Atlas of Genetics and Cytogenetics in Oncology and Haematology

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ACACB (acetyl-CoA carboxylase beta)

Identity

Other namesACC2
ACCB
HACC275
HGNC (Hugo) ACACB
LocusID (NCBI) 32
Location 12q24.11
Location_base_pair Starts at 109577202 and ends at 109706030 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)ACACB   85
Entrez_Gene (NCBI)ACACB  32  acetyl-CoA carboxylase beta
Cards
GeneCards (Weizmann)ACACB
Ensembl (Hinxton)ENSG00000076555 [Gene_View]  chr12:109577202-109706030 [Contig_View]  ACACB [Vega]
AceView (NCBI)ACACB
Genatlas (Paris)ACACB
SOURCE (Stanford)NM_001093
Genomic and cartography
GoldenPath (UCSC)ACACB  -  12q24.11   chr12:109577202-109706030 +  12q24.11   [Description]    (hg19-Feb_2009)
EnsemblACACB - 12q24.11 [CytoView]
Mapping of homologs : NCBIACACB [Mapview]
OMIM601557   
Gene and transcription
Genbank (Entrez)AB209110 AJ575431 AJ575592 AK302469 AK302502
RefSeq transcript (SRS)NM_001093
RefSeq transcript (Entrez)NM_001093
RefSeq genomic (SRS)AC_000144 NC_000012 NC_018923 NT_009775 NW_001838062 NW_004078075
RefSeq genomic (Entrez)AC_000144 NC_000012 NC_018923 NT_009775 NW_001838062 NW_004078075
Consensus coding sequences : CCDS (NCBI)ACACB
Cluster EST : UnigeneHs.234898 [ SRS ] Hs.234898 [ NCBI ]
CGAP (NCI)Hs.234898
Alternative Splicing : Fast-db (Paris)GSHG0006989
Alternative Splicing GalleryENSG00000076555
Gene ExpressionACACB [ NCBI-GEO ]   ACACB [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO00763 (SRS) O00763 (Uniprot)
NextProtO00763
With graphics : InterProO00763
Splice isoforms : SwissVarO00763(Swissvar)
Domaine pattern : Prosite (SRS)ATP_GRASP (PS50975)    BC (PS50979)    BIOTIN (PS00188)    BIOTINYL_LIPOYL (PS50968)    COA_CT_CTER (PS50989)    COA_CT_NTER (PS50980)    CPSASE_1 (PS00866)    CPSASE_2 (PS00867)   
Domaine pattern : Prosite (Expaxy)ATP_GRASP (PS50975)    BC (PS50979)    BIOTIN (PS00188)    BIOTINYL_LIPOYL (PS50968)    COA_CT_CTER (PS50989)    COA_CT_NTER (PS50980)    CPSASE_1 (PS00866)    CPSASE_2 (PS00867)   
Domains : Interpro (SRS)AcCoA_COase_cen    ATP-grasp    ATP_grasp_subdomain_1    ATP_grasp_subdomain_2    Biotin_carboxylation_dom    Biotin_COase_C    Biotin_lipoyl    CarbamoylP_synth_lsu_N    Carboxyl_trans    CbamoylP_synth_lsu-like_ATP-bd    COA_CT_C    COA_CT_N    PreATP-grasp_dom    Rudment_hybrid_motif    Single_hybrid_motif   
Domains : Interpro (EBI)AcCoA_COase_cen    ATP-grasp    ATP_grasp_subdomain_1    ATP_grasp_subdomain_2    Biotin_carboxylation_dom    Biotin_COase_C    Biotin_lipoyl    CarbamoylP_synth_lsu_N    Carboxyl_trans    CbamoylP_synth_lsu-like_ATP-bd    COA_CT_C    COA_CT_N    PreATP-grasp_dom    Rudment_hybrid_motif    Single_hybrid_motif   
Related proteins : CluSTrO00763
Domain families : Pfam (SRS)ACC_central (PF08326)    Biotin_carb_C (PF02785)    Biotin_lipoyl (PF00364)    Carboxyl_trans (PF01039)    CPSase_L_chain (PF00289)    CPSase_L_D2 (PF02786)   
Domain families : Pfam (Sanger)ACC_central (PF08326)    Biotin_carb_C (PF02785)    Biotin_lipoyl (PF00364)    Carboxyl_trans (PF01039)    CPSase_L_chain (PF00289)    CPSase_L_D2 (PF02786)   
