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FXYD5 (FXYD domain containing ion transport regulator 5)

Identity

Other namesDYSAD
Dysadherin
HSPC113
IWU-1
IWU1
KCT1
OIT2
PRO6241
RIC
UNQ2561
HGNC (Hugo) FXYD5
LocusID (NCBI) 53827
Location 19q13.12
Location_base_pair Starts at 35645845 and ends at 35660788 bp from pter ( according to hg19-Feb_2009)  [Mapping]

DNA/RNA

Transcription 0.9 kb mRNA; 534 bp open reading frame.

Protein

 
  Dysadherin protein consists of 178 amino acids.
Description The deduced amino acid sequence consisted of two hydrophobic regions corresponding to a signal peptide and a transmembrane domain (146-162), a serine-, threonine-, and proline-rich extracellular domain, which is a target for O-glycosylation, anda short cytoplasmic region containing positively charged amino acid residues.
Expression Endothelial cell, T lymphocytes, basal cell of squamous epithelium.
Localisation Cell membrane
Homology The transmembrane domain of dysadherin and mouse RIC especially showed a very high degree of similarity to other ion channels such as Mat-8 chloride channel, phospholemman, which is the major plasma membrane substrate for cAMPdependent protein kinase and protein kinase C, and the subunit of Na, K-ATPase.

Implicated in

Entity Various cancers
Disease Dysadherin, newly identified cell membrane glycoprotein, downregulates E-cadherin and promotes cancer invasion and metastasis. A reverse correlation between dysadherin expression and E-cadherin expression was observed in various cancers. Increased dysadherin expression was correlated with poor prognosis with head and neck squamous cell carcinoma, esophageal carcinoma, gastric carcinoma, colorectal carcinoma, melanoma and so on. Dysadherin expression in epitheloid sarcomas could be a used as powerful diagnostic marker for distinguishing epithelioid sarcomas from malignant rabdoid tumors.
  

External links

Nomenclature
HGNC (Hugo)FXYD5   4029
Cards
AtlasFXYD5ID40652ch19q13
Entrez_Gene (NCBI)FXYD5  53827  FXYD domain containing ion transport regulator 5
GeneCards (Weizmann)FXYD5
Ensembl (Hinxton)ENSG00000089327 [Gene_View]  chr19:35645845-35660788 [Contig_View]  FXYD5 [Vega]
ICGC DataPortalENSG00000089327
cBioPortalFXYD5
AceView (NCBI)FXYD5
Genatlas (Paris)FXYD5
WikiGenes53827
SOURCE (Princeton)NM_001164605 NM_014164 NM_144779
Genomic and cartography
GoldenPath (UCSC)FXYD5  -  19q13.12   chr19:35645845-35660788 +  19q13.12   [Description]    (hg19-Feb_2009)
EnsemblFXYD5 - 19q13.12 [CytoView]
Mapping of homologs : NCBIFXYD5 [Mapview]
OMIM606669   
Gene and transcription
Genbank (Entrez)AA044211 AA296696 AB072911 AF161462 AF177940
RefSeq transcript (Entrez)NM_001164605 NM_014164 NM_144779
RefSeq genomic (Entrez)AC_000151 NC_000019 NC_018930 NT_011109 NW_001838494 NW_004929415
Consensus coding sequences : CCDS (NCBI)FXYD5
Cluster EST : UnigeneHs.333418 [ NCBI ]
CGAP (NCI)Hs.333418
Alternative Splicing : Fast-db (Paris)GSHG0014822
Alternative Splicing GalleryENSG00000089327
Gene ExpressionFXYD5 [ NCBI-GEO ]     FXYD5 [ SEEK ]   FXYD5 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96DB9 (Uniprot)
NextProtQ96DB9  [Medical]
With graphics : InterProQ96DB9
Splice isoforms : SwissVarQ96DB9 (Swissvar)
Domaine pattern : Prosite (Expaxy)FXYD (PS01310)   
Domains : Interpro (EBI)Ion-transport_regulator_FXYD [organisation]  
Related proteins : CluSTrQ96DB9
Domain families : Pfam (Sanger)ATP1G1_PLM_MAT8 (PF02038)   
Domain families : Pfam (NCBI)pfam02038   
Domain structure : Prodom (Prabi Lyon)PD005989 (PD005989)   
DMDM Disease mutations53827
Blocks (Seattle)Q96DB9
Human Protein AtlasENSG00000089327 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasQ96DB9
HPRD09448
IPIIPI00419588   IPI00220419   IPI00909621   IPI00789942   
Protein Interaction databases
DIP (DOE-UCLA)Q96DB9
IntAct (EBI)Q96DB9
FunCoupENSG00000089327
BioGRIDFXYD5
InParanoidQ96DB9
Interologous Interaction database Q96DB9
IntegromeDBFXYD5
STRING (EMBL)FXYD5
Ontologies - Pathways
Ontology : AmiGOactin binding  ion channel activity  integral component of membrane  microvillus assembly  ion transmembrane transport  cadherin binding  negative regulation of calcium-dependent cell-cell adhesion  
Ontology : EGO-EBIactin binding  ion channel activity  integral component of membrane  microvillus assembly  ion transmembrane transport  cadherin binding  negative regulation of calcium-dependent cell-cell adhesion  
Protein Interaction DatabaseFXYD5
Wikipedia pathwaysFXYD5
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)FXYD5
snp3D : Map Gene to Disease53827
SNP (GeneSNP Utah)FXYD5
SNP : HGBaseFXYD5
Genetic variants : HAPMAPFXYD5
Exome VariantFXYD5
1000_GenomesFXYD5 
ICGC programENSG00000089327 
Somatic Mutations in Cancer : COSMICFXYD5 
CONAN: Copy Number AnalysisFXYD5 
Mutations and Diseases : HGMDFXYD5
Genomic VariantsFXYD5  FXYD5 [DGVbeta]
dbVarFXYD5
ClinVarFXYD5
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM606669   
MedgenFXYD5
GENETestsFXYD5
Disease Genetic AssociationFXYD5
Huge Navigator FXYD5 [HugePedia]  FXYD5 [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneFXYD5
Homology/Alignments : Family Browser (UCSC)FXYD5
Phylogenetic Trees/Animal Genes : TreeFamFXYD5
Chemical/Protein Interactions : CTD53827
Chemical/Pharm GKB GenePA28445
Clinical trialFXYD5
Cancer Resource (Charite)ENSG00000089327
Other databases
Probes
Litterature
PubMed35 Pubmed reference(s) in Entrez
CoreMineFXYD5
iHOPFXYD5
OncoSearchFXYD5

