ABCG1 (ATP binding cassette subfamily G member 1)

2014-08-01  

Identity

HGNC
LOCATION
21q22.3
LOCUSID
ALIAS
ABC8,WHITE1
FUSION GENES

Other Information

Locus ID:

NCBI: 9619
MIM: 603076
HGNC: 73
Ensembl: ENSG00000160179

Variants:

dbSNP: 9619
ClinVar: 9619
TCGA: ENSG00000160179
COSMIC: ABCG1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000160179ENST00000343687P45844
ENSG00000160179ENST00000347800P45844
ENSG00000160179ENST00000361802P45844
ENSG00000160179ENST00000398437E9PGV9
ENSG00000160179ENST00000398449P45844
ENSG00000160179ENST00000398457P45844
ENSG00000160179ENST00000450121C9JKD9

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
ABC transportersKEGGko02010
ABC transportersKEGGhsa02010
Transmembrane transport of small moleculesREACTOMER-HSA-382551
ABC-family proteins mediated transportREACTOMER-HSA-382556
ABC transporters in lipid homeostasisREACTOMER-HSA-1369062
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Lipid digestion, mobilization, and transportREACTOMER-HSA-73923
Lipoprotein metabolismREACTOMER-HSA-174824
HDL-mediated lipid transportREACTOMER-HSA-194223

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA128406956fluorouracilChemicalClinicalAnnotationassociatedPD26352872
PA446108Colorectal NeoplasmsDiseaseClinicalAnnotationassociatedPD26352872
PA450085irinotecanChemicalClinicalAnnotationassociatedPD26352872
PA450198leucovorinChemicalClinicalAnnotationassociatedPD26352872

References

Pubmed IDYearTitleCitations
160540532005ABCG1 has a critical role in mediating cholesterol efflux to HDL and preventing cellular lipid accumulation.214
163573172006ABCA1 and ABCG1 synergize to mediate cholesterol export to apoA-I.104
169022472006ABCA1 and ABCG1 or ABCG4 act sequentially to remove cellular cholesterol and generate cholesterol-rich HDL.91
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
159943272005ABCG1 redistributes cell cholesterol to domains removable by high density lipoprotein but not by lipid-depleted apolipoproteins.75
255839932015DNA methylation of lipid-related genes affects blood lipid levels.61
188272832009Effects of acceptor composition and mechanism of ABCG1-mediated cellular free cholesterol efflux.53
168579502006Macrophage ABCG1 deletion disrupts lipid homeostasis in alveolar macrophages and moderately influences atherosclerotic lesion development in LDL receptor-deficient mice.51
167026022006Efflux of sphingomyelin, cholesterol, and phosphatidylcholine by ABCG1.48
171218372007Role of ABCG1 and ABCA1 in regulation of neuronal cholesterol efflux to apolipoprotein E discs and suppression of amyloid-beta peptide generation.48

Citation

Dessen P

ABCG1 (ATP binding cassette subfamily G member 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54096/abcg1