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Entity | Bladder cancer |
Oncogenesis | FOXQ1 was overexpressed in bladder cancer samples. Depletion of FOXQ1 expression in bladder cancer cell lines reduced invasiveness and EMT markers (Zhu et al., 2013). |
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Entity | Breast cancer |
Prognosis | FOXQ1 expression in breast cancer patients is associated with poor survival, high grade, metastatic status and basal-like phenotype (Qiao et al., 2011). |
Oncogenesis | FOXQ1 overexpression was observed in invasive breast cancer cell lines compared to non-invasive. FOXQ1 expression increases breast cancer cell proliferation, migration and invasion in vitro and metastasis in vivo (Zhang et al., 2011). FOXQ1 promotes an EMT phenotype through transcriptional regulation of CDH1 (Qiao et al., 2011; Zhang et al., 2011). |
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Entity | Colorectal cancer |
Oncogenesis | Several studies have shown FOXQ1 to be overexpressed in colorectal tumor samples compared to healthy colonocytes (Bieller et al., 2001; Sabates-Bellver et al., 2007; Kaneda et al., 2010; Christensen et al., 2013). The increased expression of FOXQ1 could be due to a hyperactive Wnt pathway in these tumors. Wnt activity directly correlates with FOXQ1 expression in colorectal cancer cell lines and β-catenin can bind to the promoter of FOXQ1 and increase transcription (Christensen et al., 2013). FOXQ1 expression can induce an EMT phenotype (Qiao et al., 2011; Abba et al., 2013). FOXQ1 does not increase growth but seems to protect from apoptosis (Kaneda et al., 2010; Qiao et al., 2011; Abba et al., 2013). The anti-apoptotic effect was mediated through FOXQ1 regulation of p21 (Kaneda et al., 2010). |
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Entity | Gastric cancer |
Prognosis | The expression of FOXQ1 was a prognostic factor for overall survival and correlated with tumor size, grade and tumor-node metastasis stage (Liang et al., 2013). |
Oncogenesis | FOXQ1 increases migration and proliferation by downregulating NRXN3. |
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Entity | Glioma |
Disease | Tumors that arise from the glial cells, the most common site is the brain. |
Oncogenesis | FOXQ1 increased migration and proliferation by downregulating NRXN3 (Sun et al., 2013). |
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Entity | Hepatocarcinoma |
Cytogenetics | FOXQ1 correlated with overall worse survival and higher recurrence (Wang et al., 2013; Xia et al., 2014). |
Oncogenesis | In hepatocarcinoma FOXQ1 directly activated the EMT transcription factor ZEB2. This led to an EMT phenotype and increased lung metastasis. FOXQ1 and ZEB2 expression correlated positively in hepatocarcinoma samples but inversely with CDH1. FOXQ1 induced metastasis through regulation of VersicanV1, which promoted tumor-associated-macrophages attraction. Also, similarly to colorectal cancer expression of FOXQ1 was regulated by the Wnt pathway in hepatocarcinoma (Xia et al., 2014). |
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Entity | Non-small-cell lung carcinoma |
Prognosis | FOXQ1 expression was associated with poor prognosis and EMT (Feng et al., 2012). |
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Entity | Ovarian cancer |
Oncogenesis | FOXQ1 expression increased ovarian cancer cell proliferation, invasion and induced an EMT phenotype (Gao et al., 2012). |
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Unraveling the role of FOXQ1 in colorectal cancer metastasis. |
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PMID 22761930 |
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PMID 23203039 |
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Impairment of gastric acid secretion and increase of embryonic lethality in Foxq1-deficient mice. |
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The winged helix/forkhead transcription factor Foxq1 regulates differentiation of hair in satin mice. |
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PMID 11309849 |
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FOXQ1 is overexpressed in colorectal cancer and enhances tumorigenicity and tumor growth. |
