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ABCC10 (ATP-binding cassette, sub-family C (CFTR/MRP), member 10)

Written2014-04Elizabeth Hopper-Borge, Natalya Domanitskaya
Fox Chase Cancer Center, Developmental Therapeutics Program, Philadelphia, PA, USA

(Note : for Links provided by Atlas : click)


Alias (NCBI)EST182763
HGNC (Hugo) ABCC10
HGNC Alias symbEST182763
HGNC Previous nameATP-binding cassette, sub-family C (CFTR/MRP), member 10
LocusID (NCBI) 89845
Atlas_Id 47655
Location 6p21.1  [Link to chromosome band 6p21]
Location_base_pair Starts at 43431751 and ends at 43450425 bp from pter ( according to GRCh38/hg38-Dec_2013)  [Mapping ABCC10.png]
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ABCC10 (6p21.1)::CUL9 (6p21.1)ABCC10 (6p21.1)::MAN2A2 (15q26.1)ABCC10 (6p21.1)::PGBD5 (1q42.13)
ABCC10 (6p21.1)::PPP2R5D (6p21.1)


Note Contains 22 exons and 21 introns (Kao et al., 2003).
Description The gene encompasses 23065 bases.
Transcription Transcript is 744 bps, and has 10 splice variants.

In normal tissue
A study of the ABCC10 promoter revealed that the presence of E2F and Sp1 sites are required for maximum transcription. In addition other elements were found in the promoter including: cAMP-responsive element binding protein, estrogen receptor binding site, hepatic nuclear factor, progesterone receptor binding site, and sterol regulatory element binding protein (Dabrowska and Sirotnak, 2004).
ABCC10 transcript is widespread at low levels (Hopper et al., 2001; Maher et al., 2005) with highest expression in the pancreas. Decreased expression is observed in activated resting T and B cells (Takayanagi et al., 2004).

In cancer
In cell lines: In terms of cancer, the ABCC10 gene is expressed in human tumor cell lines, HepG2, CWR22RV1 and TSU-PR1 at greater or equal levels than ABCC1, ABCC2 and ABCC3. Novel ABCC10 transcripts have been identified in HepG2, and CWR22RV1 cells. These transcripts are heterogeneic and imply complexity in the exons and introns of this region (Dabrowska and Sirotnak, 2004).
In breast cancer: ABCC10 transcript is upregulated in breast tumors treated with 5-fluorouracil, anthracycline, cyclophosphamide or taxane based neoadjuvant chemotherapy in comparison with normal tissue. Further, ABCC10 transcript expression is associated with ER positive breast cancer (Hlavac et al., 2013).
In acute myeloid leukemia: ABCC10 transcript is also expressed in acute myeloid leukemia (Hu et al., 2011).
In hepatocellular carcinoma: Transcripts from ABCC10 and various other transporters including: ABCB6, ABCC1, ABCC4, ABCC5, and ABCC12 are upregulated in over 50% hepatocellular carcinoma in untreated patients. It was also observed that microRNA let-7a/e is able to downregulate ABCC10 transcript (Borel et al., 2012).


Description Unglycosylated ABCC10 is ~158 kDa (Hopper et al., 2001).
ABCC10, like ABCC1, 2, 3 and 6 (see figure above A) has an N-terminal membrane spanning domain (MSD) that is not present in ABCC4, 5, 11 or 12 (figure above B). All ABCC subfamily members contain two Nucleotide Binding Domains (NBD).
Expression ABCC10 has been detected in various human occular-absorption barrier tissues including, the iris ciliary body, corneal epithelium, conjuntive epithelium, and retina (Chen et al., 2013).
ABCC10 is expressed in cell lines derived from acute myeloid leukemia (Hu et al., 2011).
Localisation Localizes basolaterally in ABCC10-transfected LLC-pK1 cells (Malofeeva et al., 2012).
Function In vitro
ABCC10 transports estrogen β glucuronide, and exhibits modest transport of leukotrienes. Similar to other subfamily members ABCC10 can efflux lipophilic anions (Chen et al., 2003).
ABCC10 is a drug efflux pump that is able to mediate transport of taxanes in vivo. In vitro studies have shown that ABCC10 confers resistance to a variety of hydrophobic drugs, including paclitaxel, docetaxel, vincristine, vinblastine, epothilone B, cytarabine, in a glutathione independent manner (Hopper-Borge et al., 2004; Hopper-Borge et al., 2009)
Prior work has shown that ABCC10 may have a role in natural killer cell mediated lysis. A report demonstrated that a peptide derived from ABCC10 binds to HLA-E and inhibits NK cell-mediated lysis in a CD94 and class I-dependent fashion (Wooden et al., 2005).
ABCC10 ATPase activity is stimulated by estradiol glucuronide, leukotriene, tamoxifen, docetaxel and ARA-C (Malofeeva et al., 2012).

