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FCGR2B (Fc fragment of IgG, low affinity IIb, receptor (CD32))

Written2002-02Mary Callanan, Dominique Leroux
Lymphoma Research Group - Groupe de Recherche sur les Lymphomes - EMI0353, Institut Albert Bonniot, Université Joseph Fourier Grenoble 1, La Tronche 38706, France

(Note : for Links provided by Atlas : click)

Identity

Alias_namesFCG2
FCGR2
Fc fragment of IgG, low affinity IIb, receptor for (CD32)
Fc fragment of IgG, low affinity IIb, receptor (CD32)
Alias_symbol (synonym)CD32
CD32B
HGNC (Hugo) FCGR2B
LocusID (NCBI) 2213
Atlas_Id 397
Location 1q23.3  [Link to chromosome band 1q23]
Location_base_pair Starts at 161632905 and ends at 161648444 bp from pter ( according to hg19-Feb_2009)  [Mapping FCGR2B.png]
Local_order location, by FISH/genome sequencing; FCGR2B is contained within a locus that spans approximately 200kb and that encodes 5 low affinity IgG Fc receptor genes.The published gene orientation is as follows; Cen 1q -- 3' FCGR2A 5' -- 5'- FCGR3A - 3' -- 3' FCGR2B 5' -- 5' - FCGR3B - 3' -- 5'- FCGR2C- 3'.
 
  Probe(s) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics
Fusion genes
(updated 2016)
FCGR2B (1q23.3) / ? ()IGH (14q32.33) / FCGR2B (1q23.3)IGHG1 (14q32.33) / FCGR2B (1q23.3)
Ig () / FCGR2B (1q23.3)

DNA/RNA

Description The FCGR2B gene spans a 15kb genomic region; Gene orientation : centromere - 3' FCGR2B 5' - telomere; 8 exons (denoted S1, S2, EC1, EC2, TM, IC1, IC2, IC3). S1 and S2 encode the signal peptide domain, EC1 and EC2 encode the extracellular domain, TM encodes the transmembrane domain and IC1, IC2, IC3 encode the intracytoplasmic region.
Transcription 1.7kb mRNA. Two alternately spliced mRNA exist in humans; FcgRIIb1 and FcgRIIb2 (a 19 aa insertion encoded by IC1 is present in b1 but not in b2).

Protein

Note called Fc gamma RIIB
Description 40kD transmembrane glycoprotein that possesses an intracytoplasmic Immunoreceptor Tyrosine-based Inhibition Motif (ITIM) (encoded by IC3).
Expression B, myeloid and mast cells.
Localisation Transmembrane.
Function Low affinity IgG Fc receptor. Founding member ITIM family of immune inhibitory receptors. Fc gamma RIIB functions to down-regulate activatory responses mediated by Immunoreceptor Tyrosine-based Inhibition Motif (ITAM) bearing receptors such as the B-cell receptor on B cells. For example, on B-cells, negative regulation of B-cell receptor activatory signalling is initiated through co-recruitment of BCR and Fc gamma RIIB to IgG/ immune complexes. This leads to tyrosyl phosphorylation of the Fc gamma RIIB ITIM motif / recruitment of the inositol phosphatase SHIP and activation of the adaptor protein Dok - these events ultimately lead to the inhibition of ITAM-dependant Ca++ mobilisation and cellular proliferation (reduced MAPK signalling), respectively.
A proapoptotic signal through the Fc gamma RIIB transmembrane sequence has been described in conditions of homo-aggregation of Fc gamma RII on murine B cells.
Homology Contains two immunoglobulin-like C2 domains.

Implicated in

Note
Entity 1q21-23 rearrangements in NHL (Nnon-Hodgkins Lymphoma)
Disease NHL (< 5% of cases with 1q21-23 breaks)
Prognosis It is now known that cytogenetically determined 1q21-23 breaks can target a diversity of 1q21-23 genes. Early data has suggested a poor prognosis for 1q21 rearrangements in diffuse large cell lymphoma.
Cytogenetics Deregulation of the FCGR2B gene by chromosomal translocation was first demonstrated in 3 NHL patients that showed a t(1;22)(q22;q22) in association with a t(14;18)(q32;q21). Two further cases of NHL with rearrangements affecting the FCGR2B region have since been identified. Both cases also showed t(14;18)(see below for description). This suggests a role for this deregulation in lymphoma progression.
Hybrid/Mutated Gene Dysregulation of the FCGR2B gene has been identified as a consequence of a t(1;22)(q22;q11) (3 patients) and t(1;14)(q21;q32) (1 patient). The FCGR2B coding sequence and promoter region appear to remain intact in these translocations. The principal consequence is overexpression of the Fc gamma RIIb2 isoform of Fc gamma RIIB. Deregulation of FCGR2B most likely occurs as a consequence of Ig gene transcriptional enhancer activity. Other mechanisms may exist ; an NHL patient with dup(1)(q21q25) and rearrangement in the FCGR2B region has also been identified.
Abnormal Protein None
Oncogenesis Contribution of FCGR2B deregulation to lymphoma development or progression is currently not known.
  

