Atlas of Genetics and Cytogenetics in Oncology and Haematology


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ABCC2 (ATP binding cassette subfamily C member 2)

Identity

Alias (NCBI)ABC30
CMOAT
DJS
MRP2
cMRP
HGNC (Hugo) ABCC2
HGNC Alias symbDJS
MRP2
cMRP
HGNC Previous nameCMOAT
HGNC Previous namecanalicular multispecific organic anion transporter 1
 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
LocusID (NCBI) 1244
Atlas_Id 539
Location 10q24.2  [Link to chromosome band 10q24]
Location_base_pair Starts at 99782640 and ends at 99852594 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
SEPT7P2 (7p12.3) / ABCC2 (10q24.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)ABCC2   53
Cards
Entrez_Gene (NCBI)ABCC2    ATP binding cassette subfamily C member 2
AliasesABC30; CMOAT; DJS; MRP2; 
cMRP
GeneCards (Weizmann)ABCC2
Ensembl hg19 (Hinxton)ENSG00000023839 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000023839 [Gene_View]  ENSG00000023839 [Sequence]  chr10:99782640-99852594 [Contig_View]  ABCC2 [Vega]
ICGC DataPortalENSG00000023839
TCGA cBioPortalABCC2
AceView (NCBI)ABCC2
Genatlas (Paris)ABCC2
SOURCE (Princeton)ABCC2
Genetics Home Reference (NIH)ABCC2
Genomic and cartography
GoldenPath hg38 (UCSC)ABCC2  -     chr10:99782640-99852594 +  10q24.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ABCC2  -     10q24.2   [Description]    (hg19-Feb_2009)
GoldenPathABCC2 - 10q24.2 [CytoView hg19]  ABCC2 - 10q24.2 [CytoView hg38]
ImmunoBaseENSG00000023839
Genome Data Viewer NCBIABCC2 [Mapview hg19]  
OMIM237500   601107   
Gene and transcription
Genbank (Entrez)BC136419 BM765259 CB120555 U49248 U63970
RefSeq transcript (Entrez)NM_000392
Consensus coding sequences : CCDS (NCBI)ABCC2
Gene ExpressionABCC2 [ NCBI-GEO ]   ABCC2 [ EBI - ARRAY_EXPRESS ]   ABCC2 [ SEEK ]   ABCC2 [ MEM ]
Gene Expression Viewer (FireBrowse)ABCC2 [ Firebrowse - Broad ]
GenevisibleExpression of ABCC2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1244
GTEX Portal (Tissue expression)ABCC2
Human Protein AtlasENSG00000023839-ABCC2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92887   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ92887  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ92887
PhosPhoSitePlusQ92887
Domaine pattern : Prosite (Expaxy)ABC_TM1F (PS50929)    ABC_TRANSPORTER_1 (PS00211)    ABC_TRANSPORTER_2 (PS50893)   
Domains : Interpro (EBI)AAA+_ATPase    ABC1_TM_dom    ABC1_TM_sf    ABC_transporter-like    ABC_transporter_CS    ABCC2    Multidrug-R_assoc    P-loop_NTPase   
Domain families : Pfam (Sanger)ABC_membrane (PF00664)    ABC_tran (PF00005)   
Domain families : Pfam (NCBI)pfam00664    pfam00005   
Domain families : Smart (EMBL)AAA (SM00382)  
Conserved Domain (NCBI)ABCC2
SuperfamilyQ92887
AlphaFold pdb e-kbQ92887   
Human Protein Atlas [tissue]ENSG00000023839-ABCC2 [tissue]
HPRD03065
Protein Interaction databases
DIP (DOE-UCLA)Q92887
IntAct (EBI)Q92887
BioGRIDABCC2
STRING (EMBL)ABCC2
ZODIACABCC2
Ontologies - Pathways
QuickGOQ92887
Ontology : AmiGOprotein binding  ATP binding  plasma membrane  integral component of plasma membrane  drug transmembrane transport  inflammatory response  response to oxidative stress  female pregnancy  organic anion transmembrane transporter activity  ABC-type xenobiotic transporter activity  response to heat  cell surface  cell surface  negative regulation of gene expression  bilirubin transmembrane transporter activity  ABC-type glutathione S-conjugate transporter activity  mercury ion transport  bile acid and bile salt transport  canalicular bile acid transport  bilirubin transport  prostaglandin transport  membrane  apical plasma membrane  apical plasma membrane  protein domain specific binding  cellular chloride ion homeostasis  response to methotrexate  brush border membrane  response to estradiol  response to glucagon  cellular response to drug  bile acid signaling pathway  heme catabolic process  xenobiotic catabolic process  ATPase-coupled transmembrane transporter activity  ATPase-coupled transmembrane transporter activity  xenobiotic transmembrane transporter activity  response to estrogen  intercellular canaliculus  drug export  response to arsenic-containing substance  intracellular canaliculus  transmembrane transport  transmembrane transport  thyroid hormone transport  transepithelial transport  cellular response to lipopolysaccharide  cellular response to interleukin-1  cellular response to interleukin-6  cellular response to tumor necrosis factor  cellular response to dexamethasone stimulus  leukotriene transport  response to antineoplastic agent  regulation of bile acid secretion  transport across blood-brain barrier  benzylpenicillin metabolic process  response to 17alpha-ethynylestradiol  xenobiotic detoxification by transmembrane export across the plasma membrane  xenobiotic transport across blood-brain barrier  
