Atlas of Genetics and Cytogenetics in Oncology and Haematology
GAS7 (growth arrest-specific 7)
| Identity |
| Other names | KIAA0394 |
| HGNC (Hugo) | GAS7 |
| LocusID (NCBI) | 8522 |
| Location | 17p13 |
| Location_base_pair | Starts at 9813926 and ends at 9929623 bp from pter ( according to hg19-Feb_2009) [Mapping] |
 | |
| Probe(s) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics | |
| DNA/RNA |
| Description | genomic sequence 167 kb; 14 exons |
| Transcription | 8 kb mRNA; various splicings in the mouse |
| Protein |
| Description | 412 aa |
| Expression | in quiescent/terminally differenciated cells, like other GAS (herien the name Growth Arrest-Specific); selective expression in growth-arrested fibroblasts; GAS7 is predominantly expressed in the brain (in particular, in the mouse, in Purkinje cells of the cerebellum, at lower level in other tissues such as the heart and the testes); gas7 expression is associated with neurite formation (and overproduction of gas7 in neuroblastoma cells promotes neurite-like outgrowth) which suggests that GAS7 may have a role in promoting, and possibly maintaining, maturation and morphological differentiation of cerebellar neurons |
| Implicated in |
| Entity | treatment-related acute non lymphocytic leukemia with t(11;17)(q23;p13) |
| Disease | only one case: a 13-year-old boy, with a M4 ANLL and a karyotype with an apparent del(11)(q23) (finally proved to be in reality a cryptic t(11;17)(q23;p13)); four months later the patient died; other cases of t(11;17)(q23;p13) have been described but the involvement of GAS7 has not been proved |
| Hybrid/Mutated Gene | 5' MLL-3' GAS7; breakpoint in MLL intron 8, in MLL bcr; GAS7 breakpoint upstream of exon 1; fusion of mLL exon 7 or exon 8 to GAS7 exon 2 |
| External links |
| Bibliography |
| gas7: A gene expressed preferentially in growth-arrested fibroblasts and terminally differentiated Purkinje neurons affects neurite formation. |
| Ju YT, Chang AC, She BR, Tsaur ML, Hwang HM, Chao CC, Cohen SN, Lin-Chao S |
| Proceedings of the National Academy of Sciences of the United States of America. 1998 ; 95 (19) : 11423-11428. |
| PMID 9736752 |
| Detection of leukemia-associated MLL-GAS7 translocation early during chemotherapy with DNA topoisomerase II inhibitors. |
| Megonigal MD, Cheung NK, Rappaport EF, Nowell PC, Wilson RB, Jones DH, Addya K, Leonard DG, Kushner BH, Williams TM, Lange BJ, Felix CA |
| Proceedings of the National Academy of Sciences of the United States of America. 2000 ; 97 (6) : 2814-2819. |
| PMID 10706619 |
| REVIEW articles | automatic search in PubMed |
| Last year publications | automatic search in PubMed |
| Contributor(s) |
| Written | 06-2000 | Jean-Loup Huret |
| Citation |
| This paper should be referenced as such : |
| Huret JL . GAS7 (growth arrest-specific 7). Atlas Genet Cytogenet Oncol Haematol. June 2000 . URL : http://AtlasGeneticsOncology.org/Genes/GAS7ID257.html |
This paper is referenced by INIST as such : |
| http://documents.irevues.inist.fr/bitstream/2042/37631/1/06-2000-GAS7ID257.pdf [ Bibliographic record ] |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Sat Apr 28 15:08:45 CEST 2012 |
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