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FOXO1 (Forkhead box O1)

Written2008-05Roddy O'Connor, Frederic G Barr
Department of Pathology, Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA

(Note : for Links provided by Atlas : click)

Identity

Alias_namesFKHR
FOXO1A
forkhead homolog in rhabdomyosarcoma
Alias_symbol (synonym)FKH1
Other alias
HGNC (Hugo) FOXO1
LocusID (NCBI) 2308
Atlas_Id 83
Location 13q14.11  [Link to chromosome band 13q14]
Location_base_pair Starts at 40555664 and ends at 40666597 bp from pter ( according to hg19-Feb_2009)  [Mapping FOXO1.png]
Fusion genes
(updated 2016)
EML2 (19q13.32) / FOXO1 (13q14.11)FOXO1 (13q14.11) / CCNY (10p11.21)FOXO1 (13q14.11) / ELF1 (13q14.11)
FOXO1 (13q14.11) / FGFR1 (8p11.23)FOXO1 (13q14.11) / FOXO1 (13q14.11)FOXO1 (13q14.11) / PAX3 (2q36.1)
FOXO1 (13q14.11) / PAX7 (1p36.13)FOXO1 (13q14.11) / RB1CC1 (8q11.23)MAGI1 (3p14.1) / FOXO1 (13q14.11)
PAX3 (2q36.1) / FOXO1 (13q14.11)PAX7 (1p36.13) / FOXO1 (13q14.11)

DNA/RNA

Description The FOXO1 gene extends approximately 110 kb and consists of 3 exons.
Transcription Only a single transcript has been reported to be expressed from the FOXO1 gene, measuring 5.7 kb in length and containing an open reading frame of 1965 bp. At the RNA level, the gene is widely expressed.

Protein

Description A single protein of 655 amino acids is expressed. This protein is a transcription factor with a forkhead box-containing DNA binding domain in the N-terminal region and an acidic, serine/threonine-rich transcriptional activation domain in the C-terminal region.
Expression The protein is widely expressed. Covalent attachment of ubiquitin moieties (polyubiquitination) targets FOXO1 protein for degradation, and thus FOXO1 expression can be regulated by the ubiquitin-dependent proteasome. AKT is implicated in the regulation of FOXO1 expression by its enhancement of FOXO1 ubiquitination and proteolysis.
Localisation The FOXO1 protein shuttles between the nucleus and cytoplasm. The subcellular localization and hence the transcriptional activity of FOXO1 is regulated by intracellular kinases. FOXO1 contains three AKT-phosphorylation motifs [RxRxx(S/T)]. Phosphorylation of these sites by AKT promotes nuclear exclusion, association with 14-3-3 adaptor proteins and cytosolic retention. The serum and glucocorticoid-inducible kinase ( SGK ), dual-specificity tyrosine-phosphorylated regulated kinase DYRK1A and cyclin-dependent kinase 2 ( CDK2 ) may also similarly phosphorylate FOXO1 and contribute to its subceullar localization, thereby acting combinatorially to suppress FOXO1 transcriptional activity. Although the role of phosphatases in FOXO1 activation is unclear, PTEN may have a role in countering the effects of these kinases.
Function FOXO1 plays an important role in many cellular processes. As a transcription factor, FOXO1 induces expression of target genes involved in apoptosis, glucose metabolism, cell cycle progression, and differentiation. There is increasing evidence of a role for FOXO1 as a tumor suppressor. FOXO1 transcriptional responses are also implicated in cellular protection following DNA damage and oxidative stress, which may be related to a role in longevity.
Homology The first FOX transcription factor fork head was identified in Drosophila. The subsequent cloning of mammalian FOX transcription factors revealed a common DNA-binding domain (forkhead box) that is highly conserved across species including Drosophila melanogaster, C. elegans and Homo sapiens. Within the larger FOX transcription factor family, there is a subfamily of which FOXO1 is the prototype. Additional members of this FOXO subfamily are: FOXO3 (FKHRL1, FOXO2), FOXO4 (AFX), FOXO6.
A gene homologous to FOXO subfamily members, daf-16, has also been identified in C. elegans and has facilitated analysis of the functional regulation of mammalian FOXO subfamily members. FOXO members share consensus phosphorylaton motifs for multiple kinases including AKT, CDK2, DYRK1A and SGK. Phosphorylation of these motifs regulates subcellular localization, DNA affinity, and protein-protein interactions. Of note, three of the genes in the FOXO1 subfamily are involved in cancer associated-chromosomal translocations. In addition to the rearrangement of FOXO1 in alveolar rhabdomyosarcoma (discussed below), FOXO3 and FOXO4 are joined with the MLL gene by translocations in acute myeloid leukemias.

