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FOXE1 (forkhead box E1 (thyroid transcription factor 2))

Written2010-05Isabella Venza, Maria Visalli, Diana Teti, Mario Venza
Department of Surgical Specialities, Azienda Ospedaliera Universitaria G Martino, Via Consolare Valeria, 1 (Gazzi) 98125, Messina, Italy (IV); Department of Experimental Pathology, Microbiology, Azienda Ospedaliera Universitaria G Martino, Via Consolare Valeria, 1 (Gazzi) 98125, Messina, Italy (MVi, DT); Department of Neurosciences, Psychiatry, Anaesthesiology, Azienda Ospedaliera Universitaria G Martino, Via Consolare Valeria, 1 (Gazzi) 98125, Messina, Italy (MVe)

(Note : for Links provided by Atlas : click)

Identity

Alias_namesFKHL15
TITF2
FOXE2
forkhead box E2
forkhead box E1 (thyroid transcription factor 2)
Alias_symbol (synonym)TTF-2
HFKH4
Other aliasHFKL5
TTF2
HGNC (Hugo) FOXE1
LocusID (NCBI) 2304
Atlas_Id 47197
Location 9q22.33  [Link to chromosome band 9q22]
Location_base_pair Starts at 100615537 and ends at 100618997 bp from pter ( according to hg19-Feb_2009)  [Mapping FOXE1.png]

DNA/RNA

 
  Schematic diagram of the human FOXE1 gene.
Description The gene consists of 1 exon and is intronless; the 5' and the 3' parts of the exon are non-coding.
Transcription 3461 bp transcript with a 1121 bp of coding sequence.

Protein

 
  Diagrammatic representation of the functional domains of human FOXE1 protein.
Description The FOXE1 protein is 373-amino acid long and its molecular weight is 42 kDa. It contains a forkhead DNA-binding domain, 2 putative nuclear localization signals (NLS) which flank the DNA-binding domain, and a polyalanine (polyA) stretch of variable length. Population-based studies found polymorphism of the polyA tract lengths varying from 11 to 19 residues with the 14 as the most frequent allele (Venza et al., 2006; Macchia et al., 1999; Hishinuma et al., 2001; Tonacchera et al., 2004; Santarpia et al., 2007; Carre et al., 2007).
Expression In humans, FOXE1 is expressed at the embryonic Carnegie stage (CS) 15 in the thyroid primordium and persists in the thyroid gland throughout development. At the same embryonic stage, FOXE1 is also detectable in the thymus and in the oropharyngeal epithelium. At 11 weeks of development it is present in the tracheal and esophageal epithelium (Trueba et al., 2005).
In mice, FOXE1 is expressed at embryonic day E8.5 in the endoderm corresponding to the floor of the foregut, at E9.2-9.3 in the epithelium lining the anterior foregut and the posterior stomodeum, including the pharyngeal membrane, and in the migrating thyroid primordium and at E9.5 in the craniopharyngeal ectoderm involved in palate formation. Later, at E10.5 FOXE1 expression is transcribed along all the endoderm of the foregut lining the visceral pouch of the branchial arches (Zannini et al., 1997; Dathan et al., 2002).
Localisation Nuclear.
Function FOXE1 regulates the transcription of thyroglobulin (Tg) and thyroid peroxidase (TPO), and represses transcriptional activation of TTF-1 and PAX8 on the Tg and TPO promoters. The gene plays an important role in thyroid development, secondary palate closure and hair follicle morphogenesis. FOXE1 is also implicated in malignancy.
Homology Member of the forkhead box E (FOXE) subfamily which itself is a part of the large FOX gene family of transcription factors, characterized by sharing a common 100 amino acid forkhead domain. FOXE proteins (FOXE-1, -2, -3, -4) are widely expressed in a range of tissues, have diverse roles in development and metabolism and have been implicated in various forms of cancer and disease.

