| Identity |
| Other names | ENL (eleven nineteen leukemia) |
| LTG19 | |
| MLLT1 (myeloid/lymphoid leukemia translocated to, 1) | |
| HGNC (Hugo) | MLLT1 |
| Location | 19p13.3 |
| Location_base_pair | Starts at 6161392 and ends at 6230959 bp from pter ( according to hg18-Mar_2006) [Mapping] |
| Local_order | not far from E2A, also in 19p13.3; LYL1 is in 19p13.2-p13.1 and ELL in 19p13.1 |
| DNA/RNA |
| Transcription | 4.7 kb mRNA; coding sequence: 1.7 kb |
| Protein |
| Description | 559 amino acids; 62 kDa; serine/proline rich protein; contains a nuclear targeting sequence and a consensus sequence for ATP/GTP binding |
| Expression | wide |
| Localisation | nuclear |
| Function | transcription activator |
| Homology | with AF9 |
| Implicated in |
| Entity | t(11.19)(q23;p13.3) /acute leukaemias --> MLL - ENL |
| Disease | ALL (CD19+), biphenotypic AL, ANLL (M4/M5); mainly congenital; treatment related leukaemia |
| Prognosis | very poor, except in rare T-cell cases |
| Cytogenetics | detected with G banding |
| Hybrid/Mutated Gene | 5' MLL - 3' ENL |
| Abnormal Protein | AT hook and DNA methyltransferase from MLL fused to, most often, the nearly entire ENL |
| External links |
| Bibliography |
| Identification of MLL and chimeric MLL gene products involved in 11q23 translocation and possible mechanisms of leukemogenesis by MLL truncation. |
| Joh T, Kagami Y, Yamamoto K, Segawa T, Takizawa J, Takahashi T, Ueda R, Seto M |
| Oncogene. 1996 ; 13 (9) : 1945-1953. |
| PMID 8934541 |
| Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias. |
| Tkachuk DC, Kohler S, Cleary ML |
| Cell. 1992 ; 71 (4) : 691-700. |
| PMID 1423624 |
| Chromosome abnormalities in leukaemia: the 11q23 paradigm. |
| Young BD, Saha V |
| Cancer surveys. 1996 ; 28 : 225-245. |
| PMID 8977038 |
| Molecular basis of 11q23 rearrangements in hematopoietic malignant proliferations. |
| Bernard OA, Berger R |
| Genes, chromosomes & cancer. 1995 ; 13 (2) : 75-85. |
| PMID 7542910 |
| 11q23 rearrangements in acute leukemia. |
| Rubnitz JE, Behm FG, Downing JR |
| Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 1996 ; 10 (1) : 74-82. |
| PMID 8558942 |
| REVIEW articles | automatic search in PubMed |
| Last year publications | automatic search in PubMed |
| Contributor(s) |
| Written | 12-1997 | Jean-Loup Huret |
| Citation |
| This paper should be referenced as such : |
| Huret JL . MLLT1 (myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1). Atlas Genet Cytogenet Oncol Haematol. December 1997 . URL : http://AtlasGeneticsOncology.org/Genes/ENL.html |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Sat Jun 27 16:37:42 CEST 2009 |
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