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ABI2 (abl interactor 2)

Identity

Alias_namesabl-interactor 2
Alias_symbol (synonym)ABI-2
AIP-1
ABI2B
AblBP3
argBPIA
SSH3BP2
Other aliasAIP1
argBP1
argBPIB
HGNC (Hugo) ABI2
LocusID (NCBI) 10152
Atlas_Id 494
Location 2q33.2  [Link to chromosome band 2q33]
Location_base_pair Starts at 203328239 and ends at 203432173 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ABI2 (2q33.2) / GOLGA4 (3p22.2)CALM1 (14q32.11) / ABI2 (2q33.2)KMT2A (11q23.3) / ABI2 (2q33.2)
KMT2A ABI2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(2;11)(q33;q23) KMT2A/ABI2


External links

Nomenclature
HGNC (Hugo)ABI2   24011
Cards
Entrez_Gene (NCBI)ABI2  10152  abl interactor 2
AliasesABI-2; ABI2B; AIP-1; AIP1; 
AblBP3; SSH3BP2; argBP1; argBPIA; argBPIB
GeneCards (Weizmann)ABI2
Ensembl hg19 (Hinxton)ENSG00000138443 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000138443 [Gene_View]  ENSG00000138443 [Sequence]  chr2:203328239-203432173 [Contig_View]  ABI2 [Vega]
ICGC DataPortalENSG00000138443
TCGA cBioPortalABI2
AceView (NCBI)ABI2
Genatlas (Paris)ABI2
WikiGenes10152
SOURCE (Princeton)ABI2
Genetics Home Reference (NIH)ABI2
Genomic and cartography
GoldenPath hg38 (UCSC)ABI2  -     chr2:203328239-203432173 +  2q33.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ABI2  -     2q33.2   [Description]    (hg19-Feb_2009)
GoldenPathABI2 - 2q33.2 [CytoView hg19]  ABI2 - 2q33.2 [CytoView hg38]
ImmunoBaseENSG00000138443
Mapping of homologs : NCBIABI2 [Mapview hg19]  ABI2 [Mapview hg38]
OMIM606442   
Gene and transcription
Genbank (Entrez)AF085867 AF260261 AK054863 AK294429 AK297537
RefSeq transcript (Entrez)NM_001282925 NM_001282926 NM_001282927 NM_001282932 NM_001375662 NM_001375663 NM_001375664 NM_001375665 NM_001375666 NM_001375667 NM_001375668 NM_001375669 NM_001375670 NM_001375671 NM_001375672 NM_001375673 NM_001375674 NM_001375675 NM_001375676 NM_001375677 NM_001375678 NM_001375679 NM_001375680 NM_001375681 NM_001375682 NM_001375683 NM_001375684 NM_001375685 NM_001375686 NM_001375687 NM_001375688 NM_001375689 NM_001375690 NM_001375691 NM_001375692 NM_001375693 NM_001375695 NM_001375696 NM_001375698 NM_001375699 NM_001375702 NM_001375704 NM_001375706 NM_001375707 NM_001375708 NM_001375709 NM_001375710 NM_001375711 NM_001375712 NM_001375714 NM_001375717 NM_001375719 NM_001375721 NM_001375722 NM_001375723 NM_001375724 NM_001375725 NM_001375726 NM_001375727 NM_001375728 NM_001375729 NM_001375730 NM_001375731 NM_001375732 NM_001375733 NM_001375734 NM_001375735 NM_001375736 NM_001375737 NM_001375738 NM_001375739 NM_001375740 NM_001375741 NM_001375742 NM_001375743 NM_001375744 NM_001375745 NM_001375746 NM_001375747 NM_001375748 NM_001375749 NM_001375750 NM_001375751 NM_001375752 NM_001375753 NM_001375754 NM_001375755 NM_005759
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ABI2
Alternative Splicing GalleryENSG00000138443
Gene ExpressionABI2 [ NCBI-GEO ]   ABI2 [ EBI - ARRAY_EXPRESS ]   ABI2 [ SEEK ]   ABI2 [ MEM ]
Gene Expression Viewer (FireBrowse)ABI2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10152
GTEX Portal (Tissue expression)ABI2
Human Protein AtlasENSG00000138443-ABI2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NYB9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NYB9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NYB9
Splice isoforms : SwissVarQ9NYB9
PhosPhoSitePlusQ9NYB9
Domaine pattern : Prosite (Expaxy)SH3 (PS50002)    T_SNARE (PS50192)   
Domains : Interpro (EBI)ABI    ABI2    Abi2_SH3    Abl-interactor_HHR_dom    SH3-like_dom_sf    SH3_domain    T_SNARE_dom   
Domain families : Pfam (Sanger)Abi_HHR (PF07815)    SH3_9 (PF14604)   
Domain families : Pfam (NCBI)pfam07815    pfam14604   
Domain families : Smart (EMBL)SH3 (SM00326)  
Conserved Domain (NCBI)ABI2
DMDM Disease mutations10152
Blocks (Seattle)ABI2
PDB (RSDB)2ED0    3P8C    4N78   
PDB Europe2ED0    3P8C    4N78   
PDB (PDBSum)2ED0    3P8C    4N78   
PDB (IMB)2ED0    3P8C    4N78   
Structural Biology KnowledgeBase2ED0    3P8C    4N78   
