Atlas of Genetics and Cytogenetics in Oncology and Haematology
Dear Colleagues,
The Atlas, once more, is in great danger, and I will have to proceed to a collective economic lay-off of all the team involved in the Atlas before the begining of April 2015 (a foundation having suddenly withdrawn its commitment to support the Atlas). I ask you herein if any Scientific Society (a Society of Cytogenetics, of Clinical Genetics, of Hematology, or a Cancer Society, or any other...), any University and/or Hospital, any Charity, or any database would be interested in taking over the Atlas, in whole or in part. If taking charge of the whole lot is too big, a consortium of various actors could be the solution (I am myself trying to find partners). Could you please spread the information, contact the relevant authorities, and find partners.
Survival of the Atlas will be critically dependant upon your ability to find solutions (and urgently!).
Kind regards.
Jean-Loup Huret jlhuret@AtlasGeneticsOncology.org
Donations are also welcome
If each casual visitor gives 3 Euros or Dollars, the Atlas is saved in a week !
If each professional gives 100 Euros or Dollars once a year (now), the Atlas is saved in 2 weeks !
Don't let the Atlas imminent demise
Note: we send fiscal receipts for donations equal or above 50 Euros or Dollars
FANCC (Fanconi anaemia complementation group C)
| Identity |
| Other names | FAC |
| FACC | |
| FA3 | |
| HGNC (Hugo) | FANCC |
| LocusID (NCBI) | 2176 |
| Location | 9q22.32 |
| Location_base_pair | Starts at 97861336 and ends at 98079991 bp from pter ( according to hg19-Feb_2009) [Mapping] |
| Local_order | Next to PTCH and XPAC !! |
 | |
| Probe(s) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics. | |
| DNA/RNA |
| Description | 14 exons; spans 80 kb. |
| Transcription | mRNA of 2.3, 3.2, and 4.6 kb (alternative splicing in 5', variable 3' untranslated region, exon 13 skipping). |
| Protein |
| Description | 558 amino acids; 63 kDa. |
| Expression | Wide, in particular in the bones; high expression in proliferating cells, low in differentiated cells. |
| Localisation | Cytoplasmic (mostly) and nuclear. |
| Function | - FANCA and FANCG form a complex in the cytoplasm, through a N-term FANCA (involving the nuclear localization signal) - FANCG interaction; FANCC join the complex; phosphorylation of FANCA would induce its translocation into the nucleus. This FA complex translocates into the nucleus, where FANCE and FANCF are present; FANCE and FANCF join the complex. The FA complex subsequently interacts with FANCD2 by monoubiquitination of FANCD2 during S phase or following DNA damage. Activated (ubiquinated ) FANCD2, downstream in the FA pathway, will then interact with other proteins involved in DNA repair, possibly BRCA1; after DNA repair, FANCD2 return to the non-ubiquinated form. - FANCC may have mutlifunctional roles, in addition to its involvement in the FA pathway. FANCC binds to cdc2 (mitotic cyclin-dependent kinase), STAT1, GRP94 (a chaperon protein), NADPH, and a number of other proteins; involved in DNA repair and in suppressing interferon gamma induced cellular apoptosis. There are 15 FA genes that make up the FA pathway. Among these FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCM and FANCL form the core complex. During G1 phase of cell cycle these proteins are localized in the cytoplasm. During S phase or during DNA damage FANCA and FANCG at first form a