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ETV4 (ets variant 4)

Written2010-11Yasuyoshi Miyata
Department of Urology, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan

(Note : for Links provided by Atlas : click)

Identity

Alias_namesets variant gene 4 (E1A enhancer-binding protein
Alias_symbol (synonym)E1A-F
E1AF
PEA3
Other aliasPEAS3
HGNC (Hugo) ETV4
LocusID (NCBI) 2118
Atlas_Id 133
Location 17q21.31  [Link to chromosome band 17q21]
Location_base_pair Starts at 43527843 and ends at 43546432 bp from pter ( according to hg19-Feb_2009)  [Mapping ETV4.png]
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CANT1 (17q25.3) / ETV4 (17q21.31)DDX5 (17q23.3) / ETV4 (17q21.31)DHX8 (17q21.31) / ETV4 (17q21.31)
ETV4 (17q21.31) / CANT1 (17q25.3)ETV4 (17q21.31) / CCL16 (17q12)ETV4 (17q21.31) / DDX5 (17q23.3)
ETV4 (17q21.31) / EDIL3 (5q14.3)ETV4 (17q21.31) / EWSR1 (22q12.2)ETV4 (17q21.31) / KLK2 (19q13.33)
ETV4 (17q21.31) / TMPRSS2 (21q22.3)EWSR1 (22q12.2) / ETV4 (17q21.31)KLK2 (19q13.33) / ETV4 (17q21.31)
SLC45A3 (1q32.1) / ETV4 (17q21.31)TMPRSS2 (21q22.3) / ETV4 (17q21.31)UBTF (17q21.31) / ETV4 (17q21.31)
XPO7 (8p21.3) / ETV4 (17q21.31)

DNA/RNA

 
  GeneLoc map region.
Description The gene spans approximately 30 kb and contained 14 exons. The largest exon (901 bp) contains the end of the ETS domain, the carboxy-terminal domain and the 3'-untranslated region. The remaining exons varied from 48 bp (exon 5) to 266 bp (exon 9).

Protein

Description ETV4 is a member of ets-oncogene family transcription factors that were cloned by the ability to bind to enhancer motifs of the adenovirus E1A gene (Lavia et al., 2003). It is composed of 555 amino acids, which has a molecular weight ranging 61~70 kDa.
Localisation Nuclear (Monté et al., 1994; Takahashi et al., 2005). Ubiquitinated protein is localized in the dot-like structure in the nuclear (Takahashi et al., 2005).
Function ETV4 is capable of regulating transcription by binding to the Ets-binding site in the promoter of its target genes. Biologically, it contributes in a number of processes including neuronal pathfinding, mammary gland development, and male sexual function (Laing et al., 2000; Ladle et al., 2002; Kurpios et al., 2003). In various malignancies, its over-expression has been observed and it was also associated with tumor progression and outcome of patients with these malignancies. As mechanism of such function, regulation of hepatocyte growth factor (HGF)-induced cell migration (Hakuma et al., 2005), HER2-mediated malignant potential (Benz et al., 1997), and other ETV4-related factors including cyclooxygenase (COX)-2 and matrix metalloproteinases (MMPs) have been reported (Higashino et al., 1995; Horiuchi et al., 2003; Shindoh et al., 2004). In addition, ETV4 promotes cell cycle progression via upregulation of cyclin D3 transcription in breast cancer cell (MDA231 cell) (Jiang et al., 2007). In contrast, ETV4 function as negative regulator of sonic hedgehog expression (Mao et al., 2009).

Implicated in

Note
  
Entity Breast cancer
Disease Over-expression of ETV4 has been detected in human cancer cell lines (Baert et al., 1997). In animal model and human tissues, its over-expression was also found and it was associated with malignant potential including invasion and metastasis (Trimble et al., 1993; De Launoit et al., 2000; Benz et al., 1997; Bièche et al., 2004). Such ETV4-related functions are controlled via regulation of cyclin D3 transcription (Jiang et al., 2007), HER-2/Neu (Benz et al., 1997), and MMPs (Bièche et al., 2004).
  
