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FURIN (furin (paired basic amino acid cleaving enzyme))

Written2012-04Abdel-Majid Khatib, Fatma Sfaxi
University Bordeaux 1, INSERM U1029, Avenue des Facultes, Batiment B2, Talence 33405, France

(Note : for Links provided by Atlas : click)

Identity

Alias_namesPCSK3
FUR
PACE
paired basic amino acid cleaving enzyme (furin, membrane associated receptor protein)
furin (paired basic amino acid cleaving enzyme)
Alias_symbol (synonym)SPC1
Other alias
HGNC (Hugo) FURIN
LocusID (NCBI) 5045
Atlas_Id 40646
Location 15q26.1  [Link to chromosome band 15q26]
Location_base_pair Starts at 90871539 and ends at 90883458 bp from pter ( according to hg19-Feb_2009)  [Mapping FURIN.png]
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
C3 (19p13.3) / FURIN (15q26.1)COX6C (8q22.2) / FURIN (15q26.1)FLOT2 (17q11.2) / FURIN (15q26.1)
FURIN (15q26.1) / ANKRD11 (16q24.3)FURIN (15q26.1) / COTL1 (16q24.1)FURIN (15q26.1) / FLOT2 (17q11.2)
FURIN (15q26.1) / FURIN (15q26.1)FURIN (15q26.1) / PCNX3 (11q13.1)FURIN (15q26.1) / TNFSF12-TNFSF13 (17p13.1)
SLCO2B1 (11q13.4) / FURIN (15q26.1)

DNA/RNA

 
Description This gene can be found on chromosome 15 at location: 89212826-89227692.
Transcription The DNA sequence contains 16 exons and the transcript length: 4244 bps translated to a 794 residues protein.

Protein

 
Description Furin is a member of the family of subtilisin/kexin-like proprotein convertases (PCs) that process protein at basic residues. This protein is produced as a 104 kDa zymogen that is converted into a 98 kDa mature following autocatalytic cleavage at two sites. The cleavages occur during enzyme progression from the endoplasmic reticulum to the trans golgi network (TGN).
Expression Expression of Furin in different tissues was localized by northern blot, in situ hybridization and histochemistry. These analyses demonstrated that Furin is ubiquitously expressed. However, high expression of Furin was found in liver and spleen.
Localisation Furin cycle between the cell surface and the TGN.
Function Furin is involved in the activation of precursor proteins by cleavage on a single or paired basic residue. Precursors are usually cleaved at the general motif (K/R)-(X)n-(K/R)↓, where n= 0, 2, 4 or 6. Furin substrates include growth factors and their receptors (such as pro-TGFb, pro-IGF-1, 2, pro-PDGF-A, B, insulin-R, IGF1-R, R-PTPm, Notch), neurotrophins (pro-NGF, -BDNF,- NT3), prohormones (pro-PTH, pro-endothelin, proparathyroid hormone), blood coagulation factors (pro-Von Willebrand Factor, pro-Factor VII, pro-Factor IX, pro-Factor X), integrins (α3, α6, αv, α5 and α4 chains) and various metalloendopeptidases (stromelysin-3, ADAM, ADAMTS, MT1-MMP). The activation of these substrates by Furin, implicated directly the latter to cell proliferation, survival, migration, invasion and homeostasis.
Homology The Furin catalytic domain has a high percentage of homology with those of the other PCs which range from 70% (between PACE4 and Furin) to 54% (between PC2 and Furin).

Implicated in

Note
  
Entity Cancer
Note To date Furin is expressed in all tissues and cell lines examined so far but at very low levels as compared to tumor cells and tissues. Inhibition of Furin activity or expression in tumor cells reduced dramatically their malignant phenotype (proliferation, invasion, migration...) and their ability to induce tumor growth.
  
  
Entity Head and neck squamous cell carcinomas (HNSCCs)
Note While Furin expression is undetectable in non metastasing head and neck squamous cell carcinomas its overexpressed in more aggressive lines.
  
  
Entity Ovarian epithelial cancer
Note A comparative study of the Furin expression between normal human ovarian surface epithelium and cancer cell lines as well as ovarian epithelial cancer specimens revealed that Furin is only expressed in cancer cell lines especially in primary tumors from patients whose life expectancy don't exceed five years.
  
  
Entity Oral tongue squamous cell carcinoma
Note The Furin expression was found to be correlated with the grade of oral tongue squamous carcinoma. The highest Furin expression was found in the most aggressive line of squamous cell carcinoma (SCC) and the least Furin expression in the less aggressive line.
  
