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GAS7 (growth arrest-specific 7)

Written2000-06Jean-Loup Huret
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

(Note : for Links provided by Atlas : click)

Identity

Other aliasKIAA0394
LocusID (NCBI) 8522
Atlas_Id 257
Location 17p13.1  [Link to chromosome band 17p13]
Location_base_pair Starts at and ends at bp from pter
 
  Probe(s) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ABR (17p13.3) / GAS7 (17p13.1)ACTA1 (1q42.13) / GAS7 (17p13.1)AIFM2 (10q22.1) / GAS7 (17p13.1)
FXR2 (17p13.1) / GAS7 (17p13.1)GAS7 (17p13.1) / AFF1 (4q21.3)GAS7 (17p13.1) / CHRM3 (1q43)
GAS7 (17p13.1) / DENND5A (11p15.4)GAS7 (17p13.1) / ELAVL2 (9p21.3)GAS7 (17p13.1) / GABRE (Xq28)
GAS7 (17p13.1) / GAS7 (17p13.1)GAS7 (17p13.1) / KMT2A (11q23.3)GAS7 (17p13.1) / MYH1 (17p13.1)
KMT2A (11q23.3) / GAS7 (17p13.1)

DNA/RNA

Description genomic sequence 167 kb; 14 exons
Transcription 8 kb mRNA; various splicings in the mouse

Protein

Description 412 aa
Expression in quiescent/terminally differenciated cells, like other GAS (herien the name Growth Arrest-Specific); selective expression in growth-arrested fibroblasts; GAS7 is predominantly expressed in the brain (in particular, in the mouse, in Purkinje cells of the cerebellum, at lower level in other tissues such as the heart and the testes); gas7 expression is associated with neurite formation (and overproduction of gas7 in neuroblastoma cells promotes neurite-like outgrowth) which suggests that GAS7 may have a role in promoting, and possibly maintaining, maturation and morphological differentiation of cerebellar neurons

Implicated in

Note
  
Entity treatment-related acute non lymphocytic leukemia with t(11;17)(q23;p13)
Disease only one case: a 13-year-old boy, with a M4 AML and a karyotype with an apparent del(11)(q23) (finally proved to be in reality a cryptic t(11;17)(q23;p13)); four months later the patient died; other cases of t(11;17)(q23;p13) have been described but the involvement of GAS7 has not been proved
Hybrid/Mutated Gene 5' MLL-3' GAS7; breakpoint in MLL intron 8, in MLL bcr; GAS7 breakpoint upstream of exon 1; fusion of mLL exon 7 or exon 8 to GAS7 exon 2
  

Bibliography

gas7: A gene expressed preferentially in growth-arrested fibroblasts and terminally differentiated Purkinje neurons affects neurite formation.
Ju YT, Chang AC, She BR, Tsaur ML, Hwang HM, Chao CC, Cohen SN, Lin-Chao S
Proceedings of the National Academy of Sciences of the United States of America. 1998 ; 95 (19) : 11423-11428.
PMID 9736752
 
Detection of leukemia-associated MLL-GAS7 translocation early during chemotherapy with DNA topoisomerase II inhibitors.
Megonigal MD, Cheung NK, Rappaport EF, Nowell PC, Wilson RB, Jones DH, Addya K, Leonard DG, Kushner BH, Williams TM, Lange BJ, Felix CA
Proceedings of the National Academy of Sciences of the United States of America. 2000 ; 97 (6) : 2814-2819.
PMID 10706619
 

Citation

This paper should be referenced as such :
Huret, JL
GAS7 (growth arrest-specific 7)
Atlas Genet Cytogenet Oncol Haematol. 2000;4(3):95-95.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Genes/GAS7ID257.html


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 3 ]
  t(11;17)(q23;p13) KMT2A/GAS7
11q23 rearrangements (KMT2A) in leukaemia
t(11;17)(q23;p13) KMT2A/GAS7


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  ABR/GAS7 (17p13)
GAS7/MYH1 (17p13)


External links

Nomenclature
Cards
AtlasGAS7ID257.txt
Aliases
Genomic and cartography
Gene and transcription
RefSeq transcript (Entrez)
RefSeq genomic (Entrez)
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)8522
Protein : pattern, domain, 3D structure
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Protein Interaction databases
Ontologies - Pathways
Clinical trials, drugs, therapy
Miscellaneous
canSAR (ICR) (select the gene name)
Probes
Litterature
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed


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indexed on : Thu Oct 18 17:37:21 CEST 2018

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jlhuret@AtlasGeneticsOncology.org.