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FUS (fusion involved in t (12;16) in malignant liposarcoma)

Written2004-07PA Pérez-Mancera, Isidro Sánchez-Garía
Laboratorio 13, Instituto de Biologia Molecular y Celular del Cancer (IBMCC), Centro de Investigacion del Cancer, Campus Unamuno, 37.007-Salamanca, Spain

(Note : for Links provided by Atlas : click)

Identity

Alias_namesALS6
fusion, derived from t(12;16) malignant liposarcoma
amyotrophic lateral sclerosis 6
fusion (involved in t(12;16) in malignant liposarcoma)
fused in sarcoma
Alias_symbol (synonym)TLS
FUS1
hnRNP-P2
HNRNPP2
Other aliasTLS (translocated in liposarcoma)
HGNC (Hugo) FUS
LocusID (NCBI) 2521
Atlas_Id 44
Location 16p11.2  [Link to chromosome band 16p11]
Location_base_pair Starts at 31180110 and ends at 31194871 bp from pter ( according to hg19-Feb_2009)  [Mapping FUS.png]
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ATF1 (12q13.12) / FUS (16p11.2)CEBPZ (2p22.2) / FUS (16p11.2)CREB3L1 (11p11.2) / FUS (16p11.2)
CREB3L2 (7q33) / FUS (16p11.2)DDIT3 (12q13.3) / FUS (16p11.2)EIF4A2 (3q27.3) / FUS (16p11.2)
ERBB4 (2q34) / FUS (16p11.2)ERG (21q22.2) / FUS (16p11.2)FEV (2q35) / FUS (16p11.2)
FUS (16p11.2) / ACTN4 (19q13.2)FUS (16p11.2) / ADNP2 (18q23)FUS (16p11.2) / ATF1 (12q13.12)
FUS (16p11.2) / CEBPZ (2p22.2)FUS (16p11.2) / CHD1 (5q15)FUS (16p11.2) / CREB3L1 (11p11.2)
FUS (16p11.2) / CREB3L2 (7q33)FUS (16p11.2) / DDIT3 (12q13.3)FUS (16p11.2) / ERG (21q22.2)
FUS (16p11.2) / FEV (2q35)FUS (16p11.2) / FUS (16p11.2)FUS (16p11.2) / GDNF (5p13.2)
FUS (16p11.2) / KLF17 (1p34.1)FUS (16p11.2) / LTBP3 (11q13.1)FUS (16p11.2) / MAEA (4p16.3)
FUS (16p11.2) / MARS (12q13.3)FUS (16p11.2) / NFATC2 (20q13.2)FUS (16p11.2) / NMNAT2 (1q25.3)
FUS (16p11.2) / NR4A3 (9q22.33)FUS (16p11.2) / NR4A3 (9q31.1)FUS (16p11.2) / PHLDB2 (3q13.2)
FUS (16p11.2) / POU5F1 (6p21.33)FUS (16p11.2) / PRSS36 (16p11.2)FUS (16p11.2) / PSMB7 (9q33.3)
FUS (16p11.2) / RUNX1 (21q22.12)FUS (16p11.2) / SET (9q34.11)FUS (16p11.2) / SRR (17p13.3)
GDNF (5p13.2) / FUS (16p11.2)NOVA1 (14q12) / FUS (16p11.2)SRSF11 (1p31.1) / FUS (16p11.2)
VRK2 (2p16.1) / FUS (16p11.2)

DNA/RNA

Description The gene has 15 exons, and the total genomic sequence spanning the FUS gene is approx. 12 Kb.
Transcription Transcript lenght: 1,9 Kb. There are two isoforms produced by an alternative splicing that involved the exon 4a (145 bp) or the exon 4b (142 bp).

Protein

 
Description 526 amino acids (isoform with the exon 4a) or 525 aa (isoform with the exon 4b), 68 Kda. The protein contains different domains:
  • a N-terminal SYQG-rich region;
  • a RGG-rich region;
  • a RNA binding domain;
  • a RGG-rich region;
  • a Cys2/Cys2-zinc finger motif and;
  • a C-terminal RGG-rich region.

    • Expression FUS is expressed in a housekeeping pattern.
    Localisation Nuclear, although FUS shuttles from the nucleus to the cytoplasm in a large complex that contains mRNA and hnRNPs.
    Function FUS is a RNA-binding protein that is identical to hnRNP P2 and may be implicated in mRNA metabolism. FUS seems to have a function as a heterogeneous ribonuclear protein (hnRNP)-like chaperone of RNA. In addition, it has been suggested that FUS might have a role in the BCR/ABL-mediated leukemogenesis.
    Homology FUS forms a sub-family of RNA binding proteins with EWS and RBP56/hTAFII68. FUS has homologous in mouse (fus), rat (pigpen) and Drosophila (Cabeza/SARFH).