In vivo
Abcc10 protects thymus, spleen and bone marrow when exposed to paclitaxel in vivo. Abcc10 loss promotes loss of white blood cells, increased weight loss and increased lethality in mice exposed to high doses of paclitaxel (Hopper-Borge et al., 2011).

Homology ABCC10 exhibits structural and/or functional homology with other ABC transporters: CFTR, ABCC1, ABCC2, ABCC3, ABCC6. However, ABCC10 shares the lowest amino acid identity (33.8%) to ABCC1 compared to ABCC2, ABCC3, ABCC4, ABCC5 and ABCC6 (Hopper et al., 2001).
ABCC10 is present in many species including: drosophila melanogaster, xenopus, saccharomyces cerevisiae, danio rerio, sus scrofa, mus musculus, latimeria chalumnae, felis catus, bos taurus, tetranychus urticae (Schippert et al., 2008; Dermauw et al., 2013). ABCC10 is present in all placental mammals, similar to other subfamily members, ABCC1, ABCC3, ABCC4-7, and ABCC9 (Moitra and Dean, 2011).

Implicated in

Entity Non small cell lung cancer
Note In vitro cellular resistance in non small cell lung cancer. ABCC10 expression is a predictive biomarker for the resistance to paclitaxel in non-small cell lung cancer (Oguri et al., 2008). ABCC10/MRP7 expression is associated with vinorelbine resistance in non-small cell lung cancer (Bessho et al., 2009). Another study implicated ABCC10 in gemcitabine resistance mechanisms in non small cell carcinoma cell lines (Ikeda et al., 2011).
ABCC10 is overexpressed in NSCLC. The expression of ABCC10 in adenocarcinoma is higher than in squamous cell carcinoma. ABCC10 expression in adenocarcinoma correlates with pathological grades and TNM stages (Wang et al., 2009).
Entity Head and neck cancer
Note Multidrug resistance protein 7 expression is involved in cross-resistance to docetaxel in salivary gland adenocarcinoma cell lines (Naramoto et al., 2007).
Entity Ovarian cancer
Note A ovarian carcinoma xenograft model demonstrated that intermittant docetaxel dosing of tumors promotes upregulation of MRP7 and other drug resistance genes including btubulin III, Akt2, and thioredoxin. However, when the dosing was continuous the various resistance genes did not upregulate (De Souza et al., 2011).
Entity Acute myeloid leukemia
Note ABCC10 may play a role in Ara-C resistance mechanisms in acute myeloid leukemia (Hu et al., 2011). ABCC10 transcript is more highly expressed in childhood AML than in many normal samples (Steinbach et al., 2006).
Entity Breast cancer
Note In metastatic breast cancer, a difference in progression-free survival (PFS) was found between circulating stem cells (CTCs) positive and CTCs-negative patients. PFS was shorter in patients whose CTCs expressed two or more ABCC subfamilies, including ABCC10 (Gradilone et al., 2011).
ABCC10 expression may confer therapeutic resistance in solid breast tumors (submitted, Domanitskaya et al.).
Entity Colorectal cancer
Note An inverse correlation between ABCC10 transcript and tumor aggressiveness and tumor grade severity was found in colorectal cancer (Hlavata et al., 2012).
Entity Human immunodeficiency virus
Note ABCC10 polymorphisms contribute to the development of kidney tubular dysfunction (KTD) in some HIV patients (Giacomet et al., 2013). ABCC10 polymorphisms modulate blood levels of the anti HIV drugs tenofivir, and nevapirine (Pushpakom et al., 2011; Liptrott et al., 2012).
Entity Parkinson's disease
Note ABCC10 inhibits methylmercury-associated animal toxicity and dopaminergic neurodegeneration in Caenorhabditis elegans (Vanduyn and Nass, 2014).