Implicated in

Note
  
Entity Thyroid carcinoma
Disease Genome-wide association studies (GWAS) showed a significant correlation of the rs965513 variant located 57-kb upstream to FOXE1 with follicular thyroid carcinoma (FTC) (Gudmundsson et al., 2009) as well as with sporadic or radiation-related papillary thyroid carcinoma (PTC) (Gudmundsson et al., 2009; Takahashi et al., 2010). A detailed analysis of the PTC-risk conferring haplotype identified rs1867277 as a highly correlated putative functional variant within the FOXE1 promoter (Landa et al., 2009). Functional assays revealed that the rs1867277 G allele partially impairs the recruitment of USF1 and USF2 factors to the FOXE1 promoter and alters the expression status of the FOXE1 gene (Landa et al., 2009).
  
  
Entity Pancreatic cancer
Disease Aberrant CpG methylation of FOXE1 was detected in pancreatic cancer cell lines and in a series of resected primary pancreatic carcinomas (Sato et al., 2003) as well as in familial and sporadic pancreatic adenocarcinoma specimens (Brune et al., 2008). FOXE1 was also prevalently methylated in the surgical pancreatic juice of patients with pancreatic ductal adenocarcinoma, less frequently in samples of intraductal papillary mucinous neoplasms, but never in patients with chronic pancreatitis (Matsubayashi et al., 2006).
  
  
Entity Breast cancer
Disease DNA hypermethylation events in the CpG islands of FOXE1 promoter were present in plasma samples from breast cancer patients (Weisenberger et al., 2008).
  
  
Entity Cutaneous squamous cell carcinoma (SCC)
Disease A higher frequency of FOXE1 promoter hypermethylation was found in cutaneous SCCs (55%), as compared with the adjacent uninvolved skin (12%) and blood control samples (9%). FOXE1 methylation was frequently seen in association with a complete absence or downregulation of gene expression. Treatment with the demethylating agent 5-Aza-2'-deoxycytidine resulted in profound reactivation of FOXE1 expression (Venza et al., 2010a). It was also reported that expansions of the polyA tract (16 alanine) of FOXE1 predisposes to cutaneous SCC (Venza et al., 2010b).
  
  
Entity Bamforth-lazarus syndrome
Disease Homozygous, human loss-of-function mutations located within the forkhead domain of FOXE1 (A65V, S57N and R72S) cause the Bamforth-Lazarus syndrome, which includes congenital hypothyroidism, cleft palate and spiky hair, with or without choanal atresia, bifid epiglottis, and ocular hypertelorism, depending on the severity of the mutation (Clifton-Bligh et al., 1998; Castanet et al., 2002; Baris et al., 2006). In vitro studies showed the complete lack of DNA binding and transcriptional activity of A65V (Clifton-Bligh et al., 1998) and R102C (Baris et al., 2006), and the partial preservation of function with the S57N (Castanet et al., 2002) mutant FOXE1 proteins, respectively.
  
  
Entity Non-syndromic cleft lip with or without cleft palate (NS CL/P)
Disease Rare missense mutations in FOXE1 (A207V and D285V) have been associated with isolated clefting (Vieira et al., 2005). Fine-mapping association studies showed genome-wide significant SNPs in or near FOXE1 region (rs3758249, rs4460498, rs1443434, rs993501) in CLP patients (Marazita et al., 2009; Moreno et al., 2009). Recently, the novel homozygous polymorphism C(-1204)G in the FOXE1 promoter region that prevented the binding of MYF-5, a myogenic regulatory factor essential for the muscle-dependent craniofacial skeletal development and the fusion of primary and secondary palate, was found in non-syndromic CP patients (Venza et al., 2009).
  
  
Entity Premature ovarian failure (POF)
Disease Variation in FOXE1 polyalanine length from the most frequently occurring 14 alanine allele to the 16 allele increases the risk of developing POF (Watkins et al., 2006).
  

