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GATA3 (GATA binding protein 3)

Written2011-12Mathieu Tremblay, Maxime Bouchard
Goodman Cancer Research Centre, Department of Biochemistry, McGill University, Montreal, Canada

(Note : for Links provided by Atlas : click)

Identity

Other aliasHDR
HDRS
MGC2346
MGC5199
MGC5445
LocusID (NCBI) 2625
Atlas_Id 107
Location 10p14  [Link to chromosome band 10p14]
Location_base_pair Starts at and ends at bp from pter
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
GATA3 (10p14) / TAF3 (10p14)RHOB (2p24.1) / GATA3 (10p14)

DNA/RNA

Description The GATA3 locus spans 20,51 kb and contains 6 exons.
Transcription Two alternative exons 1 (1a and 1b) of the Gata3 locus are spliced to a common second exon, which contains the translation start site. All transcripts share exons 2 to 5 but transcript 1a and 1b splice to two variant exons 6 (6a and 6b respectively) giving rise to isoform a (1a-2-5-6a) and isoform b (1b-2-5-6b) (see figure 1) (Asnagli et al., 2002). The functional significance of these isoforms is unclear.

Protein

 
  Figure 1. White boxes indicate a non-coding exonic sequence, and black boxes indicate coding sequences. Gata3 encodes a protein containing 2 transactivation domains (TA1 and TA2) and 2 Zn Finger domains (Zn1 and Zn2).
Description The full length GATA3 protein contain either 443 AA (isoform a) or 444 AA (isoform b), corresponding to molecular weights of 47,9 kDa and 48,0 kDa respectively. The GATA3 protein contains two zinc finger motifs of a distinctive form CXNCX (17) and CNXC as well as two transactivation domains (TA1 and TA2). The N-terminal Zn finger (Zn1) is known to stabilize DNA binding and interact with other zinc finger proteins, whereas the C-terminal Zn finger (Zn2) binds DNA.
Expression Hematopoietic system (blood, bone marrow, thymus, B, T, erythroid and myeloid lineages), blood vessels (endothelial cells), adipocytes, adrenal gland, ear, eye, bladder, mammary gland, prostate, seminal vesicle, kidney, CNS, hair follicle.
Localisation Mostly nuclear.
Function GATA3 acts as a transcription factor which binds to the consensus DNA sequence 5'-(A/T)GATA(A/G)-3'.

Gata3 gene inactivation in the mouse is embryonic lethal at mid-gestation (between embryonic days E11 and E12) (Tsai et al., 1994; Pandolfi et al., 1995). These mice display massive internal bleeding, marked growth retardation, severe deformities of the brain and spinal cord, and gross aberrations in fetal liver hematopoiesis. Lethality of Gata3 mutant embryos can be rescued by administration of catechol intermediates during pregnancy as it corrects the reduction in noradrenalin synthesis in the sympathetic nervous system (SNS) caused by reduced expression of tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH). Pharmacologically rescued mutant embryos present developmental defects in structures derived from cephalic neural crest cells (Lim et al., 2000).
In the kidney, Gata3 is important for nephric (Wolffian) duct elongation and metanephric kidney induction (Grote et al., 2006; Grote et al., 2008). Conditional inactivation of Gata3 in the nephric duct leads to hydronephrosis and defective ureter maturation, partly due to the downregulation of the receptor tyrosine kinase gene Ret (Song et al., 2009; Chia et al., 2011).

