AAK1 (AP2 associated kinase 1)

2006-10-01  

Identity

HGNC
LOCATION
2p13.3
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 22848
MIM: 616405
HGNC: 19679
Ensembl: ENSG00000115977

Variants:

dbSNP: 22848
ClinVar: 22848
TCGA: ENSG00000115977
COSMIC: AAK1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000115977ENST00000406297Q2M2I8
ENSG00000115977ENST00000409068E9PG46
ENSG00000115977ENST00000409085Q2M2I8
ENSG00000115977ENST00000606389A0A096LP25
ENSG00000115977ENST00000623317A0A096LNZ0
ENSG00000115977ENST00000624900A0A096LP60

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Clathrin-mediated endocytosisREACTOMER-HSA-8856828
Cargo recognition for clathrin-mediated endocytosisREACTOMER-HSA-8856825

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
197726292009Genomewide association study for onset age in Parkinson disease.41
268539402016Family-wide Structural Analysis of Human Numb-Associated Protein Kinases.32
256534442015AP-2-associated protein kinase 1 and cyclin G-associated kinase regulate hepatitis C virus entry and are potential drug targets.27
174948692007A novel AAK1 splice variant functions at multiple steps of the endocytic pathway.20
214641242011The adaptor-associated kinase 1, AAK1, is a positive regulator of the Notch pathway.17
258521902015Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy.12
306056882019WNT Activates the AAK1 Kinase to Promote Clathrin-Mediated Endocytosis of LRP6 and Establish a Negative Feedback Loop.5

Citation

Dessen P

AAK1 (AP2 associated kinase 1)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43099/aak1