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ABHD3 (abhydrolase domain containing 3, phospholipase)

Identity

Alias (NCBI)LABH3
HGNC (Hugo) ABHD3
HGNC Alias symbLABH3
LocusID (NCBI) 171586
Atlas_Id 60060
Location 18q11.2  [Link to chromosome band 18q11]
Location_base_pair Starts at 21650901 and ends at 21704774 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ESCO1 (18q11.2) / ABHD3 (18q11.2)ROCK1 (18q11.1) / ABHD3 (18q11.2)ZFAND2A (7p22.3) / ABHD3 (18q11.2)
ROCK1 ABHD3ESCO1 ABHD3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)ABHD3   18718
Cards
Entrez_Gene (NCBI)ABHD3    abhydrolase domain containing 3, phospholipase
AliasesLABH3
GeneCards (Weizmann)ABHD3
Ensembl hg19 (Hinxton)ENSG00000158201 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000158201 [Gene_View]  ENSG00000158201 [Sequence]  chr18:21650901-21704774 [Contig_View]  ABHD3 [Vega]
ICGC DataPortalENSG00000158201
TCGA cBioPortalABHD3
AceView (NCBI)ABHD3
Genatlas (Paris)ABHD3
SOURCE (Princeton)ABHD3
Genetics Home Reference (NIH)ABHD3
Genomic and cartography
GoldenPath hg38 (UCSC)ABHD3  -     chr18:21650901-21704774 -  18q11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ABHD3  -     18q11.2   [Description]    (hg19-Feb_2009)
GoldenPathABHD3 - 18q11.2 [CytoView hg19]  ABHD3 - 18q11.2 [CytoView hg38]
ImmunoBaseENSG00000158201
Genome Data Viewer NCBIABHD3 [Mapview hg19]  
OMIM612197   
Gene and transcription
Genbank (Entrez)AF007152 AK024880 AK024992 AK298728 AV654056
RefSeq transcript (Entrez)NM_001308256 NM_001308257 NM_138340
Consensus coding sequences : CCDS (NCBI)ABHD3
Gene ExpressionABHD3 [ NCBI-GEO ]   ABHD3 [ EBI - ARRAY_EXPRESS ]   ABHD3 [ SEEK ]   ABHD3 [ MEM ]
Gene Expression Viewer (FireBrowse)ABHD3 [ Firebrowse - Broad ]
GenevisibleExpression of ABHD3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)171586
GTEX Portal (Tissue expression)ABHD3
Human Protein AtlasENSG00000158201-ABHD3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8WU67   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8WU67  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8WU67
PhosPhoSitePlusQ8WU67
Domaine pattern : Prosite (Expaxy)UPF0017 (PS01133)   
Domains : Interpro (EBI)AB_hydrolase    AB_hydrolase_1    AB_hydrolase_4_CS    ABHD4   
Domain families : Pfam (Sanger)Abhydrolase_1 (PF00561)   
Domain families : Pfam (NCBI)pfam00561   
Conserved Domain (NCBI)ABHD3
SuperfamilyQ8WU67
AlphaFold pdb e-kbQ8WU67   
Human Protein Atlas [tissue]ENSG00000158201-ABHD3 [tissue]
HPRD12405
Protein Interaction databases
DIP (DOE-UCLA)Q8WU67
IntAct (EBI)Q8WU67
BioGRIDABHD3
STRING (EMBL)ABHD3
ZODIACABHD3
Ontologies - Pathways
QuickGOQ8WU67
Ontology : AmiGOphospholipase A2 activity  phospholipase A2 activity  cellular_component  plasma membrane  phosphatidylcholine biosynthetic process  acetylesterase activity  phospholipase A1 activity  phospholipase A1 activity  integral component of membrane  short-chain carboxylesterase activity  cellular lipid metabolic process  phosphatidylcholine metabolic process  phosphatidylcholine metabolic process  acylglycerol lipase activity  medium-chain fatty acid biosynthetic process  medium-chain fatty acid catabolic process  phosphatidylserine 1-acylhydrolase activity  1-acyl-2-lysophosphatidylserine acylhydrolase activity  phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)  phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)  
Ontology : EGO-EBIphospholipase A2 activity  phospholipase A2 activity  cellular_component  plasma membrane  phosphatidylcholine biosynthetic process  acetylesterase activity  phospholipase A1 activity  phospholipase A1 activity  integral component of membrane  short-chain carboxylesterase activity  cellular lipid metabolic process  phosphatidylcholine metabolic process  phosphatidylcholine metabolic process  acylglycerol lipase activity  medium-chain fatty acid biosynthetic process  medium-chain fatty acid catabolic process  phosphatidylserine 1-acylhydrolase activity  1-acyl-2-lysophosphatidylserine acylhydrolase activity  phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)  phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)  
NDEx NetworkABHD3
Atlas of Cancer Signalling NetworkABHD3
Wikipedia pathwaysABHD3
Orthology - Evolution
OrthoDB171586
GeneTree (enSembl)ENSG00000158201
Phylogenetic Trees/Animal Genes : TreeFamABHD3
Homologs : HomoloGeneABHD3
Homology/Alignments : Family Browser (UCSC)ABHD3
Gene fusions - Rearrangements
Fusion : QuiverABHD3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerABHD3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ABHD3
dbVarABHD3
ClinVarABHD3
MonarchABHD3
1000_GenomesABHD3 
Exome Variant ServerABHD3
GNOMAD BrowserENSG00000158201
Varsome BrowserABHD3
ACMGABHD3 variants
VarityQ8WU67
Genomic Variants (DGV)ABHD3 [DGVbeta]
DECIPHERABHD3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisABHD3 
Mutations
ICGC Data PortalABHD3 
TCGA Data PortalABHD3 
Broad Tumor PortalABHD3
OASIS PortalABHD3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICABHD3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DABHD3
Mutations and Diseases : HGMDABHD3
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaABHD3
DgiDB (Drug Gene Interaction Database)ABHD3
DoCM (Curated mutations)ABHD3
CIViC (Clinical Interpretations of Variants in Cancer)ABHD3
Cancer3DABHD3
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612197   
Orphanet
DisGeNETABHD3
MedgenABHD3
Genetic Testing Registry ABHD3
NextProtQ8WU67 [Medical]
GENETestsABHD3
Target ValidationABHD3
Huge Navigator ABHD3 [HugePedia]
ClinGenABHD3
Clinical trials, drugs, therapy
MyCancerGenomeABHD3
Protein Interactions : CTDABHD3
Pharm GKB GenePA38659
PharosQ8WU67
Clinical trialABHD3
Miscellaneous
canSAR (ICR)ABHD3
HarmonizomeABHD3
DataMed IndexABHD3
Probes
Litterature
PubMed13 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXABHD3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:41:17 CEST 2021

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