  
Entity Breast cancer
Note Furin was shown to be overexpressed in breast cancer cell lines and breast tumor tissues.
  
  
Entity Viral infections
Note By activating various viral envelope glycoproteins, Furin is involved in numerous viral infections. These include HIV-gp160, RSV-Pr95env, NDV-F, Influenza haemagglutinin-HA, CMV-gB, SFV-p62.
  
  
Entity Bacterial infections
Note The involvement of Furin in bacterial infections was suggested by its capacity to activate the various classes of bacterial toxins such as the Diphteria toxin, Pseudomonas Aerugenosa exotoxin A, Botulinum neurotoxin, Bordetella dermonecrotic toxin, Anthrax and aerolysin.
  
  
Entity Neurodegenerative pathology
Note Furin can activate the α and β-secretase which are implicated in the cleavage of amyloid-β the principal component of senile plaques.
  

Bibliography

Furin-, ADAM 10-, and gamma-secretase-mediated cleavage of a receptor tyrosine phosphatase and regulation of beta-catenin's transcriptional activity.
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PMID 16648485
 
The ordered and compartment-specfific autoproteolytic removal of the furin intramolecular chaperone is required for enzyme activation.
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PMID 11799113
 
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PMID 16102752
 
Furin inhibition results in absent or decreased invasiveness and tumorigenicity of human cancer cells.
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Proc Natl Acad Sci U S A. 2001 Aug 28;98(18):10326-31. Epub 2001 Aug 21.
PMID 11517338
 
Increased furin activity enhances the malignant phenotype of human head and neck cancer cells.
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PMID 12547702
 
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Enhancing the proteolytic maturation of human immunodeficiency virus type 1 envelope glycoproteins.
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Development and characterisation of an assay for furin activity.
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PMID 21112328
 
Furin directly cleaves proMMP-2 in the trans-Golgi network resulting in a nonfunctioning proteinase.
Cao J, Rehemtulla A, Pavlaki M, Kozarekar P, Chiarelli C.
J Biol Chem. 2005 Mar 25;280(12):10974-80. Epub 2005 Jan 6.
PMID 15637056
 
Tumour growth inhibition and anti-metastatic activity of a mutated furin-resistant Semaphorin 3E isoform.
Casazza A, Kigel B, Maione F, Capparuccia L, Kessler O, Giraudo E, Mazzone M, Neufeld G, Tamagnone L.
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PMID 22247010
 
Thyroid hormone promotes cell invasion through activation of furin expression in human hepatoma cell lines.
Chen RN, Huang YH, Lin YC, Yeh CT, Liang Y, Chen SL, Lin KH.
Endocrinology. 2008 Aug;149(8):3817-31. Epub 2008 May 8.
PMID 18467449
 
The role of furin in papillomavirus infection.
Day PM, Schiller JT.
Future Microbiol. 2009 Dec;4(10):1255-62. (REVIEW)
PMID 19995186
 
In vivo bioluminescence imaging of furin activity in breast cancer cells using bioluminogenic substrates.
Dragulescu-Andrasi A, Liang G, Rao J.
Bioconjug Chem. 2009 Aug 19;20(8):1660-6. Epub 2009 Jul 31.
PMID 19642690
 
Processing of transforming growth factor beta 1 precursor by human furin convertase.
Dubois CM, Laprise MH, Blanchette F, Gentry LE, Leduc R.
J Biol Chem. 1995 May 5;270(18):10618-24.
PMID 7737999
 
Interaction of Mint3 with Furin regulates the localization of Furin in the trans-Golgi network.
Han J, Wang Y, Wang S, Chi C.
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PMID 18544638
 
Characterization of Alzheimer's beta -secretase protein BACE. A pepsin family member with unusual properties.
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PMID 10887202
 
Furin is an endogenous regulator of alpha-secretase associated APP processing.
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Biochem Biophys Res Commun. 2006 Oct 20;349(2):654-9. Epub 2006 Aug 22.
PMID 16942750
 
Synthetic small molecule furin inhibitors derived from 2,5-dideoxystreptamine.
Jiao GS, Cregar L, Wang J, Millis SZ, Tang C, O'Malley S, Johnson AT, Sareth S, Larson J, Thomas G.
Proc Natl Acad Sci U S A. 2006 Dec 26;103(52):19707-12. Epub 2006 Dec 18.
PMID 17179036
 
[Furin and its biological role].
Kibirev VK, Osadchuk TV, Radavskii IuL.
Ukr Biokhim Zh. 2007 Nov-Dec;79(6):5-18. (REVIEW)
PMID 18712106
 