  
Entity Gastric cancer
Disease Correlated with tumor progression via up-regulation of matrilysin in human tissues (Yamamoto et al., 2004).
  
  
Entity Lung cancer
Disease ETV4 expression was not detected in normal lung tissues. On the other hand, it is expressed in distal lung epithelium during lung development and in human lung cancer cells (Hiroumi et al., 2001; Liu et al., 2003). It was reported to be associated with cell invasion (Hiroumi et al., 2001) and metastasis via regulation of caveolin-1 transcription (Sloan et al., 2009) and Met-related factors (Hakuma et al., 2005).
  
  
Entity Malignant melanoma
Disease In cell lines, ETV4 plays important roles for malignant behavior including invasion and metastasis thorough up-regulation of MT1-MMP (Hata et al., 2008).
  
  
Entity Prostate cancer
Disease In human tissues, its expression in cancer cell was significantly higher than that in normal cells and it was also positively associated with pT stage. This finding was influenced with regulation of MMP-7 and MMP-9, but not of MMP-1, MMP-3, and MMP-14 (MT1-MMP) (Maruta et al., 2009).
  
  
Entity Colorectal cancer
Disease In early stage of colorectal carcinogenesis, its over-expression plays important roles through MMPs, COX-2, and iNos (Nosho et al., 2005).
  

Breakpoints

 

Bibliography

Expression of the PEA3 group of ETS-related transcription factors in human breast-cancer cells.
Baert JL, Monte D, Musgrove EA, Albagli O, Sutherland RL, de Launoit Y.
Int J Cancer. 1997 Mar 4;70(5):590-7.
PMID 9052761
 
HER2/Neu and the Ets transcription activator PEA3 are coordinately upregulated in human breast cancer.
Benz CC, O'Hagan RC, Richter B, Scott GK, Chang CH, Xiong X, Chew K, Ljung BM, Edgerton S, Thor A, Hassell JA.
Oncogene. 1997 Sep 25;15(13):1513-25.
PMID 9380403
 
Expression of PEA3/E1AF/ETV4, an Ets-related transcription factor, in breast tumors: positive links to MMP2, NRG1 and CGB expression.
Bieche I, Tozlu S, Girault I, Onody P, Driouch K, Vidaud M, Lidereau R.
Carcinogenesis. 2004 Mar;25(3):405-11. Epub 2003 Nov 21.
PMID 14633660
 
E1AF/PEA3 activates the Rho/Rho-associated kinase pathway to increase the malignancy potential of non-small-cell lung cancer cells.
Hakuma N, Kinoshita I, Shimizu Y, Yamazaki K, Yoshida K, Nishimura M, Dosaka-Akita H.
Cancer Res. 2005 Dec 1;65(23):10776-82.
PMID 16322223
 
Expression of E1AF, an ets-oncogene transcription factor, highly correlates with malignant phenotype of malignant melanoma through up-regulation of the membrane-type-1 matrix metalloproteinase gene.
Hata H, Kitamura T, Higashino F, Hida K, Yoshida K, Ohiro Y, Totsuka Y, Kitagawa Y, Shindoh M.
Oncol Rep. 2008 May;19(5):1093-8.
PMID 18425363
 
Ets-related protein E1A-F can activate three different matrix metalloproteinase gene promoters.
Higashino F, Yoshida K, Noumi T, Seiki M, Fujinaga K.
Oncogene. 1995 Apr 6;10(7):1461-3.
PMID 7731700
 
Expression of E1AF/PEA3, an Ets-related transcription factor in human non-small-cell lung cancers: its relevance in cell motility and invasion.
Hiroumi H, Dosaka-Akita H, Yoshida K, Shindoh M, Ohbuchi T, Fujinaga K, Nishimura M.
Int J Cancer. 2001 Sep;93(6):786-91.
PMID 11519038
 