Bibliography

A novel missense mutation in human TTF-2 (FKHL15) gene associated with congenital hypothyroidism but not athyreosis.
Baris I, Arisoy AE, Smith A, Agostini M, Mitchell CS, Park SM, Halefoglu AM, Zengin E, Chatterjee VK, Battaloglu E.
J Clin Endocrinol Metab. 2006 Oct;91(10):4183-7. Epub 2006 Aug 1.
PMID 16882747
 
Genetic and epigenetic alterations of familial pancreatic cancers.
Brune K, Hong SM, Li A, Yachida S, Abe T, Griffith M, Yang D, Omura N, Eshleman J, Canto M, Schulick R, Klein AP, Hruban RH, Iacobuzio-Donohue C, Goggins M.
Cancer Epidemiol Biomarkers Prev. 2008 Dec;17(12):3536-42.
PMID 19064568
 
Polymorphic length of FOXE1 alanine stretch: evidence for genetic susceptibility to thyroid dysgenesis.
Carre A, Castanet M, Sura-Trueba S, Szinnai G, Van Vliet G, Trochet D, Amiel J, Leger J, Czernichow P, Scotet V, Polak M.
Hum Genet. 2007 Dec;122(5):467-76. Epub 2007 Aug 24.
PMID 17717707
 
A novel loss-of-function mutation in TTF-2 is associated with congenital hypothyroidism, thyroid agenesis and cleft palate.
Castanet M, Park SM, Smith A, Bost M, Leger J, Lyonnet S, Pelet A, Czernichow P, Chatterjee K, Polak M.
Hum Mol Genet. 2002 Aug 15;11(17):2051-9.
PMID 12165566
 
Mutation of the gene encoding human TTF-2 associated with thyroid agenesis, cleft palate and choanal atresia.
Clifton-Bligh RJ, Wentworth JM, Heinz P, Crisp MS, John R, Lazarus JH, Ludgate M, Chatterjee VK.
Nat Genet. 1998 Aug;19(4):399-401.
PMID 9697705
 
Distribution of the titf2/foxe1 gene product is consistent with an important role in the development of foregut endoderm, palate, and hair.
Dathan N, Parlato R, Rosica A, De Felice M, Di Lauro R.
Dev Dyn. 2002 Aug;224(4):450-6.
PMID 12203737
 
Common variants on 9q22.33 and 14q13.3 predispose to thyroid cancer in European populations.
Gudmundsson J, Sulem P, Gudbjartsson DF, Jonasson JG, Sigurdsson A, Bergthorsson JT, He H, Blondal T, Geller F, Jakobsdottir M, Magnusdottir DN, Matthiasdottir S, Stacey SN, Skarphedinsson OB, Helgadottir H, Li W, Nagy R, Aguillo E, Faure E, Prats E, Saez B, Martinez M, Eyjolfsson GI, Bjornsdottir US, Holm H, Kristjansson K, Frigge ML, Kristvinsson H, Gulcher JR, Jonsson T, Rafnar T, Hjartarsson H, Mayordomo JI, de la Chapelle A, Hrafnkelsson J, Thorsteinsdottir U, Kong A, Stefansson K.
Nat Genet. 2009 Apr;41(4):460-4. Epub 2009 Feb 6.
PMID 19198613
 
Polymorphism of the polyalanine tract of thyroid transcription factor-2 gene in patients with thyroid dysgenesis.
Hishinuma A, Ohyama Y, Kuribayashi T, Nagakubo N, Namatame T, Shibayama K, Arisaka O, Matsuura N, Ieiri T.
Eur J Endocrinol. 2001 Oct;145(4):385-9.
PMID 11580993
 
The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors.
Landa I, Ruiz-Llorente S, Montero-Conde C, Inglada-Perez L, Schiavi F, Leskela S, Pita G, Milne R, Maravall J, Ramos I, Andia V, Rodriguez-Poyo P, Jara-Albarran A, Meoro A, del Peso C, Arribas L, Iglesias P, Caballero J, Serrano J, Pico A, Pomares F, Gimenez G, Lopez-Mondejar P, Castello R, Merante-Boschin I, Pelizzo MR, Mauricio D, Opocher G, Rodriguez-Antona C, Gonzalez-Neira A, Matias-Guiu X, Santisteban P, Robledo M.
PLoS Genet. 2009 Sep;5(9):e1000637. Epub 2009 Sep 4.
PMID 19730683
 
Cloning, chromosomal localization and identification of polymorphisms in the human thyroid transcription factor 2 gene (TITF2).
Macchia PE, Mattei MG, Lapi P, Fenzi G, Di Lauro R.
Biochimie. 1999 May;81(5):433-40.
PMID 10403172
 