complex in the cytoplasm followed by its interaction with FANCC. Then the complex translocates to the nucleus. In the nucleus other FA proteins like FANCE, F, B, M and L interact with the complex. They cooperatively bind to form the core complex. FANCL has E3 ubiquitin ligase activity. The core complex then activates FANCD2 and FANCI by monoubiquitination. The activated FANCD2-FANCI complex then interact with other FA genes like FANCP/SLX4, FANCD1/BRCA2, FANCJ/BRIP1 and FANCN/PALB2 for efficient DNA repair. FANCC helps in accumulation of FANCE and it has role in foci formation of MRE11/RAD50/NBS1 complex in response to intrastrand crosslink inducers. FANCC binds to cdc2 (mitotic cyclin-dependent kinase), it is necessary for DNA damage-induced G2/M checkpoint in vitro and in vivo. In response to oxidative DNA damage, FANCC prevents premature senescence in hematopoietic stem cells. It interacts with cytochrome p-450 reductase and NADPH during increased production of reactive oxygen species (ROS). In hematopoietic stem cells it regulates apoptosis, self renewal capacity and cell cycle control. It inhibits activity of dsRNA dependent protein kinase mediated death signaling pathway by interacting with Hsp70. FANCC and p53 cooperatively work in apoptosis. It has role in suppressing interferon gamma induced cellular apoptosis. In normal oral epithelium, a gradual increase of FANCC protein expression from basal to parabasal layer to spinous layer suggesting its role in cellular proliferation and differentiation. FANCC is important for proper functioning of monocytes/macrophages. It suppresses TNFα production in mononuclear phagocytes by suppressing TLR8 activity. FANCC interacts with STAT1, GRP94 (a chaperon protein). It has role in telomere attrition and telomere recombination. |
| Homology | No known homology. |
| Mutations |
| Germinal | Most mutations are found in exon1, intron 4, and exon 14. |
| Implicated in |
| Entity | Fanconi anaemia (FA) |
| Note | FACC is implicated in the FA complementation group C; it represents about 15% of FA cases. |
| Disease | Fanconi anaemia is a chromosome instability syndrome/cancer prone disease (at risk of leukaemia). |
| Prognosis | - Fanconi anaemia's prognosis is poor; mean survival is 16 years: patients die of bone marrow failure (infections, haemorrhages), leukaemia, or androgen therapy related liver tumours. - It has recently been shown that significant phenotypic differences were found between the various complementation groups. FA group C patients had less somatic abnormalities. However, there is a certain clinical heterogeneity. |
| Cytogenetics | Spontaneous,chromatid/chromosome breaks; increased rate of breaks compared to control, when induced by breaking agent. |
| Hybrid/Mutated Gene | Mutations in exon 4, 13 leading to deletion of exon 9 were reported in Brazilian Fanconi Anemia patients. |
| Oncogenesis | Fanconi anemia patients are prone to develop head and neck, esophageal, gastrointestinal, vulvar and anal cancers. Frequent deletion and promoter methylation are observed in FANCC gene in oral cancer, breast cancer, acute leukemia and pancreatic cancer. |
| Entity | Diabetes and obesity |
| Note | FANCC prevents diabetes and obesity. |
| To be noted |
| Apart from its function in DNA damage repair, FANCC plays important role in apoptosis, cell cycle, differentiation and innate immunity. |
| External links |
| Bibliography |
