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FSCN1 (fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus))

Written2008-11Shoichi Nagai, Christian A Smith, Soma Mondal, James T Rutka
The Arthur, Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada

(Note : for Links provided by Atlas : click)

Identity

Alias_namesSNL
singed (Drosophila)-like (sea urchin fascin homolog like)
fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)
Alias_symbol (synonym)p55
FLJ38511
Other aliasHSN
FAN1
FASCIN1
HGNC (Hugo) FSCN1
LocusID (NCBI) 6624
Atlas_Id 44342
Location 7p22.1  [Link to chromosome band 7p22]
Location_base_pair Starts at 5632436 and ends at 5646287 bp from pter ( according to hg19-Feb_2009)  [Mapping FSCN1.png]
Fusion genes
(updated 2016)
CDC42EP3 (2p22.2) / FSCN1 (7p22.1)FSCN1 (7p22.1) / CALM1 (14q32.11)FSCN1 (7p22.1) / FAR1 (11p15.2)
SIK1 (21q22.3) / FSCN1 (7p22.1)

DNA/RNA

 
Description The gene encompasses 13,833 bp of DNA.
Transcription The length of the transcript is 2,819 bp containing 1,482 bp open reading frame.

Protein

Description FSCN1 encodes a 493-amino acid protein fascin with a molecular mass of 55 kD. Fascin was first isolated from sea urchin egg extracts, and then identified in Drosophila and in B-lymphocytes.
Expression Fascin is widely expressed including the brain, blood, colon, lung, breast, ovary, and testis. In the brain, fascin expression has been localized to neurons, glial cells, and endothelial cells.
Localisation Fascin colocalizes with filopodia, membrane ruffles, lamellopodia, microspikes, focal adhesions, cytoplasm and actin stress fibers. Additionally, fascin has been shown to localize to lamellipodia and filopodia in growth cones of cultured neurons.
Function Fascin is an actin-bundling protein that provides rigidity to filopodial bundles to efficiently push the membrane forward during cytoskeleton remodeling and cell migration.

Mutations

Germinal unknown
Somatic unknown

Implicated in

Note
  
Entity Glioma
Disease Fascin expression increases with increasing histological grade of glioma and is associated with adhesion, migration, and invasion of glioma cells.
  
  
Entity Cancer
Disease High-level expression of fascin has been observed in several types of human neoplasms, such as cancer of colon, breast, lung, kidney, ovary, cervix, and esophagus. It correlates with lymph node or distant metastasis in cancers of colon, kidney, and esophagus, and plays a role as an independent marker of poor prognosis. It is also associated with increased cellular proliferation in non-small cell lung adenocarcinoma, colon carcinoma, and esophageal squamous cell carcinoma. In colon adenocarcinoma and esophageal carcinoma cells, fascin is associated with cellular motility and invasive properties.
  

Bibliography

Expression of fascin in oral and oropharyngeal squamous cell carcinomas has prognostic significance - a tissue microarray study of 129 cases.
Chen SF, Yang SF, Li JW, Nieh PC, Lin SY, Fu E, Bai CY, Jin JS, Lin CY, Nieh S.
Histopathology. 2007 Oct;51(4):581.
PMID 17650213
 
C-erbB-2/HER-2 upregulates fascin, an actin-bundling protein associated with cell motility, in human breast cancer cell lines.
Grothey A, Hashizume R, Ji H, Tubb BE, Patrick CW Jr, Yu D, Mooney EE, McCrea PD.
Oncogene. 2000 Oct 5;19(42):4864-75.
PMID 11039904
 
Prognostic significance of fascin expression in advanced colorectal cancer: an immunohistochemical study of colorectal adenomas and adenocarcinomas.
Hashimoto Y, Skacel M, Lavery IC, Mukherjee AL, Casey G, Adams JC.
BMC Cancer. 2006 Oct 9;6:241.
PMID 17029629
 
