ABCC3 (ATP binding cassette subfamily C member 3)

2003-08-01  

Identity

HGNC
LOCATION
17q21.33
LOCUSID
ALIAS
ABC31,EST90757,MLP2,MOAT-D,MRP3,cMOAT2
FUSION GENES

Other Information

Locus ID:

NCBI: 8714
MIM: 604323
HGNC: 54
Ensembl: ENSG00000108846

Variants:

dbSNP: 8714
ClinVar: 8714
TCGA: ENSG00000108846
COSMIC: ABCC3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000108846ENST00000285238O15438
ENSG00000108846ENST00000427699O15438
ENSG00000108846ENST00000502426O15438
ENSG00000108846ENST00000505699O15438
ENSG00000108846ENST00000510633H0Y8T5
ENSG00000108846ENST00000513511D6RJE5
ENSG00000108846ENST00000513745H0Y8Q6
ENSG00000108846ENST00000515585H0Y9T4
ENSG00000108846ENST00000515707D6RAB7

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
ABC transportersKEGGko02010
ABC transportersKEGGhsa02010
Bile secretionKEGGko04976
Bile secretionKEGGhsa04976
Transmembrane transport of small moleculesREACTOMER-HSA-382551
ABC-family proteins mediated transportREACTOMER-HSA-382556
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Bile acid and bile salt metabolismREACTOMER-HSA-194068
Recycling of bile acids and saltsREACTOMER-HSA-159418
Antifolate resistanceKEGGko01523
Antifolate resistanceKEGGhsa01523

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA162263534OtotoxicityDiseaseClinicalAnnotationassociatedPD25141953, 27457817, 31666714
PA166169457tonsillectomyDiseaseVariantAnnotationassociatedPK
PA443937Drug ToxicityDiseaseClinicalAnnotationassociatedPD25141953, 27457817, 31666714
PA445062NeoplasmsDiseaseClinicalAnnotationassociatedPD25141953, 27457817, 31666714
PA445208PainDiseaseClinicalAnnotationassociatedPK32090339
PA445522Respiratory InsufficiencyDiseaseVariantAnnotationassociatedPK
PA445601OsteosarcomaDiseaseClinicalAnnotationassociatedPD22016816
PA445687Sleep Apnea SyndromesDiseaseVariantAnnotationassociatedPK
PA446155Precursor Cell Lymphoblastic Leukemia-LymphomaDiseaseClinicalAnnotationassociatedPKPD21606946
PA449014cisplatinChemicalClinicalAnnotationassociatedPD22016816, 25141953, 27457817, 31666714
PA449165cyclophosphamideChemicalClinicalAnnotationassociatedPD22016816
PA449412doxorubicinChemicalClinicalAnnotationassociatedPD22016816
PA450163lamivudineChemicalPathwayassociated
PA450428methotrexateChemicalClinicalAnnotation, PathwayassociatedPKPD21317831, 21606946, 22016816
PA450550morphineChemicalClinicalAnnotation, VariantAnnotationassociatedPK32090339
PA451879vincristineChemicalClinicalAnnotation, PathwayassociatedPD22016816

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
118505322002Tissue distribution and induction of human multidrug resistant protein 3.41
156883702005Expression and localization of human multidrug resistance protein (ABCC) family members in pancreatic carcinoma.40
217991802011ABCC multidrug transporters in childhood neuroblastoma: clinical and biological effects independent of cytotoxic drug efflux.36
180387662007Nrf2-dependent and -independent induction of ABC transporters ABCC1, ABCC2, and ABCG2 in HepG2 cells under oxidative stress.34
185939402008Functional genomics identifies ABCC3 as a mediator of taxane resistance in HER2-amplified breast cancer.34
162783982005MRP3, BCRP, and P-glycoprotein activities are prognostic factors in adult acute myeloid leukemia.33
221057592012Elevated hepatic multidrug resistance-associated protein 3/ATP-binding cassette subfamily C 3 expression in human obstructive cholestasis is mediated through tumor necrosis factor alpha and c-Jun NH2-terminal kinase/stress-activated protein kinase-signaling pathway.33
235883042013Replication of TPMT and ABCC3 genetic variants highly associated with cisplatin-induced hearing loss in children.33

Citation

Dessen P

ABCC3 (ATP binding cassette subfamily C member 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/540/abcc3