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ACADL (acyl-CoA dehydrogenase long chain)

Identity

Alias (NCBI)ACAD4
LCAD
HGNC (Hugo) ACADL
HGNC Alias symbLCAD
ACAD4
HGNC Previous nameacyl-Coenzyme A dehydrogenase, long chain
LocusID (NCBI) 33
Atlas_Id 60072
Location 2q34  [Link to chromosome band 2q34]
Location_base_pair Starts at 210187923 and ends at 210225447 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ACADL (2q34) / KANSL1L (2q34)ACADL (2q34) / MAML2 (11q21)KANSL1L (2q34) / ACADL (2q34)
XRCC5 (2q35) / ACADL (2q34)C2orf67 ACADLXRCC5 ACADL

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)ACADL   88
Cards
Entrez_Gene (NCBI)ACADL    acyl-CoA dehydrogenase long chain
AliasesACAD4; LCAD
GeneCards (Weizmann)ACADL
Ensembl hg19 (Hinxton)ENSG00000115361 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000115361 [Gene_View]  ENSG00000115361 [Sequence]  chr2:210187923-210225447 [Contig_View]  ACADL [Vega]
ICGC DataPortalENSG00000115361
TCGA cBioPortalACADL
AceView (NCBI)ACADL
Genatlas (Paris)ACADL
SOURCE (Princeton)ACADL
Genetics Home Reference (NIH)ACADL
Genomic and cartography
GoldenPath hg38 (UCSC)ACADL  -     chr2:210187923-210225447 -  2q34   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ACADL  -     2q34   [Description]    (hg19-Feb_2009)
GoldenPathACADL - 2q34 [CytoView hg19]  ACADL - 2q34 [CytoView hg38]
ImmunoBaseENSG00000115361
Genome Data Viewer NCBIACADL [Mapview hg19]  
OMIM609576   
Gene and transcription
Genbank (Entrez)AK296161 AK313498 BC039063 BC064549 DC350098
RefSeq transcript (Entrez)NM_001608
Consensus coding sequences : CCDS (NCBI)ACADL
Gene ExpressionACADL [ NCBI-GEO ]   ACADL [ EBI - ARRAY_EXPRESS ]   ACADL [ SEEK ]   ACADL [ MEM ]
Gene Expression Viewer (FireBrowse)ACADL [ Firebrowse - Broad ]
GenevisibleExpression of ACADL in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)33
GTEX Portal (Tissue expression)ACADL
Human Protein AtlasENSG00000115361-ACADL [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP28330   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP28330  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP28330
PhosPhoSitePlusP28330
Domaine pattern : Prosite (Expaxy)ACYL_COA_DH_1 (PS00072)    ACYL_COA_DH_2 (PS00073)   
Domains : Interpro (EBI)Acyl-CoA_DH_CS    Acyl-CoA_Oxase/DH_cen-dom    AcylCo_DH-like_C    AcylCo_DH/oxidase_C    AcylCoA_DH/ox_N    AcylCoA_DH/ox_N_sf    AcylCoA_DH/oxidase_NM_dom    LCAD   
Domain families : Pfam (Sanger)Acyl-CoA_dh_1 (PF00441)    Acyl-CoA_dh_M (PF02770)    Acyl-CoA_dh_N (PF02771)   
Domain families : Pfam (NCBI)pfam00441    pfam02770    pfam02771   
Conserved Domain (NCBI)ACADL
SuperfamilyP28330
AlphaFold pdb e-kbP28330   
Human Protein Atlas [tissue]ENSG00000115361-ACADL [tissue]
HPRD01939
Protein Interaction databases
DIP (DOE-UCLA)P28330
IntAct (EBI)P28330
BioGRIDACADL
STRING (EMBL)ACADL
ZODIACACADL
Ontologies - Pathways
QuickGOP28330
Ontology : AmiGOfatty-acyl-CoA binding  temperature homeostasis  acyl-CoA dehydrogenase activity  long-chain-acyl-CoA dehydrogenase activity  long-chain-acyl-CoA dehydrogenase activity  protein binding  mitochondrion  mitochondrial matrix  fatty acid beta-oxidation  palmitoyl-CoA oxidase activity  palmitoyl-CoA oxidase activity  carnitine metabolic process, CoA-linked  carnitine metabolic process, CoA-linked  mitochondrial membrane  fatty acid beta-oxidation using acyl-CoA dehydrogenase  fatty acid beta-oxidation using acyl-CoA dehydrogenase  carnitine catabolic process  long-chain fatty acid catabolic process  identical protein binding  cellular lipid catabolic process  negative regulation of fatty acid biosynthetic process  negative regulation of fatty acid oxidation  flavin adenine dinucleotide binding  regulation of cholesterol metabolic process  positive regulation of cold-induced thermogenesis  
