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FANCC (Fanconi anaemia complementation group C)

Written1998-02Jean-Loup Huret
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France
Updated2002-06Jean-Loup Huret
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France
Updated2012-07Hemantika Dasgupta, Chinmay Kumar Panda
Chittaranjan National Cancer Institute, 37, S P Mukherjee Road, Kolkata 700026, India

(Note : for Links provided by Atlas : click)

Identity

Alias_namesFACC
Alias_symbol (synonym)FAC
FA3
Other alias
HGNC (Hugo) FANCC
LocusID (NCBI) 2176
Atlas_Id 101
Location 9q22.32  [Link to chromosome band 9q22]
Location_base_pair Starts at 95099054 and ends at 95317709 bp from pter ( according to hg19-Feb_2009)  [Mapping FANCC.png]
Local_order Next to PTCH and XPAC !!
 
  Probe(s) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics.
Fusion genes
(updated 2016)		FANCC (9q22.32) / C9orf3 (9q22.32)FANCC (9q22.32) / DDX31 (9q34.13)FANCC (9q22.32) / NDE1 (16p13.11)
FANCC (9q22.32) / NOL4L20q11.21 ()FANCC (9q22.32) / ROR2 (9q22.31)

DNA/RNA

Description 14 exons; spans 80 kb.
Transcription mRNA of 2.3, 3.2, and 4.6 kb (alternative splicing in 5', variable 3' untranslated region, exon 13 skipping).

Protein

Description 558 amino acids; 63 kDa.
Expression Wide, in particular in the bones; high expression in proliferating cells, low in differentiated cells.
Localisation Cytoplasmic (mostly) and nuclear.
Function - FANCA and FANCG form a complex in the cytoplasm, through a N-term FANCA (involving the nuclear localization signal) - FANCG interaction; FANCC join the complex; phosphorylation of FANCA would induce its translocation into the nucleus. This FA complex translocates into the nucleus, where FANCE and FANCF are present; FANCE and FANCF join the complex. The FA complex subsequently interacts with FANCD2 by monoubiquitination of FANCD2 during S phase or following DNA damage. Activated (ubiquinated ) FANCD2, downstream in the FA pathway, will then interact with other proteins involved in DNA repair, possibly BRCA1; after DNA repair, FANCD2 return to the non-ubiquinated form.
- FANCC may have mutlifunctional roles, in addition to its involvement in the FA pathway. FANCC binds to cdc2 (mitotic cyclin-dependent kinase), STAT1, GRP94 (a chaperon protein), NADPH, and a number of other proteins; involved in DNA repair and in suppressing interferon gamma induced cellular apoptosis.
There are 15 FA genes that make up the FA pathway. Among these FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCM and FANCL form the core complex. During G1 phase of cell cycle these proteins are localized in the cytoplasm. During S phase or during DNA damage FANCA and FANCG at first form a complex in the cytoplasm followed by its interaction with FANCC. Then the complex translocates to the nucleus. In the nucleus other FA proteins like FANCE, F, B, M and L interact with the complex. They cooperatively bind to form the core complex. FANCL has E3 ubiquitin ligase activity. The core complex then activates FANCD2 and FANCI by monoubiquitination. The activated FANCD2-FANCI complex then interact with other FA genes like FANCP/SLX4, FANCD1/BRCA2, FANCJ/BRIP1 and FANCN/PALB2 for efficient DNA repair.
FANCC helps in accumulation of FANCE and it has role in foci formation of MRE11/RAD50/NBS1 complex in response to intrastrand crosslink inducers.
FANCC binds to cdc2 (mitotic cyclin-dependent kinase), it is necessary for DNA damage-induced G2/M checkpoint in vitro and in vivo.
In response to oxidative DNA damage, FANCC prevents premature senescence in hematopoietic stem cells. It interacts with cytochrome p-450 reductase and NADPH during increased production of reactive oxygen species (ROS).
In hematopoietic stem cells it regulates apoptosis, self renewal capacity and cell cycle control. It inhibits activity of dsRNA dependent protein kinase mediated death signaling pathway by interacting with Hsp70. FANCC and p53 cooperatively work in apoptosis. It has role in suppressing interferon gamma induced cellular apoptosis.
In normal oral epithelium, a gradual increase of FANCC protein expression from basal to parabasal layer to spinous layer suggesting its role in cellular proliferation and differentiation.
FANCC is important for proper functioning of monocytes/macrophages. It suppresses TNFα production in mononuclear phagocytes by suppressing TLR8 activity.
FANCC interacts with STAT1, GRP94 (a chaperon protein). It has role in telomere attrition and telomere recombination.
Homology No known homology.