Gata3 plays an important role in mammary gland maturation and cancer. The conditional deletion of Gata3 in the mouse mammary epithelium is associated with a failure in terminal end bud formation at puberty causing severe defects in mammary development. Moreover, Gata3 loss in adult mice leads to an expansion of undifferentiated luminal cells and basement-membrane detachment, which promotes tumor dissemination (Kouros-Mehr et al., 2006; Asselin-Labat et al., 2007; Kouros-Mehr et al., 2008; Kouros-Mehr et al., 2008; Dydensborg et al., 2009).
Reexpression of Gata3 drives invasive breast cancer cells to undergo the reversal of epithelial-mesenchymal transition, reducing both the tumorigenicity and metastatic potential through reduction of lysyl oxidase (LOX) expression, a metastasis-promoting, matrix-remodeling protein (Chu et al., 2011; Yan et al., 2010). Moreover, Gata3 interact with BRCA1 to repress the expression of genes associated with triple-negative and basal-like breast cancer (BLBCs) including Foxc1, Foxc2, Cxcl1 and P-cadherin. Loss of GATA3 expression also contributes to drug resistance and epithelial-to-mesenchymal transition-like phenotypes associated with aggressive BLBCs (Tkocz et al., 2011).

In T cells, Gata3 acts at multiple stages of thymocyte differentiation. It is indispensable for early thymic progenitor differentiation (Hosoya et al., 2009) and for thymocytes to pass through beta selection and T cell commitment. Gata3 is also necessary for single-positive CD4 thymocyte development as well as for Th1-Th2 lineage commitment (Ting et al., 1996; Zhang et al., 1997; Zheng and Flavell, 1997; Zhang et al., 1998; Pai et al., 2003). As master regulator of Th2 lineage commitment, GATA3 acts either as a transcriptional activator or repressor through direct action at many critical loci encoding cytokines, cytokine receptors, signaling molecules as well as transcription factors that are involved in the regulation of T(h)1 and T(h)2 differentiation (Jenner et al., 2009). For example, it regulates the expression of Th2 lineage specific cytokine gene such as IL5 and repress the Th1 lineage specific genes IL-12 receptor β2 and STAT4 as well as neutralizing RUNX3 function through protein-protein interaction. Mice lacking Gata3 produce IFN-gamma rather than Th2 cytokines (IL5 and IL13) in response to infection (Zhu et al., 2004). It acts in mutual opposition to the transcription factor T-bet, as T-bet promotes whereas GATA3 represses Fut7 transcription (Hwang et al., 2005). It also acts with Tbx21 to regulate cell lineage-specific expression of lymphocyte homing receptors and cytokine in both Th1 and Th2 lymphocyte subsets (Chen et al., 2006). Enforced expression of Gata3 during T cell development induced CD4(+)CD8(+) double-positive (DP) T cell lymphoma (Nawijn et al., 2001a; Nawijn et al., 2001b).

Gata3 is essential for the expression of the cytokines IL-4, IL-5 and IL-13 that mediate allergic inflammation. Gata3 overexpression causes enhanced allergen-induced airway inflammation and airway remodeling, including subepithelial fibrosis, and smooth muscle cell hyperplasia (Kiwamoto et al., 2006). It additionally has a critical function in regulatory T cells and immune tolerance since deletion of Gata3 specifically in regulatory T cells led to a spontaneous inflammatory disorder in mice (Wang et al., 2011).

Gata3 is critical for the differentiation and survival of parathyroid progenitor cells through regulation of GCM2/B (Grigorieva et al., 2010). Gata3 is essential for the survival but not the differentiation of sympathetic neurons and adrenal chromaffin cells (Tsarovina et al., 2010) and acts with Hand2 to induce noradrenergic genes during development (Pellegrino et al., 2011).

Gata3 drives trophoblast differentiation and has been shown to induce a trophoblast cell fate in embryonic stem cells (Ralston et al., 2010). Gata3 and its close paralog Gata2 are important for trophectoderm lineage specification (Ray et al., 2009).

During adipogenesis, Gata3 is a negative regulator of differentiation which needs to be downregulated to permit expression of the peroxisome proliferator-activated receptor-gamma and preadipocyte to adipocyte transition (Tong et al., 2000).

In keratinocytes, Gata3 is a key regulator of KLK1 expression and is involved in growth control and the maintenance of a differentiated state in epithelial cells (Son do et al., 2009).
In hair follicle morphogenesis Gata3 controls cell fate decision between the inner root sheath and hair shaft cell (Kaufman et al., 2003; Kurek et al., 2007).