The role of fascin in the migration and invasiveness of malignant glioma cells.
Hwang JH, Smith CA, Salhia B, Rutka JT.
Neoplasia. 2008 Feb;10(2):149-59.
PMID 18283337
 
Fascin, an actin-bundling protein, modulates colonic epithelial cell invasiveness and differentiation in vitro.
Jawhari AU, Buda A, Jenkins M, Shehzad K, Sarraf C, Noda M, Farthing MJ, Pignatelli M, Adams JC.
Am J Pathol. 2003 Jan;162(1):69-80.
PMID 12507891
 
Actin bundling protein fascin expression in ovarian neoplasms: comparison of histopathologic features of tumors obtained by the first and secondary cytoreduction surgeries.
Kabukcuoglu S, Ozalp SS, Oner U, Bildirici K, Yalcin OT, Oge T, Colak E.
Eur J Gynaecol Oncol. 2006;27(2):123-8.
PMID 16620052
 
Independent prognostic value of fascin immunoreactivity in stage I nonsmall cell lung cancer.
Pelosi G, Pastorino U, Pasini F, Maissoneuve P, Fraggetta F, Iannucci A, Sonzogni A, De Manzoni G, Terzi A, Durante E, Bresaola E, Pezzella F, Viale G.
Br J Cancer. 2003 Feb 24;88(4):537-47.
PMID 12592367
 
Expression of fascin, an actin-bundling protein, in astrocytomas of varying grades.
Peraud A, Mondal S, Hawkins C, Mastronardi M, Bailey K, Rutka JT.
Brain Tumor Pathol. 2003;20(2):53-8.
PMID 14756441
 
Independent prognostic value of fascin immunoreactivity in stage III-IV colonic adenocarcinoma.
Puppa G, Maisonneuve P, Sonzogni A, Masullo M, Chiappa A, Valerio M, Zampino MG, Franceschetti I, Capelli P, Chilosi M, Menestrina F, Viale G, Pelosi G.
Br J Cancer. 2007 Apr 10;96(7):1118-26. Epub 2007 Mar 20.
PMID 17375048
 
Fascin expression in 90 patients with glioblastoma multiforme.
Roma AA, Prayson RA.
Ann Diagn Pathol. 2005 Dec;9(6):307-11.
PMID 16308158
 
Role of fascin in the proliferation and invasiveness of esophageal carcinoma cells.
Xie JJ, Xu LY, Zhang HH, Cai WJ, Mai RQ, Xie YM, Yang ZM, Niu YD, Shen ZY, Li EM.
Biochem Biophys Res Commun. 2005 Nov 11;337(1):355-62.
PMID 16185662
 
Fascin is a potential biomarker for early-stage oesophageal squamous cell carcinoma.
Zhang H, Xu L, Xiao D, Xie J, Zeng H, Cai W, Niu Y, Yang Z, Shen Z, Li E.
J Clin Pathol. 2006 Sep;59(9):958-64. Epub 2006 Mar 8.
PMID 16524962
 
Biologic significance of fascin expression in clear cell renal cell carcinoma: systematic analysis of primary and metastatic tumor tissues using a tissue microarray technique.
Zigeuner R, Droschl N, Tauber V, Rehak P, Langner C.
Urology. 2006 Sep;68(3):518-22. Epub 2006 Sep 18.
PMID 16979727
 

Citation

This paper should be referenced as such :
Nagai, S ; Smith, CA ; Mondal, S ; Rutka, JT
FSCN1 (fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus))
Atlas Genet Cytogenet Oncol Haematol. 2009;13(10):724-725.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Genes/FSCN1ID44342ch7p22.html