Ontology : EGO-EBIfatty-acyl-CoA binding  temperature homeostasis  acyl-CoA dehydrogenase activity  long-chain-acyl-CoA dehydrogenase activity  long-chain-acyl-CoA dehydrogenase activity  protein binding  mitochondrion  mitochondrial matrix  fatty acid beta-oxidation  palmitoyl-CoA oxidase activity  palmitoyl-CoA oxidase activity  carnitine metabolic process, CoA-linked  carnitine metabolic process, CoA-linked  mitochondrial membrane  fatty acid beta-oxidation using acyl-CoA dehydrogenase  fatty acid beta-oxidation using acyl-CoA dehydrogenase  carnitine catabolic process  long-chain fatty acid catabolic process  identical protein binding  cellular lipid catabolic process  negative regulation of fatty acid biosynthetic process  negative regulation of fatty acid oxidation  flavin adenine dinucleotide binding  regulation of cholesterol metabolic process  positive regulation of cold-induced thermogenesis  
Pathways : KEGGPropanoate metabolism    Fatty acid metabolism    beta-Alanine metabolism    Valine, leucine and isoleucine degradation    PPAR signaling pathway   
NDEx NetworkACADL
Atlas of Cancer Signalling NetworkACADL
Wikipedia pathwaysACADL
Orthology - Evolution
OrthoDB33
GeneTree (enSembl)ENSG00000115361
Phylogenetic Trees/Animal Genes : TreeFamACADL
Homologs : HomoloGeneACADL
Homology/Alignments : Family Browser (UCSC)ACADL
Gene fusions - Rearrangements
Fusion : QuiverACADL
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerACADL [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ACADL
dbVarACADL
ClinVarACADL
MonarchACADL
1000_GenomesACADL 
Exome Variant ServerACADL
GNOMAD BrowserENSG00000115361
Varsome BrowserACADL
ACMGACADL variants
VarityP28330
Genomic Variants (DGV)ACADL [DGVbeta]
DECIPHERACADL [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisACADL 
Mutations
ICGC Data PortalACADL 
TCGA Data PortalACADL 
Broad Tumor PortalACADL
OASIS PortalACADL [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICACADL  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DACADL
Mutations and Diseases : HGMDACADL
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaACADL
DgiDB (Drug Gene Interaction Database)ACADL
DoCM (Curated mutations)ACADL
CIViC (Clinical Interpretations of Variants in Cancer)ACADL
Cancer3DACADL
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609576   
Orphanet14473   
DisGeNETACADL
MedgenACADL
Genetic Testing Registry ACADL
NextProtP28330 [Medical]
GENETestsACADL
Target ValidationACADL
Huge Navigator ACADL [HugePedia]
ClinGenACADL
Clinical trials, drugs, therapy
MyCancerGenomeACADL
Protein Interactions : CTDACADL
Pharm GKB GenePA24424
PharosP28330
Clinical trialACADL
Miscellaneous
canSAR (ICR)ACADL
HarmonizomeACADL
DataMed IndexACADL
Probes
Litterature
PubMed34 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXACADL
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:41:20 CEST 2021

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