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KDM4C (Gene amplified in squamous cell carcinoma 1)

Identity

Other namesJMJD2C
GASC1 (Gene amplified in squamous cell carcinoma 1)
KIAA0780
HGNC (Hugo) KDM4C
LocusID (NCBI) 23081
Location 9p24.1
Location_base_pair Starts at 6757641 and ends at 7170920 bp from pter ( according to hg19-Feb_2009)  [Mapping]

DNA/RNA

Note At least 22 exons spanning approximately 417194 bps. 4239 bp mRNA; coding sequence: 3171 bp

Protein

Description 1056 ammino acid; possesses PHD domain

Implicated in

Entity amplification and overexpression in cell lines derived from esophageal squamous cell carcinomas
  

External links

Nomenclature
HGNC (Hugo)KDM4C   17071
Cards
AtlasGASC1ID432
Entrez_Gene (NCBI)KDM4C  23081  lysine (K)-specific demethylase 4C
GeneCards (Weizmann)KDM4C
Ensembl (Hinxton)ENSG00000107077 [Gene_View]  chr9:6757641-7170920 [Contig_View]  KDM4C [Vega]
ICGC DataPortalENSG00000107077
AceView (NCBI)KDM4C
Genatlas (Paris)KDM4C
WikiGenes23081
SOURCE (Princeton)NM_001146694 NM_001146695 NM_001146696 NM_015061
Genomic and cartography
GoldenPath (UCSC)KDM4C  -  9p24.1   chr9:6757641-7170920 +  9p24-p23   [Description]    (hg19-Feb_2009)
EnsemblKDM4C - 9p24-p23 [CytoView]
Mapping of homologs : NCBIKDM4C [Mapview]
OMIM605469   
Gene and transcription
Genbank (Entrez)AB018323 AB037901 AF085959 AI017056 AK296401
RefSeq transcript (Entrez)NM_001146694 NM_001146695 NM_001146696 NM_015061
RefSeq genomic (Entrez)AC_000141 NC_000009 NC_018920 NT_008413 NW_001839149 NW_004929342
Consensus coding sequences : CCDS (NCBI)KDM4C
Cluster EST : UnigeneHs.709425 [ NCBI ]
CGAP (NCI)Hs.709425
Alternative Splicing : Fast-db (Paris)GSHG0030014
Alternative Splicing GalleryENSG00000107077
Gene ExpressionKDM4C [ NCBI-GEO ]     KDM4C [ SEEK ]   KDM4C [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H3R0 (Uniprot)
NextProtQ9H3R0  [Medical]
With graphics : InterProQ9H3R0
Splice isoforms : SwissVarQ9H3R0 (Swissvar)
Catalytic activity : Enzyme1.14.11.- [ Enzyme-Expasy ]   1.14.11.-1.14.11.- [ IntEnz-EBI ]   1.14.11.- [ BRENDA ]   1.14.11.- [ KEGG ]   
Domaine pattern : Prosite (Expaxy)JMJC (PS51184)    JMJN (PS51183)   
Domains : Interpro (EBI)JmjC_dom    TF_JmjN    Tudor    Znf_FYVE_PHD    Znf_PHD   
Related proteins : CluSTrQ9H3R0
Domain families : Pfam (Sanger)JmjC (PF02373)    JmjN (PF02375)   
Domain families : Pfam (NCBI)pfam02373    pfam02375   
Domain families : Smart (EMBL)JmjC (SM00558)  JmjN (SM00545)  PHD (SM00249)  TUDOR (SM00333)  
DMDM Disease mutations23081
Blocks (Seattle)Q9H3R0
PDB (SRS)2XDP    2XML   
PDB (PDBSum)2XDP    2XML   
PDB (IMB)2XDP    2XML   
PDB (RSDB)2XDP    2XML   
Human Protein AtlasENSG00000107077
Peptide AtlasQ9H3R0
HPRD12016
IPIIPI00027642   IPI00645825   IPI01018984   IPI00910024   IPI01010286   IPI00878778   IPI00929542   IPI00552718   IPI00878239   
Protein Interaction databases
DIP (DOE-UCLA)Q9H3R0
IntAct (EBI)Q9H3R0
FunCoupENSG00000107077
BioGRIDKDM4C
IntegromeDBKDM4C
STRING (EMBL)KDM4C
Ontologies - Pathways
QuickGOQ9H3R0
Ontology : AmiGOnuclear chromatin  transcription, DNA-templated  regulation of transcription from RNA polymerase II promoter  zinc ion binding  positive regulation of cell proliferation  enzyme binding  histone demethylase activity (H3-K9 specific)  histone demethylase activity (H3-K9 specific)  histone H3-K9 demethylation  histone H3-K9 demethylation  androgen receptor binding  dioxygenase activity  oxidation-reduction process  
Ontology : EGO-EBInuclear chromatin  transcription, DNA-templated  regulation of transcription from RNA polymerase II promoter  zinc ion binding  positive regulation of cell proliferation  enzyme binding  histone demethylase activity (H3-K9 specific)  histone demethylase activity (H3-K9 specific)  histone H3-K9 demethylation  histone H3-K9 demethylation  androgen receptor binding  dioxygenase activity  oxidation-reduction process  
Protein Interaction DatabaseKDM4C
Wikipedia pathwaysKDM4C
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)KDM4C
SNP (GeneSNP Utah)KDM4C
SNP : HGBaseKDM4C
Genetic variants : HAPMAPKDM4C
1000_GenomesKDM4C 
ICGC programENSG00000107077 
CONAN: Copy Number AnalysisKDM4C 
Somatic Mutations in Cancer : COSMICKDM4C 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
DECIPHER (Syndromes)9:6757641-7170920
Mutations and Diseases : HGMDKDM4C
OMIM605469   
MedgenKDM4C
GENETestsKDM4C
Disease Genetic AssociationKDM4C
Huge Navigator KDM4C [HugePedia]  KDM4C [HugeCancerGEM]
Genomic VariantsKDM4C  KDM4C [DGVbeta]
Exome VariantKDM4C
dbVarKDM4C
ClinVarKDM4C
snp3D : Map Gene to Disease23081
DGIdb (Curated mutations)KDM4C
DGIdb (Drug Gene Interaction db)KDM4C
General knowledge
Homologs : HomoloGeneKDM4C
Homology/Alignments : Family Browser (UCSC)KDM4C
Phylogenetic Trees/Animal Genes : TreeFamKDM4C
Chemical/Protein Interactions : CTD23081
Chemical/Pharm GKB GenePA164721503
Clinical trialKDM4C
Cancer Resource (Charite)ENSG00000107077
Other databases
Probes
Litterature
PubMed35 Pubmed reference(s) in Entrez
CoreMineKDM4C
GoPubMedKDM4C
iHOPKDM4C