External links

Nomenclature
HGNC (Hugo)FSCN1   11148
Cards
AtlasFSCN1ID44342ch7p22
Entrez_Gene (NCBI)FSCN1  6624  fascin actin-bundling protein 1
AliasesFAN1; HSN; SNL; p55
GeneCards (Weizmann)FSCN1
Ensembl hg19 (Hinxton)ENSG00000075618 [Gene_View]  chr7:5632436-5646287 [Contig_View]  FSCN1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000075618 [Gene_View]  chr7:5632436-5646287 [Contig_View]  FSCN1 [Vega]
ICGC DataPortalENSG00000075618
TCGA cBioPortalFSCN1
AceView (NCBI)FSCN1
Genatlas (Paris)FSCN1
WikiGenes6624
SOURCE (Princeton)FSCN1
Genetics Home Reference (NIH)FSCN1
Genomic and cartography
GoldenPath hg19 (UCSC)FSCN1  -     chr7:5632436-5646287 +  7p22   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)FSCN1  -     7p22   [Description]    (hg38-Dec_2013)
EnsemblFSCN1 - 7p22 [CytoView hg19]  FSCN1 - 7p22 [CytoView hg38]
Mapping of homologs : NCBIFSCN1 [Mapview hg19]  FSCN1 [Mapview hg38]
OMIM602689   
Gene and transcription
Genbank (Entrez)AK095254 AK095830 AK125295 AK316607 BC000521
RefSeq transcript (Entrez)NM_003088
RefSeq genomic (Entrez)NC_000007 NC_018918 NG_030004 NT_007819 NW_004929329
Consensus coding sequences : CCDS (NCBI)FSCN1
Cluster EST : UnigeneHs.118400 [ NCBI ]
CGAP (NCI)Hs.118400
Alternative Splicing GalleryENSG00000075618
Gene ExpressionFSCN1 [ NCBI-GEO ]   FSCN1 [ EBI - ARRAY_EXPRESS ]   FSCN1 [ SEEK ]   FSCN1 [ MEM ]
Gene Expression Viewer (FireBrowse)FSCN1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6624
GTEX Portal (Tissue expression)FSCN1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ16658   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ16658  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ16658
Splice isoforms : SwissVarQ16658
PhosPhoSitePlusQ16658
Domains : Interpro (EBI)Actin_cross-linking    Fascin    Fascin-domain    Fascin_metazoans    FSCN1   
Domain families : Pfam (Sanger)Fascin (PF06268)   
Domain families : Pfam (NCBI)pfam06268   
Conserved Domain (NCBI)FSCN1
DMDM Disease mutations6624
Blocks (Seattle)FSCN1
PDB (SRS)1DFC    3LLP    3O8K    3P53    4GOV    4GOY    4GP0    4GP3   
PDB (PDBSum)1DFC    3LLP    3O8K    3P53    4GOV    4GOY    4GP0    4GP3   
PDB (IMB)1DFC    3LLP    3O8K    3P53    4GOV    4GOY    4GP0    4GP3   
PDB (RSDB)1DFC    3LLP    3O8K    3P53    4GOV    4GOY    4GP0    4GP3   
Structural Biology KnowledgeBase1DFC    3LLP    3O8K    3P53    4GOV    4GOY    4GP0    4GP3   
SCOP (Structural Classification of Proteins)1DFC    3LLP    3O8K    3P53    4GOV    4GOY    4GP0    4GP3   
CATH (Classification of proteins structures)1DFC    3LLP    3O8K    3P53    4GOV    4GOY    4GP0    4GP3   
SuperfamilyQ16658
Human Protein AtlasENSG00000075618
Peptide AtlasQ16658
HPRD04068
IPIIPI00163187   IPI00894286   IPI00747810   IPI00744143   IPI00894471   IPI00893542   
Protein Interaction databases
DIP (DOE-UCLA)Q16658
IntAct (EBI)Q16658
FunCoupENSG00000075618
BioGRIDFSCN1
STRING (EMBL)FSCN1
ZODIACFSCN1
Ontologies - Pathways
QuickGOQ16658
Ontology : AmiGOstress fiber  ruffle  podosome  actin binding  protein binding  cytoplasm  cytosol  cytoskeleton  microvillus  cell-cell junction  cell-cell junction assembly  drug binding  cell proliferation  positive regulation of lamellipodium assembly  actin cytoskeleton  cell migration  lamellipodium  microspike assembly  microspike assembly  actin cytoskeleton organization  filopodium  growth cone  protein binding, bridging  cell projection membrane  regulation of microvillus assembly  regulation of actin cytoskeleton organization  establishment of apical/basal cell polarity  myelin sheath  microspike  poly(A) RNA binding  cell motility  actin filament binding  actin filament bundle assembly  positive regulation of filopodium assembly  positive regulation of filopodium assembly  extracellular exosome  invadopodium  positive regulation of podosome assembly  positive regulation of extracellular matrix disassembly  