Mutations

 
  Figure 1. Diagram of t(2;13)(q35;q14) and t(1;13)(p36;q14) chromosomal translocations.
Germinal Inherited mutations of FOXO1 have not been identified.
Somatic The FOXO1 gene is rearranged by the recurrent acquired chromosomal translocations - t(2;13)(q35;q14) and t(1;13)(p36;q14) - in the myogenic soft tissue cancer alveolar rhabdomyosarcoma. As a result of the 2;13 or 1;13 translocation, portions of the PAX3 or PAX7 gene (on chromosomes 2 or 1, respectively) are juxtaposed with portions of the FOXO1 gene. In particular, the 5' region of PAX3 or PAX7, including the first seven exons of either gene, is joined to the 3' region of FOXO1, including its last two exons. Though the reciprocal chimeric gene is also generated, the PAX3-FOXO1 and PAX7-FOXO1 chimeric genes are more consistent and highly expressed, and result in expression of fusion proteins consisting of the intact PAX3 or PAX7 N-terminal DNA binding domain fused in-framed to the intact FOXO1 C-terminal transcriptional activation domain.
FOXO1 was identified as only gene within a minimal common region of deletion in chromosomal region 13q14 in prostate carcinoma. FOXO1 deletion was detected in about 30% of prostate cancer samples, and additional cases were identified with reduced expression without evidence of deletion. Based on functional testing in prostate cancer cell lines that indicated that FOXO1 affected cell proliferation, survival, and androgen receptor signaling, the combined data indicates that FOXO1 is a tumor suppressor gene in prostate cancer.

Implicated in

Note
  
Entity Alveolar Rhabdomyosarcoma (ARMS)
Disease ARMS is one subtype of a family of pediatric soft tissue tumors that is related to the skeletal muscle lineage. In contrast to embryonal rhabdomyosarcoma (ERMS), the other major subtype in this family, ARMS often occurs in adolescents and young adults, with primary tumors located in the vicinity of skeletal muscle, such as in the extremities and trunk.
Prognosis The overall prognosis for patients with ARMS is less favorable compared to those with ERMS. The three year survival rate for patients without metastatic diseae was 66% (IRS-IV clinical trial), and evidence of metastasis decreased the survival rate to only 16%. The pathogenesis of metastatic ARMS is associated with an early and wide dissemination, often involving bone marrow, and to poor response to chemotherapy. One study also indicates that for metastatic patients, tumors with a PAX3-FKHR fusion have a poorer outcome than tumors with a PAX7-FKHR fusion. In contrast, there is no reported difference in outcome between these subtypes in patients with non-metastatic tumors.
Cytogenetics Translocations involving the q14 band on chromosome 13 and the q35 band on chromosome 2 - t(2;13)(q35;q14) - distinguish ARMS from other soft tissue sarcomas. An additional 1;13 translocation - t(1;13)(p36;q14) - has been identified in a smaller number of ARMS cases.
 
Figure 2. Generation of chimeric genes by the 2;13 and 1;13 translocations in ARMS. The exons of the wild-type and fusion genes are shown as boxes above each map and the translocation breakpoint distributions are shown as line segments below the map of the wild-type genes
 
Figure 3. Comparison of wild-type and fusion products associated with the 2;13 and 1;13 translocations. The paired box, octapeptide, homeobox and fork head domain are indicated as open boxes, and transcriptional domains (DNA binding domain, DBD; transcriptional activiation domain) are shown as solid bars. The sites phosphorylated by Akt are indicated by stars. The vertical dash line indicates the translocation fusion point
  
  
Entity Prostate carcinoma
Disease Adenocarcinoma of the prostate is a malignant tumor arising from the glandular epithelium of the prostate gland.
Prognosis In several studies in prostate cancer correlating outcome and chromosomal changes detected by allelic loss or comparative genomic hybridization, deletions or losses involving chromosomal region 13q14 were not found to be correlated with significant differences in outcome.
Cytogenetics One of the most frequent deletions in prostate cancer involves the q arm of chromosome 13. There are two common regions of deletion in the q arm of chromosome 13: 13q14 and 13q21.
  