Polyarginine inhibits gp160 processing by furin and suppresses productive human immunodeficiency virus type 1 infection.
Kibler KV, Miyazato A, Yedavalli VS, Dayton AI, Jacobs BL, Dapolito G, Kim SJ, Jeang KT.
J Biol Chem. 2004 Nov 19;279(47):49055-63. Epub 2004 Sep 14.
PMID 15371436
 
Identification of a second human subtilisin-like protease gene in the fes/fps region of chromosome 15.
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p38 kinase is crucial for osteopontin-induced furin expression that supports cervical cancer progression.
Kumar V, Behera R, Lohite K, Karnik S, Kundu GC.
Cancer Res. 2010 Dec 15;70(24):10381-91. Epub 2010 Oct 27.
PMID 20980434
 
ADAMTS-1 is an active metalloproteinase associated with the extracellular matrix.
Kuno K, Terashima Y, Matsushima K.
J Biol Chem. 1999 Jun 25;274(26):18821-6.
PMID 10373500
 
The structure of the TGF-beta latency associated peptide region determines the ability of the proprotein convertase furin to cleave TGF-betas.
Kusakabe M, Cheong PL, Nikfar R, McLennan IS, Koishi K.
J Cell Biochem. 2008 Jan 1;103(1):311-20.
PMID 17516499
 
Opposing function of the proprotein convertases furin and PACE4 on breast cancer cells' malignant phenotypes: role of tissue inhibitors of metalloproteinase-1.
Lapierre M, Siegfried G, Scamuffa N, Bontemps Y, Calvo F, Seidah NG, Khatib AM.
Cancer Res. 2007 Oct 1;67(19):9030-4.
PMID 17909005
 
Influence of a single nucleotide polymorphism in the P1 promoter of the furin gene on transcription activity and hepatitis B virus infection.
Lei RX, Shi H, Peng XM, Zhu YH, Cheng J, Chen GH.
Hepatology. 2009 Sep;50(3):763-71.
PMID 19492430
 
Loss-of-function point mutations and two-furin domain derivatives provide insights about R-spondin2 structure and function.
Li SJ, Yen TY, Endo Y, Klauzinska M, Baljinnyam B, Macher B, Callahan R, Rubin JS.
Cell Signal. 2009 Jun;21(6):916-25.
PMID 19385064
 
Endoproteolytic processing of integrin pro-alpha subunits involves the redundant function of furin and proprotein convertase (PC) 5A, but not paired basic amino acid converting enzyme (PACE) 4, PC5B or PC7.
Lissitzky JC, Luis J, Munzer JS, Benjannet S, Parat F, Chretien M, Marvaldi J, Seidah NG.
Biochem J. 2000 Feb 15;346 Pt 1:133-8.
PMID 10657249
 
Processing of pro-PTHRP by the prohormone convertase, furin: effect on biological activity.
Liu B, Goltzman D, Rabbani SA.
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PMID 7539217
 
Human ADAM 12 (meltrin alpha) is an active metalloprotease.
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J Biol Chem. 1998 Jul 3;273(27):16993-7.
PMID 9642263
 
The Notch1 receptor is cleaved constitutively by a furin-like convertase.
Logeat F, Bessia C, Brou C, LeBail O, Jarriault S, Seidah NG, Israel A.
Proc Natl Acad Sci U S A. 1998 Jul 7;95(14):8108-12.
PMID 9653148
 
Human carcinoma cell growth and invasiveness is impaired by the propeptide of the ubiquitous proprotein convertase furin.
Lopez de Cicco R, Bassi DE, Zucker S, Seidah NG, Klein-Szanto AJ.
Cancer Res. 2005 May 15;65(10):4162-71.
PMID 15899807
 
The tyrosine kinase c-Src directly mediates growth factor-induced Notch-1 and Furin interaction and Notch-1 activation in pancreatic cancer cells.
Ma YC, Shi C, Zhang YN, Wang LG, Liu H, Jia HT, Zhang YX, Sarkar FH, Wang ZS.
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PMID 22479394
 
Furin interacts with proMT1-MMP and integrin alphaV at specialized domains of renal cell plasma membrane.
Mayer G, Boileau G, Bendayan M.
J Cell Sci. 2003 May 1;116(Pt 9):1763-73.
PMID 12665557
 
Comparative analysis of expression of the proprotein convertases furin, PACE4, PC1 and PC2 in human lung tumours.
Mbikay M, Sirois F, Yao J, Seidah NG, Chretien M.
Br J Cancer. 1997;75(10):1509-14.
PMID 9166946
 
