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ACADVL (acyl-CoA dehydrogenase, very long chain)

Identity

Other namesACAD6
LCACD
VLCAD
HGNC (Hugo) ACADVL
LocusID (NCBI) 37
Atlas_Id 50037
Location 17p13.1
Location_base_pair Starts at 7123150 and ends at 7128586 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ACADVL (17p13.1) / ACADVL (17p13.1)ACADVL (17p13.1) / DLG4 (17p13.1)BRD9 (5p15.33) / ACADVL (17p13.1)
PRKDC (8q11.21) / ACADVL (17p13.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ACADVL   92
Cards
Entrez_Gene (NCBI)ACADVL  37  acyl-CoA dehydrogenase, very long chain
GeneCards (Weizmann)ACADVL
Ensembl hg19 (Hinxton)ENSG00000072778 [Gene_View]  chr17:7123150-7128586 [Contig_View]  ACADVL [Vega]
Ensembl hg38 (Hinxton)ENSG00000072778 [Gene_View]  chr17:7123150-7128586 [Contig_View]  ACADVL [Vega]
ICGC DataPortalENSG00000072778
TCGA cBioPortalACADVL
AceView (NCBI)ACADVL
Genatlas (Paris)ACADVL
WikiGenes37
SOURCE (Princeton)ACADVL
Genomic and cartography
GoldenPath hg19 (UCSC)ACADVL  -     chr17:7123150-7128586 +  17p13.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ACADVL  -     17p13.1   [Description]    (hg38-Dec_2013)
EnsemblACADVL - 17p13.1 [CytoView hg19]  ACADVL - 17p13.1 [CytoView hg38]
Mapping of homologs : NCBIACADVL [Mapview hg19]  ACADVL [Mapview hg38]
OMIM201475   609575   
Gene and transcription
Genbank (Entrez)AA643658 AK056083 AK056956 AK058109 AK097243
RefSeq transcript (Entrez)NM_000018 NM_001033859 NM_001270447 NM_001270448
RefSeq genomic (Entrez)NC_000017 NC_018928 NG_007975 NT_010718 NW_004929405
Consensus coding sequences : CCDS (NCBI)ACADVL
Cluster EST : UnigeneHs.437178 [ NCBI ]
CGAP (NCI)Hs.437178
Alternative Splicing : Fast-db (Paris)GSHG0012182
Alternative Splicing GalleryENSG00000072778
Gene ExpressionACADVL [ NCBI-GEO ]   ACADVL [ EBI - ARRAY_EXPRESS ]   ACADVL [ SEEK ]   ACADVL [ MEM ]
Gene Expression Viewer (FireBrowse)ACADVL [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)37
Protein : pattern, domain, 3D structure
UniProt/SwissProtP49748 (Uniprot)
NextProtP49748  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP49748
Splice isoforms : SwissVarP49748 (Swissvar)
Catalytic activity : Enzyme1.3.8.9 [ Enzyme-Expasy ]   1.3.8.91.3.8.9 [ IntEnz-EBI ]   1.3.8.9 [ BRENDA ]   1.3.8.9 [ KEGG ]   
PhosPhoSitePlusP49748
Domaine pattern : Prosite (Expaxy)ACYL_COA_DH_1 (PS00072)    ACYL_COA_DH_2 (PS00073)   
Domains : Interpro (EBI)Acyl-CoA_DH_CS    Acyl-CoA_Oxase/DH_cen-dom    AcylCo_DH/oxidase_C    AcylCoA_DH/ox_N    AcylCoA_DH/oxidase_NM_dom   
Domain families : Pfam (Sanger)Acyl-CoA_dh_1 (PF00441)    Acyl-CoA_dh_M (PF02770)    Acyl-CoA_dh_N (PF02771)   
Domain families : Pfam (NCBI)pfam00441    pfam02770    pfam02771   
DMDM Disease mutations37
Blocks (Seattle)ACADVL
PDB (SRS)2UXW    3B96   
PDB (PDBSum)2UXW    3B96   
PDB (IMB)2UXW    3B96   
PDB (RSDB)2UXW    3B96   
Structural Biology KnowledgeBase2UXW    3B96   
SCOP (Structural Classification of Proteins)2UXW    3B96   
CATH (Classification of proteins structures)2UXW    3B96   
SuperfamilyP49748
Human Protein AtlasENSG00000072778
Peptide AtlasP49748
HPRD01940
IPIIPI01013108   IPI00178744   IPI00937735   IPI00793599   IPI00028031   
Protein Interaction databases
DIP (DOE-UCLA)P49748
IntAct (EBI)P49748
FunCoupENSG00000072778
BioGRIDACADVL
STRING (EMBL)ACADVL
ZODIACACADVL
Ontologies - Pathways
QuickGOP49748