Breakpoints

 

Bibliography

Proteasomal degradation of the FoxO1 transcriptional regulator in cells transformed by the P3k and Akt oncoproteins.
Aoki M, Jiang H, Vogt PK.
Proc Natl Acad Sci U S A. 2004 Sep 14;101(37):13613-7.
PMID 15342912
 
Upregulation of FOXO1 and FOXO3a following denervation and dexamethasone treatment.
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Rearrangement of the PAX3 paired box gene in the paediatric solid tumour alveolar rhabdomyosarcoma.
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Mechanism for transcriptional gain of function resulting from chromosomal translocation in alveolar rhabdomyosarcoma.
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Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1.
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FKHR (FOXO1a) is required for myotube fusion of primary mouse myoblasts.
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Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor.
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Cell. 1999 Mar 19;96(6):857-68.
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Regulation of the Forkhead transcription factor AFX by Ral-dependent phosphorylation of threonines 447 and 451.
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PMID 11689711
 
Functional interaction between beta-catenin and FOXO in oxidative stress signaling.
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Science. 2005 May 20;308(5725):1181-4.
PMID 15905404
 
Abnormal angiogenesis in Foxo1 (Fkhr)-deficient mice.
Furuyama T, Kitayama K, Shimoda Y, Ogawa M, Sone K, Yoshida-Araki K, Hisatsune H, Nishikawa S, Nakayama K, Nakayama K, Ikeda K, Motoyama N, Mori N.
J Biol Chem. 2004 Aug 13;279(33):34741-9.
PMID 15184386
 
FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons.
Gilley J, Coffer PJ, Ham J.
J Cell Biol. 2003 Aug 18;162(4):613-22.
PMID 12913110
 
CDK2-dependent phosphorylation of FOXO1 as an apoptotic response to DNA damage.
Huang H, Regan KM, Lou Z, Chen J, Tindall DJ.
Science. 2006 Oct 13;314(5797):294-7.
PMID 17038621
 
Forkhead transcription factor FoxO1 transduces insulin-like growth factor's signal to p27Kip1 in primary skeletal muscle satellite cells.
Machida S, Spangenburg EE, Booth FW.
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PMID 12891709
 
Mammalian SIRT1 represses forkhead transcription factors.
Motta MC, Divecha N, Lemieux M, Kamel C, Chen D, Gu W, Bultsma Y, McBurney M, Guarente L.
Cell. 2004 Feb 20;116(4):551-63.
PMID 14980222
 
The forkhead transcription factor Foxo1 regulates adipocyte differentiation.
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Dev Cell. 2003 Jan;4(1):119-29.
PMID 12530968
 
Forkhead transcription factors are critical effectors of cell death and cell cycle arrest downstream of PTEN.
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PMID 11073996
 
The coactivator p300 directly acetylates the forkhead transcription factor Foxo1 and stimulates Foxo1-induced transcription.
Perrot V, Rechler MM.
Mol Endocrinol. 2005 Sep;19(9):2283-98.
PMID 15890677
 
Akt activation promotes degradation of tuberin and FOXO3a via the proteasome.
Plas DR, Thompson CB.
J Biol Chem. 2003 Apr 4;278(14):12361-6.
PMID 12517744
 
Involvement of Foxo transcription factors in angiogenesis and postnatal neovascularization.
Potente M, Urbich C, Sasaki K, Hofmann WK, Heeschen C, Aicher A, Kollipara R, DePinho RA, Zeiher AM, Dimmeler S.
J Clin Invest. 2005 Sep;115(9):2382-92.
PMID 16100571
 
Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction.
Puigserver P, Rhee J, Donovan J, Walkey CJ, Yoon JC, Oriente F, Kitamura Y, Altomonte J, Dong H, Accili D, Spiegelman BM.
Nature. 2003 May 29;423(6939):550-5.
PMID 12754525
 
Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation.
Seoane J, Le HV, Shen L, Anderson SA, Massague J.
Cell. 2004 Apr 16;117(2):211-23.
PMID 15084259
 