    Mutations

    Germinal In the mouse, germline mutation in the fus gene produces male sterility, sensitivity to radiation, defective B-lymphocyte development and activation, chromosomal instability and perinatal death.

    Implicated in

    Note
    Note The FUS gene is implicated in several chromosomal translocations associated to both solid tumors and leukemias. The result of these chromosomal translocations are gene fusions. FUS contributes to these fusions with its N-terminal part, just before the RNA-binding domain. This domain confers to the fusion protein a transcriptional activation domain. These fusion genes generated as a result of chromosomal rearragements are used to monitor diagnosis and treatment.
     
      
      
    Entity t(12;16)(q13;p11) chromosomal translocation. It produces the fusion protein FUS/ATF-1.
    Disease Angiomatoid fibrous histiocytoma (AFH).
    Hybrid/Mutated Gene FUS was interrupted at codon 175 (exon 5) and fused to codon 110 (exon 5) of ATF-1, resulting in an in-frame junction with a glycine to valine (GGT to GTT) transition.
      
      
    Entity t(7;16)(q33;p11) chromosomal translocation. It produces the fusion protein FUS/CREB3L2 (also known as BBF2H7).
    Disease Low grade fibromyxoid sarcoma (LGFMS).
    Hybrid/Mutated Gene The breakpoints in the fusion transcripts are produced between the exons 6 or 7 of FUS and the exon 5 of CREB3L2.
      
      
    Entity t(12;16)(q13;p11) chromosomal translocation. It produces the fusion protein FUS/DDIT3 (also known as CHOP).
    Disease Myxoid liposarcoma (MLS).
    Hybrid/Mutated Gene 9 different types of fusions between the genes FUS and DDIT3 have been reported. The most frequent rearragements join the exons 5, 7 or 8 of FUS with the exon 2 of DDIT3.
    Oncogenesis The unequivocally relation between FUS/DDIT3 and the MLS was shown by the generation of a transgenic mouse model expressing FUS/DDIT3 from a housekeeping promoter.
      
      
    Entity t(16;21)(p11;q22) chromosomal translocation. It produces the fusion protein FUS/ERG.
    Disease Acute myeloid leukemia (AML).
    Hybrid/Mutated Gene The junction of both genes is produced between the exons 6 or 7 of FUS and the exon 9 of ERG,or between the exon 8 of FUS and the exon 7 of ERG.
      

    Breakpoints

     

    Bibliography

    Expression patterns of the human sarcoma-associated genes FUS and EWS and the genomic structure of FUS.
    Aman P, Panagopoulos I, Lassen C, Fioretos T, Mencinger M, Toresson H, Höglund M, Forster A, Rabbitts TH, Ron D, Mandahl N, Mitelman F
    Genomics. 1996 ; 37 (1) : 1-8.
    PMID 8921363
     
    Rearrangement of the transcription factor gene CHOP in myxoid liposarcomas with t(12;16)(q13;p11).
    Aman P, Ron D, Mandahl N, Fioretos T, Heim S, Arheden K, Willén H, Rydholm A, Mitelman F
    Genes, chromosomes & cancer. 1992 ; 5 (4) : 278-285.
    PMID 1283316
     
    Identification of hnRNP P2 as TLS/FUS using electrospray mass spectrometry.
    Calvio C, Neubauer G, Mann M, Lamond AI
    RNA (New York, N.Y.). 1995 ; 1 (7) : 724-733.
    PMID 7585257
     
    Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma.
    Crozat A, Aman P, Mandahl N, Ron D
    Nature. 1993 ; 363 (6430) : 640-644.
    PMID 8510758
     
    Fus deficiency in mice results in defective B-lymphocyte development and activation, high levels of chromosomal instability and perinatal death.
    Hicks GG, Singh N, Nashabi A, Mai S, Bozek G, Klewes L, Arapovic D, White EK, Koury MJ, Oltz EM, Van Kaer L, Ruley HE
    Nature genetics. 2000 ; 24 (2) : 175-179.
    PMID 10655065
     
    Dual transforming activities of the FUS (TLS)-ERG leukemia fusion protein conferred by two N-terminal domains of FUS (TLS).
    Ichikawa H, Shimizu K, Katsu R, Ohki M
    Molecular and cellular biology. 1999 ; 19 (11) : 7639-7650.
    PMID 10523652
     