Mutations

Germinal Most mutations are found in exon1, intron 4, and exon 14.

Implicated in

Note
  
Entity Fanconi anaemia (FA)
Note FACC is implicated in the FA complementation group C; it represents about 15% of FA cases.
Disease Fanconi anaemia is a chromosome instability syndrome/cancer prone disease (at risk of leukaemia).
Prognosis - Fanconi anaemia's prognosis is poor; mean survival is 16 years: patients die of bone marrow failure (infections, haemorrhages), leukaemia, or androgen therapy related liver tumours.
- It has recently been shown that significant phenotypic differences were found between the various complementation groups. FA group C patients had less somatic abnormalities. However, there is a certain clinical heterogeneity.
Cytogenetics Spontaneous,chromatid/chromosome breaks; increased rate of breaks compared to control, when induced by breaking agent.
Hybrid/Mutated Gene Mutations in exon 4, 13 leading to deletion of exon 9 were reported in Brazilian Fanconi Anemia patients.
Oncogenesis Fanconi anemia patients are prone to develop head and neck, esophageal, gastrointestinal, vulvar and anal cancers.
Frequent deletion and promoter methylation are observed in FANCC gene in oral cancer, breast cancer, acute leukemia and pancreatic cancer.
  
  
Entity Diabetes and obesity
Note FANCC prevents diabetes and obesity.
  

To be noted

Apart from its function in DNA damage repair, FANCC plays important role in apoptosis, cell cycle, differentiation and innate immunity.

Bibliography

p38 MAPK inhibition suppresses the TLR-hypersensitive phenotype in FANCC- and FANCA-deficient mononuclear phagocytes.
Anur P, Yates J, Garbati MR, Vanderwerf S, Keeble W, Rathbun K, Hays LE, Tyner JW, Svahn J, Cappelli E, Dufour C, Bagby GC.
Blood. 2012 Mar 1;119(9):1992-2002. Epub 2012 Jan 10.
PMID 22234699
 
The Fanconi anemia family of genes and its correlation with breast cancer susceptibility and breast cancer features.
Barroso E, Pita G, Arias JI, Menendez P, Zamora P, Blanco M, Benitez J, Ribas G.
Breast Cancer Res Treat. 2009 Dec;118(3):655-60. Epub 2009 Jun 18.
PMID 19536649
 
Genetic heterogeneity among Fanconi anemia heterozygotes and risk of cancer.
Berwick M, Satagopan JM, Ben-Porat L, Carlson A, Mah K, Henry R, Diotti R, Milton K, Pujara K, Landers T, Dev Batish S, Morales J, Schindler D, Hanenberg H, Hromas R, Levran O, Auerbach AD.
Cancer Res. 2007 Oct 1;67(19):9591-6.
PMID 17909071
 
Regulation of the Fanconi anemia group C protein through proteolytic modification.
Brodeur I, Goulet I, Tremblay CS, Charbonneau C, Delisle MC, Godin C, Huard C, Khandjian EW, Buchwald M, Levesque G, Carreau M.
J Biol Chem. 2004 Feb 6;279(6):4713-20. Epub 2003 Nov 18.
PMID 14625294
 
Breaks at telomeres and TRF2-independent end fusions in Fanconi anemia.
Callen E, Samper E, Ramirez MJ, Creus A, Marcos R, Ortega JJ, Olive T, Badell I, Blasco MA, Surralles J.
Hum Mol Genet. 2002 Feb 15;11(4):439-44.
PMID 11854176
 
Germ line Fanconi anemia complementation group C mutations and pancreatic cancer.
Couch FJ, Johnson MR, Rabe K, Boardman L, McWilliams R, de Andrade M, Petersen G.
Cancer Res. 2005 Jan 15;65(2):383-6.
PMID 15695377
 
