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ABI2 (abl interactor 2)

Identity

Alias_namesabl-interactor 2
Alias_symbol (synonym)ABI-2
AIP-1
ABI2B
AblBP3
argBPIA
SSH3BP2
Other aliasargBP1
argBPIB
HGNC (Hugo) ABI2
LocusID (NCBI) 10152
Atlas_Id 494
Location 2q33.2  [Link to chromosome band 2q33]
Location_base_pair Starts at 203328239 and ends at 203432173 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ABI2 (2q33.2) / GOLGA4 (3p22.2)CALM1 (14q32.11) / ABI2 (2q33.2)KMT2A (11q23.3) / ABI2 (2q33.2)
KMT2A 11q23.3 / ABI2 2q33.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(2;11)(q33;q23) KMT2A/ABI2


External links

Nomenclature
HGNC (Hugo)ABI2   24011
Cards
Entrez_Gene (NCBI)ABI2  10152  abl interactor 2
AliasesABI-2; ABI2B; AIP-1; AblBP3; 
SSH3BP2; argBP1; argBPIA; argBPIB
GeneCards (Weizmann)ABI2
Ensembl hg19 (Hinxton)ENSG00000138443 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000138443 [Gene_View]  chr2:203328239-203432173 [Contig_View]  ABI2 [Vega]
ICGC DataPortalENSG00000138443
TCGA cBioPortalABI2
AceView (NCBI)ABI2
Genatlas (Paris)ABI2
WikiGenes10152
SOURCE (Princeton)ABI2
Genetics Home Reference (NIH)ABI2
Genomic and cartography
GoldenPath hg38 (UCSC)ABI2  -     chr2:203328239-203432173 +  2q33.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ABI2  -     2q33.2   [Description]    (hg19-Feb_2009)
EnsemblABI2 - 2q33.2 [CytoView hg19]  ABI2 - 2q33.2 [CytoView hg38]
Mapping of homologs : NCBIABI2 [Mapview hg19]  ABI2 [Mapview hg38]
OMIM606442   
Gene and transcription
Genbank (Entrez)AF085867 AF260261 AK054863 AK294429 AK297537
RefSeq transcript (Entrez)NM_001282925 NM_001282926 NM_001282927 NM_001282932 NM_005759
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ABI2
Cluster EST : UnigeneHs.471156 [ NCBI ]
CGAP (NCI)Hs.471156
Alternative Splicing GalleryENSG00000138443
Gene ExpressionABI2 [ NCBI-GEO ]   ABI2 [ EBI - ARRAY_EXPRESS ]   ABI2 [ SEEK ]   ABI2 [ MEM ]
Gene Expression Viewer (FireBrowse)ABI2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10152
GTEX Portal (Tissue expression)ABI2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NYB9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NYB9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NYB9
Splice isoforms : SwissVarQ9NYB9
PhosPhoSitePlusQ9NYB9
Domaine pattern : Prosite (Expaxy)SH3 (PS50002)    T_SNARE (PS50192)   
Domains : Interpro (EBI)ABI    ABI1/ABI2    Abl-interactor_HHR_dom    SH3_domain    T_SNARE_dom   
Domain families : Pfam (Sanger)Abi_HHR (PF07815)    SH3_9 (PF14604)   
Domain families : Pfam (NCBI)pfam07815    pfam14604   
Domain families : Smart (EMBL)SH3 (SM00326)  
Conserved Domain (NCBI)ABI2
DMDM Disease mutations10152
Blocks (Seattle)ABI2
PDB (SRS)2ED0    3P8C    4N78   
PDB (PDBSum)2ED0    3P8C    4N78   
PDB (IMB)2ED0    3P8C    4N78   
PDB (RSDB)2ED0    3P8C    4N78   
Structural Biology KnowledgeBase2ED0    3P8C    4N78   
SCOP (Structural Classification of Proteins)2ED0    3P8C    4N78   
CATH (Classification of proteins structures)2ED0    3P8C    4N78   
SuperfamilyQ9NYB9
Human Protein AtlasENSG00000138443
Peptide AtlasQ9NYB9
IPIIPI00442210   IPI00442211   IPI00442214   IPI00925810   IPI00921951   IPI00927073   IPI00299588   IPI00925186   IPI00924519   IPI00926730   IPI00925454   IPI00927544   IPI00927787   IPI00924464   IPI00926527   
Protein Interaction databases
DIP (DOE-UCLA)Q9NYB9
IntAct (EBI)Q9NYB9