    Translocation t(12;16)(q13;p11) in myxoid liposarcoma and round cell liposarcoma: molecular and cytogenetic analysis.
    Knight JC, Renwick PJ, Cin PD, Van den Berghe H, Fletcher CD
    Cancer research. 1995 ; 55 (1) : 24-27.
    PMID 7805034
     
    Consistent detection of TLS/FUS-ERG chimeric transcripts in acute myeloid leukemia with t(16;21)(p11;q22) and identification of a novel transcript.
    Kong XT, Ida K, Ichikawa H, Shimizu K, Ohki M, Maseki N, Kaneko Y, Sako M, Kobayashi Y, Tojou A, Miura I, Kakuda H, Funabiki T, Horibe K, Hamaguchi H, Akiyama Y, Bessho F, Yanagisawa M, Hayashi Y
    Blood. 1997 ; 90 (3) : 1192-1199.
    PMID 9242552
     
    Male sterility and enhanced radiation sensitivity in TLS(-/-) mice.
    Kuroda M, Sok J, Webb L, Baechtold H, Urano F, Yin Y, Chung P, de Rooij DG, Akhmedov A, Ashley T, Ron D
    The EMBO journal. 2000 ; 19 (3) : 453-462.
    PMID 10654943
     
    Genomic structure of the human RBP56/hTAFII68 and FUS/TLS genes.
    Morohoshi F, Ootsuka Y, Arai K, Ichikawa H, Mitani S, Munakata N, Ohki M
    Gene. 1998 ; 221 (2) : 191-198.
    PMID 9795213
     
    Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia.
    Mullighan CG, Goorha S, Radtke I, Miller CB, Coustan-Smith E, Dalton JD, Girtman K, Mathew S, Ma J, Pounds SB, Su X, Pui CH, Relling MV, Evans WE, Shurtleff SA, Downing JR
    Nature. 2007 ; 446 (7137) : 758-764.
    PMID 17344859
     
    Expression of the FUS domain restores liposarcoma development in CHOP transgenic mice.
    Pérez-Mancera PA, Pérez-Losada J, Sánchez-Martín M, Rodríguez-García MA, Flores T, Battaner E, Gutiérrez-Adán A, Pintado B, Sánchez-García I
    Oncogene. 2002 ; 21 (11) : 1679-1684.
    PMID 11896599
     
    The chimeric FUS/CREB3l2 gene is specific for low-grade fibromyxoid sarcoma.
    Panagopoulos I, Storlazzi CT, Fletcher CD, Fletcher JA, Nascimento A, Domanski HA, Wejde J, Brosjö O, Rydholm A, Isaksson M, Mandahl N, Mertens F
    Genes, chromosomes & cancer. 2004 ; 40 (3) : 218-228.
    PMID 15139001
     
    TLS/FUS, a pro-oncogene involved in multiple chromosomal translocations, is a novel regulator of BCR/ABL-mediated leukemogenesis.
    Perrotti D, Bonatti S, Trotta R, Martinez R, Skorski T, Salomoni P, Grassilli E, Lozzo RV, Cooper DR, Calabretta B
    The EMBO journal. 1998 ; 17 (15) : 4442-4455.
    PMID 9687511
     
    TLS/FUS fusion domain of TLS/FUS-erg chimeric protein resulting from the t(16;21) chromosomal translocation in human myeloid leukemia functions as a transcriptional activation domain.
    Prasad DD, Ouchida M, Lee L, Rao VN, Reddy ES
    Oncogene. 1994 ; 9 (12) : 3717-3729.
    PMID 7970732
     
    Fusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation t(12;16) in malignant liposarcoma.
    Rabbitts TH, Forster A, Larson R, Nathan P
    Nature genetics. 1993 ; 4 (2) : 175-180.
    PMID 7503811
     
    Transcriptional activation by TAL1 and FUS-CHOP proteins expressed in acute malignancies as a result of chromosomal abnormalities.
    S´nchez-Garcí I, Rabbitts TH
    Proceedings of the National Academy of Sciences of the United States of America. 1994 ; 91 (17) : 7869-7873.
    PMID 8058726
     
    Fusion of the FUS and BBF2H7 genes in low grade fibromyxoid sarcoma.
    Storlazzi CT, Mertens F, Nascimento A, Isaksson M, Wejde J, Brosjo O, Mandahl N, Panagopoulos I
    Human molecular genetics. 2003 ; 12 (18) : 2349-2358.
    PMID 12915480
     
