ACAP2 (ArfGAP with coiled-coil, ankyrin repeat and PH domains 2)

2016-04-01  

Identity

HGNC
LOCATION
3q29
LOCUSID
ALIAS
CENTB2,CNT-B2
FUSION GENES

Other Information

Locus ID:

NCBI: 23527
MIM: 607766
HGNC: 16469
Ensembl: ENSG00000114331

Variants:

dbSNP: 23527
ClinVar: 23527
TCGA: ENSG00000114331
COSMIC: ACAP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000114331ENST00000326793Q15057
ENSG00000114331ENST00000439666C9J8L1
ENSG00000114331ENST00000439758H7C3Q8
ENSG00000114331ENST00000447662F8WAU0
ENSG00000114331ENST00000450200H7C3K3
ENSG00000114331ENST00000618471A0A087X1H5
ENSG00000114331ENST00000635383A0A0U1RQT1

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
110504342000Cytohesins and centaurins: mediators of PI 3-kinase-regulated Arf signaling.41
302128242018The CircRNA-ACAP2/Hsa-miR-21-5p/ Tiam1 Regulatory Feedback Circuit Affects the Proliferation, Migration, and Invasion of Colon Cancer SW480 Cells.28
180037472008Substrate specificities and activities of AZAP family Arf GAPs in vivo.10
285662862017Rab35 protein regulates evoked exocytosis of endothelial Weibel-Palade bodies.4
309056722019Rab35/ACAP2 and Rab35/RUSC2 Complex Structures Reveal Molecular Basis for Effector Recognition by Rab35 GTPase.2
258532172015Human ACAP2 is a homolog of C. elegans CNT-1 that promotes apoptosis in cancer cells.1
318637742020CircACAP2 promotes breast cancer proliferation and metastasis by targeting miR-29a/b-3p-COL5A1 axis.1

Citation

Dessen P

ACAP2 (ArfGAP with coiled-coil, ankyrin repeat and PH domains 2)

Atlas Genet Cytogenet Oncol Haematol. 2016-04-01

Online version: http://atlasgeneticsoncology.org/gene/55721/acap2