Ontology : AmiGOfatty-acyl-CoA binding  temperature homeostasis  acyl-CoA dehydrogenase activity  long-chain-acyl-CoA dehydrogenase activity  nucleus  nucleolus  cytoplasm  mitochondrion  mitochondrion  mitochondrial inner membrane  mitochondrial matrix  fatty acid beta-oxidation  electron carrier activity  energy derivation by oxidation of organic compounds  very-long-chain-acyl-CoA dehydrogenase activity  epithelial cell differentiation  fatty acid beta-oxidation using acyl-CoA dehydrogenase  fatty acid beta-oxidation using acyl-CoA dehydrogenase  IRE1-mediated unfolded protein response  mitochondrial nucleoid  very long-chain fatty acid catabolic process  negative regulation of fatty acid biosynthetic process  negative regulation of fatty acid oxidation  flavin adenine dinucleotide binding  oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor  lipid homeostasis  regulation of cholesterol metabolic process  
Ontology : EGO-EBIfatty-acyl-CoA binding  temperature homeostasis  acyl-CoA dehydrogenase activity  long-chain-acyl-CoA dehydrogenase activity  nucleus  nucleolus  cytoplasm  mitochondrion  mitochondrion  mitochondrial inner membrane  mitochondrial matrix  fatty acid beta-oxidation  electron carrier activity  energy derivation by oxidation of organic compounds  very-long-chain-acyl-CoA dehydrogenase activity  epithelial cell differentiation  fatty acid beta-oxidation using acyl-CoA dehydrogenase  fatty acid beta-oxidation using acyl-CoA dehydrogenase  IRE1-mediated unfolded protein response  mitochondrial nucleoid  very long-chain fatty acid catabolic process  negative regulation of fatty acid biosynthetic process  negative regulation of fatty acid oxidation  flavin adenine dinucleotide binding  oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor  lipid homeostasis  regulation of cholesterol metabolic process  
Pathways : KEGGFatty acid degradation   
NDEx Network
Atlas of Cancer Signalling NetworkACADVL
Wikipedia pathwaysACADVL
Orthology - Evolution
OrthoDB37
GeneTree (enSembl)ENSG00000072778
Phylogenetic Trees/Animal Genes : TreeFamACADVL
Homologs : HomoloGeneACADVL
Homology/Alignments : Family Browser (UCSC)ACADVL
Gene fusions - Rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerACADVL [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ACADVL
dbVarACADVL
ClinVarACADVL
1000_GenomesACADVL 
Exome Variant ServerACADVL
ExAC (Exome Aggregation Consortium)ACADVL (select the gene name)
SNP (GeneSNP Utah)ACADVL
SNP : HGBaseACADVL
Genetic variants : HAPMAPACADVL
Genomic Variants (DGV)ACADVL [DGVbeta]
Mutations
ICGC Data PortalACADVL 
TCGA Data PortalACADVL 
Broad Tumor PortalACADVL
OASIS PortalACADVL [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICACADVL 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)**PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch ACADVL
DgiDB (Drug Gene Interaction Database)ACADVL
DoCM (Curated mutations)ACADVL (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ACADVL (select a term)
intoGenACADVL
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)17:7123150-7128586
CONAN: Copy Number AnalysisACADVL 
Mutations and Diseases : HGMDACADVL
OMIM201475    609575   
MedgenACADVL
Genetic Testing Registry ACADVL
NextProtP49748 [Medical]
TSGene37
GENETestsACADVL
Huge Navigator ACADVL [HugePedia]  ACADVL [HugeCancerGEM]
snp3D : Map Gene to Disease37
BioCentury BCIQACADVL
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD37
Chemical/Pharm GKB GenePA24428
Clinical trialACADVL
Miscellaneous
canSAR (ICR)ACADVL (select the gene name)
Probes
Litterature
PubMed56 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineACADVL
GoPubMedACADVL
iHOPACADVL
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat Apr 16 17:34:29 CEST 2016

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