Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

AATK (apoptosis associated tyrosine kinase)

Identity

Alias (NCBI)AATYK
AATYK1
LMR1
LMTK1
PPP1R77
p35BP
HGNC (Hugo) AATK
HGNC Alias symbAATYK
KIAA0641
LMTK1
LMR1
AATYK1
PPP1R77
HGNC Alias namelemur tyrosine kinase 1
 protein phosphatase 1, regulatory subunit 77
LocusID (NCBI) 9625
Atlas_Id 43100
Location 17q25.3  [Link to chromosome band 17q25]
Location_base_pair Starts at 81117296 and ends at 81131948 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AATK (17q25.3) / LAMA5 (20q13.33)AATK (17q25.3) / USP32 (17q23.1)LAMA5 (20q13.33) / AATK (17q25.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)AATK   21
Cards
Entrez_Gene (NCBI)AATK    apoptosis associated tyrosine kinase
AliasesAATYK; AATYK1; LMR1; LMTK1; 
PPP1R77; p35BP
GeneCards (Weizmann)AATK
Ensembl hg19 (Hinxton)ENSG00000181409 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000181409 [Gene_View]  ENSG00000181409 [Sequence]  chr17:81117296-81131948 [Contig_View]  AATK [Vega]
ICGC DataPortalENSG00000181409
TCGA cBioPortalAATK
AceView (NCBI)AATK
Genatlas (Paris)AATK
SOURCE (Princeton)AATK
Genetics Home Reference (NIH)AATK
Genomic and cartography
GoldenPath hg38 (UCSC)AATK  -     chr17:81117296-81131948 -  17q25.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)AATK  -     17q25.3   [Description]    (hg19-Feb_2009)
GoldenPathAATK - 17q25.3 [CytoView hg19]  AATK - 17q25.3 [CytoView hg38]
ImmunoBaseENSG00000181409
Genome Data Viewer NCBIAATK [Mapview hg19]  
OMIM605276   
Gene and transcription
Genbank (Entrez)AB014541 AK094931 AK131395 AK131529 AK309099
RefSeq transcript (Entrez)NM_001080395 NM_004920
Consensus coding sequences : CCDS (NCBI)AATK
Gene ExpressionAATK [ NCBI-GEO ]   AATK [ EBI - ARRAY_EXPRESS ]   AATK [ SEEK ]   AATK [ MEM ]
Gene Expression Viewer (FireBrowse)AATK [ Firebrowse - Broad ]
GenevisibleExpression of AATK in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9625
GTEX Portal (Tissue expression)AATK
Human Protein AtlasENSG00000181409-AATK [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6ZMQ8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6ZMQ8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6ZMQ8
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ6ZMQ8
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_TYR (PS00109)   
Domains : Interpro (EBI)Kinase-like_dom_sf    LMTK1_c    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser-Thr/Tyr_kinase_cat_dom    Tyr_kinase_AS   
Domain families : Pfam (Sanger)PK_Tyr_Ser-Thr (PF07714)   
Domain families : Pfam (NCBI)pfam07714   
Conserved Domain (NCBI)AATK
SuperfamilyQ6ZMQ8
AlphaFold pdb e-kbQ6ZMQ8   
Human Protein Atlas [tissue]ENSG00000181409-AATK [tissue]
HPRD05591
Protein Interaction databases
DIP (DOE-UCLA)Q6ZMQ8
IntAct (EBI)Q6ZMQ8
BioGRIDAATK
STRING (EMBL)AATK
ZODIACAATK
Ontologies - Pathways
QuickGOQ6ZMQ8
Ontology : AmiGOprotein kinase activity  protein tyrosine kinase activity  protein binding  ATP binding  cellular_component  protein phosphorylation  brain development  biological_process  integral component of membrane  peptidyl-tyrosine autophosphorylation  perinuclear region of cytoplasm  protein serine kinase activity  protein threonine kinase activity  
Ontology : EGO-EBIprotein kinase activity  protein tyrosine kinase activity  protein binding  ATP binding  cellular_component  protein phosphorylation  brain development  biological_process  integral component of membrane  peptidyl-tyrosine autophosphorylation  perinuclear region of cytoplasm  protein serine kinase activity  protein threonine kinase activity  
NDEx NetworkAATK
Atlas of Cancer Signalling NetworkAATK
Wikipedia pathwaysAATK
Orthology - Evolution
OrthoDB9625
GeneTree (enSembl)ENSG00000181409
Phylogenetic Trees/Animal Genes : TreeFamAATK
Homologs : HomoloGeneAATK
Homology/Alignments : Family Browser (UCSC)AATK
Gene fusions - Rearrangements
Fusion : MitelmanAATK/LAMA5 [17q25.3/20q13.33]  
Fusion : MitelmanAATK/USP32 [17q25.3/17q23.1]  
Fusion : MitelmanLAMA5/AATK [20q13.33/17q25.3]  
Fusion : QuiverAATK
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerAATK [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)AATK
dbVarAATK
ClinVarAATK
MonarchAATK
1000_GenomesAATK 
Exome Variant ServerAATK
GNOMAD BrowserENSG00000181409
Varsome BrowserAATK
ACMGAATK variants
VarityQ6ZMQ8
Genomic Variants (DGV)AATK [DGVbeta]
DECIPHERAATK [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisAATK 
Mutations
ICGC Data PortalAATK 
TCGA Data PortalAATK 
Broad Tumor PortalAATK
OASIS PortalAATK [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICAATK  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DAATK
Mutations and Diseases : HGMDAATK
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaAATK
DgiDB (Drug Gene Interaction Database)AATK
DoCM (Curated mutations)AATK
CIViC (Clinical Interpretations of Variants in Cancer)AATK
Cancer3DAATK
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605276   
Orphanet
DisGeNETAATK
MedgenAATK
Genetic Testing Registry AATK
NextProtQ6ZMQ8 [Medical]
GENETestsAATK
Target ValidationAATK
Huge Navigator AATK [HugePedia]
ClinGenAATK
Clinical trials, drugs, therapy
MyCancerGenomeAATK
Protein Interactions : CTDAATK
Pharm GKB GenePA24370
PharosQ6ZMQ8
Clinical trialAATK
Miscellaneous
canSAR (ICR)AATK
HarmonizomeAATK
DataMed IndexAATK
Probes
Litterature
PubMed27 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXAATK
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 14:57:57 CEST 2021

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.