ABCC10/MRP7 is associated with vinorelbine resistance in non-small cell lung cancer.
Bessho Y, Oguri T, Ozasa H, Uemura T, Sakamoto H, Miyazaki M, Maeno K, Sato S, Ueda R.
Oncol Rep. 2009 Jan;21(1):263-8.
PMID 19082471
Diagnostic and therapeutic potential of miRNA signatures in patients with hepatocellular carcinoma.
Borel F, Konstantinova P, Jansen PL.
J Hepatol. 2012 Jun;56(6):1371-83. doi: 10.1016/j.jhep.2011.11.026. Epub 2012 Feb 5. (REVIEW)
PMID 22314424
Expression of efflux transporters in human ocular tissues.
Chen P, Chen H, Zang X, Chen M, Jiang H, Han S, Wu X.
Drug Metab Dispos. 2013 Nov;41(11):1934-48. doi: 10.1124/dmd.113.052704. Epub 2013 Aug 26.
PMID 23979916
Characterization of the transport properties of human multidrug resistance protein 7 (MRP7, ABCC10).
Chen ZS, Hopper-Borge E, Belinsky MG, Shchaveleva I, Kotova E, Kruh GD.
Mol Pharmacol. 2003 Feb;63(2):351-8.
PMID 12527806
Regulation of transcription of the human MRP7 gene. Characteristics of the basal promoter and identification of tumor-derived transcripts encoding additional 5' end heterogeneity.
Dabrowska M, Sirotnak FM.
Gene. 2004 Oct 27;341:129-39.
PMID 15474296
Chemotherapy dosing schedule influences drug resistance development in ovarian cancer.
De Souza R, Zahedi P, Badame RM, Allen C, Piquette-Miller M.
Mol Cancer Ther. 2011 Jul;10(7):1289-99. doi: 10.1158/1535-7163.MCT-11-0058. Epub 2011 May 6.
PMID 21551263
A burst of ABC genes in the genome of the polyphagous spider mite Tetranychus urticae.
Dermauw W, Osborne EJ, Clark RM, Grbic M, Tirry L, Van Leeuwen T.
BMC Genomics. 2013 May 10;14:317. doi: 10.1186/1471-2164-14-317.
PMID 23663308
Tenofovir-induced renal tubular dysfunction in vertically HIV-infected patients associated with polymorphisms in ABCC2, ABCC4 and ABCC10 genes.
Giacomet V, Cattaneo D, Vigano A, Nannini P, Manfredini V, Ramponi G, Clementi E, Zuccotti GV.
Pediatr Infect Dis J. 2013 Oct;32(10):e403-5. doi: 10.1097/INF.0b013e31829e6c9c.
PMID 24067562
Circulating tumor cells (CTCs) in metastatic breast cancer (MBC): prognosis, drug resistance and phenotypic characterization.
Gradilone A, Naso G, Raimondi C, Cortesi E, Gandini O, Vincenzi B, Saltarelli R, Chiapparino E, Spremberg F, Cristofanilli M, Frati L, Agliano AM, Gazzaniga P.
Ann Oncol. 2011 Jan;22(1):86-92. doi: 10.1093/annonc/mdq323. Epub 2010 Jul 5.
PMID 20603432
The expression profile of ATP-binding cassette transporter genes in breast carcinoma.
Hlavac V, Brynychova V, Vaclavikova R, Ehrlichova M, Vrana D, Pecha V, Kozevnikovova R, Trnkova M, Gatek J, Kopperova D, Gut I, Soucek P.
Pharmacogenomics. 2013 Apr;14(5):515-29. doi: 10.2217/pgs.13.26.
PMID 23556449
The role of ABC transporters in progression and clinical outcome of colorectal cancer.