Domain families : Pfam (NCBI)pfam08326    pfam02785    pfam00364    pfam01039    pfam00289    pfam02786   
Domain families : Smart (EMBL)Biotin_carb_C (SM00878)  
DMDM32
Blocks (Seattle)O00763
PDB (SRS)2DN8    2HJW    2KCC    3FF6    3GID    3GLK    3JRW    3JRX    3TDC   
PDB (PDBSum)2DN8    2HJW    2KCC    3FF6    3GID    3GLK    3JRW    3JRX    3TDC   
PDB (IMB)2DN8    2HJW    2KCC    3FF6    3GID    3GLK    3JRW    3JRX    3TDC   
PDB (RSDB)2DN8    2HJW    2KCC    3FF6    3GID    3GLK    3JRW    3JRX    3TDC   
Human Protein AtlasENSG00000076555
HPRD07044
IPIIPI00013003   IPI00157056   IPI00848209   IPI01018762   IPI01009637   IPI01015400   IPI01015814   
Protein Interaction databases
DIP (DOE-UCLA)O00763
IntAct (EBI)O00763
FunCoupENSG00000076555
REACTOMEACACB
Protein Interaction Database32
BioGRIDACACB
InParanoidO00763
Interologous Interaction database O00763
IntegromeDBACACB
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)ACACB
SNP (GeneSNP Utah)ACACB
SNP : HGBaseACACB
Genetic variants : HAPMAPACACB
Somatic Mutations in Cancer : COSMICACACB 
CONAN: Copy Number AnalysisACACB 
Mutations and Diseases : HGMDACACB
OMIM601557   
GENETests601557   
Disease Genetic AssociationACACB
Huge Navigator ACACB [HugePedia]  ACACB [HugeCancerGEM]
Genomic VariantsACACB  ACACB [DGVbeta]
ClinVarACACB
snp3D : Map Gene to Disease32
General knowledge
Homologs : HomoloGeneACACB
Homology/Alignments : Family Browser (UCSC)ACACB
Phylogenetic Trees/Animal Genes : TreeFamACACB
Catalytic activity : Enzyme6.4.1.2 [ Enzyme-Expasy ]   6.4.1.2 [ Enzyme-SRS ]   6.4.1.2 [ IntEnz-EBI ]   6.4.1.2 [ BRENDA ]   6.4.1.2 [ KEGG ]   
Chemical/Protein Interactions : CTD32
Chemical/Pharm GKB GenePA24422
Clinical trialACACB
Cancer Resource (Charite)ENSG00000076555
Ontology : AmiGOacetyl-CoA carboxylase activity  biotin carboxylase activity  protein binding  ATP binding  cytoplasm  mitochondrion  cytosol  acetyl-CoA metabolic process  energy reserve metabolic process  fatty acid biosynthetic process  carnitine shuttle  endomembrane system  membrane  positive regulation of cellular metabolic process  cellular lipid metabolic process  small molecule metabolic process  metal ion binding  protein homotetramerization  malonyl-CoA biosynthetic process  
Ontology : EGO-EBIacetyl-CoA carboxylase activity  biotin carboxylase activity  protein binding  ATP binding  cytoplasm  mitochondrion  cytosol  acetyl-CoA metabolic process  energy reserve metabolic process  fatty acid biosynthetic process  carnitine shuttle  endomembrane system  membrane  positive regulation of cellular metabolic process  cellular lipid metabolic process  small molecule metabolic process  metal ion binding  protein homotetramerization  malonyl-CoA biosynthetic process  
Pathways : KEGGPropanoate metabolismPyruvate metabolismAdipocytokine signaling pathwayFatty acid biosynthesisInsulin signaling pathway
Other databases
Probes
Litterature
PubMed55 Pubmed reference(s) in Entrez
PubGeneACACB
iHOPACACB
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jun 14 17:57:26 CEST 2013
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