| Cloning of cDNAs for Fanconi's anaemia by functional complementation. |
| Strathdee CA, Gavish H, Shannon WR, Buchwald M. |
| Nature. 1992 Apr 30;356(6372):763-7. |
| PMID 1574115 |
| Characterisation of the exon structure of the Fanconi anaemia group C gene by vectorette PCR. |
| Gibson RA, Buchwald M, Roberts RG, Mathew CG. |
| Hum Mol Genet. 1993 Jan;2(1):35-8. |
| PMID 8490620 |
| Molecular biology of Fanconi anemia: implications for diagnosis and therapy. |
| D'Andrea AD, Grompe M. |
| Blood. 1997 Sep 1;90(5):1725-36. (REVIEW) |
| PMID 9292505 |
| Fanconi anemia proteins FANCA, FANCC, and FANCG/XRCC9 interact in a functional nuclear complex. |
| Garcia-Higuera I, Kuang Y, Naf D, Wasik J, d'Andrea AD. |
| Mol Cell Biol. 1999 Jul;19(7):4866-73. |
| PMID 10373536 |
| Association of complementation group and mutation type with clinical outcome in fanconi anemia. European Fanconi Anemia Research Group. |
| Faivre L, Guardiola P, Lewis C, Dokal I, Ebell W, Zatterale A, Altay C, Poole J, Stones D, Kwee ML, van Weel-Sipman M, Havenga C, Morgan N, de Winter J, Digweed M, Savoia A, Pronk J, de Ravel T, Jansen S, Joenje H, Gluckman E, Mathew CG. |
| Blood. 2000 Dec 15;96(13):4064-70. |
| PMID 11110674 |
| Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway. |
| Garcia-Higuera I, Taniguchi T, Ganesan S, Meyn MS, Timmers C, Hejna J, Grompe M, d'Andrea AD. |
| Mol Cell. 2001 Feb;7(2):249-62. |
| PMID 11239454 |
| Fanconi anemia and DNA repair. |
| Grompe M, d'Andrea A. |
| Hum Mol Genet. 2001 Oct 1;10(20):2253-9. (REVIEW) |
| PMID 11673408 |
| Direct interactions of the five known Fanconi anaemia proteins suggest a common functional pathway. |
| Medhurst AL, Huber PA, Waisfisz Q, de Winter JP, Mathew CG. |
| Hum Mol Genet. 2001 Feb 15;10(4):423-9. |
| PMID 11157805 |
| The Fanconi anemia complementation group C gene product: structural evidence of multifunctionality. |
| Pang Q, Christianson TA, Keeble W, Diaz J, Faulkner GR, Reifsteck C, Olson S, Bagby GC. |
| Blood. 2001 Sep 1;98(5):1392-401. |
| PMID 11520787 |
| Fanconi anemia proteins localize to chromatin and the nuclear matrix in a DNA damage- and cell cycle-regulated manner. |
| Qiao F, Moss A, Kupfer GM. |
| J Biol Chem. 2001 Jun 29;276(26):23391-6. Epub 2001 Apr 10. |
| PMID 11297559 |
| Current knowledge on the pathophysiology of Fanconi anemia: from genes to phenotypes. |
| Yamashita T, Nakahata T. |
| Int J Hematol. 2001 Jul;74(1):33-41. (REVIEW) |
| PMID 11530803 |
| Breaks at telomeres and TRF2-independent end fusions in Fanconi anemia. |
| Callen E, Samper E, Ramirez MJ, Creus A, Marcos R, Ortega JJ, Olive T, Badell I, Blasco MA, Surralles J. |
| Hum Mol Genet. 2002 Feb 15;11(4):439-44. |
| PMID 11854176 |
| The anti-apoptotic function of Hsp70 in the interferon-inducible double-stranded RNA-dependent protein kinase-mediated death signaling pathway requires the Fanconi anemia protein, FANCC. |
| Pang Q, Christianson TA, Keeble W, Koretsky T, Bagby GC. |
| J Biol Chem. 2002 Dec 20;277(51):49638-43. Epub 2002 Oct 22. |
| PMID 12397061 |
| DNA cross-link-dependent RAD50/MRE11/NBS1 subnuclear assembly requires the Fanconi anemia C protein. |
| Pichierri P, Averbeck D, Rosselli F. |
| Hum Mol Genet. 2002 Oct 1;11(21):2531-46. |
| PMID 12354779 |
| Fanconi anemia type C and p53 cooperate in apoptosis and tumorigenesis. |
| Freie B, Li X, Ciccone SL, Nawa K, Cooper S, Vogelweid C, Schantz L, Haneline LS, Orazi A, Broxmeyer HE, Lee SH, Clapp DW. |
