| Nomenclature | | HGNC (Hugo) | KDM4C 17071 |
| Entrez_Gene (NCBI) | KDM4C 23081 lysine (K)-specific demethylase 4C |
| Cards | | Atlas | GASC1ID432 |
| GeneCards (Weizmann) | KDM4C |
| Ensembl (Hinxton) | ENSG00000107077 [Gene_View] chr9:6757641-7170920 [Contig_View] KDM4C [Vega] |
| AceView (NCBI) | KDM4C |
| Genatlas (Paris) | KDM4C |
| SOURCE (Stanford) | NM_001146694 NM_001146695 NM_001146696 NM_015061 |
| Genomic and cartography | | GoldenPath (UCSC) | KDM4C - 9p24.1 chr9:6757641-7170920 + 9p24-p23 [Description] (hg19-Feb_2009) |
| Ensembl | KDM4C - 9p24-p23 [CytoView] |
| Mapping of homologs : NCBI | KDM4C [Mapview] |
| OMIM | 605469 |
| Gene and transcription |
| Genbank (Entrez) | AB018323 AB037901 AF085959 AI017056 AK296401 |
| RefSeq transcript (SRS) | NM_001146694 NM_001146695 NM_001146696 NM_015061 |
| RefSeq transcript (Entrez) | NM_001146694 NM_001146695 NM_001146696 NM_015061 |
| RefSeq genomic (SRS) | AC_000141 NC_000009 NC_018920 NT_008413 NW_001839149 NW_004078038 |
| RefSeq genomic (Entrez) | AC_000141 NC_000009 NC_018920 NT_008413 NW_001839149 NW_004078038 |
| Consensus coding sequences : CCDS (NCBI) | KDM4C |
| Cluster EST : Unigene | Hs.709425 [ SRS ] Hs.709425 [ NCBI ] |
| CGAP (NCI) | Hs.709425 |
| Alternative Splicing : Fast-db (Paris) | GSHG0030014 |
| Alternative Splicing Gallery | ENSG00000107077 |
| Gene Expression | KDM4C [ NCBI-GEO ] KDM4C [ EBI - ARRAY_EXPRESS ] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | Q9H3R0 (SRS) Q9H3R0 (Uniprot) |
| NextProt | Q9H3R0 |
| With graphics : InterPro | Q9H3R0 |
| Splice isoforms : SwissVar | Q9H3R0(Swissvar) |
| Domaine pattern : Prosite (SRS) | JMJC (PS51184) JMJN (PS51183) TUDOR (PS50304) ZF_PHD_1 (PS01359) ZF_PHD_2 (PS50016) |
| Domaine pattern : Prosite (Expaxy) | JMJC (PS51184) JMJN (PS51183) TUDOR (PS50304) ZF_PHD_1 (PS01359) ZF_PHD_2 (PS50016) |
| Domains : Interpro (SRS) | JmjC_dom TF_JmjN Tudor Znf_PHD Znf_RING/FYVE/PHD |
| Domains : Interpro (EBI) | JmjC_dom TF_JmjN Tudor Znf_PHD Znf_RING/FYVE/PHD |
| Related proteins : CluSTr | Q9H3R0 |
| Domain families : Pfam (SRS) | JmjC (PF02373) JmjN (PF02375) |
| Domain families : Pfam (Sanger) | JmjC (PF02373) JmjN (PF02375) |
| Domain families : Pfam (NCBI) | pfam02373 pfam02375 |
| Domain families : Smart (EMBL) | JmjC (SM00558) JmjN (SM00545) PHD (SM00249) TUDOR (SM00333) |
| DMDM | 23081 |
| Blocks (Seattle) | Q9H3R0 |
| PDB (SRS) | 2XDP 2XML |
| PDB (PDBSum) | 2XDP 2XML |
| PDB (IMB) | 2XDP 2XML |
| PDB (RSDB) | 2XDP 2XML |
| Human Protein Atlas | ENSG00000107077 |
| HPRD | 12016 |
| IPI | IPI00027642 IPI00645825 IPI01018984 IPI00910024 IPI01010286 IPI00878778 IPI00929542 IPI00552718 IPI00878239 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | Q9H3R0 |
| IntAct (EBI) | Q9H3R0 |
| FunCoup | ENSG00000107077 |
| REACTOME | KDM4C |