Molecular biology of Fanconi anemia: implications for diagnosis and therapy.
D'Andrea AD, Grompe M.
Blood. 1997 Sep 1;90(5):1725-36. (REVIEW)
PMID 9292505
 
Association of complementation group and mutation type with clinical outcome in fanconi anemia. European Fanconi Anemia Research Group.
Faivre L, Guardiola P, Lewis C, Dokal I, Ebell W, Zatterale A, Altay C, Poole J, Stones D, Kwee ML, van Weel-Sipman M, Havenga C, Morgan N, de Winter J, Digweed M, Savoia A, Pronk J, de Ravel T, Jansen S, Joenje H, Gluckman E, Mathew CG.
Blood. 2000 Dec 15;96(13):4064-70.
PMID 11110674
 
Fanconi anemia type C and p53 cooperate in apoptosis and tumorigenesis.
Freie B, Li X, Ciccone SL, Nawa K, Cooper S, Vogelweid C, Schantz L, Haneline LS, Orazi A, Broxmeyer HE, Lee SH, Clapp DW.
Blood. 2003 Dec 1;102(12):4146-52. Epub 2003 Jul 10.
PMID 12855557
 
A role for the Fanconi anemia C protein in maintaining the DNA damage-induced G2 checkpoint.
Freie BW, Ciccone SL, Li X, Plett PA, Orschell CM, Srour EF, Hanenberg H, Schindler D, Lee SH, Clapp DW.
J Biol Chem. 2004 Dec 3;279(49):50986-93. Epub 2004 Sep 17.
PMID 15377654
 
Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway.
Garcia-Higuera I, Taniguchi T, Ganesan S, Meyn MS, Timmers C, Hejna J, Grompe M, d'Andrea AD.
Mol Cell. 2001 Feb;7(2):249-62.
PMID 11239454
 
Association of FANCC and PTCH1 with the development of early dysplastic lesions of the head and neck.
Ghosh A, Ghosh S, Maiti GP, Mukherjee S, Mukherjee N, Chakraborty J, Roy A, Roychoudhury S, Panda CK.
Ann Surg Oncol. 2012 Jul;19 Suppl 3:S528-38. Epub 2011 Aug 23.
PMID 21861228
 
Characterisation of the exon structure of the Fanconi anaemia group C gene by vectorette PCR.
Gibson RA, Buchwald M, Roberts RG, Mathew CG.
Hum Mol Genet. 1993 Jan;2(1):35-8.
PMID 8490620
 
FANCC, FANCE, and FANCD2 form a ternary complex essential to the integrity of the Fanconi anemia DNA damage response pathway.
Gordon SM, Alon N, Buchwald M.
J Biol Chem. 2005 Oct 28;280(43):36118-25. Epub 2005 Aug 26.
PMID 16127171
 
Fanconi anemia and DNA repair.
Grompe M, d'Andrea A.
Hum Mol Genet. 2001 Oct 1;10(20):2253-9. (REVIEW)
PMID 11673408
 
Lack of self-renewal capacity in Fancc-/- stem cells after ex vivo expansion.
Habi O, Delisle MC, Messier N, Carreau M.
Stem Cells. 2005 Sep;23(8):1135-41. Epub 2005 Jul 14.
PMID 16020692
 
Human FANCC is hypomorphic in murine Fancc-deficient cells.
Hays LE, Keeble WW, Yates JE, Rathbun RK, Koretsky T, Olson SB, Sun Z, Clapp DW, Bagby GC Jr.
Blood. 2010 Sep 23;116(12):2057-60. Epub 2010 Jun 16.
PMID 20554974
 
Hypermethylation of the FANCC and FANCL promoter regions in sporadic acute leukaemia.
Hess CJ, Ameziane N, Schuurhuis GJ, Errami A, Denkers F, Kaspers GJ, Cloos J, Joenje H, Reinhardt D, Ossenkoppele GJ, Zwaan CM, Waisfisz Q.
Cell Oncol. 2008;30(4):299-306.
PMID 18607065
 