PAX3-FKHR and PAX7-FKHR gene fusions are prognostic indicators in alveolar rhabdomyosarcoma: a report from the Children's Oncology Group.
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PMID 12039929
 
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J Immunol. 2002 May 15;168(10):5024-31.
PMID 11994454
 
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Van Der Heide LP, Hoekman MF, Smidt MP.
Biochem J. 2004 Jun 1;380(Pt 2):297-309.
PMID 15005655
 
The homeotic gene fork head encodes a nuclear protein and is expressed in the terminal regions of the Drosophila embryo.
Weigel D, Jurgens G, Kuttner F, Seifert E, Jackle H.
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PMID 2566386
 
The ubiquitin signal: assembly, recognition and termination. Symposium on ubiquitin and signaling.
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EMBO Rep. 2005 Sep;6(9):815-20.
PMID 16113643
 
The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation site.
Woods YL, Rena G, Morrice N, Barthel A, Becker W, Guo S, Unterman TG, Cohen P.
Biochem J. 2001 May 1;355(Pt 3):597-607.
PMID 11311120
 
Analysis of the transforming and growth suppressive activities of the PAX3-FKHR oncoprotein.
Xia SJ, Barr FG.
Oncogene. 2004 Sep 9;23(41):6864-71.
PMID 15286710
 
Regulation of the forkhead transcription factor FKHR, but not the PAX3-FKHR fusion protein, by the serine/threonine kinase Akt.
del Peso L, Gonzalez VM, Hernandez R, Barr FG, Nunez G.
Oncogene. 1999 Dec 2;18(51):7328-33.
PMID 10602488
 
FOXO4 transcriptional activity is regulated by monoubiquitination and USP7/HAUSP.
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PMID 16964248
 

Citation

This paper should be referenced as such :
O'Connor, R ; Barr, FG
FOXO1 (Forkhead box O1)
Atlas Genet Cytogenet Oncol Haematol. 2009;13(4):268-272.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Genes/FOXO1ID83ch13q14.html


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(X;11)(q13;q23) KMT2A/FOXO4


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 6 ]
  Soft Tissues: Alveolar rhabdomyosarcoma
Soft Tissues: Rhabdomyosarcoma
Soft tissue tumors: an overview
Soft Tissues: Rhabdomyosarcomas with t(11;22)(q24;q12) EWSR1/FLI1
Soft Tissues: Alveolar rhabdomyosarcoma with t(1;13)(p36;q14) PAX7/FOXO1
Soft Tissues: Alveolar rhabdomyosarcoma with t(2;13)(q35;q14) PAX3/FOXO1


