to inorganic substance  protein kinase binding  neuronal cell body  positive regulation of apoptotic process  synapse  response to electrical stimulus  positive regulation of lipid kinase activity  cytoplasmic side of lysosomal membrane  regulation of chaperone-mediated autophagy  
Pathways : KEGGRNA transport    Legionellosis   
REACTOMEQ05639 [protein]
REACTOME PathwaysR-HSA-156842 [pathway]   
NDEx NetworkEEF1A2
Atlas of Cancer Signalling NetworkEEF1A2
Wikipedia pathwaysEEF1A2
Orthology - Evolution
GeneTree (enSembl)ENSG00000101210
Phylogenetic Trees/Animal Genes : TreeFamEEF1A2
Homologs : HomoloGeneEEF1A2
Homology/Alignments : Family Browser (UCSC)EEF1A2
Gene fusions - Rearrangements
Fusion : MitelmanEEF1A2/DKKL1 [20q13.33/19q13.33]  
Fusion PortalEEF1A2 20q13.33 DKKL1 19q13.33 BRCA
Fusion : Fusion_HubACAP3--EEF1A2    ADRM1--EEF1A2    ADSSL1--EEF1A2    ATP2A1--EEF1A2    DES--EEF1A2    DNAJA4--EEF1A2    EEF1A1--EEF1A2    EEF1A2--DKKL1    EEF1A2--EEF1A2    EEF1A2--ELAC2    EEF1A2--FRG1B    EEF1A2--GNB2L1    EEF1A2--HSA-MIR-6723    EEF1A2--MYH7    EEF1A2--NHP2   
EEF1A2--SLC29A2    EEF1A2--TG    EEF1A2--ZBTB46    GPX4--EEF1A2    LOC101928295--EEF1A2    LRRC37A4--EEF1A2    MTAP--EEF1A2    MYBPC3--EEF1A2    MYH7--EEF1A2    NEB--EEF1A2    RIPK1--EEF1A2    SMARCD2--EEF1A2    TNNC1--EEF1A2   
Fusion : QuiverEEF1A2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerEEF1A2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)EEF1A2
Exome Variant ServerEEF1A2
GNOMAD BrowserENSG00000101210
Varsome BrowserEEF1A2
Genetic variants : HAPMAP1917
Genomic Variants (DGV)EEF1A2 [DGVbeta]
DECIPHEREEF1A2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisEEF1A2 
ICGC Data PortalEEF1A2 
TCGA Data PortalEEF1A2 
Broad Tumor PortalEEF1A2
OASIS PortalEEF1A2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICEEF1A2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DEEF1A2
Mutations and Diseases : HGMDEEF1A2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch EEF1A2
DgiDB (Drug Gene Interaction Database)EEF1A2
DoCM (Curated mutations)EEF1A2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)EEF1A2 (select a term)
NCG6 (London) select EEF1A2
Cancer3DEEF1A2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
OMIM602959    616393    616409   
Orphanet18028    23427   
Genetic Testing Registry EEF1A2
NextProtQ05639 [Medical]
Target ValidationEEF1A2
Huge Navigator EEF1A2 [HugePedia]
snp3D : Map Gene to Disease1917
BioCentury BCIQEEF1A2
Clinical trials, drugs, therapy
Protein Interactions : CTD1917
Pharm GKB GenePA36219
Clinical trialEEF1A2
canSAR (ICR)EEF1A2 (select the gene name)
DataMed IndexEEF1A2
PubMed137 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 12 12:40:50 CEST 2020

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