Association of ets-related transcriptional factor E1AF expression with tumour progression and overexpression of MMP-1 and matrilysin in human colorectal cancer.
Horiuchi S, Yamamoto H, Min Y, Adachi Y, Itoh F, Imai K.
J Pathol. 2003 Aug;200(5):568-76.
PMID 12898592
 
E1AF promotes breast cancer cell cycle progression via upregulation of Cyclin D3 transcription.
Jiang J, Wei Y, Liu D, Zhou J, Shen J, Chen X, Zhang S, Kong X, Gu J.
Biochem Biophys Res Commun. 2007 Jun 22;358(1):53-8. Epub 2007 Apr 18.
PMID 17467662
 
Function of PEA3 Ets transcription factors in mammary gland development and oncogenesis.
Kurpios NA, Sabolic NA, Shepherd TG, Fidalgo GM, Hassell JA.
J Mammary Gland Biol Neoplasia. 2003 Apr;8(2):177-90. (REVIEW)
PMID 14635793
 
The role of the ETS gene PEA3 in the development of motor and sensory neurons.
Ladle DR, Frank E.
Physiol Behav. 2002 Dec;77(4-5):571-6.
PMID 12527001
 
Male sexual dysfunction in mice bearing targeted mutant alleles of the PEA3 ets gene.
Laing MA, Coonrod S, Hinton BT, Downie JW, Tozer R, Rudnicki MA, Hassell JA.
Mol Cell Biol. 2000 Dec;20(24):9337-45.
PMID 11094084
 
Emerging roles of DNA tumor viruses in cell proliferation: new insights into genomic instability.
Lavia P, Mileo AM, Giordano A, Paggi MG.
Oncogene. 2003 Sep 29;22(42):6508-16. (REVIEW)
PMID 14528275
 
Role for ETS domain transcription factors Pea3/Erm in mouse lung development.
Liu Y, Jiang H, Crawford HC, Hogan BL.
Dev Biol. 2003 Sep 1;261(1):10-24.
PMID 12941618
 
Fgf-dependent Etv4/5 activity is required for posterior restriction of Sonic Hedgehog and promoting outgrowth of the vertebrate limb.
Mao J, McGlinn E, Huang P, Tabin CJ, McMahon AP.
Dev Cell. 2009 Apr;16(4):600-6.
PMID 19386268
 
E1AF expression is associated with extra-prostatic growth and matrix metalloproteinase-7 expression in prostate cancer.
Maruta S, Sakai H, Kanda S, Hayashi T, Kanetake H, Miyata Y.
APMIS. 2009 Nov;117(11):791-6.
PMID 19845529
 
Molecular cloning and characterization of human ERM, a new member of the Ets family closely related to mouse PEA3 and ER81 transcription factors.
Monte D, Baert JL, Defossez PA, de Launoit Y, Stehelin D.
Oncogene. 1994 May;9(5):1397-406.
PMID 8152800
 
Association of Ets-related transcriptional factor E1AF expression with overexpression of matrix metalloproteinases, COX-2 and iNOS in the early stage of colorectal carcinogenesis.
Nosho K, Yoshida M, Yamamoto H, Taniguchi H, Adachi Y, Mikami M, Hinoda Y, Imai K.
Carcinogenesis. 2005 May;26(5):892-9. Epub 2005 Feb 3.
PMID 15695237
 
E1AF, an ets-oncogene family transcription factor.
Shindoh M, Higashino F, Kohgo T.
Cancer Lett. 2004 Dec 8;216(1):1-8. (REVIEW)
PMID 15500943
 
Increased PEA3/E1AF and decreased Net/Elk-3, both ETS proteins, characterize human NSCLC progression and regulate caveolin-1 transcription in Calu-1 and NCI-H23 NSCLC cell lines.
Sloan KA, Marquez HA, Li J, Cao Y, Hinds A, O'Hara CJ, Kathuria S, Ramirez MI, Williams MC, Kathuria H.
Carcinogenesis. 2009 Aug;30(8):1433-42. Epub 2009 May 29.
PMID 19483189
 
