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A2ML1 (alpha-2-macroglobulin like 1)

Identity

Alias_namesCPAMD9
C3 and PZP-like, alpha-2-macroglobulin domain containing 9
Alias_symbol (synonym)FLJ25179
Other aliasp170
HGNC (Hugo) A2ML1
LocusID (NCBI) 144568
Atlas_Id 60005
Location 12p13.31  [Link to chromosome band 12p13]
Location_base_pair Starts at 8845004 and ends at 8876781 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
A2ML1 (12p13.31) / PHC1 (12p13.31)A2ML1 (12p13.31) / SNX29 (16p13.13)CD163 (12p13.31) / A2ML1 (12p13.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)A2ML1   23336
Cards
Entrez_Gene (NCBI)A2ML1  144568  alpha-2-macroglobulin like 1
AliasesCPAMD9; p170
GeneCards (Weizmann)A2ML1
Ensembl hg19 (Hinxton)ENSG00000166535 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000166535 [Gene_View]  chr12:8845004-8876781 [Contig_View]  A2ML1 [Vega]
ICGC DataPortalENSG00000166535
TCGA cBioPortalA2ML1
AceView (NCBI)A2ML1
Genatlas (Paris)A2ML1
WikiGenes144568
SOURCE (Princeton)A2ML1
Genetics Home Reference (NIH)A2ML1
Genomic and cartography
GoldenPath hg38 (UCSC)A2ML1  -     chr12:8845004-8876781 +  12p13.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)A2ML1  -     12p13.31   [Description]    (hg19-Feb_2009)
EnsemblA2ML1 - 12p13.31 [CytoView hg19]  A2ML1 - 12p13.31 [CytoView hg38]
Mapping of homologs : NCBIA2ML1 [Mapview hg19]  A2ML1 [Mapview hg38]
OMIM610627   
Gene and transcription
Genbank (Entrez)AK057908 AK096448 AK122624 AK123591 AK123592
RefSeq transcript (Entrez)NM_001282424 NM_144670
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)A2ML1
Cluster EST : UnigeneHs.620532 [ NCBI ]
CGAP (NCI)Hs.620532
Alternative Splicing GalleryENSG00000166535
Gene ExpressionA2ML1 [ NCBI-GEO ]   A2ML1 [ EBI - ARRAY_EXPRESS ]   A2ML1 [ SEEK ]   A2ML1 [ MEM ]
Gene Expression Viewer (FireBrowse)A2ML1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)144568
GTEX Portal (Tissue expression)A2ML1
Protein : pattern, domain, 3D structure
UniProt/SwissProtA8K2U0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtA8K2U0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProA8K2U0
Splice isoforms : SwissVarA8K2U0
PhosPhoSitePlusA8K2U0
Domaine pattern : Prosite (Expaxy)ALPHA_2_MACROGLOBULIN (PS00477)   
Domains : Interpro (EBI)A-macroglobulin_rcpt-bd    A2M_comp    A2M_N    A2M_N_2    Ig_E-set    Macroglobln_a2    MacrogloblnA2_CS    MacrogloblnA2_thiol-ester-bond    Terpenoid_cyclase/PrenylTrfase   
Domain families : Pfam (Sanger)A2M (PF00207)    A2M_comp (PF07678)    A2M_N (PF01835)    A2M_N_2 (PF07703)    A2M_recep (PF07677)    Thiol-ester_cl (PF10569)   
Domain families : Pfam (NCBI)pfam00207    pfam07678    pfam01835    pfam07703    pfam07677    pfam10569   
Domain families : Smart (EMBL)A2M (SM01360)  A2M_N_2 (SM01359)  A2M_recep (SM01361)  
Conserved Domain (NCBI)A2ML1
DMDM Disease mutations144568
Blocks (Seattle)A2ML1
SuperfamilyA8K2U0
Human Protein AtlasENSG00000166535
Peptide AtlasA8K2U0
HPRD08684
IPIIPI00419215   IPI01010670   IPI01010684   IPI01014551   IPI01015019   IPI01015381   
Protein Interaction databases
DIP (DOE-UCLA)A8K2U0
IntAct (EBI)A8K2U0
FunCoupENSG00000166535
BioGRIDA2ML1
STRING (EMBL)A2ML1
ZODIACA2ML1
Ontologies - Pathways
QuickGOA8K2U0
Ontology : AmiGOserine-type endopeptidase inhibitor activity  extracellular space  negative regulation of endopeptidase activity  peptidase inhibitor activity  regulation of endopeptidase activity  extracellular exosome  
Ontology : EGO-EBIserine-type endopeptidase inhibitor activity  extracellular space  negative regulation of endopeptidase activity  peptidase inhibitor activity  regulation of endopeptidase activity  extracellular exosome  
NDEx NetworkA2ML1
Atlas of Cancer Signalling NetworkA2ML1
Wikipedia pathwaysA2ML1
Orthology - Evolution
OrthoDB144568
GeneTree (enSembl)ENSG00000166535
Phylogenetic Trees/Animal Genes : TreeFamA2ML1
HOVERGENA8K2U0
HOGENOMA8K2U0
Homologs : HomoloGeneA2ML1
Homology/Alignments : Family Browser (UCSC)A2ML1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerA2ML1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)A2ML1
dbVarA2ML1
ClinVarA2ML1
1000_GenomesA2ML1 
Exome Variant ServerA2ML1
ExAC (Exome Aggregation Consortium)A2ML1 (select the gene name)
Genetic variants : HAPMAP144568
Genomic Variants (DGV)A2ML1 [DGVbeta]
DECIPHERA2ML1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisA2ML1 
Mutations
ICGC Data PortalA2ML1 
TCGA Data PortalA2ML1 
Broad Tumor PortalA2ML1
OASIS PortalA2ML1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICA2ML1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDA2ML1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch A2ML1
DgiDB (Drug Gene Interaction Database)A2ML1
DoCM (Curated mutations)A2ML1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)A2ML1 (select a term)
intoGenA2ML1
Cancer3DA2ML1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610627   
Orphanet206   
MedgenA2ML1
Genetic Testing Registry A2ML1
NextProtA8K2U0 [Medical]
TSGene144568
GENETestsA2ML1
Target ValidationA2ML1
Huge Navigator A2ML1 [HugePedia]
snp3D : Map Gene to Disease144568
BioCentury BCIQA2ML1
ClinGenA2ML1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD144568
Chemical/Pharm GKB GenePA142670460
Clinical trialA2ML1
Miscellaneous
canSAR (ICR)A2ML1 (select the gene name)
Probes
Litterature
PubMed23 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineA2ML1
EVEXA2ML1
GoPubMedA2ML1
iHOPA2ML1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 15:36:55 CEST 2017

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