External links

Nomenclature
HGNC (Hugo)FOXO1   3819
Cards
AtlasFOXO1ID83ch13q14
Entrez_Gene (NCBI)FOXO1  2308  forkhead box O1
AliasesFKH1; FKHR; FOXO1A
GeneCards (Weizmann)FOXO1
Ensembl hg19 (Hinxton)ENSG00000150907 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000150907 [Gene_View]  chr13:40555664-40666597 [Contig_View]  FOXO1 [Vega]
ICGC DataPortalENSG00000150907
TCGA cBioPortalFOXO1
AceView (NCBI)FOXO1
Genatlas (Paris)FOXO1
WikiGenes2308
SOURCE (Princeton)FOXO1
Genetics Home Reference (NIH)FOXO1
Genomic and cartography
GoldenPath hg38 (UCSC)FOXO1  -     chr13:40555664-40666597 -  13q14.11   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FOXO1  -     13q14.11   [Description]    (hg19-Feb_2009)
EnsemblFOXO1 - 13q14.11 [CytoView hg19]  FOXO1 - 13q14.11 [CytoView hg38]
Mapping of homologs : NCBIFOXO1 [Mapview hg19]  FOXO1 [Mapview hg38]
OMIM136533   268220   
Gene and transcription
Genbank (Entrez)AF032885 AK310511 BC021981 BC070065 BT007455
RefSeq transcript (Entrez)NM_002015
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FOXO1
Cluster EST : UnigeneHs.370666 [ NCBI ]
CGAP (NCI)Hs.370666
Alternative Splicing GalleryENSG00000150907
Gene ExpressionFOXO1 [ NCBI-GEO ]   FOXO1 [ EBI - ARRAY_EXPRESS ]   FOXO1 [ SEEK ]   FOXO1 [ MEM ]
Gene Expression Viewer (FireBrowse)FOXO1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2308
GTEX Portal (Tissue expression)FOXO1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ12778   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ12778  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ12778
Splice isoforms : SwissVarQ12778
PhosPhoSitePlusQ12778
Domaine pattern : Prosite (Expaxy)FORK_HEAD_2 (PS00658)    FORK_HEAD_3 (PS50039)   
Domains : Interpro (EBI)Fork_head_dom    FOXO-TAD    FOXO_KIX-bd    TF_fork_head_CS_2    WHTH_DNA-bd_dom   
Domain families : Pfam (Sanger)Forkhead (PF00250)    FOXO-TAD (PF16676)    FOXO_KIX_bdg (PF16675)   
Domain families : Pfam (NCBI)pfam00250    pfam16676    pfam16675   
Domain families : Smart (EMBL)FH (SM00339)  
Conserved Domain (NCBI)FOXO1
DMDM Disease mutations2308
Blocks (Seattle)FOXO1
PDB (SRS)3CO6    3CO7    3COA    4LG0    5DUI   
PDB (PDBSum)3CO6    3CO7    3COA    4LG0    5DUI   
PDB (IMB)3CO6    3CO7    3COA    4LG0    5DUI   
PDB (RSDB)3CO6    3CO7    3COA    4LG0    5DUI   
Structural Biology KnowledgeBase3CO6    3CO7    3COA    4LG0    5DUI   
SCOP (Structural Classification of Proteins)3CO6    3CO7    3COA    4LG0    5DUI   
CATH (Classification of proteins structures)3CO6    3CO7    3COA    4LG0    5DUI   
SuperfamilyQ12778
Human Protein AtlasENSG00000150907
Peptide AtlasQ12778
HPRD00645
IPIIPI00289866   
Protein Interaction databases
DIP (DOE-UCLA)Q12778
IntAct (EBI)Q12778
FunCoupENSG00000150907
BioGRIDFOXO1
STRING (EMBL)FOXO1
ZODIACFOXO1
Ontologies - Pathways
QuickGOQ12778
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II transcription factor activity, sequence-specific DNA binding  transcription factor activity, transcription factor binding  transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding  transcription coactivator binding  blood vessel development  temperature homeostasis  cellular glucose homeostasis  chromatin binding  protein binding  nucleus  nucleoplasm  cytoplasm  mitochondrion  cytosol  cytosol  transcription, DNA-templated  protein acetylation  autophagy  apoptotic process  cellular response to DNA damage stimulus  beta-catenin binding  insulin receptor signaling pathway  cellular response to starvation  cellular response to starvation  positive regulation of autophagy  endocrine pancreas development  ubiquitin protein ligase binding  cellular response to insulin stimulus  negative regulation of stress-activated MAPK cascade  cellular response to oxidative stress  regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter  positive regulation of apoptotic process  negative regulation of apoptotic process  sequence-specific DNA binding  fat cell differentiation  negative regulation of fat cell differentiation  positive regulation of gluconeogenesis  positive regulation of protein catabolic process  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  protein phosphatase 2A binding  enamel mineralization  cellular response to hydrogen peroxide  cellular response to cold  cellular response to hyperoxia  cellular response to dexamethasone stimulus  cellular response to nitric oxide  negative regulation of canonical Wnt signaling pathway  neuronal stem cell population maintenance  response to fluoride  regulation of neural precursor cell proliferation  regulation of reactive oxygen species metabolic process  regulation of energy homeostasis  