E1AF degradation by a ubiquitin-proteasome pathway.
Takahashi A, Higashino F, Aoyagi M, Yoshida K, Itoh M, Kobayashi M, Totsuka Y, Kohgo T, Shindoh M.
Biochem Biophys Res Commun. 2005 Feb 11;327(2):575-80.
PMID 15629152
 
PEA3 is overexpressed in mouse metastatic mammary adenocarcinomas.
Trimble MS, Xin JH, Guy CT, Muller WJ, Hassell JA.
Oncogene. 1993 Nov;8(11):3037-42.
PMID 7692372
 
Expression of ets-related transcriptional factor E1AF is associated with tumor progression and over-expression of matrilysin in human gastric cancer.
Yamamoto H, Horiuchi S, Adachi Y, Taniguchi H, Nosho K, Min Y, Imai K.
Carcinogenesis. 2004 Mar;25(3):325-32. Epub 2003 Nov 6.
PMID 14604892
 
The PEA3 group of ETS-related transcription factors. Role in breast cancer metastasis.
de Launoit Y, Chotteau-Lelievre A, Beaudoin C, Coutte L, Netzer S, Brenner C, Huvent I, Baert JL.
Adv Exp Med Biol. 2000;480:107-16. (REVIEW)
PMID 10959416
 

Citation

This paper should be referenced as such :
Miyata, Y
ETV4 (ets variant 4)
Atlas Genet Cytogenet Oncol Haematol. 2011;15(7):554-556.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Genes/ETV4ID133ch17q21.html


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(16;21)(p11;q22) FUS/ERG


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 7 ]
  Soft Tissues: Angiomatoid fibrous histiocytoma
Bone tumors: an overview
Bone: Soft tissue chondroma with t(3;12)(q27;q15) HMGA2/LPP
Soft Tissues: Ewing's tumors/Primitive neurectodermal tumors (PNET)
Prostate tumors: an overview
Soft tissue tumors: an overview
Soft Tissues: Ewing's tumors/Primitive neurectodermal tumor with t(16;21)(p11;q22) FUS/ERG


