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JMJD2C (Gene amplified in squamous cell carcinoma 1)

Identity

Other namesGASC1 (Gene amplified in squamous cell carcinoma 1)
KIAA0780
HGNC (Hugo) JMJD2C
LocusID (NCBI) 23081
Location 9p23-24
Location_base_pair Starts at 6757641 and ends at 7170920 bp from pter ( according to hg19-Feb_2009)  [Mapping]

DNA/RNA

Note At least 22 exons spanning approximately 417194 bps. 4239 bp mRNA; coding sequence: 3171 bp

Protein

Description 1056 ammino acid; possesses PHD domain

Implicated in

Entity amplification and overexpression in cell lines derived from esophageal squamous cell carcinomas
  

External links

Nomenclature
HGNC (Hugo)KDM4C   17071
Entrez_Gene (NCBI)KDM4C  23081  lysine (K)-specific demethylase 4C
Cards
AtlasGASC1ID432
GeneCards (Weizmann)KDM4C
Ensembl (Hinxton)ENSG00000107077 [Gene_View]  chr9:6757641-7170920 [Contig_View]  KDM4C [Vega]
AceView (NCBI)KDM4C
Genatlas (Paris)KDM4C
euGene (Indiana)23081
SOURCE (Stanford)NM_001146694 NM_001146695 NM_001146696 NM_015061
Genomic and cartography
GoldenPath (UCSC)KDM4C  -     chr9:6757641-7170920 +  9p24.1   [Description]    (hg19-Feb_2009)
EnsemblKDM4C - 9p24.1 [CytoView]
Mapping of homologs : NCBIKDM4C [Mapview]
OMIM605469   
Gene and transcription
Genbank (Entrez)AB018323 AB037901 AF085959 AI017056 AK296401
RefSeq transcript (SRS)NM_001146694 NM_001146695 NM_001146696 NM_015061
RefSeq transcript (Entrez)NM_001146694 NM_001146695 NM_001146696 NM_015061
RefSeq genomic (SRS)AC_000141 NC_000009 NT_008413 NW_001839149
RefSeq genomic (Entrez)AC_000141 NC_000009 NT_008413 NW_001839149
Consensus coding sequences : CCDS (NCBI)KDM4C
Cluster EST : UnigeneHs.709425 [ SRS ] Hs.709425 [ NCBI ]
Alternative Splicing : Fast-db (Paris)2099
Alternative Splicing GalleryENSG00000107077
Gene ExpressionKDM4C [ NCBI-GEO ]   KDM4C [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H3R0 (SRS) Q9H3R0 (Uniprot)
With graphics : InterProQ9H3R0
Splice isoforms : SwissVarQ9H3R0(Swissvar)
Domaine pattern : Prosite (SRS)JMJC (PS51184)    JMJN (PS51183)    TUDOR (PS50304)    ZF_PHD_1 (PS01359)    ZF_PHD_2 (PS50016)   
Domaine pattern : Prosite (Expaxy)JMJC (PS51184)    JMJN (PS51183)    TUDOR (PS50304)    ZF_PHD_1 (PS01359)    ZF_PHD_2 (PS50016)   
Domains : Interpro (SRS)TF_JmjC    TF_JmjC_AAH    TF_JmjN    Tudor    Znf_PHD    Znf_RING/FYVE/PHD   
Domains : Interpro (EBI)TF_JmjC    TF_JmjC_AAH    TF_JmjN    Tudor    Znf_PHD    Znf_RING/FYVE/PHD   
Related proteins : CluSTrQ9H3R0
Domain families : Pfam (SRS)JmjC (PF02373)    JmjN (PF02375)   
Domain families : Pfam (Sanger)JmjC (PF02373)    JmjN (PF02375)   
Domain families : Pfam (NCBI)pfam02373    pfam02375   
Domain families : Smart (EMBL)JmjC (SM00558)  JmjN (SM00545)  PHD (SM00249)  TUDOR (SM00333)  
Blocks (Seattle)Q9H3R0
PDB (SRS)2XDP    2XML   
PDB (PDBSum)2XDP    2XML   
PDB (IMB)2XDP    2XML   
PDB (RSDB)2XDP    2XML   
Human Protein AtlasENSG00000107077
HPRD12016
IPIIPI00027642   IPI00645825   IPI01018984   IPI00910024   IPI01010286   IPI00878778   IPI00929542   IPI00552718   IPI00878239   
Protein Interaction databases
DIP (DOE-UCLA)Q9H3R0
IntAct (EBI)Q9H3R0
FunCoupENSG00000107077
REACTOMEKDM4C
BioGRIDKDM4C
InParanoidQ9H3R0
Interologous Interaction database Q9H3R0
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)KDM4C
SNP (GeneSNP Utah)KDM4C
SNP : HGBaseKDM4C
Genetic variants : HAPMAPKDM4C
Somatic Mutations in Cancer : COSMICKDM4C 
CONAN: Copy Number AnalysisKDM4C 
Mutations and Diseases : HGMDKDM4C
OMIM605469   
GENETests605469   
Disease Genetic AssociationKDM4C
Huge Navigator KDM4C [HugePedia]  KDM4C [HugeCancerGEM]
Genomic VariantsKDM4C
snp3D : Map Gene to Disease23081
General knowledge
Homologs : HomoloGeneKDM4C
Homology/Alignments : Family Browser (UCSC)KDM4C
Phylogenetic Trees/Animal Genes : TreeFamKDM4C
Catalytic activity : Enzyme1.14.11.- [ Enzyme-Expasy ]   1.14.11.- [ Enzyme-SRS ]   1.14.11.- [ IntEnz-EBI ]   1.14.11.- [ BRENDA ]   1.14.11.- [ KEGG ]   
Chemical/Protein Interactions : CTD23081
Chemical/Pharm GKB GenePA164721503
Clinical trialKDM4C
Cancer Resource (Charite)ENSG00000107077
Ontology : AmiGOnuclear chromatin  nucleus  regulation of transcription from RNA polymerase II promoter  zinc ion binding  positive regulation of cell proliferation  oxidoreductase activity  chromatin modification  oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen  enzyme binding  histone demethylase activity (H3-K9 specific)  histone demethylase activity (H3-K9 specific)  histone H3-K9 demethylation  histone H3-K9 demethylation  metal ion binding  androgen receptor binding  
Ontology : EGO-EBInuclear chromatin  nucleus  regulation of transcription from RNA polymerase II promoter  zinc ion binding  positive regulation of cell proliferation  oxidoreductase activity  chromatin modification  oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen  enzyme binding  histone demethylase activity (H3-K9 specific)  histone demethylase activity (H3-K9 specific)  histone H3-K9 demethylation  histone H3-K9 demethylation  metal ion binding  androgen receptor binding  
Other databases
Probes
Probes : ImagenesJMJD2C Related clones (RZPD - Berlin)
Litterature
PubMed24 Pubmed reference(s) in Entrez
PubGeneKDM4C
iHOPKDM4C