Kaneda H, Arao T, Tanaka K, Tamura D, Aomatsu K, Kudo K, Sakai K, De Velasco MA, Matsumoto K, Fujita Y, Yamada Y, Tsurutani J, Okamoto I, Nakagawa K, Nishio K. |
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PMID 20145154 |
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Increased expression of FOXQ1 is a prognostic marker for patients with gastric cancer. |
Liang SH, Yan XZ, Wang BL, Jin HF, Yao LP, Li YN, Chen M, Nie YZ, Wang X, Guo XG, Wu KC, Ding J, Fan DM. |
Tumour Biol. 2013 Oct;34(5):2605-9. doi: 10.1007/s13277-013-0808-x. Epub 2013 Apr 23. |
PMID 23609035 |
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Differences in gene expression between wild type and Hoxa1 knockout embryonic stem cells after retinoic acid treatment or leukemia inhibitory factor (LIF) removal. |
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J Biol Chem. 2005 Apr 22;280(16):16484-98. Epub 2005 Feb 18. |
PMID 15722554 |
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Evidence that the satin hair mutant gene Foxq1 is among multiple and functionally diverse regulatory targets for Hoxc13 during hair follicle differentiation. |
Potter CS, Peterson RL, Barth JL, Pruett ND, Jacobs DF, Kern MJ, Argraves WS, Sundberg JP, Awgulewitsch A. |
J Biol Chem. 2006 Sep 29;281(39):29245-55. Epub 2006 Jul 10. |
PMID 16835220 |
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FOXQ1 regulates epithelial-mesenchymal transition in human cancers. |
Qiao Y, Jiang X, Lee ST, Karuturi RK, Hooi SC, Yu Q. |
Cancer Res. 2011 Apr 15;71(8):3076-86. doi: 10.1158/0008-5472.CAN-10-2787. Epub 2011 Feb 23. |
PMID 21346143 |
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Transcriptome profile of human colorectal adenomas. |
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Mol Cancer Res. 2007 Dec;5(12):1263-75. doi: 10.1158/1541-7786.MCR-07-0267. |
PMID 18171984 |
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FoxQ1 promotes glioma cells proliferation and migration by regulating NRXN3 expression. |
Sun HT, Cheng SX, Tu Y, Li XH, Zhang S. |
PLoS One. 2013;8(1):e55693. doi: 10.1371/journal.pone.0055693. Epub 2013 Jan 30. |
PMID 23383267 |
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Transcription factor foxq1 controls mucin gene expression and granule content in mouse stomach surface mucous cells. |
Verzi MP, Khan AH, Ito S, Shivdasani RA. |
Gastroenterology. 2008 Aug;135(2):591-600. doi: 10.1053/j.gastro.2008.04.019. Epub 2008 Apr 22. |
PMID 18558092 |
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The prognostic significance of FOXQ1 oncogene overexpression in human hepatocellular carcinoma. |
Wang W, He S, Ji J, Huang J, Zhang S, Zhang Y. |
Pathol Res Pract. 2013 Jun;209(6):353-8. doi: 10.1016/j.prp.2013.03.005. Epub 2013 Mar 25. |
PMID 23623360 |
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R164C mutation in FOXQ1 H3 domain affects formation of the hair medulla. |
Wu B, Herbert Pratt C, Potter CS, Silva KA, Kennedy V, Sundberg JP. |
Exp Dermatol. 2013 Mar;22(3):234-6. doi: 10.1111/exd.12106. |
PMID 23489430 |
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Forkhead box Q1 promotes hepatocellular carcinoma metastasis by transactivating ZEB2 and VersicanV1 expression. |
Xia L, Huang W, Tian D, Zhang L, Qi X, Chen Z, Shang X, Nie Y, Wu K. |
Hepatology. 2014 Mar;59(3):958-73. doi: 10.1002/hep.26735. Epub 2014 Feb 6. |
PMID 24005989 |
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Forkhead transcription factor foxq1 promotes epithelial-mesenchymal transition and breast cancer metastasis. |
Zhang H, Meng F, Liu G, Zhang B, Zhu J, Wu F, Ethier SP, Miller F, Wu G. |
Cancer Res. 2011 Feb 15;71(4):1292-301. doi: 10.1158/0008-5472.CAN-10-2825. Epub 2011 Feb 1. |
PMID 21285253 |
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Short hairpin RNA targeting FOXQ1 inhibits invasion and metastasis via the reversal of epithelial-mesenchymal transition in bladder cancer. |
Zhu Z, Zhu Z, Pang Z, Xing Y, Wan F, Lan D, Wang H. |
Int J Oncol. 2013 Apr;42(4):1271-8. doi: 10.3892/ijo.2013.1807. Epub 2013 Feb 5. |
PMID 23403865 |
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