| Blood. 2003 Dec 1;102(12):4146-52. Epub 2003 Jul 10. |
| PMID 12855557 |
| Fanconi anaemia proteins: major roles in cell protection against oxidative damage. |
| Pagano G, Youssoufian H. |
| Bioessays. 2003 Jun;25(6):589-95. (REVIEW) |
| PMID 12766948 |
| BRCA1-independent ubiquitination of FANCD2. |
| Vandenberg CJ, Gergely F, Ong CY, Pace P, Mallery DL, Hiom K, Patel KJ. |
| Mol Cell. 2003 Jul;12(1):247-54. |
| PMID 12887909 |
| Regulation of the Fanconi anemia group C protein through proteolytic modification. |
| Brodeur I, Goulet I, Tremblay CS, Charbonneau C, Delisle MC, Godin C, Huard C, Khandjian EW, Buchwald M, Levesque G, Carreau M. |
| J Biol Chem. 2004 Feb 6;279(6):4713-20. Epub 2003 Nov 18. |
| PMID 14625294 |
| A role for the Fanconi anemia C protein in maintaining the DNA damage-induced G2 checkpoint. |
| Freie BW, Ciccone SL, Li X, Plett PA, Orschell CM, Srour EF, Hanenberg H, Schindler D, Lee SH, Clapp DW. |
| J Biol Chem. 2004 Dec 3;279(49):50986-93. Epub 2004 Sep 17. |
| PMID 15377654 |
| The Fanconi anaemia gene FANCC promotes homologous recombination and error-prone DNA repair. |
| Niedzwiedz W, Mosedale G, Johnson M, Ong CY, Pace P, Patel KJ. |
| Mol Cell. 2004 Aug 27;15(4):607-20. |
| PMID 15327776 |
| Fanconi anemia C gene product regulates expression of genes involved in differentiation and inflammation. |
| Zanier R, Briot D, Dugas du Villard JA, Sarasin A, Rosselli F. |
| Oncogene. 2004 Jun 24;23(29):5004-13. |
| PMID 15077170 |
| Germ line Fanconi anemia complementation group C mutations and pancreatic cancer. |
| Couch FJ, Johnson MR, Rabe K, Boardman L, McWilliams R, de Andrade M, Petersen G. |
| Cancer Res. 2005 Jan 15;65(2):383-6. |
| PMID 15695377 |
| FANCC, FANCE, and FANCD2 form a ternary complex essential to the integrity of the Fanconi anemia DNA damage response pathway. |
| Gordon SM, Alon N, Buchwald M. |
| J Biol Chem. 2005 Oct 28;280(43):36118-25. Epub 2005 Aug 26. |
| PMID 16127171 |
| Lack of self-renewal capacity in Fancc-/- stem cells after ex vivo expansion. |
| Habi O, Delisle MC, Messier N, Carreau M. |
| Stem Cells. 2005 Sep;23(8):1135-41. Epub 2005 Jul 14. |
| PMID 16020692 |
| Functional relationships of FANCC to homologous recombination, translesion synthesis, and BLM. |
| Hirano S, Yamamoto K, Ishiai M, Yamazoe M, Seki M, Matsushita N, Ohzeki M, Yamashita YM, Arakawa H, Buerstedde JM, Enomoto T, Takeda S, Thompson LH, Takata M. |
| EMBO J. 2005 Jan 26;24(2):418-27. Epub 2004 Dec 23. |
| PMID 15616572 |
| The nuclear accumulation of the Fanconi anemia protein FANCE depends on FANCC. |
| Leveille F, Ferrer M, Medhurst AL, Laghmani el H, Rooimans MA, Bier P, Steltenpool J, Titus TA, Postlethwait JH, Hoatlin ME, Joenje H, de Winter JP. |
| DNA Repair (Amst). 2006 May 10;5(5):556-65. Epub 2006 Feb 28. |
| PMID 16513431 |
| Evidence for subcomplexes in the Fanconi anemia pathway. |
| Medhurst AL, Laghmani el H, Steltenpool J, Ferrer M, Fontaine C, de Groot J, Rooimans MA, Scheper RJ, Meetei AR, Wang W, Joenje H, de Winter JP. |
| Blood. 2006 Sep 15;108(6):2072-80. Epub 2006 May 23. |
| PMID 16720839 |
| Novel inactivating mutations of FANCC in Brazilian patients with Fanconi anemia. |
| Yates J, Keeble W, Pals G, Ameziane N, van Spaendonk R, Olson S, Akkari Y, Pasquini R, Bagby G. |
| Hum Mutat. 2006 Feb;27(2):214. |
| PMID 16429406 |
| Genetic heterogeneity among Fanconi anemia heterozygotes and risk of cancer. |