Ontology : EGO-EBIprotein binding  ATP binding  plasma membrane  integral component of plasma membrane  drug transmembrane transport  inflammatory response  response to oxidative stress  female pregnancy  organic anion transmembrane transporter activity  ABC-type xenobiotic transporter activity  response to heat  cell surface  cell surface  negative regulation of gene expression  bilirubin transmembrane transporter activity  ABC-type glutathione S-conjugate transporter activity  mercury ion transport  bile acid and bile salt transport  canalicular bile acid transport  bilirubin transport  prostaglandin transport  membrane  apical plasma membrane  apical plasma membrane  protein domain specific binding  cellular chloride ion homeostasis  response to methotrexate  brush border membrane  response to estradiol  response to glucagon  cellular response to drug  bile acid signaling pathway  heme catabolic process  xenobiotic catabolic process  ATPase-coupled transmembrane transporter activity  ATPase-coupled transmembrane transporter activity  xenobiotic transmembrane transporter activity  response to estrogen  intercellular canaliculus  drug export  response to arsenic-containing substance  intracellular canaliculus  transmembrane transport  transmembrane transport  thyroid hormone transport  transepithelial transport  cellular response to lipopolysaccharide  cellular response to interleukin-1  cellular response to interleukin-6  cellular response to tumor necrosis factor  cellular response to dexamethasone stimulus  leukotriene transport  response to antineoplastic agent  regulation of bile acid secretion  transport across blood-brain barrier  benzylpenicillin metabolic process  response to 17alpha-ethynylestradiol  xenobiotic detoxification by transmembrane export across the plasma membrane  xenobiotic transport across blood-brain barrier  
Pathways : BIOCARTANuclear Receptors in Lipid Metabolism and Toxicity [Genes]   
Pathways : KEGGABC transporters    Bile secretion   
NDEx NetworkABCC2
Atlas of Cancer Signalling NetworkABCC2
Wikipedia pathwaysABCC2
Orthology - Evolution
OrthoDB1244
GeneTree (enSembl)ENSG00000023839
Phylogenetic Trees/Animal Genes : TreeFamABCC2
Homologs : HomoloGeneABCC2
Homology/Alignments : Family Browser (UCSC)ABCC2
Gene fusions - Rearrangements
Fusion : QuiverABCC2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerABCC2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ABCC2
dbVarABCC2
ClinVarABCC2
MonarchABCC2
1000_GenomesABCC2 
Exome Variant ServerABCC2
GNOMAD BrowserENSG00000023839
Varsome BrowserABCC2
ACMGABCC2 variants
VarityQ92887
Genomic Variants (DGV)ABCC2 [DGVbeta]
DECIPHERABCC2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisABCC2 
Mutations
ICGC Data PortalABCC2 
TCGA Data PortalABCC2 
Broad Tumor PortalABCC2
OASIS PortalABCC2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICABCC2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DABCC2
Mutations and Diseases : HGMDABCC2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaABCC2
DgiDB (Drug Gene Interaction Database)ABCC2
DoCM (Curated mutations)ABCC2
CIViC (Clinical Interpretations of Variants in Cancer)ABCC2
Cancer3DABCC2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM237500    601107   
Orphanet805   
DisGeNETABCC2
MedgenABCC2
Genetic Testing Registry ABCC2
NextProtQ92887 [Medical]
GENETestsABCC2
Target ValidationABCC2
Huge Navigator ABCC2 [HugePedia]
ClinGenABCC2
Clinical trials, drugs, therapy
MyCancerGenomeABCC2
Protein Interactions : CTDABCC2
Pharm GKB GenePA116
Pharm GKB PathwaysPA145011108   PA145011109   PA145011110   PA146123006   PA150642262   PA150981002   PA154426155   PA165292163   PA165292177   PA165816349   PA165817070   PA165860384   PA165946349   PA165964832   PA165986279   PA166041114   PA166115250   PA166117881   PA2001   PA2029   
PharosQ92887
Clinical trialABCC2
Miscellaneous
canSAR (ICR)ABCC2
HarmonizomeABCC2
DataMed IndexABCC2
Probes
Litterature
PubMed329 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXABCC2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 14:58:01 CEST 2021

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