    Genetic characterization of angiomatoid fibrous histiocytoma identifies fusion of the FUS and ATF-1 genes induced by a chromosomal translocation involving bands 12q13 and 16p11.
    Waters BL, Panagopoulos I, Allen EF
    Cancer genetics and cytogenetics. 2000 ; 121 (2) : 109-116.
    PMID 11063792
     
    TLS (FUS) binds RNA in vivo and engages in nucleo-cytoplasmic shuttling.
    Zinszner H, Sok J, Immanuel D, Yin Y, Ron D
    Journal of cell science. 1997 ; 110 ( Pt 15) : 1741-1750.
    PMID 9264461
     

    Citation

    This paper should be referenced as such :
    Pérez-Mancera, PA ; Sanchez-Garia, I
    FUS (fusion involved in t(12;16) in malignant liposarcoma)
    Atlas Genet Cytogenet Oncol Haematol. 2004;8(3):236-240.
    Free journal version : [ pdf ]   [ DOI ]
    On line version : http://AtlasGeneticsOncology.org/Genes/FUSID44.html

    Other Leukemias implicated (Data extracted from papers in the Atlas)

    Leukemias t1621ID1037 TL_t0916q34p11ID2738

    Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 14 ]

    Solid Tumors AngiomFibHistiocytID5204 EwingID5010 ExtraMyxChondroID5025 liposarcID5029 LowGradFibromyxSarcID5185
    MyxoidLipoSarcID5169 softissuTumID5042 t1621p11q22EwingID5329 TT_t0116p34p11ID104204 TT_t0116p34p11ID104205
    TT_t0516q21p11ID106544 TT_t0616p21p11ID106945 TT_t1616p11p11ID102070 TT_t1620p11q13ID102274

