ABCC5 (ATP binding cassette subfamily C member 5)

2003-06-01  

Identity

HGNC
LOCATION
3q27.1
LOCUSID
ALIAS
ABC33,EST277145,MOAT-C,MOATC,MRP5,SMRP,pABC11
FUSION GENES

Other Information

Locus ID:

NCBI: 10057
MIM: 605251
HGNC: 56
Ensembl: ENSG00000114770

Variants:

dbSNP: 10057
ClinVar: 10057
TCGA: ENSG00000114770
COSMIC: ABCC5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000114770ENST00000265586O15440
ENSG00000114770ENST00000334444O15440
ENSG00000114770ENST00000382494O15440
ENSG00000114770ENST00000392579O15440
ENSG00000114770ENST00000427120A5PKY6
ENSG00000114770ENST00000437205F8WCY8
ENSG00000114770ENST00000437341C9JZL5
ENSG00000114770ENST00000438979F8WDH3
ENSG00000114770ENST00000443376O15440
ENSG00000114770ENST00000443497H7C271
ENSG00000114770ENST00000446941E9PET4

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
ABC transportersKEGGko02010
ABC transportersKEGGhsa02010
Transmembrane transport of small moleculesREACTOMER-HSA-382551
ABC-family proteins mediated transportREACTOMER-HSA-382556
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Glycosaminoglycan metabolismREACTOMER-HSA-1630316
Hyaluronan metabolismREACTOMER-HSA-2142845
Hyaluronan biosynthesis and exportREACTOMER-HSA-2142850
Antifolate resistanceKEGGko01523
Antifolate resistanceKEGGhsa01523

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA128406956fluorouracilChemicalClinicalAnnotationassociatedPD26352872
PA131285527oxaliplatinChemicalLiterature, MultilinkAnnotationassociated24924344
PA446108Colorectal NeoplasmsDiseaseClinicalAnnotationassociatedPD26352872
PA449782glibenclamideChemicalVariantAnnotationassociatedPD27403931
PA450085irinotecanChemicalClinicalAnnotationassociatedPD26352872
PA450198leucovorinChemicalClinicalAnnotationassociatedPD26352872
PA451954zidovudineChemicalPathwayassociated22960662

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
198984822009Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy.84
126955382003Characterization of the transport of nucleoside analog drugs by the human multidrug resistance proteins MRP4 and MRP5.78
126375262003Characterization of the MRP4- and MRP5-mediated transport of cyclic nucleotides from intact cells.69
156883702005Expression and localization of human multidrug resistance protein (ABCC) family members in pancreatic carcinoma.40
199402672010Human skeletal muscle drug transporters determine local exposure and toxicity of statins.32
161567932005Modulatory effects of plant phenols on human multidrug-resistance proteins 1, 4 and 5 (ABCC1, 4 and 5).31
190774642009ATP-binding cassette C transporters in human pancreatic carcinoma cell lines. Upregulation in 5-fluorouracil-resistant cells.28
175407712007Hyaluronan export by the ABC transporter MRP5 and its modulation by intracellular cGMP.25
156319982005Expression, localization, and function of MRP5 (ABCC5), a transporter for cyclic nucleotides, in human placenta and cultured human trophoblasts: effects of gestational age and cellular differentiation.21

Citation

Dessen P

ABCC5 (ATP binding cassette subfamily C member 5)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/542/abcc5