Hypoxia-enhanced expression of the proprotein convertase furin is mediated by hypoxia-inducible factor-1: impact on the bioactivation of proproteins.
McMahon S, Grondin F, McDonald PP, Richard DE, Dubois CM.
J Biol Chem. 2005 Feb 25;280(8):6561-9. Epub 2004 Dec 15.
PMID 15611046
 
Alternative pathway for the role of furin in tumor cell invasion process. Enhanced MMP-2 levels through bioactive TGFbeta.
McMahon S, Laprise MH, Dubois CM.
Exp Cell Res. 2003 Dec 10;291(2):326-39.
PMID 14644155
 
Human furin is a calcium-dependent serine endoprotease that recognizes the sequence Arg-X-X-Arg and efficiently cleaves anthrax toxin protective antigen.
Molloy SS, Bresnahan PA, Leppla SH, Klimpel KR, Thomas G.
J Biol Chem. 1992 Aug 15;267(23):16396-402.
PMID 1644824
 
Intracellular trafficking and activation of the furin proprotein convertase: localization to the TGN and recycling from the cell surface.
Molloy SS, Thomas L, VanSlyke JK, Stenberg PE, Thomas G.
EMBO J. 1994 Jan 1;13(1):18-33.
PMID 7508380
 
Structural investigation of the HIV-1 envelope glycoprotein gp160 cleavage site.
Oliva R, Leone M, Falcigno L, D'Auria G, Dettin M, Scarinci C, Di Bello C, Paolillo L.
Chemistry. 2002 Mar 15;8(6):1467-73.
PMID 11921231
 
Elevated furin levels in human cystic fibrosis cells result in hypersusceptibility to exotoxin A-induced cytotoxicity.
Ornatowski W, Poschet JF, Perkett E, Taylor-Cousar JL, Deretic V.
J Clin Invest. 2007 Nov;117(11):3489-97.
PMID 17948127
 
Increased expression of the pro-protein convertase furin predicts decreased survival in ovarian cancer.
Page RE, Klein-Szanto AJ, Litwin S, Nicolas E, Al-Jumaily R, Alexander P, Godwin AK, Ross EA, Schilder RJ, Bassi DE.
Cell Oncol. 2007;29(4):289-99.
PMID 17641413
 
Heparin enhances the furin cleavage of HIV-1 gp160 peptides.
Pasquato A, Dettin M, Basak A, Gambaretto R, Tonin L, Seidah NG, Di Bello C.
FEBS Lett. 2007 Dec 22;581(30):5807-13. Epub 2007 Nov 26.
PMID 18037384
 
TMPRSS4-dependent activation of the epithelial sodium channel requires cleavage of the ?-subunit distal to the furin cleavage site.
Passero CJ, Mueller GM, Myerburg MM, Carattino MD, Hughey RP, Kleyman TR.
Am J Physiol Renal Physiol. 2012 Jan;302(1):F1-8. Epub 2011 Oct 12.
PMID 21993886
 
Furin Functions as a Nonproteolytic Chaperone for Matrix Metalloproteinase-28: MMP-28 Propeptide Sequence Requirement.
Pavlaki M, Zucker S, Dufour A, Calabrese N, Bahou W, Cao J.
Biochem Res Int. 2011;2011:630319. Epub 2010 Nov 1.
PMID 21152186
 
Proprotein convertase furin is preferentially expressed in T helper 1 cells and regulates interferon gamma.
Pesu M, Muul L, Kanno Y, O'Shea JJ.
Blood. 2006 Aug 1;108(3):983-5. Epub 2006 Apr 20.
PMID 16627761
 
Proprotein cleavage of E-cadherin by furin in baculovirus over-expression system: potential role of other convertases in mammalian cells.
Posthaus H, Dubois CM, Laprise MH, Grondin F, Suter MM, Muller E.
FEBS Lett. 1998 Nov 6;438(3):306-10.
PMID 9827567
 
Furin regulates the intracellular activation and the uptake rate of cell surface-associated MT1-MMP.
Remacle AG, Rozanov DV, Fugere M, Day R, Strongin AY.
Oncogene. 2006 Sep 14;25(41):5648-55. Epub 2006 Apr 24.
PMID 16636666
 
Evolutionary conserved close linkage of the c-fes/fps proto-oncogene and genetic sequences encoding a receptor-like protein.
Roebroek AJ, Schalken JA, Leunissen JA, Onnekink C, Bloemers HP, Van de Ven WJ.
EMBO J. 1986 Sep;5(9):2197-202.
PMID 3023061
 