    External links

    Nomenclature
    HGNC (Hugo)FUS   4010
    LRG (Locus Reference Genomic)LRG_655
    Cards
    AtlasFUSID44
    Entrez_Gene (NCBI)FUS  2521  FUS RNA binding protein
    AliasesALS6; ETM4; FUS1; HNRNPP2; 
    POMP75; TLS
    GeneCards (Weizmann)FUS
    Ensembl hg19 (Hinxton)ENSG00000089280 [Gene_View]
    Ensembl hg38 (Hinxton)ENSG00000089280 [Gene_View]  ENSG00000089280 [Sequence]  chr16:31180110-31194871 [Contig_View]  FUS [Vega]
    ICGC DataPortalENSG00000089280
    TCGA cBioPortalFUS
    AceView (NCBI)FUS
    Genatlas (Paris)FUS
    WikiGenes2521
    SOURCE (Princeton)FUS
    Genetics Home Reference (NIH)FUS
    Genomic and cartography
    GoldenPath hg38 (UCSC)FUS  -     chr16:31180110-31194871 +  16p11.2   [Description]    (hg38-Dec_2013)
    GoldenPath hg19 (UCSC)FUS  -     16p11.2   [Description]    (hg19-Feb_2009)
    GoldenPathFUS - 16p11.2 [CytoView hg19]  FUS - 16p11.2 [CytoView hg38]
    ImmunoBaseENSG00000089280
    Mapping of homologs : NCBIFUS [Mapview hg19]  FUS [Mapview hg38]
    OMIM137070   608030   614782   
    Gene and transcription
    Genbank (Entrez)AB208902 AI333366 AK098774 AK130774 AK290936
    RefSeq transcript (Entrez)NM_001010850 NM_001170634 NM_001170937 NM_004960
    RefSeq genomic (Entrez)
    Consensus coding sequences : CCDS (NCBI)FUS
    Cluster EST : UnigeneHs.46894 [ NCBI ]
    CGAP (NCI)Hs.46894
    Alternative Splicing GalleryENSG00000089280
    Gene ExpressionFUS [ NCBI-GEO ]   FUS [ EBI - ARRAY_EXPRESS ]   FUS [ SEEK ]   FUS [ MEM ]
    Gene Expression Viewer (FireBrowse)FUS [ Firebrowse - Broad ]
    SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
    GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
    BioGPS (Tissue expression)2521
    GTEX Portal (Tissue expression)FUS
    Human Protein AtlasENSG00000089280-FUS [pathology]   [cell]   [tissue]
    Protein : pattern, domain, 3D structure
    UniProt/SwissProtP35637   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
    NextProtP35637  [Sequence]  [Exons]  [Medical]  [Publications]
    With graphics : InterProP35637
    Splice isoforms : SwissVarP35637
    PhosPhoSitePlusP35637
    Domaine pattern : Prosite (Expaxy)RRM (PS50102)    ZF_RANBP2_1 (PS01358)    ZF_RANBP2_2 (PS50199)   
    Domains : Interpro (EBI)FUS    Nucleotide-bd_a/b_plait_sf    RBD_domain_sf    RRM_dom    TET_fam    Znf_RanBP2    Znf_RanBP2_sf   
    Domain families : Pfam (Sanger)RRM_1 (PF00076)    zf-RanBP (PF00641)   
    Domain families : Pfam (NCBI)pfam00076    pfam00641   
    Domain families : Smart (EMBL)RRM (SM00360)  ZnF_RBZ (SM00547)  
    Conserved Domain (NCBI)FUS
    DMDM Disease mutations2521
    Blocks (Seattle)FUS
    PDB (RSDB)2LA6    2LCW    4FDD    4FQ3    5W3N   
    PDB Europe2LA6    2LCW    4FDD    4FQ3    5W3N   
    PDB (PDBSum)2LA6    2LCW    4FDD    4FQ3    5W3N   
    PDB (IMB)2LA6    2LCW    4FDD    4FQ3    5W3N   
    Structural Biology KnowledgeBase2LA6    2LCW    4FDD    4FQ3    5W3N   
    SCOP (Structural Classification of Proteins)2LA6    2LCW    4FDD    4FQ3    5W3N   
    CATH (Classification of proteins structures)2LA6    2LCW    4FDD    4FQ3    5W3N   
    SuperfamilyP35637
    Human Protein Atlas [tissue]ENSG00000089280-FUS [tissue]
    Peptide AtlasP35637
    HPRD00660
    IPIIPI00221354   IPI00854677   IPI00909890   IPI00260715   IPI00645208   
    Protein Interaction databases
    DIP (DOE-UCLA)P35637
    IntAct (EBI)P35637
    FunCoupENSG00000089280
    BioGRIDFUS
    STRING (EMBL)FUS
    ZODIACFUS
    Ontologies - Pathways
    QuickGOP35637