External links

Nomenclature
HGNC (Hugo)ETV4   3493
Cards
AtlasETV4ID133ch17q21
Entrez_Gene (NCBI)ETV4  2118  ETS variant 4
AliasesE1A-F; E1AF; PEA3; PEAS3
GeneCards (Weizmann)ETV4
Ensembl hg19 (Hinxton)ENSG00000175832 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000175832 [Gene_View]  chr17:43527843-43546432 [Contig_View]  ETV4 [Vega]
ICGC DataPortalENSG00000175832
TCGA cBioPortalETV4
AceView (NCBI)ETV4
Genatlas (Paris)ETV4
WikiGenes2118
SOURCE (Princeton)ETV4
Genetics Home Reference (NIH)ETV4
Genomic and cartography
GoldenPath hg38 (UCSC)ETV4  -     chr17:43527843-43546432 -  17q21.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ETV4  -     17q21.31   [Description]    (hg19-Feb_2009)
EnsemblETV4 - 17q21.31 [CytoView hg19]  ETV4 - 17q21.31 [CytoView hg38]
Mapping of homologs : NCBIETV4 [Mapview hg19]  ETV4 [Mapview hg38]
OMIM600711   
Gene and transcription
Genbank (Entrez)AK290429 AK298872 AK299019 AK312934 AK315961
RefSeq transcript (Entrez)NM_001079675 NM_001261437 NM_001261438 NM_001261439 NM_001986
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ETV4
Cluster EST : UnigeneHs.434059 [ NCBI ]
CGAP (NCI)Hs.434059
Alternative Splicing GalleryENSG00000175832
Gene ExpressionETV4 [ NCBI-GEO ]   ETV4 [ EBI - ARRAY_EXPRESS ]   ETV4 [ SEEK ]   ETV4 [ MEM ]
Gene Expression Viewer (FireBrowse)ETV4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2118
GTEX Portal (Tissue expression)ETV4
Human Protein AtlasENSG00000175832-ETV4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP43268   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP43268  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP43268
Splice isoforms : SwissVarP43268
PhosPhoSitePlusP43268
Domaine pattern : Prosite (Expaxy)ETS_DOMAIN_1 (PS00345)    ETS_DOMAIN_2 (PS00346)    ETS_DOMAIN_3 (PS50061)   
Domains : Interpro (EBI)Ets_dom    ETS_PEA3_N    WHTH_DNA-bd_dom   
Domain families : Pfam (Sanger)Ets (PF00178)    ETS_PEA3_N (PF04621)   
Domain families : Pfam (NCBI)pfam00178    pfam04621   
Domain families : Smart (EMBL)ETS (SM00413)  
Conserved Domain (NCBI)ETV4
DMDM Disease mutations2118
Blocks (Seattle)ETV4
PDB (SRS)4CO8    4UUV   
PDB (PDBSum)4CO8    4UUV   
PDB (IMB)4CO8    4UUV   
PDB (RSDB)4CO8    4UUV   
Structural Biology KnowledgeBase4CO8    4UUV   
SCOP (Structural Classification of Proteins)4CO8    4UUV   
CATH (Classification of proteins structures)4CO8    4UUV   
SuperfamilyP43268
Human Protein Atlas [tissue]ENSG00000175832-ETV4 [tissue]
Peptide AtlasP43268
HPRD02833
IPIIPI00017382   IPI00922256   IPI01011611   IPI00955842   
Protein Interaction databases
DIP (DOE-UCLA)P43268
IntAct (EBI)P43268
FunCoupENSG00000175832
BioGRIDETV4
STRING (EMBL)ETV4
ZODIACETV4
Ontologies - Pathways
QuickGOP43268
Ontology : AmiGORNA polymerase II core promoter proximal region sequence-specific DNA binding  RNA polymerase II transcription factor activity, sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  protein binding  nucleus  nucleoplasm  nucleolus  transcription from RNA polymerase II promoter  motor neuron axon guidance  cell differentiation  negative regulation of mammary gland epithelial cell proliferation  positive regulation of transcription from RNA polymerase II promoter  stem cell differentiation  branching involved in mammary gland duct morphogenesis  regulation of branching involved in mammary gland duct morphogenesis  
Ontology : EGO-EBIRNA polymerase II core promoter proximal region sequence-specific DNA binding  RNA polymerase II transcription factor activity, sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  protein binding  nucleus  nucleoplasm  nucleolus  transcription from RNA polymerase II promoter  motor neuron axon guidance  cell differentiation  negative regulation of mammary gland epithelial cell proliferation  positive regulation of transcription from RNA polymerase II promoter  stem cell differentiation  branching involved in mammary gland duct morphogenesis  regulation of branching involved in mammary gland duct morphogenesis  