Genome scan, fine-mapping, and candidate gene analysis of non-syndromic cleft lip with or without cleft palate reveals phenotype-specific differences in linkage and association results.
Marazita ML, Lidral AC, Murray JC, Field LL, Maher BS, Goldstein McHenry T, Cooper ME, Govil M, Daack-Hirsch S, Riley B, Jugessur A, Felix T, Morene L, Mansilla MA, Vieira AR, Doheny K, Pugh E, Valencia-Ramirez C, Arcos-Burgos M.
Hum Hered. 2009;68(3):151-70. Epub 2009 Jun 11.
PMID 19521098
 
DNA methylation alterations in the pancreatic juice of patients with suspected pancreatic disease.
Matsubayashi H, Canto M, Sato N, Klein A, Abe T, Yamashita K, Yeo CJ, Kalloo A, Hruban R, Goggins M.
Cancer Res. 2006 Jan 15;66(2):1208-17.
PMID 16424060
 
FOXE1 association with both isolated cleft lip with or without cleft palate, and isolated cleft palate.
Moreno LM, Mansilla MA, Bullard SA, Cooper ME, Busch TD, Machida J, Johnson MK, Brauer D, Krahn K, Daack-Hirsch S, L'heureux J, Valencia-Ramirez C, Rivera D, Lopez AM, Moreno MA, Hing A, Lammer EJ, Jones M, Christensen K, Lie RT, Jugessur A, Wilcox AJ, Chines P, Pugh E, Doheny K, Arcos-Burgos M, Marazita ML, Murray JC, Lidral AC.
Hum Mol Genet. 2009 Dec 15;18(24):4879-96. Epub 2009 Sep 24.
PMID 19779022
 
TTF-2/FOXE1 gene polymorphisms in Sicilian patients with permanent primary congenital hypothyroidism.
Santarpia L, Valenzise M, Di Pasquale G, Arrigo T, San Martino G, Ciccio MP, Trimarchi F, De Luca F, Benvenga S.
J Endocrinol Invest. 2007 Jan;30(1):13-9.
PMID 17318017
 
Discovery of novel targets for aberrant methylation in pancreatic carcinoma using high-throughput microarrays.
Sato N, Fukushima N, Maitra A, Matsubayashi H, Yeo CJ, Cameron JL, Hruban RH, Goggins M.
Cancer Res. 2003 Jul 1;63(13):3735-42.
PMID 12839967
 
The FOXE1 locus is a major genetic determinant for radiation-related thyroid carcinoma in Chernobyl.
Takahashi M, Saenko VA, Rogounovitch TI, Kawaguchi T, Drozd VM, Takigawa-Imamura H, Akulevich NM, Ratanajaraya C, Mitsutake N, Takamura N, Danilova LI, Lushchik ML, Demidchik YE, Heath S, Yamada R, Lathrop M, Matsuda F, Yamashita S.
Hum Mol Genet. 2010 Jun 15;19(12):2516-23. Epub 2010 Mar 29.
PMID 20350937
 
Genetic analysis of TTF-2 gene in children with congenital hypothyroidism and cleft palate, congenital hypothyroidism, or isolated cleft palate.
Tonacchera M, Banco M, Lapi P, Di Cosmo C, Perri A, Montanelli L, Moschini L, Gatti G, Gandini D, Massei A, Agretti P, De Marco G, Vitti P, Chiovato L, Pinchera A.
Thyroid. 2004 Aug;14(8):584-8.
PMID 15320969
 
PAX8, TITF1, and FOXE1 gene expression patterns during human development: new insights into human thyroid development and thyroid dysgenesis-associated malformations.
Trueba SS, Auge J, Mattei G, Etchevers H, Martinovic J, Czernichow P, Vekemans M, Polak M, Attie-Bitach T.
J Clin Endocrinol Metab. 2005 Jan;90(1):455-62. Epub 2004 Oct 19.
PMID 15494458
 
Investigation into FOXE1 genetic variations in cutaneous squamous cell carcinoma.
Venza I, Visalli M, Tripodo B, Lentini M, Teti D, Venza M.
Br J Dermatol. 2010b Mar;162(3):681-3. Epub 2009 Nov 24.
PMID 19930442
 