    Ontology : AmiGOmRNA splicing, via spliceosome  DNA binding  chromatin binding  transcription coactivator activity  RNA binding  protein binding  nucleus  nucleus  nucleoplasm  nucleoplasm  polysome  regulation of transcription, DNA-templated  regulation of transcription by RNA polymerase II  RNA splicing  estrogen receptor binding  myosin V binding  ionotropic glutamate receptor binding  identical protein binding  perikaryon  regulation of RNA splicing  dendritic spine head  metal ion binding  retinoid X receptor binding  thyroid hormone receptor binding  perinuclear region of cytoplasm  protein homooligomerization  cellular response to calcium ion  positive regulation of nucleic acid-templated transcription  positive regulation of double-strand break repair via homologous recombination  
    Ontology : EGO-EBImRNA splicing, via spliceosome  DNA binding  chromatin binding  transcription coactivator activity  RNA binding  protein binding  nucleus  nucleus  nucleoplasm  nucleoplasm  polysome  regulation of transcription, DNA-templated  regulation of transcription by RNA polymerase II  RNA splicing  estrogen receptor binding  myosin V binding  ionotropic glutamate receptor binding  identical protein binding  perikaryon  regulation of RNA splicing  dendritic spine head  metal ion binding  retinoid X receptor binding  thyroid hormone receptor binding  perinuclear region of cytoplasm  protein homooligomerization  cellular response to calcium ion  positive regulation of nucleic acid-templated transcription  positive regulation of double-strand break repair via homologous recombination  
    Pathways : KEGGTranscriptional misregulation in cancer   
    REACTOMEP35637 [protein]
    REACTOME PathwaysR-HSA-72163 [pathway]   
    NDEx NetworkFUS
    Atlas of Cancer Signalling NetworkFUS
    Wikipedia pathwaysFUS
    Orthology - Evolution
    OrthoDB2521
    GeneTree (enSembl)ENSG00000089280
    Phylogenetic Trees/Animal Genes : TreeFamFUS
    HOGENOMP35637
    Homologs : HomoloGeneFUS
    Homology/Alignments : Family Browser (UCSC)FUS
    Gene fusions - Rearrangements
    Fusion : MitelmanFUS/ATF1 [16p11.2/12q13.12]  
    Fusion : MitelmanFUS/CHD1 [16p11.2/5q15]  [t(5;16)(q21;p11)]  
    Fusion : MitelmanFUS/CREB3L1 [16p11.2/11p11.2]  [t(11;16)(p11;p11)]  [t(11;16)(p11;q34)]  
    Fusion : MitelmanFUS/CREB3L2 [16p11.2/7q33]  [t(7;16)(q33;p11)]  [t(7;16)(q34;p11)]  
    Fusion : MitelmanFUS/DDIT3 [16p11.2/12q13.3]  [t(12;16)(q13;p11)]  [t(12;22)(q13;q12)]  
    Fusion : MitelmanFUS/ERG [16p11.2/21q22.2]  [t(16;21)(p11;q22)]  [t(16;21;22)(p11;q22;p11)]  
    Fusion : MitelmanFUS/FEV [16p11.2/2q35]  [t(2;16)(q35;p11)]  
    Fusion : MitelmanFUS/KLF17 [16p11.2/1p34.1]  [t(1;16)(p34;p11)]  
    Fusion : MitelmanFUS/NFATC2 [16p11.2/20q13.2]  [t(16;20)(p11;q13)]  
    Fusion : MitelmanFUS/NR4A3 [16p11.2/9q22.33]  [t(9;16)(q31;p11)]  
    Fusion : MitelmanFUS/PRSS36 [16p11.2/16p11.2]  [t(16;16)(p11;p11)]  
    Fusion : MitelmanFUS/SET [16p11.2/9q34.11]  [t(9;16)(q34;p11)]  
    Fusion : COSMICCREB3L2 [7q33]  -  FUS [16p11.2]  [fusion_842]  [fusion_847]  [fusion_848]  [fusion_860]  [fusion_861]  [fusion_870]  
    Fusion : COSMICDDIT3 [12q13.3]  -  FUS [16p11.2]  [fusion_831]  
    Fusion : COSMICFUS [16p11.2]  -  ATF1 [12q13.12]  [fusion_296]  [fusion_327]  
    Fusion : COSMICFUS [16p11.2]  -  CREB3L1 [11p11.2]  [fusion_912]  [fusion_913]  [fusion_942]  [fusion_943]  [fusion_954]  
    Fusion : COSMICFUS [16p11.2]  -  CREB3L2 [7q33]  [fusion_325]  [fusion_330]  [fusion_331]  [fusion_332]  [fusion_333]  [fusion_334]  [fusion_335]  
    [fusion_336]  [fusion_337]  [fusion_338]  [fusion_339]  [fusion_340]  [fusion_341]  [fusion_389]  [fusion_390]  [fusion_391]  [fusion_392]  
    [fusion_611]  [fusion_612]  [fusion_613]  [fusion_614]  [fusion_615]  [fusion_616]  [fusion_617]  [fusion_618]  [fusion_619]  [fusion_620]  