Functional relationships of FANCC to homologous recombination, translesion synthesis, and BLM.
Hirano S, Yamamoto K, Ishiai M, Yamazoe M, Seki M, Matsushita N, Ohzeki M, Yamashita YM, Arakawa H, Buerstedde JM, Enomoto T, Takeda S, Thompson LH, Takata M.
EMBO J. 2005 Jan 26;24(2):418-27. Epub 2004 Dec 23.
PMID 15616572
 
Towards a molecular understanding of the fanconi anemia core complex.
Hodson C, Walden H.
Anemia. 2012;2012:926787. Epub 2012 May 22.
PMID 22675617
 
Upregulation of Fanconi anemia DNA repair genes in melanoma compared with non-melanoma skin cancer.
Kao WH, Riker AI, Kushwaha DS, Ng K, Enkemann SA, Jove R, Buettner R, Zinn PO, Sanchez NP, Villa JL, d'Andrea AD, Sanchez JL, Kennedy RD, Chen CC, Matta JL.
J Invest Dermatol. 2011 Oct;131(10):2139-42. doi: 10.1038/jid.2011.181. Epub 2011 Jun 23.
PMID 21697891
 
Fanconi anemia pathway-deficient tumor cells are hypersensitive to inhibition of ataxia telangiectasia mutated.
Kennedy RD, Chen CC, Stuckert P, Archila EM, De la Vega MA, Moreau LA, Shimamura A, d'Andrea AD.
J Clin Invest. 2007 May;117(5):1440-9. Epub 2007 Apr 12.
PMID 17431503
 
Association of FANCC polymorphisms with FEV1 decline in aspirin exacerbated respiratory disease.
Kim JH, Park BL, Pasaje CF, Bae JS, Park JS, Park SW, Uh ST, Choi JS, Kim YH, Kim MK, Choi IS, Cho SH, Choi BW, Park CS, Shin HD.
Mol Biol Rep. 2012 Mar;39(3):2385-94. Epub 2011 Jun 14.
PMID 21670957
 
FANCD1/BRCA2 plays predominant role in the repair of DNA damage induced by ACNU or TMZ.
Kondo N, Takahashi A, Mori E, Noda T, Zdzienicka MZ, Thompson LH, Helleday T, Suzuki M, Kinashi Y, Masunaga S, Ono K, Hasegawa M, Ohnishi T.
PLoS One. 2011 May 9;6(5):e19659.
PMID 21573016
 
The nuclear accumulation of the Fanconi anemia protein FANCE depends on FANCC.
Leveille F, Ferrer M, Medhurst AL, Laghmani el H, Rooimans MA, Bier P, Steltenpool J, Titus TA, Postlethwait JH, Hoatlin ME, Joenje H, de Winter JP.
DNA Repair (Amst). 2006 May 10;5(5):556-65. Epub 2006 Feb 28.
PMID 16513431
 
Fanconi anemia links reactive oxygen species to insulin resistance and obesity.
Li J, Sipple J, Maynard S, Mehta PA, Rose SR, Davies SM, Pang Q.
Antioxid Redox Signal. 2012 Oct 15;17(8):1083-98. Epub 2012 Jun 25.
PMID 22482891
 
Impaired function of Fanconi anemia type C-deficient macrophages.
Liu Y, Ballman K, Li D, Khan S, Derr-Yellin E, Shou W, Haneline LS.
J Leukoc Biol. 2012 Feb;91(2):333-40. Epub 2011 Nov 21.
PMID 22106009
 
Evidence for subcomplexes in the Fanconi anemia pathway.
Medhurst AL, Laghmani el H, Steltenpool J, Ferrer M, Fontaine C, de Groot J, Rooimans MA, Scheper RJ, Meetei AR, Wang W, Joenje H, de Winter JP.
Blood. 2006 Sep 15;108(6):2072-80. Epub 2006 May 23.
PMID 16720839
 
The Fanconi anaemia gene FANCC promotes homologous recombination and error-prone DNA repair.
Niedzwiedz W, Mosedale G, Johnson M, Ong CY, Pace P, Patel KJ.
Mol Cell. 2004 Aug 27;15(4):607-20.
PMID 15327776
 
