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MLLT1 (myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1)

Written1997-12Jean-Loup Huret
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

(Note : for Links provided by Atlas : click)

Identity

Other aliasENL (eleven nineteen leukemia)
LTG19
MLLT1 (myeloid/lymphoid leukemia translocated to, 1)
LocusID (NCBI) 4298
Atlas_Id 9
Location 19p13.3  [Link to chromosome band 19p13]
Location_base_pair Starts at and ends at bp from pter
Local_order not far from E2A, also in 19p13.3; LYL1 is in 19p13.2-p13.1 and ELL in 19p13.1
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ADAMTS10 (19p13.2) / MLLT1 (19p13.3)KMT2A (11q23.3) / MLLT1 (19p13.3)KMT2B (19q13.12) / MLLT1 (19p13.3)
LRRC7 (1p31.1) / MLLT1 (19p13.3)MLLT1 (19p13.3) / KMT2A (11q23.3)MLLT1 (19p13.3) / MLLT1 (19p13.3)
MLLT1 (19p13.3) / SH3GL1 (19p13.3)MLLT1 (19p13.3) / TPRN (9q34.3)MLLT1 (19p13.3) / ZNF439 (19p13.2)
RANBP3 (19p13.3) / MLLT1 (19p13.3)SLC45A3 (1q32.1) / MLLT1 (19p13.3)

DNA/RNA

Transcription 4.7 kb mRNA; coding sequence: 1.7 kb

Protein

Description 559 amino acids; 62 kDa; serine/proline rich protein; contains a nuclear targeting sequence and a consensus sequence for ATP/GTP binding
Expression wide
Localisation nuclear
Function transcription activator
Homology with AF9

Implicated in

Note
  
Entity t(11.19)(q23;p13.3) /acute leukaemias --> KMT2A - MLLT1
Disease ALL (CD19+), biphenotypic AL, AML (M4/M5); mainly congenital; treatment related leukaemia
Prognosis very poor, except in rare T-cell cases
Cytogenetics detected with G banding
Hybrid/Mutated Gene 5' MLL - 3' ENL
Abnormal Protein AT hook and DNA methyltransferase from MLL fused to, most often, the nearly entire ENL
  

Bibliography

Molecular basis of 11q23 rearrangements in hematopoietic malignant proliferations.
Bernard OA, Berger R
Genes, chromosomes & cancer. 1995 ; 13 (2) : 75-85.
PMID 7542910
 
Identification of MLL and chimeric MLL gene products involved in 11q23 translocation and possible mechanisms of leukemogenesis by MLL truncation.
Joh T, Kagami Y, Yamamoto K, Segawa T, Takizawa J, Takahashi T, Ueda R, Seto M
Oncogene. 1996 ; 13 (9) : 1945-1953.
PMID 8934541
 
11q23 rearrangements in acute leukemia.
Rubnitz JE, Behm FG, Downing JR
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 1996 ; 10 (1) : 74-82.
PMID 8558942
 
Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias.
Tkachuk DC, Kohler S, Cleary ML
Cell. 1992 ; 71 (4) : 691-700.
PMID 1423624
 
Chromosome abnormalities in leukaemia: the 11q23 paradigm.
Young BD, Saha V
Cancer surveys. 1996 ; 28 : 225-245.
PMID 8977038
 

Citation

This paper should be referenced as such :
Huret, JL
MLLT1 (myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1)
Atlas Genet Cytogenet Oncol Haematol. 1997;1(2):66-66.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Genes/ENLID9.html


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 18 ]
  11q23 rearrangements (KMT2A) in therapy related leukaemias
t(11;19)(q23;p13.3) KMT2A/MLLT1
t(11;19)(q23;p13) KMT2A/MLLT1
11q23 rearrangements (KMT2A) in childhood acute lymphoblastic leukemia
11q23 rearrangements (KMT2A) in de novo childhood acute myeloid leukemia
11q23 rearrangements (KMT2A) in leukaemia
11q23 rearrangements (KMT2A) in therapy related leukaemias
Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN)
Infant leukaemias::Congenital leukaemias::Neonatal leukaemias
Pediatric T-Cell Acute Lymphoblastic Leukemia
der(2)t(1;2)(q12-21;q37)
t(4;11)(q21;q23) KMT2A/AFF1
t(6;11)(q27;q23) KMT2A/AFDN
t(11;16)(q23;p13.3) KMT2A/CREBBP
t(11;19)(q23;p13.3) KMT2A/MLLT1
t(11;19)(q23;p13) KMT2A/SH3GL1
T-lineage acute lymphoblastic leukemia (T-ALL)
t(11;19)(q23;p13) KMT2A/MLLT1


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 3 ]
  ADAMTS10/MLLT1 (19p13)
MLLT1/ZNF439 (19p13)
RANBP3/MLLT1 (19p13)


External links

Nomenclature
Cards
AtlasENLID9.txt
Aliases
Genomic and cartography
Gene and transcription
RefSeq transcript (Entrez)
RefSeq genomic (Entrez)
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)4298
Protein : pattern, domain, 3D structure
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Protein Interaction databases
Ontologies - Pathways
Clinical trials, drugs, therapy
Miscellaneous
canSAR (ICR) (select the gene name)
Probes
Litterature
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed


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indexed on : Thu Oct 18 17:35:09 CEST 2018

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