Atlas of Genetics and Cytogenetics in Oncology and Haematology

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ABCG2 (ATP binding cassette subfamily G member 2 (Junior blood group))

Identity

Alias (NCBI)ABC15
ABCP
BCRP
BCRP1
BMDP
CD338
CDw338
EST157481
GOUT1
MRX
MXR
MXR-1
MXR1
UAQTL1
HGNC (Hugo) ABCG2
HGNC Alias symbEST157481
MXR
BCRP
ABCP
CD338
HGNC Previous nameATP-binding cassette, sub-family G (WHITE), member 2
 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
LocusID (NCBI) 9429
Atlas_Id 546
Location 4q22.1  [Link to chromosome band 4q22]
Location_base_pair Starts at 88090269 and ends at 88158639 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ABCG2 (4q22.1) / DCAF5 (14q24.1)DCAF5 (14q24.1) / ABCG2 (4q22.1)ZKSCAN1 (7q22.1) / ABCG2 (4q22.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Head and neck: Retinoblastoma

External links

Nomenclature
HGNC (Hugo)ABCG2   74
LRG (Locus Reference Genomic)LRG_823
Cards
Entrez_Gene (NCBI)ABCG2  9429  ATP binding cassette subfamily G member 2 (Junior blood group)
AliasesABC15; ABCP; BCRP; BCRP1; 
BMDP; CD338; CDw338; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1; UAQTL1
GeneCards (Weizmann)ABCG2
Ensembl hg19 (Hinxton)ENSG00000118777 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000118777 [Gene_View]  ENSG00000118777 [Sequence]  chr4:88090269-88158639 [Contig_View]  ABCG2 [Vega]
ICGC DataPortalENSG00000118777
TCGA cBioPortalABCG2
AceView (NCBI)ABCG2
Genatlas (Paris)ABCG2
WikiGenes9429
SOURCE (Princeton)ABCG2
Genetics Home Reference (NIH)ABCG2
Genomic and cartography
GoldenPath hg38 (UCSC)ABCG2  -     chr4:88090269-88158639 -  4q22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ABCG2  -     4q22.1   [Description]    (hg19-Feb_2009)
GoldenPathABCG2 - 4q22.1 [CytoView hg19]  ABCG2 - 4q22.1 [CytoView hg38]
ImmunoBaseENSG00000118777
genome Data Viewer NCBIABCG2 [Mapview hg19]  
OMIM138900   603756   614490   
Gene and transcription
Genbank (Entrez)AB051855 AB056867 AF093771 AF093772 AF098951
RefSeq transcript (Entrez)NM_001257386 NM_001348985 NM_001348986 NM_001348987 NM_001348988 NM_001348989 NM_004827
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ABCG2
Alternative Splicing GalleryENSG00000118777
Gene ExpressionABCG2 [ NCBI-GEO ]   ABCG2 [ EBI - ARRAY_EXPRESS ]   ABCG2 [ SEEK ]   ABCG2 [ MEM ]
Gene Expression Viewer (FireBrowse)ABCG2 [ Firebrowse - Broad ]
GenevisibleExpression of ABCG2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9429
GTEX Portal (Tissue expression)ABCG2
Human Protein AtlasENSG00000118777-ABCG2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UNQ0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UNQ0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UNQ0
Splice isoforms : SwissVarQ9UNQ0
PhosPhoSitePlusQ9UNQ0
Domaine pattern : Prosite (Expaxy)ABC_TRANSPORTER_2 (PS50893)   
Domains : Interpro (EBI)AAA+_ATPase    ABC_2_trans    ABC_transporter-like    ABCG2    P-loop_NTPase   
Domain families : Pfam (Sanger)ABC2_membrane (PF01061)    ABC_tran (PF00005)   
Domain families : Pfam (NCBI)pfam01061    pfam00005   
Domain families : Smart (EMBL)AAA (SM00382)  
Conserved Domain (NCBI)ABCG2
DMDM Disease mutations9429
Blocks (Seattle)ABCG2
PDB (RSDB)5NJ3    5NJG    6ETI    6FEQ    6FFC    6HBU    6HCO    6HIJ    6HZM   
PDB Europe5NJ3    5NJG    6ETI    6FEQ    6FFC    6HBU    6HCO    6HIJ    6HZM   
PDB (PDBSum)5NJ3    5NJG    6ETI    6FEQ    6FFC    6HBU    6HCO    6HIJ    6HZM   
PDB (IMB)5NJ3    5NJG    6ETI    6FEQ    6FFC    6HBU    6HCO    6HIJ    6HZM   
Structural Biology KnowledgeBase5NJ3    5NJG    6ETI    6FEQ    6FFC    6HBU    6HCO    6HIJ    6HZM   
SCOP (Structural Classification of Proteins)5NJ3    5NJG    6ETI    6FEQ    6FFC    6HBU    6HCO    6HIJ    6HZM   
CATH (Classification of proteins structures)5NJ3    5NJG    6ETI    6FEQ    6FFC    6HBU    6HCO    6HIJ    6HZM   
SuperfamilyQ9UNQ0
Human Protein Atlas [tissue]ENSG00000118777-ABCG2 [tissue]
Peptide AtlasQ9UNQ0
HPRD04783
IPIIPI00298214   IPI00607625   IPI00965407   IPI00964954   
Protein Interaction databases
DIP (DOE-UCLA)Q9UNQ0
IntAct (EBI)Q9UNQ0
FunCoupENSG00000118777
BioGRIDABCG2
STRING (EMBL)ABCG2
ZODIACABCG2
Ontologies - Pathways
QuickGOQ9UNQ0