Bibliography

Identification of a novel gene, GASC1, within an amplicon at 9p23-24 frequently detected in esophageal cancer cell lines.
Yang ZQ, Imoto I, Fukuda Y, Pimkhaokham A, Shimada Y, Imamura M, Sugano S, Nakamura Y, Inazawa J
Cancer research. 2000 ; 60 (17) : 4735-4739.
PMID 10987278
 
A novel amplicon at 9p23 - 24 in squamous cell carcinoma of the esophagus that lies proximal to GASC1 and harbors NFIB.
Yang ZQ, Imoto I, Pimkhaokham A, Shimada Y, Sasaki K, Oka M, Inazawa J
Japanese journal of cancer research : Gann. 2001 ; 92 (4) : 423-428.
PMID 11346465
 
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written12-2002Zeng-Quan Yang
University of Michigan, Department of Radiation Oncology, RM. 7121 CCGC, 1500 E Med Ctr. Dr., Ann Arbor, MI 48109-0948, USA

Citation

This paper should be referenced as such :
Yang ZQ . JMJD2C (Gene amplified in squamous cell carcinoma 1). Atlas Genet Cytogenet Oncol Haematol. December 2002 .
URL : http://AtlasGeneticsOncology.org/Genes/GASC1ID432.html

This paper is referenced by INIST as such :
http://documents.irevues.inist.fr/bitstream/2042/37927/1/12-2002-GASC1ID432.pdf   [ Bibliographic record ]

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