| Disturbance in the HIF-1alpha pathway associated with erythrocytosis: further evidences brought by frameshift and nonsense mutations in the prolyl hydroxylase domain protein 2 (PHD2) gene. |
| Al-Sheikh M, Moradkhani K, Lopez M, Wajcman H, Préhu C |
| Blood cells, molecules & diseases. 2008 ; 40 (2) : 160-165. |
| PMID 17933562 |
| |
| Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor. |
| Appelhoff RJ, Tian YM, Raval RR, Turley H, Harris AL, Pugh CW, Ratcliffe PJ, Gleadle JM |
| The Journal of biological chemistry. 2004 ; 279 (37) : 38458-38465. |
| PMID 15247232 |
| |
| HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia. |
| Berra E, Benizri E, Ginouvès A, Volmat V, Roux D, Pouysségur J |
| The EMBO journal. 2003 ; 22 (16) : 4082-4090. |
| PMID 12912907 |
| |
| Mapping, characterization, and expression analysis of the SM-20 human homologue, c1orf12, and identification of a novel related gene, SCAND2. |
| Dupuy D, Aubert I, Dupérat VG, Petit J, Taine L, Stef M, Bloch B, Arveiler B |
| Genomics. 2000 ; 69 (3) : 348-354. |
| PMID 11056053 |
| |
| C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. |
| Epstein AC, Gleadle JM, McNeill LA, Hewitson KS, O'Rourke J, Mole DR, Mukherji M, Metzen E, Wilson MI, Dhanda A, Tian YM, Masson N, Hamilton DL, Jaakkola P, Barstead R, Hodgkin J, Maxwell PH, Pugh CW, Schofield CJ, Ratcliffe PJ |
| Cell. 2001 ; 107 (1) : 43-54. |
| PMID 11595184 |
| |
| Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor. |
| Hirsilä M, Koivunen P, Günzler V, Kivirikko KI, Myllyharju J |
| The Journal of biological chemistry. 2003 ; 278 (33) : 30772-30780. |
| PMID 12788921 |
| |
| HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing. |
| Ivan M, Kondo K, Yang H, Kim W, Valiando J, Ohh M, Salic A, Asara JM, Lane WS, Kaelin WG Jr |
| Science (New York, N.Y.). 2001 ; 292 (5516) : 464-468. |
| PMID 11292862 |
| |
| Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. |
| Jaakkola P, Mole DR, Tian YM, Wilson MI, Gielbert J, Gaskell SJ, Kriegsheim Av, Hebestreit HF, Mukherji M, Schofield CJ, Maxwell PH, Pugh CW, Ratcliffe PJ |
| Science (New York, N.Y.). 2001 ; 292 (5516) : 468-472. |
| PMID 11292861 |
| |
| Overexpression and nuclear translocation of hypoxia-inducible factor prolyl hydroxylase PHD2 in head and neck squamous cell carcinoma is associated with tumor aggressiveness. |
| Jokilehto T, Rantanen K, Luukkaa M, Heikkinen P, Grenman R, Minn H, Kronqvist P, Jaakkola PM |
| Clinical cancer research : an official journal of the American Association for Cancer Research. 2006 ; 12 (4) : 1080-1087. |
| PMID 16489060 |
| |
| Intracellular localisation of human HIF-1 alpha hydroxylases: implications for oxygen sensing. |
| Metzen E, Berchner-Pfannschmidt U, Stengel P, Marxsen JH, Stolze I, Klinger M, Huang WQ, Wotzlaw C, Hellwig-Bürgel T, Jelkmann W, Acker H, Fandrey J |
| Journal of cell science. 2003 ; 116 (Pt 7) : 1319-1326. |
| PMID 12615973 |
| |
| Regulation of the prolyl hydroxylase domain protein 2 (phd2/egln-1) gene: identification of a functional hypoxia-responsive element. |
| Metzen E, Stiehl DP, Doege K, Marxsen JH, Hellwig-Bürgel T, Jelkmann W |
| The Biochemical journal. 2005 ; 387 (Pt 3) : 711-717. |
| PMID 15563275 |
| |
| A novel erythrocytosis-associated PHD2 mutation suggests the location of a HIF binding groove. |
| Percy MJ, Furlow PW, Beer PA, Lappin TR, McMullin MF, Lee FS |
| Blood. 2007 ; 110 (6) : 2193-2196. |
| PMID 17579185 |
| |
| A family with erythrocytosis establishes a role for prolyl hydroxylase domain protein 2 in oxygen homeostasis. |
| Percy MJ, Zhao Q, Flores A, Harrison C, Lappin TR, Maxwell PH, McMullin MF, Lee FS |
| Proceedings of the National Academy of Sciences of the United States of America. 2006 ; 103 (3) : 654-659. |
| PMID 16407130 |
| |
| Placental but not heart defects are associated with elevated hypoxia-inducible factor alpha levels in mice lacking prolyl hydroxylase domain protein 2. |
| Takeda K, Ho VC, Takeda H, Duan LJ, Nagy A, Fong GH |
| Molecular and cellular biology. 2006 ; 26 (22) : 8336-8346. |
| PMID 16966370 |
| |
| Characterization and comparative analysis of the EGLN gene family. |
| Taylor MS |
| Gene. 2001 ; 275 (1) : 125-132. |
| PMID 11574160 |
| |