Hlavata I, Mohelnikova-Duchonova B, Vaclavikova R, Liska V, Pitule P, Novak P, Bruha J, Vycital O, Holubec L, Treska V, Vodicka P, Soucek P.
Mutagenesis. 2012 Mar;27(2):187-96. doi: 10.1093/mutage/ger075.
PMID 22294766
Analysis of the structure and expression pattern of MRP7 (ABCC10), a new member of the MRP subfamily.
Hopper E, Belinsky MG, Zeng H, Tosolini A, Testa JR, Kruh GD.
Cancer Lett. 2001 Jan 26;162(2):181-91.
PMID 11146224
Contribution of Abcc10 (Mrp7) to in vivo paclitaxel resistance as assessed in Abcc10(-/-) mice.
Hopper-Borge EA, Churchill T, Paulose C, Nicolas E, Jacobs JD, Ngo O, Kuang Y, Grinberg A, Westphal H, Chen ZS, Klein-Szanto AJ, Belinsky MG, Kruh GD.
Cancer Res. 2011 May 15;71(10):3649-57. doi: 10.1158/0008-5472.CAN-10-3623.
PMID 21576088
Activity of the multikinase inhibitor sorafenib in combination with cytarabine in acute myeloid leukemia.
Hu S, Niu H, Inaba H, Orwick S, Rose C, Panetta JC, Yang S, Pounds S, Fan Y, Calabrese C, Rehg JE, Campana D, Rubnitz JE, Baker SD.
J Natl Cancer Inst. 2011 Jun 8;103(11):893-905. doi: 10.1093/jnci/djr107. Epub 2011 Apr 12.
PMID 21487100
Isolation and characterization of gemcitabine-resistant human non-small cell lung cancer A549 cells.
Ikeda R, Vermeulen LC, Lau E, Jiang Z, Sachidanandam K, Yamada K, Kolesar JM.
Int J Oncol. 2011 Feb;38(2):513-9. doi: 10.3892/ijo.2010.866. Epub 2010 Dec 7.
PMID 21152861
Genomic structure, gene expression, and promoter analysis of human multidrug resistance-associated protein 7.
Kao HH, Chang MS, Cheng JF, Huang JD.
J Biomed Sci. 2003 Jan-Feb;10(1):98-110.
PMID 12566991
Association of ABCC10 polymorphisms with nevirapine plasma concentrations in the German Competence Network for HIV/AIDS.
Liptrott NJ, Pushpakom S, Wyen C, Fatkenheuer G, Hoffmann C, Mauss S, Knechten H, Brockmeyer NH, Hopper-Borge E, Siccardi M, Back DJ, Khoo SH, Pirmohamed M, Owen A; German Competence Network for HIV/AIDS.
Pharmacogenet Genomics. 2012 Jan;22(1):10-9. doi: 10.1097/FPC.0b013e32834dd82e.
PMID 22082652
Tissue distribution and hepatic and renal ontogeny of the multidrug resistance-associated protein (Mrp) family in mice.
Maher JM, Slitt AL, Cherrington NJ, Cheng X, Klaassen CD.
Drug Metab Dispos. 2005 Jul;33(7):947-55. Epub 2005 Mar 31.
PMID 15802388
Modulation of the ATPase and transport activities of broad-acting multidrug resistance factor ABCC10 (MRP7).
Malofeeva EV, Domanitskaya N, Gudima M, Hopper-Borge EA.
Cancer Res. 2012 Dec 15;72(24):6457-67. doi: 10.1158/0008-5472.CAN-12-1340. Epub 2012 Oct 19.
PMID 23087055
Evolution of ABC transporters by gene duplication and their role in human disease.
Moitra K, Dean M.
Biol Chem. 2011 Jan;392(1-2):29-37. doi: 10.1515/BC.2011.006. (REVIEW)