Oxidative stress in Fanconi anaemia: from cells and molecules toward prospects in clinical management.
Pagano G, Aiello Talamanca A, Castello G, Pallardo FV, Zatterale A, Degan P.
Biol Chem. 2011 Nov 7. [Epub ahead of print]
PMID 22059913
 
Fanconi anaemia proteins: major roles in cell protection against oxidative damage.
Pagano G, Youssoufian H.
Bioessays. 2003 Jun;25(6):589-95. (REVIEW)
PMID 12766948
 
Genetic inactivation of the Fanconi anemia gene FANCC identified in the hepatocellular carcinoma cell line HuH-7 confers sensitivity towards DNA-interstrand crosslinking agents.
Palagyi A, Neveling K, Plinninger U, Ziesch A, Targosz BS, Denk GU, Ochs S, Rizzani A, Meier D, Thasler WE, Hanenberg H, De Toni EN, Bassermann F, Schafer C, Goke B, Schindler D, Gallmeier E.
Mol Cancer. 2010 May 28;9:127.
PMID 20509860
 
The anti-apoptotic function of Hsp70 in the interferon-inducible double-stranded RNA-dependent protein kinase-mediated death signaling pathway requires the Fanconi anemia protein, FANCC.
Pang Q, Christianson TA, Keeble W, Koretsky T, Bagby GC.
J Biol Chem. 2002 Dec 20;277(51):49638-43. Epub 2002 Oct 22.
PMID 12397061
 
DNA cross-link-dependent RAD50/MRE11/NBS1 subnuclear assembly requires the Fanconi anemia C protein.
Pichierri P, Averbeck D, Rosselli F.
Hum Mol Genet. 2002 Oct 1;11(21):2531-46.
PMID 12354779
 
Fanconi anemia proteins localize to chromatin and the nuclear matrix in a DNA damage- and cell cycle-regulated manner.
Qiao F, Moss A, Kupfer GM.
J Biol Chem. 2001 Jun 29;276(26):23391-6. Epub 2001 Apr 10.
PMID 11297559
 
FANCC suppresses short telomere-initiated telomere sister chromatid exchange.
Rhee DB, Wang Y, Mizesko M, Zhou F, Haneline L, Liu Y.
Hum Mol Genet. 2010 Mar 1;19(5):879-87. Epub 2009 Dec 18.
PMID 20022886
 
Cells deficient in the FANC/BRCA pathway are hypersensitive to plasma levels of formaldehyde.
Ridpath JR, Nakamura A, Tano K, Luke AM, Sonoda E, Arakawa H, Buerstedde JM, Gillespie DA, Sale JE, Yamazoe M, Bishop DK, Takata M, Takeda S, Watanabe M, Swenberg JA, Nakamura J.
Cancer Res. 2007 Dec 1;67(23):11117-22.
PMID 18056434
 
Alterations in candidate genes PHF2, FANCC, PTCH1 and XPA at chromosomal 9q22.3 region: pathological significance in early- and late-onset breast carcinoma.
Sinha S, Singh RK, Alam N, Roy A, Roychoudhury S, Panda CK.
Mol Cancer. 2008 Nov 6;7:84.
PMID 18990233
 
Cloning of cDNAs for Fanconi's anaemia by functional complementation.
Strathdee CA, Gavish H, Shannon WR, Buchwald M.
Nature. 1992 Apr 30;356(6372):763-7.
PMID 1574115
 
BRCA1-independent ubiquitination of FANCD2.
Vandenberg CJ, Gergely F, Ong CY, Pace P, Mallery DL, Hiom K, Patel KJ.
Mol Cell. 2003 Jul;12(1):247-54.
PMID 12887909
 
TLR8-dependent TNF-(alpha) overexpression in Fanconi anemia group C cells.
Vanderwerf SM, Svahn J, Olson S, Rathbun RK, Harrington C, Yates J, Keeble W, Anderson DC, Anur P, Pereira NF, Pilonetto DV, Pasquini R, Bagby GC.
Blood. 2009 Dec 17;114(26):5290-8. Epub 2009 Oct 22.
PMID 19850743
 
Current knowledge on the pathophysiology of Fanconi anemia: from genes to phenotypes.
Yamashita T, Nakahata T.
Int J Hematol. 2001 Jul;74(1):33-41. (REVIEW)
PMID 11530803
 