Gata3 is essential for lens cells differentiation and proper cell cycle control (Maeda et al., 2009) as well as in the morphogenesis of the mouse inner ear (Karis et al., 2001; Lilleväli et al., 2004).
It plays an essential role during angiogenesis through ANGPT1-TEK and Ang-1-Tie2-mediated signaling in large vessel endothelial cells.
A role for Gata3 in the developing heart was revealed by pharmacological rescue of Gata3-null embryos, which survive until birth and harbor ventricular septal defect (VSD), double-outlet of right ventricle (DORV), anomalies of the aortic arch (AAA) and persistent truncus arteriosus (PTA) (Raid et al., 2009).

Homology GATA3 is a member of the GATA family of proteins comprising 6 paralogs. GATA1, GATA2 and GATA3 are mainly expressed in hematopoiesis, whereas GATA4, GATA5 and GATA6 are expressed in mesoderm and endoderm-derived tissue. All six GATA family members share a highly conserved double zinc-finger DNA-binding domain. GATA3 Zn fingers are most closely conserved with those of GATA1.

Mutations

Germinal Deletion of chromosome 10 (del10p) and GATA3 gene mutations leading to haploinsufficiency associated with HDR syndrome (Van Esch et al., 2000; Nesbit et al., 2004; Ali et al., 2007; Lindstrand et al., 2010).
Somatic Heterozygous frameshift mutations close to the second Zn finger domain of GATA3 are associated with familial and sporadic breast tumors (Ciocca et al., 2009; Arnold et al., 2010).

Implicated in

Note
  
Entity Sporadic breast cancer and familial breast cancer
Cytogenetics Somatic mutations in GATA3: familial breast tumors harbored heterozygous frameshift somatic mutations close to the second Zn finger domain.
Oncogenesis GATA3 is mutated in ~5% of sporadic and ~13% of familial breast tumors (Usary et al., 2004; Mehra et al., 2005; Arnold et al., 2010).
GATA3 is an important predictor of disease outcome in breast cancer patients whereby low GATA3 expression was a significant predictor of disease-related death (Yoon et al., 2010).
  
  
Entity HDR (Barakat) syndrome
Disease Familial hypoparathyroidism - deafness - renal defects syndrome.
- Hypoparathyroidism.
- Sensorineural deafness, bilateral, symmetric, deficit affecting all frequencies but slightly more marked at the higher end of the frequency range.
- Renal defects such as aplasia, dysplasia and vesicoureteral reflux, associated or not to genital tract malformation.
Prognosis Depends on the penetrance of renal defects.
Cytogenetics - Deletion of chromosome 10 (del10p).
- GATA3 gene mutations leading to functional haploinsufficiency.
 
Figure 2. Both chromosome deletion and point mutations of the GATA3 locus have been associated with HDR syndrome.
  

Bibliography

Functional characterization of GATA3 mutations causing the hypoparathyroidism-deafness-renal (HDR) dysplasia syndrome: insight into mechanisms of DNA binding by the GATA3 transcription factor.
Ali A, Christie PT, Grigorieva IV, Harding B, Van Esch H, Ahmed SF, Bitner-Glindzicz M, Blind E, Bloch C, Christin P, Clayton P, Gecz J, Gilbert-Dussardier B, Guillen-Navarro E, Hackett A, Halac I, Hendy GN, Lalloo F, Mache CJ, Mughal Z, Ong AC, Rinat C, Shaw N, Smithson SF, Tolmie J, Weill J, Nesbit MA, Thakker RV.
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PMID 17210674
 
Frequent somatic mutations of GATA3 in non-BRCA1/BRCA2 familial breast tumors, but not in BRCA1-, BRCA2- or sporadic breast tumors.
Arnold JM, Choong DY, Thompson ER; kConFab, Waddell N, Lindeman GJ, Visvader JE, Campbell IG, Chenevix-Trench G.
Breast Cancer Res Treat. 2010 Jan;119(2):491-6. Epub 2009 Feb 3.
PMID 19189213
 