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II transcription factor activity, sequence-specific DNA binding  transcription factor activity, transcription factor binding  transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding  transcription coactivator binding  blood vessel development  temperature homeostasis  cellular glucose homeostasis  chromatin binding  protein binding  nucleus  nucleoplasm  cytoplasm  mitochondrion  cytosol  cytosol  transcription, DNA-templated  protein acetylation  autophagy  apoptotic process  cellular response to DNA damage stimulus  beta-catenin binding  insulin receptor signaling pathway  cellular response to starvation  cellular response to starvation  positive regulation of autophagy  endocrine pancreas development  ubiquitin protein ligase binding  cellular response to insulin stimulus  negative regulation of stress-activated MAPK cascade  cellular response to oxidative stress  regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter  positive regulation of apoptotic process  negative regulation of apoptotic process  sequence-specific DNA binding  fat cell differentiation  negative regulation of fat cell differentiation  positive regulation of gluconeogenesis  positive regulation of protein catabolic process  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  protein phosphatase 2A binding  enamel mineralization  cellular response to hydrogen peroxide  cellular response to cold  cellular response to hyperoxia  cellular response to dexamethasone stimulus  cellular response to nitric oxide  negative regulation of canonical Wnt signaling pathway  neuronal stem cell population maintenance  response to fluoride  regulation of neural precursor cell proliferation  regulation of reactive oxygen species metabolic process  regulation of energy homeostasis  
Pathways : BIOCARTAAKT Signaling Pathway [Genes]   
Pathways : KEGGFoxO signaling pathway    Insulin signaling pathway    Thyroid hormone signaling pathway    Pathways in cancer    Transcriptional misregulation in cancer    Prostate cancer   
REACTOMEQ12778 [protein]
REACTOME PathwaysR-HSA-6785807 [pathway]   
NDEx NetworkFOXO1
Atlas of Cancer Signalling NetworkFOXO1
Wikipedia pathwaysFOXO1
Orthology - Evolution
OrthoDB2308
GeneTree (enSembl)ENSG00000150907
Phylogenetic Trees/Animal Genes : TreeFamFOXO1
HOVERGENQ12778
HOGENOMQ12778
Homologs : HomoloGeneFOXO1
Homology/Alignments : Family Browser (UCSC)FOXO1
Gene fusions - Rearrangements
Fusion : MitelmanFOXO1/ELF1 [13q14.11/13q14.11]  
Fusion : MitelmanPAX3/FOXO1 [2q36.1/13q14.11]  [t(1;13)(p36;q14)]  [t(2;13)(q36;q14)]  
Fusion : MitelmanPAX7/FOXO1 [1p36.13/13q14.11]  [t(1;13)(p36;q14)]  [t(2;13)(q36;q14)]  
Fusion : COSMICFOXO1 [13q14.11]  -  PAX3 [2q36.1]  [fusion_387]  [fusion_906]  
Fusion : COSMICPAX3 [2q36.1]  -  FOXO1 [13q14.11]  [fusion_247]  [fusion_248]  [fusion_343]  
Fusion : COSMICPAX7 [1p36.13]  -  FOXO1 [13q14.11]  [fusion_287]  [fusion_288]  [fusion_344]  
Fusion: TCGAFOXO1 13q14.11 ELF1 13q14.11 LUSC
Fusion : TICdbFOXO1 [13q14.11]  -  PAX3 [2q36.1]
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFOXO1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FOXO1
dbVarFOXO1
ClinVarFOXO1
1000_GenomesFOXO1 
Exome Variant ServerFOXO1
ExAC (Exome Aggregation Consortium)FOXO1 (select the gene name)
Genetic variants : HAPMAP2308
Genomic Variants (DGV)FOXO1 [DGVbeta]
DECIPHERFOXO1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFOXO1 
Mutations
ICGC Data PortalFOXO1 
TCGA Data PortalFOXO1 
Broad Tumor PortalFOXO1
OASIS PortalFOXO1 [ Somatic mutations - Copy number]
Cancer Gene: CensusFOXO1 
Somatic Mutations in Cancer : COSMICFOXO1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFOXO1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FOXO1
DgiDB (Drug Gene Interaction Database)FOXO1
DoCM (Curated mutations)FOXO1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FOXO1 (select a term)
intoGenFOXO1
NCG5 (London)FOXO1
Cancer3DFOXO1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM136533    268220   
Orphanet14329   
MedgenFOXO1
Genetic Testing Registry FOXO1
NextProtQ12778 [Medical]
TSGene2308
GENETestsFOXO1
Target ValidationFOXO1
Huge Navigator FOXO1 [HugePedia]
snp3D : Map Gene to Disease2308
BioCentury BCIQFOXO1
ClinGenFOXO1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2308
Chemical/Pharm GKB GenePA28237
Clinical trialFOXO1
Miscellaneous
canSAR (ICR)FOXO1 (select the gene name)
Probes
Litterature
PubMed435 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFOXO1
EVEXFOXO1
GoPubMedFOXO1
iHOPFOXO1
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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