| Berwick M, Satagopan JM, Ben-Porat L, Carlson A, Mah K, Henry R, Diotti R, Milton K, Pujara K, Landers T, Dev Batish S, Morales J, Schindler D, Hanenberg H, Hromas R, Levran O, Auerbach AD. |
| Cancer Res. 2007 Oct 1;67(19):9591-6. |
| PMID 17909071 |
| Fanconi anemia pathway-deficient tumor cells are hypersensitive to inhibition of ataxia telangiectasia mutated. |
| Kennedy RD, Chen CC, Stuckert P, Archila EM, De la Vega MA, Moreau LA, Shimamura A, d'Andrea AD. |
| J Clin Invest. 2007 May;117(5):1440-9. Epub 2007 Apr 12. |
| PMID 17431503 |
| Cells deficient in the FANC/BRCA pathway are hypersensitive to plasma levels of formaldehyde. |
| Ridpath JR, Nakamura A, Tano K, Luke AM, Sonoda E, Arakawa H, Buerstedde JM, Gillespie DA, Sale JE, Yamazoe M, Bishop DK, Takata M, Takeda S, Watanabe M, Swenberg JA, Nakamura J. |
| Cancer Res. 2007 Dec 1;67(23):11117-22. |
| PMID 18056434 |
| Inflammatory ROS promote and cooperate with the Fanconi anemia mutation for hematopoietic senescence. |
| Zhang X, Sejas DP, Qiu Y, Williams DA, Pang Q. |
| J Cell Sci. 2007 May 1;120(Pt 9):1572-83. Epub 2007 Apr 3. |
| PMID 17405815 |
| Hypermethylation of the FANCC and FANCL promoter regions in sporadic acute leukaemia. |
| Hess CJ, Ameziane N, Schuurhuis GJ, Errami A, Denkers F, Kaspers GJ, Cloos J, Joenje H, Reinhardt D, Ossenkoppele GJ, Zwaan CM, Waisfisz Q. |
| Cell Oncol. 2008;30(4):299-306. |
| PMID 18607065 |
| Alterations in candidate genes PHF2, FANCC, PTCH1 and XPA at chromosomal 9q22.3 region: pathological significance in early- and late-onset breast carcinoma. |
| Sinha S, Singh RK, Alam N, Roy A, Roychoudhury S, Panda CK. |
| Mol Cancer. 2008 Nov 6;7:84. |
| PMID 18990233 |
| The Fanconi anemia family of genes and its correlation with breast cancer susceptibility and breast cancer features. |
| Barroso E, Pita G, Arias JI, Menendez P, Zamora P, Blanco M, Benitez J, Ribas G. |
| Breast Cancer Res Treat. 2009 Dec;118(3):655-60. Epub 2009 Jun 18. |
| PMID 19536649 |
| TLR8-dependent TNF-(alpha) overexpression in Fanconi anemia group C cells. |
| Vanderwerf SM, Svahn J, Olson S, Rathbun RK, Harrington C, Yates J, Keeble W, Anderson DC, Anur P, Pereira NF, Pilonetto DV, Pasquini R, Bagby GC. |
| Blood. 2009 Dec 17;114(26):5290-8. Epub 2009 Oct 22. |
| PMID 19850743 |
| Human FANCC is hypomorphic in murine Fancc-deficient cells. |
| Hays LE, Keeble WW, Yates JE, Rathbun RK, Koretsky T, Olson SB, Sun Z, Clapp DW, Bagby GC Jr. |
| Blood. 2010 Sep 23;116(12):2057-60. Epub 2010 Jun 16. |
| PMID 20554974 |
| Genetic inactivation of the Fanconi anemia gene FANCC identified in the hepatocellular carcinoma cell line HuH-7 confers sensitivity towards DNA-interstrand crosslinking agents. |
| Palagyi A, Neveling K, Plinninger U, Ziesch A, Targosz BS, Denk GU, Ochs S, Rizzani A, Meier D, Thasler WE, Hanenberg H, De Toni EN, Bassermann F, Schafer C, Goke B, Schindler D, Gallmeier E. |
| Mol Cancer. 2010 May 28;9:127. |
| PMID 20509860 |
| FANCC suppresses short telomere-initiated telomere sister chromatid exchange. |
| Rhee DB, Wang Y, Mizesko M, Zhou F, Haneline L, Liu Y. |
| Hum Mol Genet. 2010 Mar 1;19(5):879-87. Epub 2009 Dec 18. |
| PMID 20022886 |
| Upregulation of Fanconi anemia DNA repair genes in melanoma compared with non-melanoma skin cancer. |
| Kao WH, Riker AI, Kushwaha DS, Ng K, Enkemann SA, Jove R, Buettner R, Zinn PO, Sanchez NP, Villa JL, d'Andrea AD, Sanchez JL, Kennedy RD, Chen CC, Matta JL. |
