Atlas of Genetics and Cytogenetics in Oncology and Haematology

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ABCG2 (ATP binding cassette subfamily G member 2 (Junior blood group))

Identity

Alias_namesATP-binding cassette, sub-family G (WHITE), member 2
ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
Alias_symbol (synonym)EST157481
MXR
BCRP
ABCP
CD338
Other aliasABC15
BCRP1
BMDP
CDw338
GOUT1
MRX
MXR-1
MXR1
UAQTL1
HGNC (Hugo) ABCG2
LocusID (NCBI) 9429
Atlas_Id 546
Location 4q22.1  [Link to chromosome band 4q22]
Location_base_pair Starts at 88090264 and ends at 88158859 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ABCG2 (4q22.1) / DCAF5 (14q24.1)DCAF5 (14q24.1) / ABCG2 (4q22.1)ZKSCAN1 (7q22.1) / ABCG2 (4q22.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Head and neck: Retinoblastoma

External links

Nomenclature
HGNC (Hugo)ABCG2   74
LRG (Locus Reference Genomic)LRG_823
Cards
Entrez_Gene (NCBI)ABCG2  9429  ATP binding cassette subfamily G member 2 (Junior blood group)
AliasesABC15; ABCP; BCRP; BCRP1; 
BMDP; CD338; CDw338; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1; UAQTL1
GeneCards (Weizmann)ABCG2
Ensembl hg19 (Hinxton)ENSG00000118777 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000118777 [Gene_View]  chr4:88090264-88158859 [Contig_View]  ABCG2 [Vega]
ICGC DataPortalENSG00000118777
TCGA cBioPortalABCG2
AceView (NCBI)ABCG2
Genatlas (Paris)ABCG2
WikiGenes9429
SOURCE (Princeton)ABCG2
Genetics Home Reference (NIH)ABCG2
Genomic and cartography
GoldenPath hg38 (UCSC)ABCG2  -     chr4:88090264-88158859 -  4q22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ABCG2  -     4q22.1   [Description]    (hg19-Feb_2009)
EnsemblABCG2 - 4q22.1 [CytoView hg19]  ABCG2 - 4q22.1 [CytoView hg38]
Mapping of homologs : NCBIABCG2 [Mapview hg19]  ABCG2 [Mapview hg38]
OMIM138900   603756   614490   
Gene and transcription
Genbank (Entrez)AB051855 AB056867 AF093771 AF093772 AF098951
RefSeq transcript (Entrez)NM_001257386 NM_001348985 NM_001348986 NM_001348987 NM_001348988 NM_001348989 NM_004827
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ABCG2
Cluster EST : UnigeneHs.480218 [ NCBI ]
CGAP (NCI)Hs.480218
Alternative Splicing GalleryENSG00000118777
Gene ExpressionABCG2 [ NCBI-GEO ]   ABCG2 [ EBI - ARRAY_EXPRESS ]   ABCG2 [ SEEK ]   ABCG2 [ MEM ]
Gene Expression Viewer (FireBrowse)ABCG2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9429
GTEX Portal (Tissue expression)ABCG2
Human Protein AtlasENSG00000118777-ABCG2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UNQ0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UNQ0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UNQ0
Splice isoforms : SwissVarQ9UNQ0
PhosPhoSitePlusQ9UNQ0
Domaine pattern : Prosite (Expaxy)ABC_TRANSPORTER_2 (PS50893)   
Domains : Interpro (EBI)AAA+_ATPase    ABC_2_trans    ABC_transporter-like    ABCG2    P-loop_NTPase   
Domain families : Pfam (Sanger)ABC2_membrane (PF01061)    ABC_tran (PF00005)   
Domain families : Pfam (NCBI)pfam01061    pfam00005   
Domain families : Smart (EMBL)AAA (SM00382)  
Conserved Domain (NCBI)ABCG2
DMDM Disease mutations9429
Blocks (Seattle)ABCG2
SuperfamilyQ9UNQ0
Human Protein Atlas [tissue]ENSG00000118777-ABCG2 [tissue]
Peptide AtlasQ9UNQ0
HPRD04783
IPIIPI00298214   IPI00607625   IPI00965407   IPI00964954   
Protein Interaction databases
DIP (DOE-UCLA)Q9UNQ0
IntAct (EBI)Q9UNQ0
FunCoupENSG00000118777
BioGRIDABCG2
STRING (EMBL)ABCG2
ZODIACABCG2
Ontologies - Pathways
QuickGOQ9UNQ0
Ontology : AmiGOtransporter activity  protein binding  ATP binding  nucleus  plasma membrane  plasma membrane  drug transmembrane transport  cellular iron ion homeostasis  xenobiotic transmembrane transporting ATPase activity  heme transporter activity  heme transport  integral component of membrane  apical plasma membrane  cholesterol transporter activity  mitochondrial membrane  cholesterol efflux  response to drug  ATPase activity, coupled to transmembrane movement of substances  identical protein binding  protein homodimerization activity  xenobiotic transport  receptor complex  urate metabolic process  
Ontology : EGO-EBItransporter activity  protein binding  ATP binding  nucleus  plasma membrane  plasma membrane  drug transmembrane transport  cellular iron ion homeostasis  xenobiotic transmembrane transporting ATPase activity  heme transporter activity  heme transport  integral component of membrane  apical plasma membrane  cholesterol transporter activity  mitochondrial membrane  cholesterol efflux  response to drug  ATPase activity, coupled to transmembrane movement of substances  identical protein binding  protein homodimerization activity  xenobiotic transport  receptor complex  urate metabolic process  
NDEx NetworkABCG2
Atlas of Cancer Signalling NetworkABCG2
Wikipedia pathwaysABCG2
Orthology - Evolution
OrthoDB9429
GeneTree (enSembl)ENSG00000118777
Phylogenetic Trees/Animal Genes : TreeFamABCG2
HOVERGENQ9UNQ0
HOGENOMQ9UNQ0
Homologs : HomoloGeneABCG2
Homology/Alignments : Family Browser (UCSC)ABCG2
Gene fusions - Rearrangements
Fusion : QuiverABCG2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerABCG2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ABCG2
dbVarABCG2
ClinVarABCG2
1000_GenomesABCG2 
Exome Variant ServerABCG2
ExAC (Exome Aggregation Consortium)ENSG00000118777
GNOMAD BrowserENSG00000118777
Genetic variants : HAPMAP9429
Genomic Variants (DGV)ABCG2 [DGVbeta]
DECIPHERABCG2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisABCG2 
Mutations
ICGC Data PortalABCG2 
TCGA Data PortalABCG2 
Broad Tumor PortalABCG2
OASIS PortalABCG2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICABCG2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDABCG2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ABCG2
DgiDB (Drug Gene Interaction Database)ABCG2
DoCM (Curated mutations)ABCG2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ABCG2 (select a term)
intoGenABCG2
Cancer3DABCG2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM138900    603756    614490   
Orphanet
DisGeNETABCG2
MedgenABCG2
Genetic Testing Registry ABCG2
NextProtQ9UNQ0 [Medical]
TSGene9429
GENETestsABCG2
Target ValidationABCG2
Huge Navigator ABCG2 [HugePedia]
snp3D : Map Gene to Disease9429
BioCentury BCIQABCG2
ClinGenABCG2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9429
Chemical/Pharm GKB GenePA390
Clinical trialABCG2
Miscellaneous
canSAR (ICR)ABCG2 (select the gene name)
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineABCG2
EVEXABCG2
GoPubMedABCG2
iHOPABCG2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Feb 28 12:59:26 CET 2018
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