Ontology : AmiGOprotein binding  ATP binding  nucleoplasm  plasma membrane  plasma membrane  plasma membrane  cellular iron ion homeostasis  xenobiotic transmembrane transporting ATPase activity  urate transmembrane transporter activity  biotin transmembrane transporter activity  efflux transmembrane transporter activity  efflux transmembrane transporter activity  urate transport  biotin transport  integral component of membrane  apical plasma membrane  ATPase activity  brush border membrane  mitochondrial membrane  riboflavin transmembrane transporter activity  riboflavin transport  ATPase activity, coupled to transmembrane movement of substances  identical protein binding  protein homodimerization activity  xenobiotic transmembrane transporter activity  membrane raft  urate metabolic process  transmembrane transport  transepithelial transport  urate salt excretion  external side of apical plasma membrane  export across plasma membrane  cellular detoxification  drug transport across blood-brain barrier  drug transport across blood-brain barrier  
Ontology : EGO-EBIprotein binding  ATP binding  nucleoplasm  plasma membrane  plasma membrane  plasma membrane  cellular iron ion homeostasis  xenobiotic transmembrane transporting ATPase activity  urate transmembrane transporter activity  biotin transmembrane transporter activity  efflux transmembrane transporter activity  efflux transmembrane transporter activity  urate transport  biotin transport  integral component of membrane  apical plasma membrane  ATPase activity  brush border membrane  mitochondrial membrane  riboflavin transmembrane transporter activity  riboflavin transport  ATPase activity, coupled to transmembrane movement of substances  identical protein binding  protein homodimerization activity  xenobiotic transmembrane transporter activity  membrane raft  urate metabolic process  transmembrane transport  transepithelial transport  urate salt excretion  external side of apical plasma membrane  export across plasma membrane  cellular detoxification  drug transport across blood-brain barrier  drug transport across blood-brain barrier  
Pathways : KEGGABC transporters    Bile secretion   
NDEx NetworkABCG2
Atlas of Cancer Signalling NetworkABCG2
Wikipedia pathwaysABCG2
Orthology - Evolution
OrthoDB9429
GeneTree (enSembl)ENSG00000118777
Phylogenetic Trees/Animal Genes : TreeFamABCG2
HOGENOMQ9UNQ0
Homologs : HomoloGeneABCG2
Homology/Alignments : Family Browser (UCSC)ABCG2
Gene fusions - Rearrangements
Fusion : QuiverABCG2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerABCG2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ABCG2
dbVarABCG2
ClinVarABCG2
MonarchABCG2
1000_GenomesABCG2 
Exome Variant ServerABCG2
GNOMAD BrowserENSG00000118777
Varsome BrowserABCG2
Genetic variants : HAPMAP9429
Genomic Variants (DGV)ABCG2 [DGVbeta]
DECIPHERABCG2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisABCG2 
Mutations
ICGC Data PortalABCG2 
TCGA Data PortalABCG2 
Broad Tumor PortalABCG2
OASIS PortalABCG2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICABCG2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DABCG2
Mutations and Diseases : HGMDABCG2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ABCG2
DgiDB (Drug Gene Interaction Database)ABCG2
DoCM (Curated mutations)ABCG2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ABCG2 (select a term)
intoGenABCG2
Cancer3DABCG2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM138900    603756    614490   
Orphanet
DisGeNETABCG2
MedgenABCG2
Genetic Testing Registry ABCG2
NextProtQ9UNQ0 [Medical]
TSGene9429
GENETestsABCG2
Target ValidationABCG2
Huge Navigator ABCG2 [HugePedia]
snp3D : Map Gene to Disease9429
BioCentury BCIQABCG2
ClinGenABCG2
Clinical trials, drugs, therapy
Protein Interactions : CTD9429
Pharm GKB GenePA390
Pharm GKB PathwaysPA145011108   PA145011110   PA150642262   PA150653776   PA152325160   PA154426155   PA154426903   PA164713427   PA165292163   PA165292177   PA165816270   PA165816349   PA165859361   PA165860384   PA165986279   PA166114721   PA166117881   PA2001   PA2029   
Clinical trialABCG2
Miscellaneous
canSAR (ICR)ABCG2 (select the gene name)
HarmonizomeABCG2
DataMed IndexABCG2
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineABCG2
EVEXABCG2
GoPubMedABCG2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 14 14:00:03 CEST 2020
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