Cutting edge: Identification of an alternative GATA-3 promoter directing tissue-specific gene expression in mouse and human.
Asnagli H, Afkarian M, Murphy KM.
J Immunol. 2002 May 1;168(9):4268-71.
PMID 11970965
 
Gata-3 is an essential regulator of mammary-gland morphogenesis and luminal-cell differentiation.
Asselin-Labat ML, Sutherland KD, Barker H, Thomas R, Shackleton M, Forrest NC, Hartley L, Robb L, Grosveld FG, van der Wees J, Lindeman GJ, Visvader JE.
Nat Cell Biol. 2007 Feb;9(2):201-9. Epub 2006 Dec 24.
PMID 17187062
 
Interaction of GATA-3/T-bet transcription factors regulates expression of sialyl Lewis X homing receptors on Th1/Th2 lymphocytes.
Chen GY, Osada H, Santamaria-Babi LF, Kannagi R.
Proc Natl Acad Sci U S A. 2006 Nov 7;103(45):16894-9. Epub 2006 Oct 30.
PMID 17075044
 
Nephric duct insertion is a crucial step in urinary tract maturation that is regulated by a Gata3-Raldh2-Ret molecular network in mice.
Chia I, Grote D, Marcotte M, Batourina E, Mendelsohn C, Bouchard M.
Development. 2011 May;138(10):2089-97.
PMID 21521737
 
GATA3 inhibits lysyl oxidase-mediated metastases of human basal triple-negative breast cancer cells.
Chu IM, Michalowski AM, Hoenerhoff M, Szauter KM, Luger D, Sato M, Flanders K, Oshima A, Csiszar K, Green JE.
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PMID 21892208
 
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PMID 19084267
 
GATA3 inhibits breast cancer growth and pulmonary breast cancer metastasis.
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Oncogene. 2009 Jul 23;28(29):2634-42. Epub 2009 Jun 1.
PMID 19483726
 
Gata3-deficient mice develop parathyroid abnormalities due to dysregulation of the parathyroid-specific transcription factor Gcm2.
Grigorieva IV, Mirczuk S, Gaynor KU, Nesbit MA, Grigorieva EF, Wei Q, Ali A, Fairclough RJ, Stacey JM, Stechman MJ, Mihai R, Kurek D, Fraser WD, Hough T, Condie BG, Manley N, Grosveld F, Thakker RV.
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PMID 20484821
 
Gata3 acts downstream of beta-catenin signaling to prevent ectopic metanephric kidney induction.
Grote D, Boualia SK, Souabni A, Merkel C, Chi X, Costantini F, Carroll T, Bouchard M.
PLoS Genet. 2008 Dec;4(12):e1000316. Epub 2008 Dec 26.
PMID 19112489
 
Pax 2/8-regulated Gata 3 expression is necessary for morphogenesis and guidance of the nephric duct in the developing kidney.
Grote D, Souabni A, Busslinger M, Bouchard M.
Development. 2006 Jan;133(1):53-61. Epub 2005 Nov 30.
PMID 16319112
 
GATA-3 is required for early T lineage progenitor development.
Hosoya T, Kuroha T, Moriguchi T, Cummings D, Maillard I, Lim KC, Engel JD.
J Exp Med. 2009 Dec 21;206(13):2987-3000. Epub 2009 Nov 23.
PMID 19934022
 
T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3.
Hwang ES, Szabo SJ, Schwartzberg PL, Glimcher LH.
Science. 2005 Jan 21;307(5708):430-3.
PMID 15662016
 
The transcription factors T-bet and GATA-3 control alternative pathways of T-cell differentiation through a shared set of target genes.
Jenner RG, Townsend MJ, Jackson I, Sun K, Bouwman RD, Young RA, Glimcher LH, Lord GM.
Proc Natl Acad Sci U S A. 2009 Oct 20;106(42):17876-81. Epub 2009 Oct 5.
PMID 19805038
 
Transcription factor GATA-3 alters pathway selection of olivocochlear neurons and affects morphogenesis of the ear.
Karis A, Pata I, van Doorninck JH, Grosveld F, de Zeeuw CI, de Caprona D, Fritzsch B.
J Comp Neurol. 2001 Jan 22;429(4):615-30.
PMID 11135239
 