| J Invest Dermatol. 2011 Oct;131(10):2139-42. doi: 10.1038/jid.2011.181. Epub 2011 Jun 23. |
| PMID 21697891 |
| FANCD1/BRCA2 plays predominant role in the repair of DNA damage induced by ACNU or TMZ. |
| Kondo N, Takahashi A, Mori E, Noda T, Zdzienicka MZ, Thompson LH, Helleday T, Suzuki M, Kinashi Y, Masunaga S, Ono K, Hasegawa M, Ohnishi T. |
| PLoS One. 2011 May 9;6(5):e19659. |
| PMID 21573016 |
| Oxidative stress in Fanconi anaemia: from cells and molecules toward prospects in clinical management. |
| Pagano G, Aiello Talamanca A, Castello G, Pallardo FV, Zatterale A, Degan P. |
| Biol Chem. 2011 Nov 7. [Epub ahead of print] |
| PMID 22059913 |
| p38 MAPK inhibition suppresses the TLR-hypersensitive phenotype in FANCC- and FANCA-deficient mononuclear phagocytes. |
| Anur P, Yates J, Garbati MR, Vanderwerf S, Keeble W, Rathbun K, Hays LE, Tyner JW, Svahn J, Cappelli E, Dufour C, Bagby GC. |
| Blood. 2012 Mar 1;119(9):1992-2002. Epub 2012 Jan 10. |
| PMID 22234699 |
| Association of FANCC and PTCH1 with the development of early dysplastic lesions of the head and neck. |
| Ghosh A, Ghosh S, Maiti GP, Mukherjee S, Mukherjee N, Chakraborty J, Roy A, Roychoudhury S, Panda CK. |
| Ann Surg Oncol. 2012 Jul;19 Suppl 3:S528-38. Epub 2011 Aug 23. |
| PMID 21861228 |
| Towards a molecular understanding of the fanconi anemia core complex. |
| Hodson C, Walden H. |
| Anemia. 2012;2012:926787. Epub 2012 May 22. |
| PMID 22675617 |
| Association of FANCC polymorphisms with FEV1 decline in aspirin exacerbated respiratory disease. |
| Kim JH, Park BL, Pasaje CF, Bae JS, Park JS, Park SW, Uh ST, Choi JS, Kim YH, Kim MK, Choi IS, Cho SH, Choi BW, Park CS, Shin HD. |
| Mol Biol Rep. 2012 Mar;39(3):2385-94. Epub 2011 Jun 14. |
| PMID 21670957 |
| Fanconi anemia links reactive oxygen species to insulin resistance and obesity. |
| Li J, Sipple J, Maynard S, Mehta PA, Rose SR, Davies SM, Pang Q. |
| Antioxid Redox Signal. 2012 Oct 15;17(8):1083-98. Epub 2012 Jun 25. |
| PMID 22482891 |
| Impaired function of Fanconi anemia type C-deficient macrophages. |
| Liu Y, Ballman K, Li D, Khan S, Derr-Yellin E, Shou W, Haneline LS. |
| J Leukoc Biol. 2012 Feb;91(2):333-40. Epub 2011 Nov 21. |
| PMID 22106009 |
| REVIEW articles | automatic search in PubMed |
| Last year publications | automatic search in PubMed |
| Contributor(s) |
| Written | 02-1998 | Jean-Loup Huret |
| Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France | ||
| Updated | 06-2002 | Jean-Loup Huret |
| Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France | ||
| Updated | 07-2012 | Hemantika Dasgupta, Chinmay Kumar Panda |
| Chittaranjan National Cancer Institute, 37, S P Mukherjee Road, Kolkata 700026, India |
| Citation |
| This paper should be referenced as such : |
| Dasgupta, H ; Panda, CK |
| FANCC (Fanconi anaemia complementation group C) |
| Atlas Genet Cytogenet Oncol Haematol. 2013;17(1):17-20. |
| Free journal version : [ pdf ] [ DOI ] |
| History of this paper: |
| Dasgupta, H ; Panda, CK. FANCC (Fanconi anaemia complementation group C). Atlas Genet Cytogenet Oncol Haematol. 2013;17(1):17-20. |
| http://documents.irevues.inist.fr/bitstream/handle/2042/32097/02-1998-FACC101.pdf |
| Atlas Genet Cytogenet Oncol Haematol. June 2002 |
| URL : http://AtlasGeneticsOncology.org/Genes/FACCID101.html |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Tue Feb 17 20:34:49 CET 2015 |
For comments and suggestions or contributions, please contact us