Pathways : KEGGTranscriptional misregulation in cancer   
REACTOMEP43268 [protein]
REACTOME PathwaysR-HSA-5687128 [pathway]   
NDEx NetworkETV4
Atlas of Cancer Signalling NetworkETV4
Wikipedia pathwaysETV4
Orthology - Evolution
OrthoDB2118
GeneTree (enSembl)ENSG00000175832
Phylogenetic Trees/Animal Genes : TreeFamETV4
HOVERGENP43268
HOGENOMP43268
Homologs : HomoloGeneETV4
Homology/Alignments : Family Browser (UCSC)ETV4
Gene fusions - Rearrangements
Fusion : Mitelman-/17q21.31 [ETV4/t(17;17)(p13;q21)]  
Fusion : MitelmanCANT1/ETV4 [17q25.3/17q21.31]  [t(17;17)(q25;q21)]  
Fusion : MitelmanDDX5/ETV4 [17q23.3/17q21.31]  [t(17;17)(q21;q23)]  
Fusion : MitelmanDHX8/ETV4 [17q21.31/17q21.31]  [t(17;17)(q21;q21)]  
Fusion : MitelmanETV4/CCL16 [17q21.31/17q12]  [t(17;17)(q12;q21)]  
Fusion : MitelmanEWSR1/ETV4 [22q12.2/17q21.31]  [t(17;22)(q21;q12)]  
Fusion : MitelmanKLK2/ETV4 [19q13.33/17q21.31]  [t(17;19)(q21;q13)]  
Fusion : MitelmanSLC45A3/ETV4 [1q32.1/17q21.31]  [t(1;17)(q32;q21)]  
Fusion : MitelmanTMPRSS2/ETV4 [21q22.3/17q21.31]  [del(21)(q22q22)]  [t(17;21)(q21;q22)]  
[t(21;21)(q22;q22)]  [t(7;21)(p21;q22)]  
Fusion : MitelmanUBTF/ETV4 [17q21.31/17q21.31]  [t(17;17)(q21;q21)]  
Fusion : MitelmanXPO7/ETV4 [8p21.3/17q21.31]  [t(8;17)(p21;q21)]  
Fusion : COSMICCANT1 [17q25.3]  -  ETV4 [17q21.31]  [fusion_1155]  [fusion_1156]  [fusion_1165]  
Fusion : COSMICDDX5 [17q23.3]  -  ETV4 [17q21.31]  [fusion_1166]  [fusion_1167]  
Fusion : COSMICEWSR1 [ETV4]  -  17q21.31 [208]  [fusion_209]  [fusion_280]  [fusion_285]  
Fusion : COSMICKLK2 [19q13.33]  -  ETV4 [17q21.31]  [fusion_1143]  
Fusion : COSMICTMPRSS2 [ETV4]  -  17q21.31 [144]  [fusion_212]  [fusion_213]  [fusion_214]  [fusion_44]  
Fusion: TCGA_MDACCETV4 17q21.31 CCL16 17q12 BRCA
Fusion: TCGA_MDACCTMPRSS2 21q22.3 ETV4 17q21.31 PRAD
Fusion: TCGA_MDACCXPO7 8p21.3 ETV4 17q21.31 LUAD
Tumor Fusion PortalETV4
Fusion : TICdbCANT1 [17q25.3]  -  ETV4 [17q21.31]
Fusion : TICdbEWSR1 [22q12.2]  -  ETV4 [17q21.31]
Fusion : TICdbKLK2 [19q13.33]  -  ETV4 [17q21.31]
Fusion : TICdbTMPRSS2 [21q22.3]  -  ETV4 [17q21.31]
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerETV4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ETV4
dbVarETV4
ClinVarETV4
1000_GenomesETV4 
Exome Variant ServerETV4
ExAC (Exome Aggregation Consortium)ENSG00000175832
GNOMAD BrowserENSG00000175832
Genetic variants : HAPMAP2118
Genomic Variants (DGV)ETV4 [DGVbeta]
DECIPHERETV4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisETV4 
Mutations
ICGC Data PortalETV4 
TCGA Data PortalETV4 
Broad Tumor PortalETV4
OASIS PortalETV4 [ Somatic mutations - Copy number]
Cancer Gene: CensusETV4 
Somatic Mutations in Cancer : COSMICETV4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDETV4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ETV4
DgiDB (Drug Gene Interaction Database)ETV4
DoCM (Curated mutations)ETV4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ETV4 (select a term)
intoGenETV4
NCG5 (London)ETV4
Cancer3DETV4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600711   
Orphanet3759   
DisGeNETETV4
MedgenETV4
Genetic Testing Registry ETV4
NextProtP43268 [Medical]
TSGene2118
GENETestsETV4
Target ValidationETV4
Huge Navigator ETV4 [HugePedia]
snp3D : Map Gene to Disease2118
BioCentury BCIQETV4
ClinGenETV4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2118
Chemical/Pharm GKB GenePA27907
Clinical trialETV4
Miscellaneous
canSAR (ICR)ETV4 (select the gene name)
Probes
Litterature
PubMed84 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineETV4
EVEXETV4
GoPubMedETV4
iHOPETV4
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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