GATA-3: an unexpected regulator of cell lineage determination in skin.
Kaufman CK, Zhou P, Pasolli HA, Rendl M, Bolotin D, Lim KC, Dai X, Alegre ML, Fuchs E.
Genes Dev. 2003 Sep 1;17(17):2108-22. Epub 2003 Aug 15.
PMID 12923059
 
Transcription factors T-bet and GATA-3 regulate development of airway remodeling.
Kiwamoto T, Ishii Y, Morishima Y, Yoh K, Maeda A, Ishizaki K, Iizuka T, Hegab AE, Matsuno Y, Homma S, Nomura A, Sakamoto T, Takahashi S, Sekizawa K.
Am J Respir Crit Care Med. 2006 Jul 15;174(2):142-51. Epub 2006 Apr 13.
PMID 16614350
 
GATA-3 and the regulation of the mammary luminal cell fate.
Kouros-Mehr H, Kim JW, Bechis SK, Werb Z.
Curr Opin Cell Biol. 2008b Apr;20(2):164-70. Epub 2008 Mar 21. (REVIEW)
PMID 18358709
 
Transcriptome and phenotypic analysis reveals Gata3-dependent signalling pathways in murine hair follicles.
Kurek D, Garinis GA, van Doorninck JH, van der Wees J, Grosveld FG.
Development. 2007 Jan;134(2):261-72. Epub 2006 Dec 6.
PMID 17151017
 
Partially overlapping expression of Gata2 and Gata3 during inner ear development.
Lillevali K, Matilainen T, Karis A, Salminen M.
Dev Dyn. 2004 Dec;231(4):775-81.
PMID 15499560
 
Gata3 loss leads to embryonic lethality due to noradrenaline deficiency of the sympathetic nervous system.
Lim KC, Lakshmanan G, Crawford SE, Gu Y, Grosveld F, Engel JD.
Nat Genet. 2000 Jun;25(2):209-12.
PMID 10835639
 
Molecular and clinical characterization of patients with overlapping 10p deletions.
Lindstrand A, Malmgren H, Verri A, Benetti E, Eriksson M, Nordgren A, Anderlid BM, Golovleva I, Schoumans J, Blennow E.
Am J Med Genet A. 2010 May;152A(5):1233-43.
PMID 20425828
 
Transcription factor GATA-3 is essential for lens development.
Maeda A, Moriguchi T, Hamada M, Kusakabe M, Fujioka Y, Nakano T, Yoh K, Lim KC, Engel JD, Takahashi S.
Dev Dyn. 2009 Sep;238(9):2280-91.
PMID 19623612
 
Identification of GATA3 as a breast cancer prognostic marker by global gene expression meta-analysis.
Mehra R, Varambally S, Ding L, Shen R, Sabel MS, Ghosh D, Chinnaiyan AM, Kleer CG.
Cancer Res. 2005 Dec 15;65(24):11259-64.
PMID 16357129
 
Enforced expression of GATA-3 in transgenic mice inhibits Th1 differentiation and induces the formation of a T1/ST2-expressing Th2-committed T cell compartment in vivo.
Nawijn MC, Dingjan GM, Ferreira R, Lambrecht BN, Karis A, Grosveld F, Savelkoul H, Hendriks RW.
J Immunol. 2001a Jul 15;167(2):724-32.
PMID 11441076
 
Enforced expression of GATA-3 during T cell development inhibits maturation of CD8 single-positive cells and induces thymic lymphoma in transgenic mice.
Nawijn MC, Ferreira R, Dingjan GM, Kahre O, Drabek D, Karis A, Grosveld F, Hendriks RW.
J Immunol. 2001b Jul 15;167(2):715-23.
PMID 11441075
 
