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A2M (alpha-2-macroglobulin)

Identity

Other namesCPAMD5
DKFZp779B086
FWP007
S863-7
HGNC (Hugo) A2M
Location 12p13.31
Location_base_pair Starts at 9111571 and ends at 9159825 bp from pter ( according to hg18-March_2006)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)A2M   7
Entrez_Gene (NCBI)A2M  2  alpha-2-macroglobulin
Cards
GeneCards (Weizmann)A2M
Ensembl (Hinxton)ENSG00000175899 [Gene_View]  A2M [Vega]
AceView (NCBI)A2M
Genatlas (Paris)A2M
euGene (Indiana)2
SOURCE (Stanford)NM_000014
Gene Expression (Array Express) ENSG00000175899
Genomic and cartography
GoldenPath (UCSC)A2M  -  12p13.31   chr12:9111571-9159825 -  12p13.31   [Description]    (hg18-March_2006)
EnsemblA2M - 12p13.31 [CytoView]
Mapping of homologs : NCBIA2M [Mapview]
OMIM103950   104300   
Gene and transcription
Gene : Genbank (Entrez)AB209614 AK307832 AK312482 AY591530 BC026246
Reference sequence (RefSeq transcript) :SRSNM_000014
Reference transcript : EntrezNM_000014
RefSeq genomic : SRSAC_000055 AC_000144 NC_000012 NG_011717 NT_009714 NW_001838051 NW_925295
RefSeq genomic : EntrezAC_000055 AC_000144 NC_000012 NG_011717 NT_009714 NW_001838051 NW_925295
Consensus coding sequences : CCDS NCBIA2M
Cluster EST : UnigeneHs.212838 [ SRS ] Hs.212838 [ NCBI ]
Alternative Splicing : Fast-db (Paris)2203
Protein : pattern, domain, 3D structure
Protein : UniProt/SwissProtP01023 (SRS) P01023 (Expasy) P01023 (Uniprot)
With graphics : InterProP01023
Splice isoforms : VarSplice FASTAP01023(VarSplice FASTA)
Domaine pattern : Prosite (SRS)ALPHA_2_MACROGLOBULIN (PS00477)   
Domain pattern : Prosite (Expaxy)ALPHA_2_MACROGLOBULIN (PS00477)   
Domains : Interpro (SRS)A-macroglobulin_rcpt-bd    A2M_comp    A2M_N    A2M_N_2    MacrogloblnA2    MacrogloblnA2_CS    MacrogloblnA2_thiol-ester-bond    Terpenoid_cyclase/PrenylTrfase    TonB_box_CS   
Domains : Interpro (EBI)A-macroglobulin_rcpt-bd    A2M_comp    A2M_N    A2M_N_2    MacrogloblnA2    MacrogloblnA2_CS    MacrogloblnA2_thiol-ester-bond    Terpenoid_cyclase/PrenylTrfase    TonB_box_CS   
Related proteins : CluSTrP01023
Domain families : Pfam SRSA2M (PF00207)    A2M_comp (PF07678)    A2M_N (PF01835)    A2M_N_2 (PF07703)    A2M_recep (PF07677)    Thiol-ester_cl (PF10569)   
Domain families : Pfam SangerA2M (PF00207)    A2M_comp (PF07678)    A2M_N (PF01835)    A2M_N_2 (PF07703)    A2M_recep (PF07677)    Thiol-ester_cl (PF10569)   
Domain families : Pfam NCBIpfam00207    pfam07678    pfam01835    pfam07703    pfam07677    pfam10569   
Blocks (Seattle)P01023
Crystal structure of protein : PDB SRS1BV8    2P9R   
Crystal structure of protein : PDBSum1BV8    2P9R   
Crystal structure of protein : IMB1BV8    2P9R   
Crystal structure of protein : PDB RSDB1BV8    2P9R   
HPRD00072
Protein Interaction databases
DIP (DOE-UCLA)P01023
IntAct (EBI)P01023
Polymorphism : SNP, mutations, diseases
Single Nucleotide Polymorphism (SNP) : dbSNP NCBIA2M
SNP : GeneSNP UtahA2M
SNP : HGBaseA2M
Genetic variants : HAPMAPA2M
Somatic Mutations in Cancer : COSMICA2M 
Mutations and Diseases : HGMDA2M
Hereditary diseases : OMIM103950    104300   
Hereditary diseases : GENETests103950    104300   
Diseases : Genetic AssociationA2M
General knowledge
Homologs : HomoloGeneA2M
Homology/Alignments : Family Browser UCSCA2M
Phylogenetic Trees/Animal Genes : TreeFamA2M
Chemical/Protein Interactions : CTD2
Keywords Ontology : AmiGOnegative regulation of complement activation, lectin pathway  serine-type endopeptidase inhibitor activity  extracellular region  extracellular region  extracellular space  acute-phase response  response to nutrient  response to carbon dioxide  enzyme binding  interleukin-8 binding  interleukin-1 binding  platelet alpha granule lumen  tumor necrosis factor binding  response to glucocorticoid stimulus  
Keywords Ontology : EGO-EBInegative regulation of complement activation, lectin pathway  serine-type endopeptidase inhibitor activity  extracellular region  extracellular region  extracellular space  acute-phase response  response to nutrient  response to carbon dioxide  enzyme binding  interleukin-8 binding  interleukin-1 binding  platelet alpha granule lumen  tumor necrosis factor binding  response to glucocorticoid stimulus  
Pathways : BIOCARTA
Pathways : KEGG
Other databases
Probes
Probes : ImagenesA2M Related clones (RZPD - Berlin)
Literature
PubMed142 Pubmed reference(s) in Entrez
PubGeneA2M
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated03-2009Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Feb 27 10:44:51 CET 2010
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