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ACAN (aggrecan)

Identity

Alias_namesMSK16
CSPG1
AGC1
chondroitin sulfate proteoglycan 1
aggrecan 1
Alias_symbol (synonym)CSPGCP
Other aliasAGCAN
SEDK
HGNC (Hugo) ACAN
LocusID (NCBI) 176
Atlas_Id 53972
Location 15q26.1  [Link to chromosome band 15q26]
Location_base_pair Starts at 88803443 and ends at 88875354 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ABHD2 (15q26.1) / ACAN (15q26.1)ACAN (15q26.1) / ACAN (15q26.1)CCDC97 (19q13.2) / ACAN (15q26.1)
FBLN7 (2q13) / ACAN (15q26.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ACAN   319
Cards
Entrez_Gene (NCBI)ACAN  176  aggrecan
AliasesAGC1; AGCAN; CSPG1; CSPGCP; 
MSK16; SEDK
GeneCards (Weizmann)ACAN
Ensembl hg19 (Hinxton)ENSG00000157766 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000157766 [Gene_View]  chr15:88803443-88875354 [Contig_View]  ACAN [Vega]
ICGC DataPortalENSG00000157766
TCGA cBioPortalACAN
AceView (NCBI)ACAN
Genatlas (Paris)ACAN
WikiGenes176
SOURCE (Princeton)ACAN
Genetics Home Reference (NIH)ACAN
Genomic and cartography
GoldenPath hg38 (UCSC)ACAN  -     chr15:88803443-88875354 +  15q26.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ACAN  -     15q26.1   [Description]    (hg19-Feb_2009)
EnsemblACAN - 15q26.1 [CytoView hg19]  ACAN - 15q26.1 [CytoView hg38]
Mapping of homologs : NCBIACAN [Mapview hg19]  ACAN [Mapview hg38]
OMIM155760   165800   608361   612813   
Gene and transcription
Genbank (Entrez)AK290723 BC036445 BC150624 BQ182050 BQ446640
RefSeq transcript (Entrez)NM_001135 NM_013227
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ACAN
Cluster EST : UnigeneHs.616395 [ NCBI ]
CGAP (NCI)Hs.616395
Alternative Splicing GalleryENSG00000157766
Gene ExpressionACAN [ NCBI-GEO ]   ACAN [ EBI - ARRAY_EXPRESS ]   ACAN [ SEEK ]   ACAN [ MEM ]
Gene Expression Viewer (FireBrowse)ACAN [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)176
GTEX Portal (Tissue expression)ACAN
Protein : pattern, domain, 3D structure
UniProt/SwissProtP16112   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP16112  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP16112
Splice isoforms : SwissVarP16112
PhosPhoSitePlusP16112
Domaine pattern : Prosite (Expaxy)C_TYPE_LECTIN_1 (PS00615)    C_TYPE_LECTIN_2 (PS50041)    EGF_1 (PS00022)    EGF_2 (PS01186)    EGF_3 (PS50026)    IG_LIKE (PS50835)    IG_MHC (PS00290)    LINK_1 (PS01241)    LINK_2 (PS50963)    SUSHI (PS50923)   
Domains : Interpro (EBI)C-type_lectin-like    C-type_lectin-like/link    C-type_lectin_CS    CSPG_CTLD    CTDL_fold    EGF-like_CS    EGF-like_dom    Ig-like_dom    Ig-like_fold    Ig/MHC_CS    Ig_sub    Ig_V-set    Link_dom    Sushi_SCR_CCP_dom   
Domain families : Pfam (Sanger)Lectin_C (PF00059)    Sushi (PF00084)    V-set (PF07686)    Xlink (PF00193)   
Domain families : Pfam (NCBI)pfam00059    pfam00084    pfam07686    pfam00193   
Domain families : Smart (EMBL)CCP (SM00032)  CLECT (SM00034)  EGF (SM00181)  IG (SM00409)  IGv (SM00406)  LINK (SM00445)  
Conserved Domain (NCBI)ACAN
DMDM Disease mutations176
Blocks (Seattle)ACAN
PDB (SRS)4MD4   
PDB (PDBSum)4MD4   
PDB (IMB)4MD4   
PDB (RSDB)4MD4   
Structural Biology KnowledgeBase4MD4   
SCOP (Structural Classification of Proteins)4MD4   
CATH (Classification of proteins structures)4MD4   
SuperfamilyP16112
Human Protein AtlasENSG00000157766
Peptide AtlasP16112
HPRD01123
IPIIPI00923424   IPI00923437   IPI00793748   IPI00216489   IPI00291932   IPI00027377   
Protein Interaction databases
DIP (DOE-UCLA)P16112
IntAct (EBI)P16112
FunCoupENSG00000157766
BioGRIDACAN
STRING (EMBL)ACAN
ZODIACACAN
Ontologies - Pathways
QuickGOP16112
Ontology : AmiGOskeletal system development  skeletal system development  extracellular matrix structural constituent  protein binding  hyaluronic acid binding  extracellular region  proteinaceous extracellular matrix  Golgi lumen  proteolysis  cell adhesion  central nervous system development  keratan sulfate biosynthetic process  extracellular matrix disassembly  extracellular matrix organization  carbohydrate binding  extracellular matrix  keratan sulfate catabolic process  lysosomal lumen  metal ion binding  
Ontology : EGO-EBIskeletal system development  skeletal system development  extracellular matrix structural constituent  protein binding  hyaluronic acid binding  extracellular region  proteinaceous extracellular matrix  Golgi lumen  proteolysis  cell adhesion  central nervous system development  keratan sulfate biosynthetic process  extracellular matrix disassembly  extracellular matrix organization  carbohydrate binding  extracellular matrix  keratan sulfate catabolic process  lysosomal lumen  metal ion binding  
NDEx NetworkACAN
Atlas of Cancer Signalling NetworkACAN
Wikipedia pathwaysACAN
Orthology - Evolution
OrthoDB176
GeneTree (enSembl)ENSG00000157766
Phylogenetic Trees/Animal Genes : TreeFamACAN
HOVERGENP16112
HOGENOMP16112
Homologs : HomoloGeneACAN
Homology/Alignments : Family Browser (UCSC)ACAN
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerACAN [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ACAN
dbVarACAN
ClinVarACAN
1000_GenomesACAN 
Exome Variant ServerACAN
ExAC (Exome Aggregation Consortium)ACAN (select the gene name)
Genetic variants : HAPMAP176
Genomic Variants (DGV)ACAN [DGVbeta]
DECIPHERACAN [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisACAN 
Mutations
ICGC Data PortalACAN 
TCGA Data PortalACAN 
Broad Tumor PortalACAN
OASIS PortalACAN [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICACAN  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDACAN
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ACAN
DgiDB (Drug Gene Interaction Database)ACAN
DoCM (Curated mutations)ACAN (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ACAN (select a term)
intoGenACAN
Cancer3DACAN(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM155760    165800    608361    612813   
Orphanet17946    19616    23314    12223   
MedgenACAN
Genetic Testing Registry ACAN
NextProtP16112 [Medical]
TSGene176
GENETestsACAN
Target ValidationACAN
Huge Navigator ACAN [HugePedia]
snp3D : Map Gene to Disease176
BioCentury BCIQACAN
ClinGenACAN
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD176
Chemical/Pharm GKB GenePA24616
Clinical trialACAN
Miscellaneous
canSAR (ICR)ACAN (select the gene name)
Probes
Litterature
PubMed129 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineACAN
EVEXACAN
GoPubMedACAN
iHOPACAN
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:22:26 CEST 2017

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