Selective inhibition of proprotein convertases represses the metastatic potential of human colorectal tumor cells.
Scamuffa N, Siegfried G, Bontemps Y, Ma L, Basak A, Cherel G, Calvo F, Seidah NG, Khatib AM.
J Clin Invest. 2008 Jan;118(1):352-63.
PMID 18064302
 
Cellular processing of the nerve growth factor precursor by the mammalian pro-protein convertases.
Seidah NG, Benjannet S, Pareek S, Savaria D, Hamelin J, Goulet B, Laliberte J, Lazure C, Chretien M, Murphy RA.
Biochem J. 1996 Mar 15;314 ( Pt 3):951-60.
PMID 8615794
 
Phase I trial of "bi-shRNAi(furin)/GMCSF DNA/autologous tumor cell" vaccine (FANG) in advanced cancer.
Senzer N, Barve M, Kuhn J, Melnyk A, Beitsch P, Lazar M, Lifshitz S, Magee M, Oh J, Mill SW, Bedell C, Higgs C, Kumar P, Yu Y, Norvell F, Phalon C, Taquet N, Rao DD, Wang Z, Jay CM, Pappen BO, Wallraven G, Brunicardi FC, Shanahan DM, Maples PB, Nemunaitis J.
Mol Ther. 2012 Mar;20(3):679-86. doi: 10.1038/mt.2011.269. Epub 2011 Dec 20.
PMID 22186789
 
A novel recombinant immuno-tBid with a furin site effectively suppresses the growth of HER2-positive osteosarcoma cells in vitro.
Shan LQ, Ma S, Qiu XC, Wang T, Yu SB, Ma BA, Zhou Y, Fan QY, Yang AG.
Oncol Rep. 2011 Feb;25(2):325-31. doi: 10.3892/or.2010.1074. Epub 2010 Dec 7.
PMID 21152867
 
The non-receptor tyrosine kinase c-Src mediates the PDGF-induced association between Furin and pro-MT1-MMP in HPAC pancreatic cells.
Shi C, Ma Y, Liu H, Zhang Y, Wang Z, Jia H.
Mol Cell Biochem. 2012 Mar;362(1-2):65-70. Epub 2011 Oct 25.
PMID 22038627
 
The proteolytic processing of pro-platelet-derived growth factor-A at RRKR(86) by members of the proprotein convertase family is functionally correlated to platelet-derived growth factor-A-induced functions and tumorigenicity.
Siegfried G, Khatib AM, Benjannet S, Chretien M, Seidah NG.
Cancer Res. 2003 Apr 1;63(7):1458-63.
PMID 12670890
 
New furin inhibitors based on weakly basic amidinohydrazones.
Sielaff F, Than ME, Bevec D, Lindberg I, Steinmetzer T.
Bioorg Med Chem Lett. 2011 Jan 15;21(2):836-40. Epub 2010 Nov 25.
PMID 21168329
 
Proprotein convertases in post-menopausal endometrial cancer: distinctive regulation and non-invasive diagnosis.
Singh H, Heng S, Nicholls PK, Li Y, Tai LT, Jobling T, Salamonsen LA, Nie G.
Biochem Biophys Res Commun. 2012 Mar 23;419(4):809-14. Epub 2012 Feb 27.
PMID 22390935
 
Immunohistochemical localization of subtilisin/kexin-like proprotein convertases in human atherosclerosis.
Stawowy P, Kallisch H, Borges Pereira Stawowy N, Stibenz D, Veinot JP, Grafe M, Seidah NG, Chretien M, Fleck E, Graf K.
Virchows Arch. 2005 Apr;446(4):351-9. Epub 2005 Mar 9.
PMID 15756593
 
Furin-like proprotein convertases are central regulators of the membrane type matrix metalloproteinase-pro-matrix metalloproteinase-2 proteolytic cascade in atherosclerosis.
Stawowy P, Meyborg H, Stibenz D, Borges Pereira Stawowy N, Roser M, Thanabalasingam U, Veinot JP, Chretien M, Seidah NG, Fleck E, Graf K.
Circulation. 2005 May 31;111(21):2820-7. Epub 2005 May 23.
PMID 15911696
 
Constitutive stimulation of vascular smooth muscle cells by angiotensin II derived from an adenovirus encoding a furin-cleavable fusion protein.
Takayanagi T, Bourne AM, Kimura K, Takaguri A, Elliott KJ, Eguchi K, Eguchi S.
Am J Hypertens. 2012 Mar;25(3):280-3. doi: 10.1038/ajh.2011.221. Epub 2011 Nov 24.
PMID 22113169
 