Novel inactivating mutations of FANCC in Brazilian patients with Fanconi anemia.
Yates J, Keeble W, Pals G, Ameziane N, van Spaendonk R, Olson S, Akkari Y, Pasquini R, Bagby G.
Hum Mutat. 2006 Feb;27(2):214.
PMID 16429406
 
Fanconi anemia C gene product regulates expression of genes involved in differentiation and inflammation.
Zanier R, Briot D, Dugas du Villard JA, Sarasin A, Rosselli F.
Oncogene. 2004 Jun 24;23(29):5004-13.
PMID 15077170
 
Inflammatory ROS promote and cooperate with the Fanconi anemia mutation for hematopoietic senescence.
Zhang X, Sejas DP, Qiu Y, Williams DA, Pang Q.
J Cell Sci. 2007 May 1;120(Pt 9):1572-83. Epub 2007 Apr 3.
PMID 17405815
 

Citation

This paper should be referenced as such :
Dasgupta, H ; Panda, CK
FANCC (Fanconi anaemia complementation group C)
Atlas Genet Cytogenet Oncol Haematol. 2013;17(1):17-20.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Genes/FACCID101.html
History of this paper:
Jean-Loup Huret. FACC (Fanconi anaemia complementation group C). Atlas Genet Cytogenet Oncol Haematol. 1998;2(1):10-11.
http://documents.irevues.inist.fr/bitstream/handle/2042/32097/02-1998-FACCID101.pdf
Huret, JL. FACC (Fanconi anaemia complementation group C). Atlas Genet Cytogenet Oncol Haematol. 2002;6(4):275-276.
http://documents.irevues.inist.fr/bitstream/handle/2042/37892/06-2002-FACC101.pdf

Other Cancer prone implicated (Data extracted from papers in the Atlas) [ 2 ]
  Fanconi anemia Familial Myeloproliferative Disorders

