Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

AACS (acetoacetyl-CoA synthetase)

Identity

Alias_symbol (synonym)FLJ12389
SUR-5
ACSF1
Other alias
HGNC (Hugo) AACS
LocusID (NCBI) 65985
Atlas_Id 54094
Location 12q24.31  [Link to chromosome band 12q24]
Location_base_pair Starts at 125065367 and ends at 125143333 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
AACS (12q24.31) / FBN1 (15q21.1)AACS (12q24.31) / MAL (2q11.1)PLXND1 (3q22.1) / AACS (12q24.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)AACS   21298
Cards
Entrez_Gene (NCBI)AACS  65985  acetoacetyl-CoA synthetase
AliasesACSF1; SUR-5
GeneCards (Weizmann)AACS
Ensembl hg19 (Hinxton)ENSG00000081760 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000081760 [Gene_View]  chr12:125065367-125143333 [Contig_View]  AACS [Vega]
ICGC DataPortalENSG00000081760
TCGA cBioPortalAACS
AceView (NCBI)AACS
Genatlas (Paris)AACS
WikiGenes65985
SOURCE (Princeton)AACS
Genetics Home Reference (NIH)AACS
Genomic and cartography
GoldenPath hg38 (UCSC)AACS  -     chr12:125065367-125143333 +  12q24.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)AACS  -     12q24.31   [Description]    (hg19-Feb_2009)
EnsemblAACS - 12q24.31 [CytoView hg19]  AACS - 12q24.31 [CytoView hg38]
Mapping of homologs : NCBIAACS [Mapview hg19]  AACS [Mapview hg38]
OMIM614364   
Gene and transcription
Genbank (Entrez)AB054121 AK022451 AK022740 AK024036 AK024760
RefSeq transcript (Entrez)NM_001319839 NM_001319840 NM_023928
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)AACS
Cluster EST : UnigeneHs.656073 [ NCBI ]
CGAP (NCI)Hs.656073
Alternative Splicing GalleryENSG00000081760
Gene ExpressionAACS [ NCBI-GEO ]   AACS [ EBI - ARRAY_EXPRESS ]   AACS [ SEEK ]   AACS [ MEM ]
Gene Expression Viewer (FireBrowse)AACS [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)65985
GTEX Portal (Tissue expression)AACS
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ86V21   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ86V21  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ86V21
Splice isoforms : SwissVarQ86V21
Catalytic activity : Enzyme6.2.1.16 [ Enzyme-Expasy ]   6.2.1.166.2.1.16 [ IntEnz-EBI ]   6.2.1.16 [ BRENDA ]   6.2.1.16 [ KEGG ]   
PhosPhoSitePlusQ86V21
Domaine pattern : Prosite (Expaxy)AMP_BINDING (PS00455)   
Domains : Interpro (EBI)Acac_CoA_synth    ACAS_N    AMP-binding_CS    AMP-dep_Synth/Lig   
Domain families : Pfam (Sanger)ACAS_N (PF16177)    AMP-binding (PF00501)   
Domain families : Pfam (NCBI)pfam16177    pfam00501   
Conserved Domain (NCBI)AACS
DMDM Disease mutations65985
Blocks (Seattle)AACS
SuperfamilyQ86V21
Human Protein AtlasENSG00000081760
Peptide AtlasQ86V21
HPRD12391
IPIIPI00217272   IPI00646775   IPI00789348   IPI00334184   IPI01014497   IPI00908814   IPI01012758   IPI01013962   IPI01013178   IPI01012587   IPI01011608   IPI01011295   
Protein Interaction databases
DIP (DOE-UCLA)Q86V21
IntAct (EBI)Q86V21
FunCoupENSG00000081760
BioGRIDAACS
STRING (EMBL)AACS
ZODIACAACS
Ontologies - Pathways
QuickGOQ86V21
Ontology : AmiGOliver development  protein binding  ATP binding  cytosol  fatty acid metabolic process  response to nutrient  response to purine-containing compound  acetoacetate-CoA ligase activity  positive regulation of insulin secretion  response to oleic acid  response to drug  response to starvation  response to ethanol  ketone body biosynthetic process  butyrate-CoA ligase activity  white fat cell differentiation  adipose tissue development  cellular response to glucose stimulus  cellular response to testosterone stimulus  cellular response to cholesterol  
Ontology : EGO-EBIliver development  protein binding  ATP binding  cytosol  fatty acid metabolic process  response to nutrient  response to purine-containing compound  acetoacetate-CoA ligase activity  positive regulation of insulin secretion  response to oleic acid  response to drug  response to starvation  response to ethanol  ketone body biosynthetic process  butyrate-CoA ligase activity  white fat cell differentiation  adipose tissue development  cellular response to glucose stimulus  cellular response to testosterone stimulus  cellular response to cholesterol  
Pathways : KEGGButanoate metabolism   
NDEx NetworkAACS
Atlas of Cancer Signalling NetworkAACS
Wikipedia pathwaysAACS
Orthology - Evolution
OrthoDB65985
GeneTree (enSembl)ENSG00000081760
Phylogenetic Trees/Animal Genes : TreeFamAACS
HOVERGENQ86V21
HOGENOMQ86V21
Homologs : HomoloGeneAACS
Homology/Alignments : Family Browser (UCSC)AACS
Gene fusions - Rearrangements
Fusion : MitelmanAACS/MAL [12q24.31/2q11.1]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerAACS [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)AACS
dbVarAACS
ClinVarAACS
1000_GenomesAACS 
Exome Variant ServerAACS
ExAC (Exome Aggregation Consortium)AACS (select the gene name)
Genetic variants : HAPMAP65985
Genomic Variants (DGV)AACS [DGVbeta]
DECIPHERAACS [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisAACS 
Mutations
ICGC Data PortalAACS 
TCGA Data PortalAACS 
Broad Tumor PortalAACS
OASIS PortalAACS [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICAACS  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDAACS
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch AACS
DgiDB (Drug Gene Interaction Database)AACS
DoCM (Curated mutations)AACS (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)AACS (select a term)
intoGenAACS
Cancer3DAACS(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM614364   
Orphanet
MedgenAACS
Genetic Testing Registry AACS
NextProtQ86V21 [Medical]
TSGene65985
GENETestsAACS
Target ValidationAACS
Huge Navigator AACS [HugePedia]
snp3D : Map Gene to Disease65985
BioCentury BCIQAACS
ClinGenAACS
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD65985
Chemical/Pharm GKB GenePA134940696
Clinical trialAACS
Miscellaneous
canSAR (ICR)AACS (select the gene name)
Probes
Litterature
PubMed11 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineAACS
EVEXAACS
GoPubMedAACS
iHOPAACS
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:22:13 CEST 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.