PMID 21194360
Multidrug resistance-associated protein 7 expression is involved in cross-resistance to docetaxel in salivary gland adenocarcinoma cell lines.
Naramoto H, Uematsu T, Uchihashi T, Doto R, Matsuura T, Usui Y, Uematsu S, Li X, Takahashi M, Yamaoka M, Furusawa K.
Int J Oncol. 2007 Feb;30(2):393-401.
PMID 17203221
MRP7/ABCC10 expression is a predictive biomarker for the resistance to paclitaxel in non-small cell lung cancer.
Oguri T, Ozasa H, Uemura T, Bessho Y, Miyazaki M, Maeno K, Maeda H, Sato S, Ueda R.
Mol Cancer Ther. 2008 May;7(5):1150-5. doi: 10.1158/1535-7163.MCT-07-2088. Epub 2008 Apr 29.
PMID 18445659
Genetic variants of ABCC10, a novel tenofovir transporter, are associated with kidney tubular dysfunction.
Pushpakom SP, Liptrott NJ, Rodriguez-Novoa S, Labarga P, Soriano V, Albalater M, Hopper-Borge E, Bonora S, Di Perri G, Back DJ, Khoo S, Pirmohamed M, Owen A.
J Infect Dis. 2011 Jul 1;204(1):145-53. doi: 10.1093/infdis/jir215.
PMID 21628669
Microarray analysis of retinal gene expression in chicks during imposed myopic defocus.
Schippert R, Schaeffel F, Feldkaemper MP.
Mol Vis. 2008 Aug 31;14:1589-99.
PMID 18769560
ABCA3 as a possible cause of drug resistance in childhood acute myeloid leukemia.
Steinbach D, Gillet JP, Sauerbrey A, Gruhn B, Dawczynski K, Bertholet V, de Longueville F, Zintl F, Remacle J, Efferth T.
Clin Cancer Res. 2006 Jul 15;12(14 Pt 1):4357-63.
PMID 16857811
The high turnover Drosophila multidrug resistance-associated protein shares the biochemical features of its human orthologues.
Szeri F, Ilias A, Pomozi V, Robinow S, Bakos E, Varadi A.
Biochim Biophys Acta. 2009 Feb;1788(2):402-9. doi: 10.1016/j.bbamem.2008.11.007. Epub 2008 Nov 20.
PMID 19059376
Human ATP-binding cassette transporter ABCC10: expression profile and p53-dependent upregulation.
Takayanagi S, Kataoka T, Ohara O, Oishi M, Kuo MT, Ishikawa T.
J Exp Ther Oncol. 2004 Oct;4(3):239-46.
PMID 15724843
The putative multidrug resistance protein MRP-7 inhibits methylmercury-associated animal toxicity and dopaminergic neurodegeneration in Caenorhabditis elegans.
VanDuyn N, Nass R.
J Neurochem. 2014 Mar;128(6):962-74. doi: 10.1111/jnc.12515. Epub 2013 Nov 25.
PMID 24266639
Expression and Clinical Significance of ABCC10 in the Patients with Non-small Cell Lung Cancer.
Wang P, Zhang Z, Gao K, Deng Y, Zhao J, Liu B, Li X.
Zhongguo Fei Ai Za Zhi. 2009 Aug 20;12(8):875-8. doi: 10.3779/j.issn.1009-3419.2009.08.08.
PMID 20719174
Cutting edge: HLA-E binds a peptide derived from the ATP-binding cassette transporter multidrug resistance-associated protein 7 and inhibits NK cell-mediated lysis.
Wooden SL, Kalb SR, Cotter RJ, Soloski MJ.
J Immunol. 2005 Aug 1;175(3):1383-7.
PMID 16034073