    [fusion_621]  [fusion_622]  [fusion_623]  [fusion_844]  [fusion_845]  [fusion_846]  [fusion_850]  [fusion_851]  [fusion_852]  [fusion_854]  
    [fusion_855]  [fusion_856]  [fusion_857]  [fusion_858]  [fusion_859]  [fusion_862]  [fusion_863]  [fusion_864]  [fusion_916]  [fusion_917]  
    [fusion_918]  [fusion_919]  [fusion_920]  [fusion_921]  [fusion_922]  [fusion_923]  [fusion_924]  [fusion_925]  [fusion_926]  [fusion_927]  
    [fusion_928]  [fusion_930]  [fusion_932]  [fusion_934]  [fusion_936]  [fusion_937]  [fusion_938]  [fusion_941]  [fusion_944]  [fusion_945]  
    [fusion_946]  [fusion_947]  [fusion_948]  [fusion_949]  [fusion_950]  [fusion_951]  [fusion_952]  [fusion_953]  
    Fusion : COSMICFUS [16p11.2]  -  DDIT3 [12q13.3]  [fusion_1018]  [fusion_1019]  [fusion_291]  [fusion_292]  [fusion_293]  [fusion_294]  [fusion_297]  
    [fusion_298]  [fusion_300]  [fusion_301]  [fusion_302]  [fusion_303]  [fusion_304]  [fusion_342]  [fusion_832]  [fusion_833]  [fusion_834]  
    [fusion_835]  [fusion_836]  [fusion_867]  [fusion_868]  
    Fusion : COSMICFUS [16p11.2]  -  ERG [21q22.2]  [fusion_309]  [fusion_310]  [fusion_311]  [fusion_312]  [fusion_313]  [fusion_314]  [fusion_315]  
    [fusion_316]  [fusion_318]  [fusion_319]  [fusion_320]  [fusion_329]  [fusion_624]  [fusion_625]  
    Fusion : COSMICFUS [16p11.2]  -  FEV [2q35]  [fusion_295]  [fusion_326]  
    Fusion PortalFUS 16p11.2 CHD1 5q15 BRCA
    Fusion PortalFUS 16p11.2 PRSS36 16p11.2 HNSC
    Fusion : TICdbFUS [16p11.2]  -  ATF1 [12q13.12]
    Fusion : TICdbFUS [16p11.2]  -  CREB3L1 [11p11.2]
    Fusion : TICdbFUS [16p11.2]  -  CREB3L2 [7q33]
    Fusion : TICdbFUS [16p11.2]  -  DDIT3 [12q13.3]
    Fusion : TICdbFUS [16p11.2]  -  ERG [21q22.2]
    Fusion : TICdbFUS [16p11.2]  -  FEV [2q35]
    Fusion : FusionGDB11303    14074    14075    14076    14077    14078    14079    14080    14081    14082    14083    14084    14085    14086    14087   
    14088    14089    14090    14091    14092    14093    14094    17212    27382    8404    9521   
    Fusion : Fusion_HubABCA1--FUS    ABI3BP--FUS    ANKHD1-EIF4EBP3--FUS    ANKRD11--FUS    ARAF--FUS    ARRDC2--FUS    ASAH1--FUS    ASPH--FUS    ATF1--FUS    ATXN2L--FUS    AXIN1--FUS    B2M--FUS    BBF2H7--FUS    C11ORF24--FUS    CDC16--FUS   
    CEBPZ--FUS    CHD2--FUS    CHD8--FUS    CHOP--FUS    CLDN11--FUS    CMAS--FUS    CMYA5--FUS    COL6A2--FUS    COL6A3--FUS    CREB3L1--FUS    CREB3L2--FUS    CREM--FUS    CUBN--FUS    DCBLD2--FUS    DDAH1--FUS   
    DDIT2--FUS    DDIT3--FUS    DDX17--FUS    DDX5--FUS    DHRSX--FUS    DOCK1--FUS    EIF4A1--FUS    EIF4A2--FUS    ELF4--FUS    ELK3--FUS    EMILIN2--FUS    ENAH--FUS    ENPP2--FUS    EP300--FUS    EPB41L4A--FUS   
    ERBB4--FUS    ERG--FUS    EWSR1--FUS    EXOSC9--FUS    F3--FUS    FAM160B2--FUS    FAM208B--FUS    FBXL8--FUS    FBXO7--FUS    FEV--FUS    FGF13--FUS    FIGN--FUS    FLT3LG--FUS    FN1--FUS    FNDC3B--FUS   
    FUS--ACTN4    FUS--ADNP2    FUS--ATF    FUS--ATF1    FUS--ATRAID    FUS--BBF2H7    FUS--C9ORF72    FUS--CBFB    FUS--CCDC91    FUS--CEBPZ    FUS--CHD1    FUS--CHD2    FUS--CHOP    FUS--COG1    FUS--COPS6   
    FUS--CREB1    FUS--CREB3L1    FUS--CREB3L2    FUS--CREM    FUS--CTTN    FUS--DDIT3    FUS--ERG    FUS--FEV    FUS--FLI1    FUS--FUS    FUS--GABRA3    FUS--GBF1    FUS--GDNF    FUS--GSK3B    FUS--HSA-MIR-6723   
    FUS--IL9R    FUS--KCTD5    FUS--KLF17    FUS--LGMN    FUS--LTBP3    FUS--MAEA    FUS--MAPKAPK2    FUS--MARS    FUS--MSL3    FUS--NCATC2    FUS--NCL    FUS--NFATC2    FUS--NMNAT2    FUS--NR4A3    FUS--OCREB3L2   
    FUS--OFUS    FUS--ORAI3    FUS--PASK    FUS--PHLDB2    FUS--PISD    FUS--POU5F1    FUS--PRKCA    FUS--PRSS36    FUS--PSMB7    FUS--PTMA    FUS--PUM1    FUS--RER1    FUS--RUNX1    FUS--SERPINA1    FUS--SRR   