SKI-1 and Furin generate multiple RGMa fragments that regulate axonal growth.
Tassew NG, Charish J, Seidah NG, Monnier PP.
Dev Cell. 2012 Feb 14;22(2):391-402.
PMID 22340500
 
Role for furin in tumor necrosis factor alpha-induced activation of the matrix metalloproteinase/sphingolipid mitogenic pathway.
Tellier E, Negre-Salvayre A, Bocquet B, Itohara S, Hannun YA, Salvayre R, Auge N.
Mol Cell Biol. 2007 Apr;27(8):2997-3007. Epub 2007 Feb 5.
PMID 17283058
 
Recycling of furin from the plasma membrane. Functional importance of the cytoplasmic tail sorting signals and interaction with the AP-2 adaptor medium chain subunit.
Teuchert M, Berghofer S, Klenk HD, Garten W.
J Biol Chem. 1999 Dec 17;274(51):36781-9.
PMID 10593987
 
Computational prediction of furin cleavage sites by a hybrid method and understanding mechanism underlying diseases.
Tian S, Huajun W, Wu J.
Sci Rep. 2012;2:261. Epub 2012 Feb 16.
PMID 22355773
 
Furin cleavage of the HIV-1 Tat protein.
Tikhonov I, Ruckwardt TJ, Berg S, Hatfield GS, David Pauza C.
FEBS Lett. 2004 May 7;565(1-3):89-92.
PMID 15135058
 
Posttranslational processing of hepcidin in human hepatocytes is mediated by the prohormone convertase furin.
Valore EV, Ganz T.
Blood Cells Mol Dis. 2008 Jan-Feb;40(1):132-8. Epub 2007 Oct 1.
PMID 17905609
 
BCL-2-induced glioma cell invasiveness depends on furin-like proteases.
Wick W, Wild-Bode C, Frank B, Weller M.
J Neurochem. 2004 Dec;91(6):1275-83.
PMID 15584904
 
Expression of a human proprotein processing enzyme: correct cleavage of the von Willebrand factor precursor at a paired basic amino acid site.
Wise RJ, Barr PJ, Wong PA, Kiefer MC, Brake AJ, Kaufman RJ.
Proc Natl Acad Sci U S A. 1990 Dec;87(23):9378-82.
PMID 2251280
 
Mutation of the f-protein cleavage site of avian paramyxovirus type 7 results in furin cleavage, fusion promotion, and increased replication in vitro but not increased replication, tissue tropism, or virulence in chickens.
Xiao S, Khattar SK, Subbiah M, Collins PL, Samal SK.
J Virol. 2012 Apr;86(7):3828-38. Epub 2012 Jan 18.
PMID 22258248
 
Regulation of membrane type-1 matrix metalloproteinase activation by proprotein convertases.
Yana I, Weiss SJ.
Mol Biol Cell. 2000 Jul;11(7):2387-401.
PMID 10888676
 
The proprotein convertase furin in human trophoblast: Possible role in promoting trophoblast cell migration and invasion.
Zhou Z, Shen T, Zhang BH, Lv XY, Lin HY, Zhu C, Xue LQ, Wang H.
Placenta. 2009 Nov;30(11):929-38. Epub 2009 Oct 22.
PMID 19853298
 

Citation

This paper should be referenced as such :
Khatib, AM ; Sfaxi, F
FURIN (furin (paired basic amino acid cleaving enzyme))
Atlas Genet Cytogenet Oncol Haematol. 2012;16(9):639-643.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Genes/FURINID40646ch15q26.html