Characterization of GATA3 mutations in the hypoparathyroidism, deafness, and renal dysplasia (HDR) syndrome.
Nesbit MA, Bowl MR, Harding B, Ali A, Ayala A, Crowe C, Dobbie A, Hampson G, Holdaway I, Levine MA, McWilliams R, Rigden S, Sampson J, Williams AJ, Thakker RV.
J Biol Chem. 2004 May 21;279(21):22624-34. Epub 2004 Feb 24.
PMID 14985365
 
Critical roles for transcription factor GATA-3 in thymocyte development.
Pai SY, Truitt ML, Ting CN, Leiden JM, Glimcher LH, Ho IC.
Immunity. 2003 Dec;19(6):863-75.
PMID 14670303
 
Targeted disruption of the GATA3 gene causes severe abnormalities in the nervous system and in fetal liver haematopoiesis.
Pandolfi PP, Roth ME, Karis A, Leonard MW, Dzierzak E, Grosveld FG, Engel JD, Lindenbaum MH.
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PMID 7550312
 
Cytokines inhibit norepinephrine transporter expression by decreasing Hand2.
Pellegrino MJ, Parrish DC, Zigmond RE, Habecker BA.
Mol Cell Neurosci. 2011 Mar;46(3):671-80. Epub 2011 Jan 15.
PMID 21241805
 
Lack of Gata3 results in conotruncal heart anomalies in mouse.
Raid R, Krinka D, Bakhoff L, Abdelwahid E, Jokinen E, Karner M, Malva M, Meier R, Pelliniemi LJ, Ploom M, Sizarov A, Pooga M, Karis A.
Mech Dev. 2009 Jan-Feb;126(1-2):80-9. Epub 2008 Oct 15.
PMID 18955134
 
Gata3 regulates trophoblast development downstream of Tead4 and in parallel to Cdx2.
Ralston A, Cox BJ, Nishioka N, Sasaki H, Chea E, Rugg-Gunn P, Guo G, Robson P, Draper JS, Rossant J.
Development. 2010 Feb;137(3):395-403.
PMID 20081188
 
Context-dependent function of regulatory elements and a switch in chromatin occupancy between GATA3 and GATA2 regulate Gata2 transcription during trophoblast differentiation.
Ray S, Dutta D, Rumi MA, Kent LN, Soares MJ, Paul S.
J Biol Chem. 2009 Feb 20;284(8):4978-88. Epub 2008 Dec 23.
PMID 19106099
 
Abundant expression of Kallikrein 1 gene in human keratinocytes was mediated by GATA3.
Son do N, Li L, Katsuyama H, Komatsu N, Saito M, Tanii H, Saijoh K.
Gene. 2009 May 1;436(1-2):121-7. Epub 2009 Feb 13.
PMID 19232384
 
Critical role for GATA3 in mediating Tie2 expression and function in large vessel endothelial cells.
Song H, Suehiro J, Kanki Y, Kawai Y, Inoue K, Daida H, Yano K, Ohhashi T, Oettgen P, Aird WC, Kodama T, Minami T.
J Biol Chem. 2009 Oct 16;284(42):29109-24. Epub 2009 Aug 12.
PMID 19674970
 
Transcription factor GATA-3 is required for development of the T-cell lineage.
Ting CN, Olson MC, Barton KP, Leiden JM.
Nature. 1996 Dec 5;384(6608):474-8.
PMID 8945476
 
BRCA1 and GATA3 corepress FOXC1 to inhibit the pathogenesis of basal-like breast cancers.
Tkocz D, Crawford NT, Buckley NE, Berry FB, Kennedy RD, Gorski JJ, Harkin DP, Mullan PB.
Oncogene. 2011 Nov 28. doi: 10.1038/onc.2011.531. [Epub ahead of print]
PMID 22120723
 
Function of GATA transcription factors in preadipocyte-adipocyte transition.
Tong Q, Dalgin G, Xu H, Ting CN, Leiden JM, Hotamisligil GS.
Science. 2000 Oct 6;290(5489):134-8.
PMID 11021798
 
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Tsai FY, Keller G, Kuo FC, Weiss M, Chen J, Rosenblatt M, Alt FW, Orkin SH.
Nature. 1994 Sep 15;371(6494):221-6.
PMID 8078582
 