    FUS--SUPT5H    FUS--TFCP2    FUS--U2AF2    FUS--UPP1    FUS--VPS13C    GAS6--FUS    GCA--FUS    GDNF--FUS    GPR183--FUS    GSTZ1--FUS    HBB--FUS    HBEGF--FUS    HMCN1--FUS    HNRNPA2B1--FUS    HNRNPH1--FUS   
    HNRNPM--FUS    IFITM10--FUS    IFT172--FUS    IKZF2--FUS    IL1R1--FUS    ITGA1--FUS    ITGA6--FUS    ITGAM--FUS    ITPR2--FUS    JAG1--FUS    JAK2--FUS    JMY--FUS    KDM4B--FUS    KLF17--FUS    KLRC3--FUS   
    KRT1--FUS    LRCH3--FUS    MLLT3--FUS    MTMR9--FUS    MZT2A--FUS    NFATC3--FUS    NID1--FUS    NOVA1--FUS    NPRL3--FUS    NR4A3--FUS    NUP214--FUS    OBSCN--FUS    PAPD7--FUS    PARP1--FUS    PCMTD1--FUS   
    PDLIM3--FUS    PEMT--FUS    PICALM--FUS    PLCB4--FUS    POU5F1--FUS    PTPN12--FUS    PTPRC--FUS    PTS--FUS    R3HDM2--FUS    RAN--FUS    RASA3--FUS    RP11-196G11.1--FUS    RPN2--FUS    SAP18--FUS    SCARA3--FUS   
    SF1--FUS    SGK2--FUS    SHANK3--FUS    SHPK--FUS    SIK1--FUS    SLC36A4--FUS    SLCO2A1--FUS    SMAD1--FUS    SMG1--FUS    SNX15--FUS    SOD2--FUS    SPRED1--FUS    SRSF11--FUS    SYNE2--FUS    TCF25--FUS   
    TG--FUS    TGFBR2--FUS    TIAL1--FUS    TMEM241--FUS    TNKS--FUS    TPO--FUS    TPR--FUS    TTLL7--FUS    TTN--FUS    UBN1--FUS    UNC5B--FUS    USP14--FUS    VAMP2--FUS    VPS8--FUS    VRK2--FUS   
    ZEB2--FUS   
    Fusion : QuiverFUS
    Polymorphisms : SNP and Copy number variants
    NCBI Variation ViewerFUS [hg38]
    dbSNP Single Nucleotide Polymorphism (NCBI)FUS
    dbVarFUS
    ClinVarFUS
    1000_GenomesFUS 
    Exome Variant ServerFUS
    ExAC (Exome Aggregation Consortium)ENSG00000089280
    GNOMAD BrowserENSG00000089280
    Varsome BrowserFUS
    Genetic variants : HAPMAP2521
    Genomic Variants (DGV)FUS [DGVbeta]
    DECIPHERFUS [patients]   [syndromes]   [variants]   [genes]  
    CONAN: Copy Number AnalysisFUS 
    Mutations
    ICGC Data PortalFUS 
    TCGA Data PortalFUS 
    Broad Tumor PortalFUS
    OASIS PortalFUS [ Somatic mutations - Copy number]
    Somatic Mutations in Cancer : COSMICFUS  [overview]  [genome browser]  [tissue]  [distribution]  
    Somatic Mutations in Cancer : COSMIC3DFUS
    Mutations and Diseases : HGMDFUS
    intOGen PortalFUS
    LOVD (Leiden Open Variation Database)Whole genome datasets
    LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
    LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
    LOVD (Leiden Open Variation Database)Mendelian genes
    BioMutasearch FUS
    DgiDB (Drug Gene Interaction Database)FUS
    DoCM (Curated mutations)FUS (select the gene name)
    CIViC (Clinical Interpretations of Variants in Cancer)FUS (select a term)
    intoGenFUS
    NCG5 (London)FUS
    Cancer3DFUS(select the gene name)
    Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
    Diseases
    OMIM137070    608030    614782   
    Orphanet106    20341    21137    11147    14540   
    DisGeNETFUS
    MedgenFUS
    Genetic Testing Registry FUS
    NextProtP35637 [Medical]
    TSGene2521
    GENETestsFUS
    Target ValidationFUS
    Huge Navigator FUS [HugePedia]
    snp3D : Map Gene to Disease2521
    BioCentury BCIQFUS
    ClinGenFUS
    Clinical trials, drugs, therapy
    Chemical/Protein Interactions : CTD2521
    Chemical/Pharm GKB GenePA28425
    Clinical trialFUS
    Miscellaneous
    canSAR (ICR)FUS (select the gene name)
    DataMed IndexFUS
    Probes
    Litterature
    PubMed413 Pubmed reference(s) in Entrez
    GeneRIFsGene References Into Functions (Entrez)
    CoreMineFUS
    EVEXFUS
    GoPubMedFUS
    iHOPFUS
    REVIEW articlesautomatic search in PubMed
    Last year publicationsautomatic search in PubMed

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