This paper should be referenced as such :
E Hopper-Borge, N Domanitskaya
ABCC10 (ATP-binding cassette, sub-family C (CFTR/MRP), member 10)
Atlas Genet Cytogenet Oncol Haematol. 2014;18(12):928-931.
Free journal version : [ pdf ]   [ DOI ]

External links


HGNC (Hugo)ABCC10   52
Atlas Explorer : (Salamanque)ABCC10
Entrez_Gene (NCBI)ABCC10    ATP binding cassette subfamily C member 10
AliasesEST182763; MRP7; SIMRP7
GeneCards (Weizmann)ABCC10
Ensembl hg19 (Hinxton)ENSG00000124574 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000124574 [Gene_View]  ENSG00000124574 [Sequence]  chr6:43431751-43450425 [Contig_View]  ABCC10 [Vega]
ICGC DataPortalENSG00000124574
TCGA cBioPortalABCC10
AceView (NCBI)ABCC10
Genatlas (Paris)ABCC10
SOURCE (Princeton)ABCC10
Genetics Home Reference (NIH)ABCC10
Genomic and cartography
GoldenPath hg38 (UCSC)ABCC10  -     chr6:43431751-43450425 +  6p21.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ABCC10  -     6p21.1   [Description]    (hg19-Feb_2009)
GoldenPathABCC10 - 6p21.1 [CytoView hg19]  ABCC10 - 6p21.1 [CytoView hg38]
Genome Data Viewer NCBIABCC10 [Mapview hg19]  
Gene and transcription
Genbank (Entrez)AK000002 AK024446 AL122095 AL133613 AY032599
RefSeq transcript (Entrez)NM_001198934 NM_001350518 NM_033450
Consensus coding sequences : CCDS (NCBI)ABCC10
Gene ExpressionABCC10 [ NCBI-GEO ]   ABCC10 [ EBI - ARRAY_EXPRESS ]   ABCC10 [ SEEK ]   ABCC10 [ MEM ]
Gene Expression Viewer (FireBrowse)ABCC10 [ Firebrowse - Broad ]
GenevisibleExpression of ABCC10 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)89845
GTEX Portal (Tissue expression)ABCC10
Human Protein AtlasENSG00000124574-ABCC10 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ5T3U5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ5T3U5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ5T3U5
Domaine pattern : Prosite (Expaxy)ABC_TM1F (PS50929)    ABC_TRANSPORTER_1 (PS00211)    ABC_TRANSPORTER_2 (PS50893)   
Domains : Interpro (EBI)AAA+_ATPase    ABC1_TM_dom    ABC1_TM_sf    ABC_transporter-like    ABC_transporter_CS    P-loop_NTPase   
Domain families : Pfam (Sanger)ABC_membrane (PF00664)    ABC_tran (PF00005)   
Domain families : Pfam (NCBI)pfam00664    pfam00005   
Domain families : Smart (EMBL)AAA (SM00382)  
Conserved Domain (NCBI)ABCC10
AlphaFold pdb e-kbQ5T3U5   
Human Protein Atlas [tissue]ENSG00000124574-ABCC10 [tissue]
Protein Interaction databases
IntAct (EBI)Q5T3U5
Ontologies - Pathways
Ontology : AmiGOATP binding  lysosomal membrane  plasma membrane  plasma membrane  leukotriene metabolic process  lipid transport  ABC-type xenobiotic transporter activity  ABC-type glutathione S-conjugate transporter activity  inorganic anion transport  membrane  integral component of membrane  basolateral plasma membrane  ATPase-coupled transmembrane transporter activity  xenobiotic transport  ATPase-coupled inorganic anion transmembrane transporter activity  transmembrane transport  transmembrane transport  leukotriene transport  ABC-type transporter activity  
Ontology : EGO-EBIATP binding  lysosomal membrane  plasma membrane  plasma membrane  leukotriene metabolic process  lipid transport  ABC-type xenobiotic transporter activity  ABC-type glutathione S-conjugate transporter activity  inorganic anion transport  membrane  integral component of membrane  basolateral plasma membrane  ATPase-coupled transmembrane transporter activity  xenobiotic transport  ATPase-coupled inorganic anion transmembrane transporter activity  transmembrane transport  transmembrane transport  leukotriene transport  ABC-type transporter activity  
REACTOMEQ5T3U5 [protein]
REACTOME PathwaysR-HSA-382556 [pathway]   
NDEx NetworkABCC10
Atlas of Cancer Signalling NetworkABCC10
Wikipedia pathwaysABCC10
Orthology - Evolution
GeneTree (enSembl)ENSG00000124574
Phylogenetic Trees/Animal Genes : TreeFamABCC10
Homologs : HomoloGeneABCC10
Homology/Alignments : Family Browser (UCSC)ABCC10
Gene fusions - Rearrangements
Fusion : MitelmanABCC10::PPP2R5D [6p21.1/6p21.1]  
Fusion : FusionHubABCC10--CUL9    ABCC10--MAN2A2    ABCC10--PGBD5    ABCC10--PPP2R5D    ABCC10--RPS12    MINK1--ABCC10    PHF1--ABCC10    TJAP1--ABCC10   
Fusion : QuiverABCC10
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerABCC10 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ABCC10
Exome Variant ServerABCC10
GNOMAD BrowserENSG00000124574
Varsome BrowserABCC10
ACMGABCC10 variants
Genomic Variants (DGV)ABCC10 [DGVbeta]
DECIPHERABCC10 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisABCC10 
ICGC Data PortalABCC10 
TCGA Data PortalABCC10 
Broad Tumor PortalABCC10
OASIS PortalABCC10 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICABCC10  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DABCC10
Mutations and Diseases : HGMDABCC10
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
DgiDB (Drug Gene Interaction Database)ABCC10
DoCM (Curated mutations)ABCC10
CIViC (Clinical Interpretations of Variants in Cancer)ABCC10
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Genetic Testing Registry ABCC10
NextProtQ5T3U5 [Medical]
Target ValidationABCC10
Huge Navigator ABCC10 [HugePedia]
Clinical trials, drugs, therapy
Protein Interactions : CTDABCC10
Pharm GKB GenePA24392
Pharm GKB PathwaysPA150981002   PA155028030   PA165950411   
Clinical trialABCC10
DataMed IndexABCC10
PubMed39 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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