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ACADM (acyl-CoA dehydrogenase, C-4 to C-12 straight chain)

Identity

Alias_namesacyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain
Alias_symbol (synonym)MCAD
MCADH
ACAD1
Other alias
HGNC (Hugo) ACADM
LocusID (NCBI) 34
Atlas_Id 60073
Location 1p31.1  [Link to chromosome band 1p31]
Location_base_pair Starts at 75724347 and ends at 75763678 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
EGFR (7p11.2) / ACADM (1p31.1)MAGOH (1p32.3) / ACADM (1p31.1)RABGGTB (1p31.1) / ACADM (1p31.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(1;7)(p31;p11) EGFR/ACADM


External links

Nomenclature
HGNC (Hugo)ACADM   89
LRG (Locus Reference Genomic)LRG_838
Cards
Entrez_Gene (NCBI)ACADM  34  acyl-CoA dehydrogenase, C-4 to C-12 straight chain
AliasesACAD1; MCAD; MCADH
GeneCards (Weizmann)ACADM
Ensembl hg19 (Hinxton)ENSG00000117054 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000117054 [Gene_View]  chr1:75724347-75763678 [Contig_View]  ACADM [Vega]
ICGC DataPortalENSG00000117054
TCGA cBioPortalACADM
AceView (NCBI)ACADM
Genatlas (Paris)ACADM
WikiGenes34
SOURCE (Princeton)ACADM
Genetics Home Reference (NIH)ACADM
Genomic and cartography
GoldenPath hg38 (UCSC)ACADM  -     chr1:75724347-75763678 +  1p31.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ACADM  -     1p31.1   [Description]    (hg19-Feb_2009)
EnsemblACADM - 1p31.1 [CytoView hg19]  ACADM - 1p31.1 [CytoView hg38]
Mapping of homologs : NCBIACADM [Mapview hg19]  ACADM [Mapview hg38]
OMIM201450   607008   
Gene and transcription
Genbank (Entrez)AF251043 AK296045 AK301005 AK301039 AK301717
RefSeq transcript (Entrez)NM_000016 NM_001127328 NM_001286042 NM_001286043 NM_001286044
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ACADM
Cluster EST : UnigeneHs.445040 [ NCBI ]
CGAP (NCI)Hs.445040
Alternative Splicing GalleryENSG00000117054
Gene ExpressionACADM [ NCBI-GEO ]   ACADM [ EBI - ARRAY_EXPRESS ]   ACADM [ SEEK ]   ACADM [ MEM ]
Gene Expression Viewer (FireBrowse)ACADM [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)34
GTEX Portal (Tissue expression)ACADM
Human Protein AtlasENSG00000117054-ACADM [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP11310   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP11310  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP11310
Splice isoforms : SwissVarP11310
Catalytic activity : Enzyme1.3.8.7 [ Enzyme-Expasy ]   1.3.8.71.3.8.7 [ IntEnz-EBI ]   1.3.8.7 [ BRENDA ]   1.3.8.7 [ KEGG ]   
PhosPhoSitePlusP11310
Domaine pattern : Prosite (Expaxy)ACYL_COA_DH_1 (PS00072)    ACYL_COA_DH_2 (PS00073)   
Domains : Interpro (EBI)Acyl-CoA_DH_CS    Acyl-CoA_Oxase/DH_cen-dom    AcylCo_DH/oxidase_C    AcylCoA_DH/ox_N    AcylCoA_DH/oxidase_NM_dom    MCAD   
Domain families : Pfam (Sanger)Acyl-CoA_dh_1 (PF00441)    Acyl-CoA_dh_M (PF02770)    Acyl-CoA_dh_N (PF02771)   
Domain families : Pfam (NCBI)pfam00441    pfam02770    pfam02771   
Conserved Domain (NCBI)ACADM
DMDM Disease mutations34
Blocks (Seattle)ACADM
PDB (SRS)1EGC    1EGD    1EGE    1T9G    2A1T    4P13   
PDB (PDBSum)1EGC    1EGD    1EGE    1T9G    2A1T    4P13   
PDB (IMB)1EGC    1EGD    1EGE    1T9G    2A1T    4P13   
PDB (RSDB)1EGC    1EGD    1EGE    1T9G    2A1T    4P13   
Structural Biology KnowledgeBase1EGC    1EGD    1EGE    1T9G    2A1T    4P13   
SCOP (Structural Classification of Proteins)1EGC    1EGD    1EGE    1T9G    2A1T    4P13   
CATH (Classification of proteins structures)1EGC    1EGD    1EGE    1T9G    2A1T    4P13   
SuperfamilyP11310
Human Protein Atlas [tissue]ENSG00000117054-ACADM [tissue]
Peptide AtlasP11310
HPRD08447
IPIIPI00005040   IPI00895801   IPI01014812   IPI01015888   IPI00513827   IPI00976367   IPI00983404   IPI00975691   IPI00982718   IPI00978036   IPI00984447   
Protein Interaction databases
DIP (DOE-UCLA)P11310
IntAct (EBI)P11310
FunCoupENSG00000117054
BioGRIDACADM
STRING (EMBL)ACADM
ZODIACACADM
Ontologies - Pathways
QuickGOP11310
Ontology : AmiGO###############################################################################################################################################################################################################################################################                                          
Ontology : EGO-EBI###############################################################################################################################################################################################################################################################                                          
Pathways : KEGGFatty acid metabolism    PPAR signaling pathway    Propanoate metabolism    beta-Alanine metabolism    Valine, leucine and isoleucine degradation   
NDEx NetworkACADM
Atlas of Cancer Signalling NetworkACADM
Wikipedia pathwaysACADM
Orthology - Evolution
OrthoDB34
GeneTree (enSembl)ENSG00000117054
Phylogenetic Trees/Animal Genes : TreeFamACADM
HOVERGENP11310
HOGENOMP11310
Homologs : HomoloGeneACADM
Homology/Alignments : Family Browser (UCSC)ACADM
Gene fusions - Rearrangements
Fusion : QuiverACADM
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerACADM [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ACADM
dbVarACADM
ClinVarACADM
1000_GenomesACADM 
Exome Variant ServerACADM
ExAC (Exome Aggregation Consortium)ENSG00000117054
GNOMAD BrowserENSG00000117054
Genetic variants : HAPMAP34
Genomic Variants (DGV)ACADM [DGVbeta]
DECIPHERACADM [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisACADM 
Mutations
ICGC Data PortalACADM 
TCGA Data PortalACADM 
Broad Tumor PortalACADM
OASIS PortalACADM [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICACADM  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDACADM
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)**PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch ACADM
DgiDB (Drug Gene Interaction Database)ACADM
DoCM (Curated mutations)ACADM (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ACADM (select a term)
intoGenACADM
Cancer3DACADM(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM201450    607008   
Orphanet3570   
DisGeNETACADM
MedgenACADM
Genetic Testing Registry ACADM
NextProtP11310 [Medical]
TSGene34
GENETestsACADM
Target ValidationACADM
Huge Navigator ACADM [HugePedia]
snp3D : Map Gene to Disease34
BioCentury BCIQACADM
ClinGenACADM
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD34
Chemical/Pharm GKB GenePA24425
Clinical trialACADM
Miscellaneous
canSAR (ICR)ACADM (select the gene name)
Probes
Litterature
PubMed1 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineACADM
EVEXACADM
GoPubMedACADM
iHOPACADM
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Feb 23 18:10:08 CET 2018

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