Bibliography

Identification of a novel gene, GASC1, within an amplicon at 9p23-24 frequently detected in esophageal cancer cell lines.
Yang ZQ, Imoto I, Fukuda Y, Pimkhaokham A, Shimada Y, Imamura M, Sugano S, Nakamura Y, Inazawa J
Cancer research. 2000 ; 60 (17) : 4735-4739.
PMID 10987278
 
A novel amplicon at 9p23 - 24 in squamous cell carcinoma of the esophagus that lies proximal to GASC1 and harbors NFIB.
Yang ZQ, Imoto I, Pimkhaokham A, Shimada Y, Sasaki K, Oka M, Inazawa J
Japanese journal of cancer research : Gann. 2001 ; 92 (4) : 423-428.
PMID 11346465
 
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written12-2002Zeng-Quan Yang
University of Michigan, Department of Radiation Oncology, RM. 7121 CCGC, 1500 E Med Ctr. Dr., Ann Arbor, MI 48109-0948, USA

Citation

This paper should be referenced as such :
Yang, ZQ
GASC1 (gene amplified in squamous cell carcinoma 1)
Atlas Genet Cytogenet Oncol Haematol. 2003;7(1):21-21.
Free online version   Free pdf version   [Bibliographic record ]
URL : http://AtlasGeneticsOncology.org/Genes/GASC1ID432.html

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indexed on : Thu Dec 4 15:37:48 CET 2014

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