External links

Nomenclature
HGNC (Hugo)FURIN   8568
Cards
AtlasFURINID40646ch15q26
Entrez_Gene (NCBI)FURIN  5045  furin, paired basic amino acid cleaving enzyme
AliasesFUR; PACE; PCSK3; SPC1
GeneCards (Weizmann)FURIN
Ensembl hg19 (Hinxton)ENSG00000140564 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000140564 [Gene_View]  chr15:90871539-90883458 [Contig_View]  FURIN [Vega]
ICGC DataPortalENSG00000140564
TCGA cBioPortalFURIN
AceView (NCBI)FURIN
Genatlas (Paris)FURIN
WikiGenes5045
SOURCE (Princeton)FURIN
Genetics Home Reference (NIH)FURIN
Genomic and cartography
GoldenPath hg38 (UCSC)FURIN  -     chr15:90871539-90883458 +  15q26.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FURIN  -     15q26.1   [Description]    (hg19-Feb_2009)
EnsemblFURIN - 15q26.1 [CytoView hg19]  FURIN - 15q26.1 [CytoView hg38]
Mapping of homologs : NCBIFURIN [Mapview hg19]  FURIN [Mapview hg38]
OMIM136950   
Gene and transcription
Genbank (Entrez)AI051906 AL110107 AL555508 BC008295 BC012181
RefSeq transcript (Entrez)NM_001289823 NM_001289824 NM_002569
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FURIN
Cluster EST : UnigeneHs.513153 [ NCBI ]
CGAP (NCI)Hs.513153
Alternative Splicing GalleryENSG00000140564
Gene ExpressionFURIN [ NCBI-GEO ]   FURIN [ EBI - ARRAY_EXPRESS ]   FURIN [ SEEK ]   FURIN [ MEM ]
Gene Expression Viewer (FireBrowse)FURIN [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5045
GTEX Portal (Tissue expression)FURIN
Human Protein AtlasENSG00000140564-FURIN [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP09958   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP09958  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP09958
Splice isoforms : SwissVarP09958
Catalytic activity : Enzyme3.4.21.75 [ Enzyme-Expasy ]   3.4.21.753.4.21.75 [ IntEnz-EBI ]   3.4.21.75 [ BRENDA ]   3.4.21.75 [ KEGG ]   
PhosPhoSitePlusP09958
Domaine pattern : Prosite (Expaxy)P_HOMO_B (PS51829)    SUBTILASE_ASP (PS00136)    SUBTILASE_HIS (PS00137)    SUBTILASE_SER (PS00138)   
Domains : Interpro (EBI)Furin_repeat    Galactose-bd-like    Growth_fac_rcpt_    Kexin/furin    Peptidase_S8/S53_dom    Peptidase_S8_Asp-AS    Peptidase_S8_His-AS    Peptidase_S8_Ser-AS    Peptidase_S8_subtilisin-rel    Propept_inh    PrprotnconvertsP    S8_pro-domain   
Domain families : Pfam (Sanger)P_proprotein (PF01483)    Peptidase_S8 (PF00082)    S8_pro-domain (PF16470)   
Domain families : Pfam (NCBI)pfam01483    pfam00082    pfam16470   
Domain families : Smart (EMBL)FU (SM00261)  
Conserved Domain (NCBI)FURIN
DMDM Disease mutations5045
Blocks (Seattle)FURIN
PDB (SRS)4OMC    4OMD    4RYD    4Z2A    5JMO    5JXG    5JXH    5JXI    5JXJ   
PDB (PDBSum)4OMC    4OMD    4RYD    4Z2A    5JMO    5JXG    5JXH    5JXI    5JXJ   
PDB (IMB)4OMC    4OMD    4RYD    4Z2A    5JMO    5JXG    5JXH    5JXI    5JXJ   
PDB (RSDB)4OMC    4OMD    4RYD    4Z2A    5JMO    5JXG    5JXH    5JXI    5JXJ   
Structural Biology KnowledgeBase4OMC    4OMD    4RYD    4Z2A    5JMO    5JXG    5JXH    5JXI    5JXJ   
SCOP (Structural Classification of Proteins)4OMC    4OMD    4RYD    4Z2A    5JMO    5JXG    5JXH    5JXI    5JXJ   
CATH (Classification of proteins structures)4OMC    4OMD    4RYD    4Z2A    5JMO    5JXG    5JXH    5JXI    5JXJ   
SuperfamilyP09958
Human Protein Atlas [tissue]ENSG00000140564-FURIN [tissue]
Peptide AtlasP09958
HPRD00653
IPIIPI00018387   IPI01014054   
Protein Interaction databases
DIP (DOE-UCLA)P09958
IntAct (EBI)P09958
FunCoupENSG00000140564
BioGRIDFURIN
STRING (EMBL)FURIN
ZODIACFURIN
Ontologies - Pathways
QuickGOP09958
Ontology : AmiGOGolgi membrane  Golgi membrane  protease binding  endopeptidase activity  endopeptidase activity  serine-type endopeptidase activity  serine-type endopeptidase activity  serine-type endopeptidase activity  serine-type endopeptidase inhibitor activity  protein binding  extracellular region  extracellular space  endoplasmic reticulum  Golgi lumen  trans-Golgi network  plasma membrane  signal peptide processing  signal peptide processing  transforming growth factor beta receptor signaling pathway  peptidase activity  cell proliferation  regulation of signal transduction  cell surface  endosome membrane  negative regulation of endopeptidase activity  membrane  integral component of membrane  protein processing  protein processing  peptide hormone processing  viral life cycle  viral protein processing  extracellular matrix disassembly  trans-Golgi network transport vesicle  extracellular matrix organization  collagen catabolic process  zymogen activation  nerve