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C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. |
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Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor. |
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HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing. |
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Overexpression and nuclear translocation of hypoxia-inducible factor prolyl hydroxylase PHD2 in head and neck squamous cell carcinoma is associated with tumor aggressiveness. |
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Intracellular localisation of human HIF-1 alpha hydroxylases: implications for oxygen sensing. |
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Regulation of the prolyl hydroxylase domain protein 2 (phd2/egln-1) gene: identification of a functional hypoxia-responsive element. |
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A novel erythrocytosis-associated PHD2 mutation suggests the location of a HIF binding groove. |
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A family with erythrocytosis establishes a role for prolyl hydroxylase domain protein 2 in oxygen homeostasis. |
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Placental but not heart defects are associated with elevated hypoxia-inducible factor alpha levels in mice lacking prolyl hydroxylase domain protein 2. |
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Characterization and comparative analysis of the EGLN gene family. |
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