The Gata3 transcription factor is required for the survival of embryonic and adult sympathetic neurons.
Tsarovina K, Reiff T, Stubbusch J, Kurek D, Grosveld FG, Parlato R, Schutz G, Rohrer H.
J Neurosci. 2010 Aug 11;30(32):10833-43.
PMID 20702712
 
Mutation of GATA3 in human breast tumors.
Usary J, Llaca V, Karaca G, Presswala S, Karaca M, He X, Langerod A, Karesen R, Oh DS, Dressler LG, Lonning PE, Strausberg RL, Chanock S, Borresen-Dale AL, Perou CM.
Oncogene. 2004 Oct 7;23(46):7669-78.
PMID 15361840
 
GATA3 haplo-insufficiency causes human HDR syndrome.
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Nature. 2000 Jul 27;406(6794):419-22.
PMID 10935639
 
An essential role of the transcription factor GATA-3 for the function of regulatory T cells.
Wang Y, Su MA, Wan YY.
Immunity. 2011 Sep 23;35(3):337-48. Epub 2011 Sep 15.
PMID 21924928
 
GATA3 inhibits breast cancer metastasis through the reversal of epithelial-mesenchymal transition.
Yan W, Cao QJ, Arenas RB, Bentley B, Shao R.
J Biol Chem. 2010 Apr 30;285(18):14042-51. Epub 2010 Feb 26.
PMID 20189993
 
Higher levels of GATA3 predict better survival in women with breast cancer.
Yoon NK, Maresh EL, Shen D, Elshimali Y, Apple S, Horvath S, Mah V, Bose S, Chia D, Chang HR, Goodglick L.
Hum Pathol. 2010 Dec;41(12):1794-801.
PMID 21078439
 
Transcription factor GATA-3 is differentially expressed in murine Th1 and Th2 cells and controls Th2-specific expression of the interleukin-5 gene.
Zhang DH, Cohn L, Ray P, Bottomly K, Ray A.
J Biol Chem. 1997 Aug 22;272(34):21597-603.
PMID 9261181
 
Differential responsiveness of the IL-5 and IL-4 genes to transcription factor GATA-3.
Zhang DH, Yang L, Ray A.
J Immunol. 1998 Oct 15;161(8):3817-21.
PMID 9780145
 
The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells.
Zheng W, Flavell RA.
Cell. 1997 May 16;89(4):587-96.
PMID 9160750
 
Conditional deletion of Gata3 shows its essential function in T(H)1-T(H)2 responses.
Zhu J, Min B, Hu-Li J, Watson CJ, Grinberg A, Wang Q, Killeen N, Urban JF Jr, Guo L, Paul WE.
Nat Immunol. 2004 Nov;5(11):1157-65. Epub 2004 Oct 10.
PMID 15475959
 

Citation

This paper should be referenced as such :
Tremblay, M ; Bouchard, M
GATA3 (GATA binding protein 3)
Atlas Genet Cytogenet Oncol Haematol. 2012;16(5):342-346.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Genes/GATA3ID107ch10p14.html


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 4 ]
  Pediatric T-Cell Acute Lymphoblastic Leukemia
Early T-cell precursor acute lymphoblastic leukemia
inv(16)(p13q24) CBFA2T3/GLIS2
Pediatric T-Cell Acute Lymphoblastic Leukemia


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 3 ]
  Breast: Ductal carcinoma
Male breast cancer
t(2;10)(p24;p14) RHOB/GATA3


External links

Nomenclature
Cards
AtlasGATA3ID107ch10p14.txt
Aliases
Genomic and cartography
Gene and transcription
RefSeq transcript (Entrez)
RefSeq genomic (Entrez)
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)2625
Protein : pattern, domain, 3D structure
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Protein Interaction databases
Ontologies - Pathways
Clinical trials, drugs, therapy
Miscellaneous
canSAR (ICR) (select the gene name)
Other databasehttp://cancergenome.broadinstitute.org/index.php?tgene=GATA3
Probes
Litterature
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed


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