A1CF (APOBEC1 complementation factor)

2017-04-01  

Identity

HGNC
LOCATION
10q11.23
LOCUSID
ALIAS
ACF,ACF64,ACF65,APOBEC1CF,ASP
FUSION GENES

Other Information

Locus ID:

NCBI: 29974
MIM: 618199
HGNC: 24086
Ensembl: ENSG00000148584

Variants:

dbSNP: 29974
ClinVar: 29974
TCGA: ENSG00000148584
COSMIC: A1CF

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000148584ENST00000282641Q9NQ94
ENSG00000148584ENST00000282641A0A024QZJ5
ENSG00000148584ENST00000373993Q9NQ94
ENSG00000148584ENST00000373993A0A024QZM7
ENSG00000148584ENST00000373995Q9NQ94
ENSG00000148584ENST00000373995A0A024QZI9
ENSG00000148584ENST00000373997Q9NQ94
ENSG00000148584ENST00000373997A0A024QZJ5
ENSG00000148584ENST00000374001Q9NQ94
ENSG00000148584ENST00000374001A0A024QZJ5
ENSG00000148584ENST00000395489F8W9F8
ENSG00000148584ENST00000395495Q9NQ94
ENSG00000148584ENST00000395495A0A024QZI9
ENSG00000148584ENST00000414883Q5T0W7

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
mRNA EditingREACTOMER-HSA-75072
mRNA Editing: C to U ConversionREACTOMER-HSA-72200
Formation of the EditosomeREACTOMER-HSA-75094

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
151483972004The structure of a yeast RNA-editing deaminase provides insight into the fold and function of activation-induced deaminase and APOBEC-1.36
160557342005Targeted deletion of the murine apobec-1 complementation factor (acf) gene results in embryonic lethality.26
259025382015Identification of DNA cleavage- and recombination-specific hnRNP cofactors for activation-induced cytidine deaminase.10
199320862010The expression of apoB mRNA editing factors is not the sole determinant for the induction of editing in differentiating Caco-2 cells.3
286794522017Interaction of the GCKR and A1CF loci with alcohol consumption to influence the risk of gout.3
311860642019Inhibition of the aberrant A1CF-FAM224A-miR-590-3p-ZNF143 positive feedback loop attenuated malignant biological behaviors of glioma cells.2
272319082016EIYMNVPV Motif is Essential for A1CF Nucleus Localization and A1CF (-8aa) Promotes Proliferation of MDA-MB-231 Cells via Up-Regulation of IL-6.1
308250952019A1CF-Axin2 signal axis regulates apoptosis and migration in Wilms tumor-derived cells through Wnt/β-catenin pathway.1

Citation

Dessen P

A1CF (APOBEC1 complementation factor)

Atlas Genet Cytogenet Oncol Haematol. 2017-04-01

Online version: http://atlasgeneticsoncology.org/gene/56761/a1cf