Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

ACADL (acyl-CoA dehydrogenase, long chain)

Identity

Alias_namesacyl-Coenzyme A dehydrogenase, long chain
Alias_symbol (synonym)LCAD
ACAD4
Other alias
HGNC (Hugo) ACADL
LocusID (NCBI) 33
Atlas_Id 60072
Location 2q34  [Link to chromosome band 2q34]
Location_base_pair Starts at 210187992 and ends at 210225491 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ACADL (2q34) / KANSL1L (2q34)ACADL (2q34) / MAML2 (11q21)KANSL1L (2q34) / ACADL (2q34)
XRCC5 (2q35) / ACADL (2q34)C2orf67 ACADLXRCC5 ACADL

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ACADL   88
Cards
Entrez_Gene (NCBI)ACADL  33  acyl-CoA dehydrogenase, long chain
AliasesACAD4; LCAD
GeneCards (Weizmann)ACADL
Ensembl hg19 (Hinxton)ENSG00000115361 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000115361 [Gene_View]  chr2:210187992-210225491 [Contig_View]  ACADL [Vega]
ICGC DataPortalENSG00000115361
TCGA cBioPortalACADL
AceView (NCBI)ACADL
Genatlas (Paris)ACADL
WikiGenes33
SOURCE (Princeton)ACADL
Genetics Home Reference (NIH)ACADL
Genomic and cartography
GoldenPath hg38 (UCSC)ACADL  -     chr2:210187992-210225491 -  2q34   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ACADL  -     2q34   [Description]    (hg19-Feb_2009)
EnsemblACADL - 2q34 [CytoView hg19]  ACADL - 2q34 [CytoView hg38]
Mapping of homologs : NCBIACADL [Mapview hg19]  ACADL [Mapview hg38]
OMIM609576   
Gene and transcription
Genbank (Entrez)AK296161 AK313498 BC039063 BC064549 DC350098
RefSeq transcript (Entrez)NM_001608
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ACADL
Cluster EST : UnigeneHs.471277 [ NCBI ]
CGAP (NCI)Hs.471277
Alternative Splicing GalleryENSG00000115361
Gene ExpressionACADL [ NCBI-GEO ]   ACADL [ EBI - ARRAY_EXPRESS ]   ACADL [ SEEK ]   ACADL [ MEM ]
Gene Expression Viewer (FireBrowse)ACADL [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)33
GTEX Portal (Tissue expression)ACADL
Human Protein AtlasENSG00000115361-ACADL [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP28330   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP28330  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP28330
Splice isoforms : SwissVarP28330
Catalytic activity : Enzyme1.3.8.8 [ Enzyme-Expasy ]   1.3.8.81.3.8.8 [ IntEnz-EBI ]   1.3.8.8 [ BRENDA ]   1.3.8.8 [ KEGG ]   
PhosPhoSitePlusP28330
Domaine pattern : Prosite (Expaxy)ACYL_COA_DH_1 (PS00072)    ACYL_COA_DH_2 (PS00073)   
Domains : Interpro (EBI)Acyl-CoA_DH_CS    Acyl-CoA_Oxase/DH_cen-dom    AcylCo_DH/oxidase_C    AcylCoA_DH/ox_N    AcylCoA_DH/oxidase_NM_dom    LCAD   
Domain families : Pfam (Sanger)Acyl-CoA_dh_1 (PF00441)    Acyl-CoA_dh_M (PF02770)    Acyl-CoA_dh_N (PF02771)   
Domain families : Pfam (NCBI)pfam00441    pfam02770    pfam02771   
Conserved Domain (NCBI)ACADL
DMDM Disease mutations33
Blocks (Seattle)ACADL
SuperfamilyP28330
Human Protein Atlas [tissue]ENSG00000115361-ACADL [tissue]
Peptide AtlasP28330
HPRD01939
IPIIPI00292695   
Protein Interaction databases
DIP (DOE-UCLA)P28330
IntAct (EBI)P28330
FunCoupENSG00000115361
BioGRIDACADL
STRING (EMBL)ACADL
ZODIACACADL
Ontologies - Pathways
QuickGOP28330
Ontology : AmiGOfatty-acyl-CoA binding  temperature homeostasis  acyl-CoA dehydrogenase activity  long-chain-acyl-CoA dehydrogenase activity  mitochondrial matrix  fatty acid beta-oxidation  palmitoyl-CoA oxidase activity  carnitine metabolic process, CoA-linked  mitochondrial membrane  fatty acid beta-oxidation using acyl-CoA dehydrogenase  carnitine catabolic process  long-chain fatty acid catabolic process  cellular lipid catabolic process  negative regulation of fatty acid biosynthetic process  negative regulation of fatty acid oxidation  flavin adenine dinucleotide binding  protein homotetramerization  oxidation-reduction process  regulation of cholesterol metabolic process  
Ontology : EGO-EBIfatty-acyl-CoA binding  temperature homeostasis  acyl-CoA dehydrogenase activity  long-chain-acyl-CoA dehydrogenase activity  mitochondrial matrix  fatty acid beta-oxidation  palmitoyl-CoA oxidase activity  carnitine metabolic process, CoA-linked  mitochondrial membrane  fatty acid beta-oxidation using acyl-CoA dehydrogenase  carnitine catabolic process  long-chain fatty acid catabolic process  cellular lipid catabolic process  negative regulation of fatty acid biosynthetic process  negative regulation of fatty acid oxidation  flavin adenine dinucleotide binding  protein homotetramerization  oxidation-reduction process  regulation of cholesterol metabolic process  
Pathways : KEGGFatty acid degradation    PPAR signaling pathway   
NDEx NetworkACADL
Atlas of Cancer Signalling NetworkACADL
Wikipedia pathwaysACADL
Orthology - Evolution
OrthoDB33
GeneTree (enSembl)ENSG00000115361
Phylogenetic Trees/Animal Genes : TreeFamACADL
HOVERGENP28330
HOGENOMP28330
Homologs : HomoloGeneACADL
Homology/Alignments : Family Browser (UCSC)ACADL
Gene fusions - Rearrangements
Fusion: TCGAC2orf67 ACADL
Fusion: TCGAXRCC5 ACADL
Fusion: Tumor Portal ACADL
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerACADL [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ACADL
dbVarACADL
ClinVarACADL
1000_GenomesACADL 
Exome Variant ServerACADL
ExAC (Exome Aggregation Consortium)ENSG00000115361
GNOMAD BrowserENSG00000115361
Genetic variants : HAPMAP33
Genomic Variants (DGV)ACADL [DGVbeta]
DECIPHERACADL [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisACADL 
Mutations
ICGC Data PortalACADL 
TCGA Data PortalACADL 
Broad Tumor PortalACADL
OASIS PortalACADL [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICACADL  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDACADL
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch ACADL
DgiDB (Drug Gene Interaction Database)ACADL
DoCM (Curated mutations)ACADL (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ACADL (select a term)
intoGenACADL
Cancer3DACADL(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609576   
Orphanet14473   
MedgenACADL
Genetic Testing Registry ACADL
NextProtP28330 [Medical]
TSGene33
GENETestsACADL
Target ValidationACADL
Huge Navigator ACADL [HugePedia]
snp3D : Map Gene to Disease33
BioCentury BCIQACADL
ClinGenACADL
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD33
Chemical/Pharm GKB GenePA24424
Clinical trialACADL
Miscellaneous
canSAR (ICR)ACADL (select the gene name)
Probes
Litterature
PubMed26 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineACADL
EVEXACADL
GoPubMedACADL
iHOPACADL
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Nov 9 11:36:51 CET 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.