FunCoupENSG00000138443
BioGRIDABI2
STRING (EMBL)ABI2
ZODIACABI2
Ontologies - Pathways
QuickGOQ9NYB9
Ontology : AmiGODNA binding  protein binding  cytoplasm  cytosol  cytoskeleton  movement of cell or subcellular component  cytoskeleton organization  cytoskeletal adaptor activity  actin polymerization or depolymerization  viral process  cell migration  Rac protein signal transduction  SH3 domain binding  SH3 domain binding  peptidyl-tyrosine phosphorylation  kinase binding  lamellipodium  filopodium  protein tyrosine kinase activator activity  SCAR complex  ubiquitin protein ligase binding  protein complex binding  Rac GTPase binding  positive regulation of protein tyrosine kinase activity  proline-rich region binding  positive regulation of Arp2/3 complex-mediated actin nucleation  
Ontology : EGO-EBIDNA binding  protein binding  cytoplasm  cytosol  cytoskeleton  movement of cell or subcellular component  cytoskeleton organization  cytoskeletal adaptor activity  actin polymerization or depolymerization  viral process  cell migration  Rac protein signal transduction  SH3 domain binding  SH3 domain binding  peptidyl-tyrosine phosphorylation  kinase binding  lamellipodium  filopodium  protein tyrosine kinase activator activity  SCAR complex  ubiquitin protein ligase binding  protein complex binding  Rac GTPase binding  positive regulation of protein tyrosine kinase activity  proline-rich region binding  positive regulation of Arp2/3 complex-mediated actin nucleation  
Pathways : BIOCARTAY branching of actin filaments [Genes]   
Pathways : KEGGRegulation of actin cytoskeleton   
NDEx NetworkABI2
Atlas of Cancer Signalling NetworkABI2
Wikipedia pathwaysABI2
Orthology - Evolution
OrthoDB10152
GeneTree (enSembl)ENSG00000138443
Phylogenetic Trees/Animal Genes : TreeFamABI2
HOVERGENQ9NYB9
HOGENOMQ9NYB9
Homologs : HomoloGeneABI2
Homology/Alignments : Family Browser (UCSC)ABI2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerABI2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ABI2
dbVarABI2
ClinVarABI2
1000_GenomesABI2 
Exome Variant ServerABI2
ExAC (Exome Aggregation Consortium)ABI2 (select the gene name)
Genetic variants : HAPMAP10152
Genomic Variants (DGV)ABI2 [DGVbeta]
DECIPHERABI2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisABI2 
Mutations
ICGC Data PortalABI2 
TCGA Data PortalABI2 
Broad Tumor PortalABI2
OASIS PortalABI2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICABI2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDABI2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ABI2
DgiDB (Drug Gene Interaction Database)ABI2
DoCM (Curated mutations)ABI2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ABI2 (select a term)
intoGenABI2
Cancer3DABI2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606442   
Orphanet
MedgenABI2
Genetic Testing Registry ABI2
NextProtQ9NYB9 [Medical]
TSGene10152
GENETestsABI2
Target ValidationABI2
Huge Navigator ABI2 [HugePedia]
snp3D : Map Gene to Disease10152
BioCentury BCIQABI2
ClinGenABI2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10152
Chemical/Pharm GKB GenePA134977642
Clinical trialABI2
Miscellaneous
canSAR (ICR)ABI2 (select the gene name)
Probes
Litterature
PubMed40 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineABI2
EVEXABI2
GoPubMedABI2
iHOPABI2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:22:23 CEST 2017

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