KDM4C (Gene amplified in squamous cell carcinoma 1)

2002-12-01 Zeng-Quan Yang Affiliation

University of Michigan, Department of Radiation Oncology, RM. 7121 CCGC, 1500 E Med Ctr. Dr., Ann Arbor, MI 48109-0948, USA

Identity

HGNC

KDM4C

LOCATION

9p24.1

LOCUSID

23081

ALIAS

GASC1,JHDM3C,JMJD2C,TDRD14C

FUSION GENES

Show Gene Fusions

DNA/RNA

Note

At least 22 exons spanning approximately 417194 bps. 4239 bp mRNA; coding sequence: 3171 bp

Proteins

Description

1056 ammino acid; possesses PHD domain

Implicated in

Entity name

amplification and overexpression in cell lines derived from esophageal squamous cell carcinomas

Bibliography

Pubmed ID	Last Year	Title	Authors
11346465	2001	A novel amplicon at 9p23 - 24 in squamous cell carcinoma of the esophagus that lies proximal to GASC1 and harbors NFIB.	Yang ZQ et al

Other Information

Locus ID:

NCBI: 23081
MIM: 605469
HGNC: 17071
Ensembl: ENSG00000107077

Variants:

dbSNP: 23081
ClinVar: 23081
TCGA: ENSG00000107077
COSMIC: KDM4C

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000107077	ENST00000381306	Q9H3R0
ENSG00000107077	ENST00000381309	Q9H3R0
ENSG00000107077	ENST00000401787	B0QZ60
ENSG00000107077	ENST00000420847	A0A0A0MSR6
ENSG00000107077	ENST00000428870	C9J879
ENSG00000107077	ENST00000438023	F8WCN1
ENSG00000107077	ENST00000536108	Q9H3R0
ENSG00000107077	ENST00000543771	Q9H3R0

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Signal Transduction	REACTOME	R-HSA-162582
Signaling by Rho GTPases	REACTOME	R-HSA-194315
RHO GTPase Effectors	REACTOME	R-HSA-195258
RHO GTPases activate PKNs	REACTOME	R-HSA-5625740
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	REACTOME	R-HSA-5625886
Chromatin organization	REACTOME	R-HSA-4839726
Chromatin modifying enzymes	REACTOME	R-HSA-3247509
HDMs demethylate histones	REACTOME	R-HSA-3214842

References

Pubmed ID	Year	Title	Citations
16732293	2006	The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3.	245
17277772	2007	Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression.	226
18713068	2008	Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1alpha.	119
23129632	2012	Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression.	89
19784073	2009	Genomic amplification and oncogenic properties of the GASC1 histone demethylase gene in breast cancer.	73
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	62
18927281	2008	Mucosa-associated lymphoid tissue lymphoma: novel translocations including rearrangements of ODZ2, JMJD2C, and CNN3.	44
26766589	2016	Targeting Aberrant Epigenetic Networks Mediated by PRMT1 and KDM4C in Acute Myeloid Leukemia.	37
20127736	2010	Genetic alterations and changes in expression of histone demethylases in prostate cancer.	30
19339270	2009	Genetic associations of 115 polymorphisms with cancers of the upper aerodigestive tract across 10 European countries: the ARCAGE project.	24

Citation

Zeng-Quan Yang

KDM4C (Gene amplified in squamous cell carcinoma 1)

Atlas Genet Cytogenet Oncol Haematol. 2002-12-01

Online version: http://atlasgeneticsoncology.org/gene/432/kdm4c