| Protein Interaction Database | 23081 |
| BioGRID | KDM4C |
| InParanoid | Q9H3R0 |
| Interologous Interaction database | Q9H3R0 |
| IntegromeDB | KDM4C |
| Polymorphism : SNP, mutations, diseases | | SNP Single Nucleotide Polymorphism (NCBI) | KDM4C |
| SNP (GeneSNP Utah) | KDM4C |
| SNP : HGBase | KDM4C |
| Genetic variants : HAPMAP | KDM4C |
| Somatic Mutations in Cancer : COSMIC | KDM4C |
| CONAN: Copy Number Analysis | KDM4C |
| Mutations and Diseases : HGMD | KDM4C |
| OMIM | 605469 |
| GENETests | 605469 |
| Disease Genetic Association | KDM4C |
| Huge Navigator |
KDM4C [HugePedia] KDM4C [HugeCancerGEM] |
| Genomic Variants | KDM4C KDM4C [DGVbeta] |
| snp3D : Map Gene to Disease | 23081 |
| General knowledge |
|---|
| Homologs : HomoloGene | KDM4C |
| Homology/Alignments : Family Browser (UCSC) | KDM4C |
| Phylogenetic Trees/Animal Genes : TreeFam | KDM4C |
| Catalytic activity : Enzyme | 1.14.11.- [ Enzyme-Expasy ] 1.14.11.- [ Enzyme-SRS ] 1.14.11.- [ IntEnz-EBI ] 1.14.11.- [ BRENDA ] 1.14.11.- [ KEGG ] |
| Chemical/Protein Interactions : CTD | 23081 |
| Chemical/Pharm GKB Gene | PA164721503 |
| Clinical trial | KDM4C |
| Cancer Resource (Charite) | ENSG00000107077 |
| Ontology : AmiGO | nuclear chromatin transcription, DNA-dependent regulation of transcription from RNA polymerase II promoter zinc ion binding positive regulation of cell proliferation oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen enzyme binding histone demethylase activity (H3-K9 specific) histone demethylase activity (H3-K9 specific) histone H3-K9 demethylation histone H3-K9 demethylation metal ion binding androgen receptor binding |
| Ontology : EGO-EBI | nuclear chromatin transcription, DNA-dependent regulation of transcription from RNA polymerase II promoter zinc ion binding positive regulation of cell proliferation oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen enzyme binding histone demethylase activity (H3-K9 specific) histone demethylase activity (H3-K9 specific) histone H3-K9 demethylation histone H3-K9 demethylation metal ion binding androgen receptor binding |
| Other databases |
| Probes |
|---|
| Litterature | | PubMed | 28 Pubmed reference(s) in Entrez |
| PubGene | KDM4C |
| iHOP | KDM4C |
| Identification of a novel gene, GASC1, within an amplicon at 9p23-24 frequently detected in esophageal cancer cell lines. |
| Yang ZQ, Imoto I, Fukuda Y, Pimkhaokham A, Shimada Y, Imamura M, Sugano S, Nakamura Y, Inazawa J |
| Cancer research. 2000 ; 60 (17) : 4735-4739. |
| PMID 10987278 |
| |
| A novel amplicon at 9p23 - 24 in squamous cell carcinoma of the esophagus that lies proximal to GASC1 and harbors NFIB. |
| Yang ZQ, Imoto I, Pimkhaokham A, Shimada Y, Sasaki K, Oka M, Inazawa J |
| Japanese journal of cancer research : Gann. 2001 ; 92 (4) : 423-428. |
| PMID 11346465 |
| |