External links

Nomenclature
HGNC (Hugo)FANCC   3584
LRG (Locus Reference Genomic)LRG_497
Cards
AtlasFACCID101
Entrez_Gene (NCBI)FANCC  2176  Fanconi anemia complementation group C
AliasesFA3; FAC; FACC
GeneCards (Weizmann)FANCC
Ensembl hg19 (Hinxton)ENSG00000158169 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000158169 [Gene_View]  chr9:95099054-95317709 [Contig_View]  FANCC [Vega]
ICGC DataPortalENSG00000158169
TCGA cBioPortalFANCC
AceView (NCBI)FANCC
Genatlas (Paris)FANCC
WikiGenes2176
SOURCE (Princeton)FANCC
Genetics Home Reference (NIH)FANCC
Genomic and cartography
GoldenPath hg38 (UCSC)FANCC  -     chr9:95099054-95317709 -  9q22.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FANCC  -     9q22.32   [Description]    (hg19-Feb_2009)
EnsemblFANCC - 9q22.32 [CytoView hg19]  FANCC - 9q22.32 [CytoView hg38]
Mapping of homologs : NCBIFANCC [Mapview hg19]  FANCC [Mapview hg38]
OMIM189960   227645   613899   
Gene and transcription
Genbank (Entrez)AI280997 AK222871 AK304887 AK310599 AK312548
RefSeq transcript (Entrez)NM_000136 NM_001243743 NM_001243744
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FANCC
Cluster EST : UnigeneHs.494529 [ NCBI ]
CGAP (NCI)Hs.494529
Alternative Splicing GalleryENSG00000158169
Gene ExpressionFANCC [ NCBI-GEO ]   FANCC [ EBI - ARRAY_EXPRESS ]   FANCC [ SEEK ]   FANCC [ MEM ]
Gene Expression Viewer (FireBrowse)FANCC [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2176
GTEX Portal (Tissue expression)FANCC
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ00597   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ00597  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ00597
Splice isoforms : SwissVarQ00597
PhosPhoSitePlusQ00597
Domains : Interpro (EBI)Fanconi   
Domain families : Pfam (Sanger)Fanconi_C (PF02106)   
Domain families : Pfam (NCBI)pfam02106   
Conserved Domain (NCBI)FANCC
DMDM Disease mutations2176
Blocks (Seattle)FANCC
SuperfamilyQ00597
Human Protein AtlasENSG00000158169
Peptide AtlasQ00597
HPRD01967
IPIIPI00023608   IPI00745713   IPI00645428   
Protein Interaction databases
DIP (DOE-UCLA)Q00597
IntAct (EBI)Q00597
FunCoupENSG00000158169
BioGRIDFANCC
STRING (EMBL)FANCC
ZODIACFANCC
Ontologies - Pathways
QuickGOQ00597
Ontology : AmiGOprotein binding  nucleus  nucleoplasm  cytoplasm  cytosol  DNA repair  nucleotide-excision repair  protein complex assembly  cellular response to oxidative stress  interstrand cross-link repair  Fanconi anaemia nuclear complex  
Ontology : EGO-EBIprotein binding  nucleus  nucleoplasm  cytoplasm  cytosol  DNA repair  nucleotide-excision repair  protein complex assembly  cellular response to oxidative stress  interstrand cross-link repair  Fanconi anaemia nuclear complex  
Pathways : BIOCARTARole of BRCA1, BRCA2 and ATR in Cancer Susceptibility [Genes]    BRCA1-dependent Ub-ligase activity [Genes]   
Pathways : KEGGFanconi anemia pathway   
REACTOMEQ00597 [protein]
REACTOME PathwaysR-HSA-6796648 [pathway]   
NDEx NetworkFANCC
Atlas of Cancer Signalling NetworkFANCC
Wikipedia pathwaysFANCC
Orthology - Evolution
OrthoDB2176
GeneTree (enSembl)ENSG00000158169
Phylogenetic Trees/Animal Genes : TreeFamFANCC
HOVERGENQ00597
HOGENOMQ00597
Homologs : HomoloGeneFANCC
Homology/Alignments : Family Browser (UCSC)FANCC
Gene fusions - Rearrangements
Fusion : MitelmanFANCC/C9orf3 [9q22.32/9q22.32]  
Fusion : MitelmanFANCC/DDX31 [9q22.32/9q34.13]  [t(9;9)(q22;q34)]  
Fusion : MitelmanFANCC/ROR2 [9q22.32/9q22.31]  [t(9;9)(q22;q22)]  
Fusion: TCGAFANCC 9q22.32 C9orf3 9q22.32 HNSC
Fusion: TCGAFANCC 9q22.32 DDX31 9q34.13 LGG
Fusion: TCGAFANCC 9q22.32 ROR2 9q22.31 PRAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFANCC [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FANCC
dbVarFANCC
ClinVarFANCC
1000_GenomesFANCC 
Exome Variant ServerFANCC
ExAC (Exome Aggregation Consortium)FANCC (select the gene name)
Genetic variants : HAPMAP2176
Genomic Variants (DGV)FANCC [DGVbeta]
DECIPHERFANCC [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFANCC 
Mutations
ICGC Data PortalFANCC 
TCGA Data PortalFANCC 
Broad Tumor PortalFANCC
OASIS PortalFANCC [ Somatic mutations - Copy number]
Cancer Gene: CensusFANCC 
Somatic Mutations in Cancer : COSMICFANCC  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFANCC
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)**PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database
LOVD (Leiden Open Variation Database)Fanconi anemia database
BioMutasearch FANCC
DgiDB (Drug Gene Interaction Database)FANCC
DoCM (Curated mutations)FANCC (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FANCC (select a term)
intoGenFANCC
NCG5 (London)FANCC
Cancer3DFANCC(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM189960    227645    613899   
Orphanet634   
MedgenFANCC
Genetic Testing Registry FANCC
NextProtQ00597 [Medical]
TSGene2176
GENETestsFANCC
Target ValidationFANCC
Huge Navigator FANCC [HugePedia]
snp3D : Map Gene to Disease2176
BioCentury BCIQFANCC
ClinGenFANCC
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2176
Chemical/Pharm GKB GenePA27997
Clinical trialFANCC
Miscellaneous
canSAR (ICR)FANCC (select the gene name)
Probes
Litterature
PubMed127 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFANCC
EVEXFANCC
GoPubMedFANCC
iHOPFANCC
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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