Ontology : EGO-EBIstress fiber  ruffle  podosome  actin binding  protein binding  cytoplasm  cytosol  cytoskeleton  microvillus  cell-cell junction  cell-cell junction assembly  drug binding  cell proliferation  positive regulation of lamellipodium assembly  actin cytoskeleton  cell migration  lamellipodium  microspike assembly  microspike assembly  actin cytoskeleton organization  filopodium  growth cone  protein binding, bridging  cell projection membrane  regulation of microvillus assembly  regulation of actin cytoskeleton organization  establishment of apical/basal cell polarity  myelin sheath  microspike  poly(A) RNA binding  cell motility  actin filament binding  actin filament bundle assembly  positive regulation of filopodium assembly  positive regulation of filopodium assembly  extracellular exosome  invadopodium  positive regulation of podosome assembly  positive regulation of extracellular matrix disassembly  
Pathways : KEGGMicroRNAs in cancer   
REACTOMEQ16658 [protein]
REACTOME Pathways6785807 [pathway]   
NDEx NetworkFSCN1
Atlas of Cancer Signalling NetworkFSCN1
Wikipedia pathwaysFSCN1
Orthology - Evolution
OrthoDB6624
GeneTree (enSembl)ENSG00000075618
Phylogenetic Trees/Animal Genes : TreeFamFSCN1
HOVERGENQ16658
HOGENOMQ16658
Homologs : HomoloGeneFSCN1
Homology/Alignments : Family Browser (UCSC)FSCN1
Gene fusions - Rearrangements
Fusion : MitelmanFSCN1/FAR1 [7p22.1/11p15.2]  
Fusion: TCGAFSCN1 7p22.1 FAR1 11p15.2 HNSC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFSCN1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FSCN1
dbVarFSCN1
ClinVarFSCN1
1000_GenomesFSCN1 
Exome Variant ServerFSCN1
ExAC (Exome Aggregation Consortium)FSCN1 (select the gene name)
Genetic variants : HAPMAP6624
Genomic Variants (DGV)FSCN1 [DGVbeta]
DECIPHER (Syndromes)7:5632436-5646287  ENSG00000075618
CONAN: Copy Number AnalysisFSCN1 
Mutations
ICGC Data PortalFSCN1 
TCGA Data PortalFSCN1 
Broad Tumor PortalFSCN1
OASIS PortalFSCN1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFSCN1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFSCN1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FSCN1
DgiDB (Drug Gene Interaction Database)FSCN1
DoCM (Curated mutations)FSCN1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FSCN1 (select a term)
intoGenFSCN1
NCG5 (London)FSCN1
Cancer3DFSCN1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602689   
Orphanet
MedgenFSCN1
Genetic Testing Registry FSCN1
NextProtQ16658 [Medical]
TSGene6624
GENETestsFSCN1
Huge Navigator FSCN1 [HugePedia]
snp3D : Map Gene to Disease6624
BioCentury BCIQFSCN1
ClinGenFSCN1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6624
Chemical/Pharm GKB GenePA128394534
Clinical trialFSCN1
Miscellaneous
canSAR (ICR)FSCN1 (select the gene name)
Probes
Litterature
PubMed152 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFSCN1
EVEXFSCN1
GoPubMedFSCN1
iHOPFSCN1
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:41:09 CET 2017

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