Bibliography

The IgG Fc receptor, FcgammaRIIB, is a target for deregulation by chromosomal translocation in malignant lymphoma.
Callanan MB, Le Baccon P, Mossuz P, Duley S, Bastard C, Hamoudi R, Dyer MJ, Klobeck G, Rimokh R, Sotto JJ, Leroux D
Proceedings of the National Academy of Sciences of the United States of America. 2000 ; 97 (1) : 309-314.
PMID 10618414
 
Deregulation of FCGR2B expression by 1q21 rearrangements in follicular lymphomas.
Chen W, Palanisamy N, Schmidt H, Teruya-Feldstein J, Jhanwar SC, Zelenetz AD, Houldsworth J, Chaganti RS
Oncogene. 2001 ; 20 (52) : 7686-7693.
PMID 11753646
 
Fc receptor biology.
Daë M
Annual review of immunology. 1997 ; 15 : 203-234.
PMID 9143687
 
Immune inhibitory receptors.
Ravetch JV, Lanier LL
Science (New York, N.Y.). 2000 ; 290 (5489) : 84-89.
PMID 11021804
 

Citation

This paper should be referenced as such :
Callanan, M ; Leroux, D
FCGR2B (Fc fragment of IgG, low affinity IIb, receptor (CD32))
Atlas Genet Cytogenet Oncol Haematol. 2002;6(2):113-114.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Genes/FCGR2BID397.html


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 6 ]
  t(1;14)(q21;q32) BCL9/IGH::t(1;22)(q21;q11) IGL/BCL9
t(1;14)(q21;q32) FCGR2B/IGH
t(1;14)(q21;q32) FCRL4/IGH
t(1;14)(q21;q32)::t(1;22)(q21;q11)
t(1;14)(q21;q32) MUC1/IGH
t(8;9)(q24;q13)