Bibliography

Dysadherin, a cancer-associated cell membrane glycoprotein, down-regulates E-cadherin and promotes metastasis.
Ino Y, Gotoh M, Sakamoto M, Tsukagoshi K, Hirohashi S.
Proc Natl Acad Sci USA. 2002; 99(1): 365-70.
PMID 11756660
 
Prognostic significance of dysadherin expression in advanced colorectal carcinoma.
Aoki S, Shimamura T, Shibata T, Nakanishi Y, Moriya Y, Sato Y, Kitajima M, Sakamoto M, Hirohashi S.
Br J Cancer. 2003; 88(5): 726-32.
PMID 12618882
 
Cell adhesion system and human cancer morphogenesis.
Hirohashi S, Kanai Y.
Cancer Sci. 2003; 94(7): 575-81. (Review)
PMID 12841864
 
Dysadherin: expression and clinical significance in thyroid carcinoma.
Sato H, Ino Y, Miura A, Abe Y, Sakai H, Ito K, Hirohashi S.
J Clin Endocrinol Metab. 2003; 88(9): 4407-12.
PMID 12970317
 
Dysadherin overexpression in pancreatic ductal adenocarcinoma reflects tumor aggressiveness: relationship to E-cadherin expression.
Shimamura T, Sakamoto M, Ino Y, Sato Y, Shimada K, Kosuge T, Sekihara H, Hirohashi S.
J Clin Oncol. 2003; 21(4): 659-67.
PMID 12586803
 
Aberrant O-glycosylation inhibits stable expression of dysadherin, a carcinoma-associated antigen, and facilitates cell-cell adhesion.
Tsuiji H, Takasaki S, Sakamoto M, Irimura T, Hirohashi S.
Glycobiology. 2003; 13(7): 521-7.
PMID 12672699
 
Prognostic significance of dysadherin expression in tongue cancer: immunohistochemical analysis of 91 cases.
Nakanishi Y, Akimoto S, Sato Y, Kanai Y, Sakamoto M, Hirohashi S.
Appl Immunohistochem Mol Morphol. 2004; 12(4): 323-8.
PMID 15536331
 
Prognostic significance of dysadherin expression in esophageal squamous cell carcinoma.
Shimada Y, Hashimoto Y, Kan T, Kawamura J, Okumura T, Soma T, Kondo K, Teratani N, Watanabe G, Ino Y, Sakamoto M, Hirohashi S, Imamura M.
Oncology. 2004; 67(1): 73-80.
PMID 15459499
 
Clinical significance of dysadherin expression in gastric cancer patients.
Shimada Y, Yamasaki S, Hashimoto Y, Ito T, Kawamura J, Soma T, Ino Y, Nakanishi Y, Sakamoto M, Hirohashi S, Imamura M.
Clin Cancer Res. 2004; 10(8): 2818-23.
PMID 15102690
 
Dysadherin expression facilitates cell motility and metastatic potential of human pancreatic cancer cells.
Shimamura T, Yasuda J, Ino Y, Gotoh M, Tsuchiya A, Nakajima A, Sakamoto M, Kanai Y, Hirohashi S.
Cancer Res. 2004; 64(19): 6989-95.
PMID 15466191
 
Prognostic significance of dysadherin expression in cervical squamous cell carcinoma.
Wu D, Qiao Y, Kristensen GB, Li S, Troen G, Holm R, Nesland JM, Suo Z.
Pathol Oncol Res. 2004; 10(4): 212-8.
PMID 15619642
 