Altered binding of MYF-5 to FOXE1 promoter in non-syndromic and CHARGE-associated cleft palate.
Venza M, Visalli M, Venza I, Torino C, Tripodo B, Melita R, Teti D.
J Oral Pathol Med. 2009 Jan;38(1):18-23.
PMID 19192046
 
Medical sequencing of candidate genes for nonsyndromic cleft lip and palate.
Vieira AR, Avila JR, Daack-Hirsch S, Dragan E, Felix TM, Rahimov F, Harrington J, Schultz RR, Watanabe Y, Johnson M, Fang J, O'Brien SE, Orioli IM, Castilla EE, Fitzpatrick DR, Jiang R, Marazita ML, Murray JC.
PLoS Genet. 2005 Dec;1(6):e64. Epub 2005 Dec 2.
PMID 16327884
 
An investigation into FOXE1 polyalanine tract length in premature ovarian failure.
Watkins WJ, Harris SE, Craven MJ, Vincent AL, Winship IM, Gersak K, Shelling AN.
Mol Hum Reprod. 2006 Mar;12(3):145-9. Epub 2006 Feb 15.
PMID 16481406
 
DNA methylation analysis by digital bisulfite genomic sequencing and digital MethyLight.
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Nucleic Acids Res. 2008 Aug;36(14):4689-98. Epub 2008 Jul 15.
PMID 18628296
 
TTF-2, a new forkhead protein, shows a temporal expression in the developing thyroid which is consistent with a role in controlling the onset of differentiation.
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PMID 9214635
 

Citation

This paper should be referenced as such :
Venza, I ; Visalli, M ; Teti, D ; Venza, M
FOXE1 (forkhead box E1 (thyroid transcription factor 2))
Atlas Genet Cytogenet Oncol Haematol. 2011;15(2):183-186.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Genes/FOXE1ID47197ch9q22.html