External links

Nomenclature
HGNC (Hugo)FCGR2B   3618
Cards
AtlasFCGR2BID397
Entrez_Gene (NCBI)FCGR2B  2213  Fc fragment of IgG receptor IIb
AliasesCD32; CD32B; FCG2; FCGR2; 
IGFR2
GeneCards (Weizmann)FCGR2B
Ensembl hg19 (Hinxton)ENSG00000072694 [Gene_View]  chr1:161632905-161648444 [Contig_View]  FCGR2B [Vega]
Ensembl hg38 (Hinxton)ENSG00000072694 [Gene_View]  chr1:161632905-161648444 [Contig_View]  FCGR2B [Vega]
ICGC DataPortalENSG00000072694
TCGA cBioPortalFCGR2B
AceView (NCBI)FCGR2B
Genatlas (Paris)FCGR2B
WikiGenes2213
SOURCE (Princeton)FCGR2B
Genetics Home Reference (NIH)FCGR2B
Genomic and cartography
GoldenPath hg19 (UCSC)FCGR2B  -     chr1:161632905-161648444 +  1q23   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)FCGR2B  -     1q23   [Description]    (hg38-Dec_2013)
EnsemblFCGR2B - 1q23 [CytoView hg19]  FCGR2B - 1q23 [CytoView hg38]
Mapping of homologs : NCBIFCGR2B [Mapview hg19]  FCGR2B [Mapview hg38]
OMIM152700   604590   611162   
Gene and transcription
Genbank (Entrez)AB050934 AB051387 AB209585 AF543826 AI692546
RefSeq transcript (Entrez)NM_001002273 NM_001002274 NM_001002275 NM_001190828 NM_004001
RefSeq genomic (Entrez)NC_000001 NC_018912 NG_023318 NT_004487 NW_004929293
Consensus coding sequences : CCDS (NCBI)FCGR2B
Cluster EST : UnigeneHs.654395 [ NCBI ]
CGAP (NCI)Hs.654395
Alternative Splicing GalleryENSG00000072694
Gene ExpressionFCGR2B [ NCBI-GEO ]   FCGR2B [ EBI - ARRAY_EXPRESS ]   FCGR2B [ SEEK ]   FCGR2B [ MEM ]
Gene Expression Viewer (FireBrowse)FCGR2B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2213
GTEX Portal (Tissue expression)FCGR2B
Protein : pattern, domain, 3D structure
UniProt/SwissProtP31994   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP31994  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP31994
Splice isoforms : SwissVarP31994
PhosPhoSitePlusP31994
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)   
Domains : Interpro (EBI)Ig-like_dom    Ig-like_fold    Ig_sub   
Domain families : Pfam (Sanger)Ig_2 (PF13895)   
Domain families : Pfam (NCBI)pfam13895   
Domain families : Smart (EMBL)IG (SM00409)  
Conserved Domain (NCBI)FCGR2B
DMDM Disease mutations2213
Blocks (Seattle)FCGR2B
PDB (SRS)2FCB    3WJJ   
PDB (PDBSum)2FCB    3WJJ   
PDB (IMB)2FCB    3WJJ   
PDB (RSDB)2FCB    3WJJ   
Structural Biology KnowledgeBase2FCB    3WJJ   
SCOP (Structural Classification of Proteins)2FCB    3WJJ   
CATH (Classification of proteins structures)2FCB    3WJJ   
SuperfamilyP31994
Human Protein AtlasENSG00000072694
Peptide AtlasP31994
HPRD06849
IPIIPI00215905   
Protein Interaction databases
DIP (DOE-UCLA)P31994
IntAct (EBI)P31994
FunCoupENSG00000072694
BioGRIDFCGR2B
STRING (EMBL)FCGR2B
ZODIACFCGR2B
Ontologies - Pathways
QuickGOP31994
Ontology : AmiGOprotein binding  plasma membrane  immune response  signal transduction  integral component of membrane  viral process  IgG binding  regulation of immune response  
Ontology : EGO-EBIprotein binding  plasma membrane  immune response  signal transduction  integral component of membrane  viral process  IgG binding  regulation of immune response  
Pathways : BIOCARTAB Lymphocyte Cell Surface Molecules [Genes]   
Pathways : KEGGPhagosome    Osteoclast differentiation    B cell receptor signaling pathway    Fc gamma R-mediated phagocytosis    Staphylococcus aureus infection    Tuberculosis    Measles   
REACTOMEP31994 [protein]
REACTOME PathwaysR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell [pathway]
NDEx NetworkFCGR2B
Atlas of Cancer Signalling NetworkFCGR2B
Wikipedia pathwaysFCGR2B
Orthology - Evolution
OrthoDB2213
GeneTree (enSembl)ENSG00000072694
Phylogenetic Trees/Animal Genes : TreeFamFCGR2B
HOVERGENP31994
HOGENOMP31994
Homologs : HomoloGeneFCGR2B
Homology/Alignments : Family Browser (UCSC)FCGR2B
Gene fusions - Rearrangements
Fusion : MitelmanIGH/FCGR2B [14q32.33/1q23.3]  [t(1;14)(q21;q32)]  
Fusion : TICdbIg [FCGR2B]  -  1q23.3 []
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFCGR2B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FCGR2B
dbVarFCGR2B
ClinVarFCGR2B
1000_GenomesFCGR2B 
Exome Variant ServerFCGR2B
ExAC (Exome Aggregation Consortium)FCGR2B (select the gene name)
Genetic variants : HAPMAP2213
Genomic Variants (DGV)FCGR2B [DGVbeta]
DECIPHER (Syndromes)1:161632905-161648444  ENSG00000072694
CONAN: Copy Number AnalysisFCGR2B 
Mutations
ICGC Data PortalFCGR2B 
TCGA Data PortalFCGR2B 
Broad Tumor PortalFCGR2B
OASIS PortalFCGR2B [ Somatic mutations - Copy number]
Cancer Gene: CensusFCGR2B 
Mutations and Diseases : HGMDFCGR2B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FCGR2B
DgiDB (Drug Gene Interaction Database)FCGR2B
DoCM (Curated mutations)FCGR2B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FCGR2B (select a term)
intoGenFCGR2B
NCG5 (London)FCGR2B
Cancer3DFCGR2B(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM152700    604590    611162   
Orphanet
MedgenFCGR2B
Genetic Testing Registry FCGR2B
NextProtP31994 [Medical]
TSGene2213
GENETestsFCGR2B
Huge Navigator FCGR2B [HugePedia]
snp3D : Map Gene to Disease2213
BioCentury BCIQFCGR2B
ClinGenFCGR2B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2213
Chemical/Pharm GKB GenePA28064
Clinical trialFCGR2B
Miscellaneous
canSAR (ICR)FCGR2B (select the gene name)
Probes
Litterature
PubMed175 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFCGR2B
EVEXFCGR2B
GoPubMedFCGR2B
iHOPFCGR2B
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Nov 18 19:59:43 CET 2016

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