Establishment of two cell lines from human gastric scirrhous carcinoma that possess the potential to metastasize spontaneously in nude mice.
Yanagihara K, Tanaka H, Takigahira M, Ino Y, Yamaguchi Y, Toge T, Sugano K, Hirohashi S.
Cancer Sci. 2004; 95(7): 575-82.
PMID 15245593
 
Clinicopathologic significance of dysadherin expression in cutaneous malignant melanoma: immunohistochemical analysis of 115 patients.
Nishizawa A, Nakanishi Y, Yoshimura K, Sasajima Y, Yamazaki N, Yamamoto A, Hanada K, Kanai Y, Hirohashi S.
Cancer. 2005; 103(8): 1693-700.
PMID 15751018
 
Prognostic significance of dysadherin expression in patients with non-small cell lung cancer.
Tamura M, Ohta Y, Tsunezuka Y, Matsumoto I, Kawakami K, Oda M, Watanabe G.
J Thorac Cardiovasc Surg. 2005; 130(3): 740-5.
PMID 16153922
 
Expression patterns of dysadherin and E-cadherin in lymph node metastases of colorectal carcinoma.
Batistatou A, Charalabopoulos AK, Scopa CD, Nakanishi Y, Kappas A, Hirohashi S, Agnantis NJ, Charalabopoulos K.
Virchows Arch. 2006; 448(6): 763-7.
PMID 16570180
 
Prognostic significance of dysadherin expression in epithelioid sarcoma and its diagnostic utility in distinguishing epithelioid sarcoma from malignant rhabdoid tumor.
Izumi T, Oda Y, Hasegawa T, Nakanishi Y, Iwasaki H, Sonobe H, Goto H, Kusakabe H, Takahira T, Kobayashi C, Kawaguchi K, Saito T, Yamamoto H, Tamiya S, Iwamoto Y, Tsuneyoshi M.
Mod Pathol. 2006; 19(6): 820-31.
PMID 16557275
 
Dysadherin expression in head and neck squamous cell carcinoma: association with lymphangiogenesis and prognostic significance.
Kyzas PA, Stefanou D, Batistatou A, Agnantis NJ, Nakanishi Y, Hirohashi S, Charalabopoulos K.
Am J Surg Pathol. 2006; 30(2): 185-93.
PMID 16434892
 
Chemokine (C-C motif) ligand 2 mediates the prometastatic effect of dysadherin in human breast cancer cells.
Nam JS, Kang MJ, Suchar AM, Shimamura T, Kohn EA, Michalowska AM, Jordan VC, Hirohashi S, Wakefield LM.
Cancer Res. 2006; 66(14): 7176-84.
PMID 16849564
 
Expression of dysadherin and E-cadherin in trophoblastic tissue in normal and abnormal pregnancies.
Batistatou A, Makrydimas G, Zagorianakou N, Zagorianakou P, Nakanishi Y, Agnantis NJ, Hirohashi S, Charalabopoulos K.
Placenta. 2007; 28(5-6): 590-2.
PMID 17084448
 
In breast carcinoma dysadherin expression is correlated with invasiveness but not with E-cadherin.
Batistatou A, Peschos D, Tsanou H, Charalabopoulos A, Nakanishi Y, Hirohashi S, Agnantis NJ, Charalabopoulos K.
Br J Cancer. 2007; 96(9): 1404-8.
PMID 17437014
 
Nuclear targeting of the growth hormone receptor results in dysregulation of cell proliferation and tumorigenesis.
Conway-Campbell BL, Wooh JW, Brooks AJ, Gordon D, Brown RJ, Lichanska AM, Chin HS, Barton CL, Boyle GM, Parsons PG, Jans DA, Waters MJ.
Proc Natl Acad Sci U S A. 2007; 104(33): 13331-6.
PMID 17690250
 
Dysadherin expression as a significant prognostic factor and as a determinant of histologic features in synovial sarcoma: special reference to its inverse relationship with E-cadherin expression.
Izumi T, Oda Y, Hasegawa T, Nakanishi Y, Kawai A, Sonobe H, Takahira T, Kobayashi C, Yamamoto H, Tamiya S, Hirohashi S, Iwamoto Y, Tsuneyoshi M.
Am J Surg Pathol. 2007; 31(1): 85-94.
PMID 17197923
 
Dysadherin: a new player in cancer progression.
Nam JS, Hirohashi S, Wakefield LM.
Cancer Lett. 2007; 255(2): 161-9. (Review)
PMID 17442482
 
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written07-2008Setsuo Hirohashi
Pathology Division, National Cancer Center Research Institute 5-1-1, Tsukiji, Chuo-ku, Tokyo 104-0045, Japan

Citation

This paper should be referenced as such :
Hirohashi, S
FXYD5 (FXYD domain containing ion transport regulator 5)
Atlas Genet Cytogenet Oncol Haematol. 2009;13(6):413-414.
Free online version   Free pdf version   [Bibliographic record ]
URL : http://AtlasGeneticsOncology.org/Genes/FXYD5ID40652ch19q13.html

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jul 30 16:48:57 CEST 2014

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