growth factor processing  negative regulation of low-density lipoprotein particle receptor catabolic process  nerve growth factor production  negative regulation of nerve growth factor production  negative regulation of transforming growth factor beta1 production  secretion by cell  lipoprotein metabolic process  regulation of protein catabolic process  peptide binding  peptide biosynthetic process  cellular protein metabolic process  membrane raft  regulation of low-density lipoprotein particle receptor biosynthetic process  metal ion binding  nerve growth factor binding  positive regulation of membrane protein ectodomain proteolysis  regulation of endopeptidase activity  extracellular exosome  cornification  dibasic protein processing  
Ontology : EGO-EBIGolgi membrane  Golgi membrane  protease binding  endopeptidase activity  endopeptidase activity  serine-type endopeptidase activity  serine-type endopeptidase activity  serine-type endopeptidase activity  serine-type endopeptidase inhibitor activity  protein binding  extracellular region  extracellular space  endoplasmic reticulum  Golgi lumen  trans-Golgi network  plasma membrane  signal peptide processing  signal peptide processing  transforming growth factor beta receptor signaling pathway  peptidase activity  cell proliferation  regulation of signal transduction  cell surface  endosome membrane  negative regulation of endopeptidase activity  membrane  integral component of membrane  protein processing  protein processing  peptide hormone processing  viral life cycle  viral protein processing  extracellular matrix disassembly  trans-Golgi network transport vesicle  extracellular matrix organization  collagen catabolic process  zymogen activation  nerve growth factor processing  negative regulation of low-density lipoprotein particle receptor catabolic process  nerve growth factor production  negative regulation of nerve growth factor production  negative regulation of transforming growth factor beta1 production  secretion by cell  lipoprotein metabolic process  regulation of protein catabolic process  peptide binding  peptide biosynthetic process  cellular protein metabolic process  membrane raft  regulation of low-density lipoprotein particle receptor biosynthetic process  metal ion binding  nerve growth factor binding  positive regulation of membrane protein ectodomain proteolysis  regulation of endopeptidase activity  extracellular exosome  cornification  dibasic protein processing  
Pathways : BIOCARTAProteolysis and Signaling of Notch [Genes]   
Pathways : KEGGInfluenza A   
REACTOMEP09958 [protein]
REACTOME PathwaysR-HSA-977225 [pathway]   
NDEx NetworkFURIN
Atlas of Cancer Signalling NetworkFURIN
Wikipedia pathwaysFURIN
Orthology - Evolution
OrthoDB5045
GeneTree (enSembl)ENSG00000140564
Phylogenetic Trees/Animal Genes : TreeFamFURIN
HOVERGENP09958
HOGENOMP09958
Homologs : HomoloGeneFURIN
Homology/Alignments : Family Browser (UCSC)FURIN
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFURIN [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FURIN
dbVarFURIN
ClinVarFURIN
1000_GenomesFURIN 
Exome Variant ServerFURIN
ExAC (Exome Aggregation Consortium)ENSG00000140564
GNOMAD BrowserENSG00000140564
Genetic variants : HAPMAP5045
Genomic Variants (DGV)FURIN [DGVbeta]
DECIPHERFURIN [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFURIN 
Mutations
ICGC Data PortalFURIN 
TCGA Data PortalFURIN 
Broad Tumor PortalFURIN
OASIS PortalFURIN [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFURIN  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFURIN
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FURIN
DgiDB (Drug Gene Interaction Database)FURIN
DoCM (Curated mutations)FURIN (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FURIN (select a term)
intoGenFURIN
NCG5 (London)FURIN
Cancer3DFURIN(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM136950   
Orphanet
MedgenFURIN
Genetic Testing Registry FURIN
NextProtP09958 [Medical]
TSGene5045
GENETestsFURIN
Target ValidationFURIN
Huge Navigator FURIN [HugePedia]
snp3D : Map Gene to Disease5045
BioCentury BCIQFURIN
ClinGenFURIN
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5045
Chemical/Pharm GKB GenePA32894
Clinical trialFURIN
Miscellaneous
canSAR (ICR)FURIN (select the gene name)
Probes
Litterature
PubMed218 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFURIN
EVEXFURIN
GoPubMedFURIN
iHOPFURIN
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Oct 12 16:22:47 CEST 2017

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