External links

Nomenclature
HGNC (Hugo)FOXE1   3806
Cards
AtlasFOXE1ID47197ch9q22
Entrez_Gene (NCBI)FOXE1  2304  forkhead box E1
AliasesFKHL15; FOXE2; HFKH4; HFKL5; 
NMTC4; TITF2; TTF-2; TTF2
GeneCards (Weizmann)FOXE1
Ensembl hg19 (Hinxton)ENSG00000178919 [Gene_View]  chr9:100615537-100618997 [Contig_View]  FOXE1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000178919 [Gene_View]  chr9:100615537-100618997 [Contig_View]  FOXE1 [Vega]
ICGC DataPortalENSG00000178919
TCGA cBioPortalFOXE1
AceView (NCBI)FOXE1
Genatlas (Paris)FOXE1
WikiGenes2304
SOURCE (Princeton)FOXE1
Genetics Home Reference (NIH)FOXE1
Genomic and cartography
GoldenPath hg19 (UCSC)FOXE1  -     chr9:100615537-100618997 +  9q22   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)FOXE1  -     9q22   [Description]    (hg38-Dec_2013)
EnsemblFOXE1 - 9q22 [CytoView hg19]  FOXE1 - 9q22 [CytoView hg38]
Mapping of homologs : NCBIFOXE1 [Mapview hg19]  FOXE1 [Mapview hg38]
OMIM241850   602617   616534   
Gene and transcription
Genbank (Entrez)BC152744 U89995 X94553
RefSeq transcript (Entrez)NM_004473
RefSeq genomic (Entrez)NC_000009 NC_018920 NG_011979 NT_008470 NW_004929366
Consensus coding sequences : CCDS (NCBI)FOXE1
Cluster EST : UnigeneHs.159234 [ NCBI ]
CGAP (NCI)Hs.159234
Alternative Splicing GalleryENSG00000178919
Gene ExpressionFOXE1 [ NCBI-GEO ]   FOXE1 [ EBI - ARRAY_EXPRESS ]   FOXE1 [ SEEK ]   FOXE1 [ MEM ]
Gene Expression Viewer (FireBrowse)FOXE1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2304
GTEX Portal (Tissue expression)FOXE1
Protein : pattern, domain, 3D structure
UniProt/SwissProtO00358   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO00358  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO00358
Splice isoforms : SwissVarO00358
PhosPhoSitePlusO00358
Domaine pattern : Prosite (Expaxy)FORK_HEAD_1 (PS00657)    FORK_HEAD_2 (PS00658)    FORK_HEAD_3 (PS50039)   
Domains : Interpro (EBI)Fork_head_dom    TF_fork_head_CS_1    TF_fork_head_CS_2    WHTH_DNA-bd_dom   
Domain families : Pfam (Sanger)Forkhead (PF00250)   
Domain families : Pfam (NCBI)pfam00250   
Domain families : Smart (EMBL)FH (SM00339)  
Conserved Domain (NCBI)FOXE1
DMDM Disease mutations2304
Blocks (Seattle)FOXE1
SuperfamilyO00358
Human Protein AtlasENSG00000178919
Peptide AtlasO00358
HPRD04014
IPIIPI00879523   
Protein Interaction databases
DIP (DOE-UCLA)O00358
IntAct (EBI)O00358
FunCoupENSG00000178919
BioGRIDFOXE1
STRING (EMBL)FOXE1
ZODIACFOXE1
Ontologies - Pathways
QuickGOO00358
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  negative regulation of transcription from RNA polymerase II promoter  RNA polymerase II transcription factor activity, sequence-specific DNA binding  DNA binding  transcription factor activity, sequence-specific DNA binding  nucleus  transcription, DNA-templated  thyroid hormone generation  anatomical structure morphogenesis  cell migration  thyroid gland development  thyroid gland development  hair follicle morphogenesis  sequence-specific DNA binding  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  thymus development  embryonic organ morphogenesis  hard palate development  soft palate development  pharynx development  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  negative regulation of transcription from RNA polymerase II promoter  RNA polymerase II transcription factor activity, sequence-specific DNA binding  DNA binding  transcription factor activity, sequence-specific DNA binding  nucleus  transcription, DNA-templated  thyroid hormone generation  anatomical structure morphogenesis  cell migration  thyroid gland development  thyroid gland development  hair follicle morphogenesis  sequence-specific DNA binding  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  thymus development  embryonic organ morphogenesis  hard palate development  soft palate development  pharynx development  
NDEx NetworkFOXE1
Atlas of Cancer Signalling NetworkFOXE1
Wikipedia pathwaysFOXE1
Orthology - Evolution
OrthoDB2304
GeneTree (enSembl)ENSG00000178919
Phylogenetic Trees/Animal Genes : TreeFamFOXE1
HOVERGENO00358
HOGENOMO00358
Homologs : HomoloGeneFOXE1
Homology/Alignments : Family Browser (UCSC)FOXE1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFOXE1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FOXE1
dbVarFOXE1
ClinVarFOXE1
1000_GenomesFOXE1 
Exome Variant ServerFOXE1
ExAC (Exome Aggregation Consortium)FOXE1 (select the gene name)
Genetic variants : HAPMAP2304
Genomic Variants (DGV)FOXE1 [DGVbeta]
DECIPHER (Syndromes)9:100615537-100618997  ENSG00000178919
CONAN: Copy Number AnalysisFOXE1 
Mutations
ICGC Data PortalFOXE1 
TCGA Data PortalFOXE1 
Broad Tumor PortalFOXE1
OASIS PortalFOXE1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFOXE1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFOXE1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FOXE1
DgiDB (Drug Gene Interaction Database)FOXE1
DoCM (Curated mutations)FOXE1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FOXE1 (select a term)
intoGenFOXE1
NCG5 (London)FOXE1
Cancer3DFOXE1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM241850    602617    616534   
Orphanet905    1470    21661   
MedgenFOXE1
Genetic Testing Registry FOXE1
NextProtO00358 [Medical]
TSGene2304
GENETestsFOXE1
Huge Navigator FOXE1 [HugePedia]
snp3D : Map Gene to Disease2304
BioCentury BCIQFOXE1
ClinGenFOXE1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2304
Chemical/Pharm GKB GenePA28223
Clinical trialFOXE1
Miscellaneous
canSAR (ICR)FOXE1 (select the gene name)
Probes
Litterature
PubMed75 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFOXE1
EVEXFOXE1
GoPubMedFOXE1
iHOPFOXE1
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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