SCOP (Structural Classification of Proteins)2ED0    3P8C    4N78   
CATH (Classification of proteins structures)2ED0    3P8C    4N78   
SuperfamilyQ9NYB9
Human Protein Atlas [tissue]ENSG00000138443-ABI2 [tissue]
Peptide AtlasQ9NYB9
IPIIPI00442210   IPI00442211   IPI00442214   IPI00925810   IPI00921951   IPI00927073   IPI00299588   IPI00925186   IPI00924519   IPI00926730   IPI00925454   IPI00927544   IPI00927787   IPI00924464   IPI00926527   
Protein Interaction databases
DIP (DOE-UCLA)Q9NYB9
IntAct (EBI)Q9NYB9
FunCoupENSG00000138443
BioGRIDABI2
STRING (EMBL)ABI2
ZODIACABI2
Ontologies - Pathways
QuickGOQ9NYB9
Ontology : AmiGODNA binding  protein binding  nucleus  cytoplasm  cytosol  cytoskeleton  adherens junction  cytoskeleton organization  cytoskeletal adaptor activity  actin polymerization or depolymerization  viral process  cell migration  Rac protein signal transduction  SH3 domain binding  SH3 domain binding  SH3 domain binding  peptidyl-tyrosine phosphorylation  kinase binding  lamellipodium  lamellipodium  SCAR complex  ubiquitin protein ligase binding  filopodium tip  dendritic spine  Rac GTPase binding  regulation of dendritic spine morphogenesis  proline-rich region binding  lens fiber cell morphogenesis  positive regulation of Arp2/3 complex-mediated actin nucleation  
Ontology : EGO-EBIDNA binding  protein binding  nucleus  cytoplasm  cytosol  cytoskeleton  adherens junction  cytoskeleton organization  cytoskeletal adaptor activity  actin polymerization or depolymerization  viral process  cell migration  Rac protein signal transduction  SH3 domain binding  SH3 domain binding  SH3 domain binding  peptidyl-tyrosine phosphorylation  kinase binding  lamellipodium  lamellipodium  SCAR complex  ubiquitin protein ligase binding  filopodium tip  dendritic spine  Rac GTPase binding  regulation of dendritic spine morphogenesis  proline-rich region binding  lens fiber cell morphogenesis  positive regulation of Arp2/3 complex-mediated actin nucleation  
Pathways : KEGGRegulation of actin cytoskeleton   
NDEx NetworkABI2
Atlas of Cancer Signalling NetworkABI2
Wikipedia pathwaysABI2
Orthology - Evolution
OrthoDB10152
GeneTree (enSembl)ENSG00000138443
Phylogenetic Trees/Animal Genes : TreeFamABI2
HOGENOMQ9NYB9
Homologs : HomoloGeneABI2
Homology/Alignments : Family Browser (UCSC)ABI2
Gene fusions - Rearrangements
Fusion : QuiverABI2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerABI2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ABI2
dbVarABI2
ClinVarABI2
1000_GenomesABI2 
Exome Variant ServerABI2
ExAC (Exome Aggregation Consortium)ENSG00000138443
GNOMAD BrowserENSG00000138443
Varsome BrowserABI2
Genetic variants : HAPMAP10152
Genomic Variants (DGV)ABI2 [DGVbeta]
DECIPHERABI2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisABI2 
Mutations
ICGC Data PortalABI2 
TCGA Data PortalABI2 
Broad Tumor PortalABI2
OASIS PortalABI2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICABI2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DABI2
Mutations and Diseases : HGMDABI2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ABI2
DgiDB (Drug Gene Interaction Database)ABI2
DoCM (Curated mutations)ABI2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ABI2 (select a term)
intoGenABI2
Cancer3DABI2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606442   
Orphanet
DisGeNETABI2
MedgenABI2
Genetic Testing Registry ABI2
NextProtQ9NYB9 [Medical]
TSGene10152
GENETestsABI2
Target ValidationABI2
Huge Navigator ABI2 [HugePedia]
snp3D : Map Gene to Disease10152
BioCentury BCIQABI2
ClinGenABI2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10152
Chemical/Pharm GKB GenePA134977642
Clinical trialABI2
Miscellaneous
canSAR (ICR)ABI2 (select the gene name)
HarmonizomeABI2
DataMed IndexABI2
Probes
Litterature
PubMed52 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineABI2
EVEXABI2
GoPubMedABI2
iHOPABI2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sun May 10 12:05:40 CEST 2020

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