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ACAP3 (ArfGAP with coiled-coil, ankyrin repeat and PH domains 3)

Identity

Alias (NCBI)CENTB5
HGNC (Hugo) ACAP3
HGNC Alias symbKIAA1716
HGNC Previous nameCENTB5
HGNC Previous namecentaurin, beta 5
LocusID (NCBI) 116983
Atlas_Id 60077
Location 1p36.33  [Link to chromosome band 1p36]
Location_base_pair Starts at 1292384 and ends at 1307889 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ACAP3 (1p36.33) / CPSF3L (1p36.33)PUSL1 (1p36.33) / ACAP3 (1p36.33)UBE2J2 (1p36.33) / ACAP3 (1p36.33)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  UBE2J2/ACAP3 (1p36)


External links

Nomenclature
HGNC (Hugo)ACAP3   16754
Cards
Entrez_Gene (NCBI)ACAP3  116983  ArfGAP with coiled-coil, ankyrin repeat and PH domains 3
AliasesCENTB5
GeneCards (Weizmann)ACAP3
Ensembl hg19 (Hinxton)ENSG00000131584 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000131584 [Gene_View]  ENSG00000131584 [Sequence]  chr1:1292384-1307889 [Contig_View]  ACAP3 [Vega]
ICGC DataPortalENSG00000131584
TCGA cBioPortalACAP3
AceView (NCBI)ACAP3
Genatlas (Paris)ACAP3
WikiGenes116983
SOURCE (Princeton)ACAP3
Genetics Home Reference (NIH)ACAP3
Genomic and cartography
GoldenPath hg38 (UCSC)ACAP3  -     chr1:1292384-1307889 -  1p36.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ACAP3  -     1p36.33   [Description]    (hg19-Feb_2009)
GoldenPathACAP3 - 1p36.33 [CytoView hg19]  ACAP3 - 1p36.33 [CytoView hg38]
ImmunoBaseENSG00000131584
genome Data Viewer NCBIACAP3 [Mapview hg19]  
Gene and transcription
Genbank (Entrez)AB051503 AF411981 AK093954 AK098490 BC004874
RefSeq transcript (Entrez)NM_030649
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ACAP3
Alternative Splicing GalleryENSG00000131584
Gene ExpressionACAP3 [ NCBI-GEO ]   ACAP3 [ EBI - ARRAY_EXPRESS ]   ACAP3 [ SEEK ]   ACAP3 [ MEM ]
Gene Expression Viewer (FireBrowse)ACAP3 [ Firebrowse - Broad ]
GenevisibleExpression of ACAP3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)116983
GTEX Portal (Tissue expression)ACAP3
Human Protein AtlasENSG00000131584-ACAP3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96P50   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96P50  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96P50
Splice isoforms : SwissVarQ96P50
PhosPhoSitePlusQ96P50
Domaine pattern : Prosite (Expaxy)ANK_REP_REGION (PS50297)    ANK_REPEAT (PS50088)    ARFGAP (PS50115)    PH_DOMAIN (PS50003)   
Domains : Interpro (EBI)ACAP3_BAR    AH/BAR_dom_sf    Ankyrin_rpt    Ankyrin_rpt-contain_dom    Ankyrin_rpt-contain_sf    ARFGAP/RecO    ArfGAP_dom    ArfGAP_dom_sf    PH-like_dom_sf    PH_domain   
Domain families : Pfam (Sanger)ArfGap (PF01412)    PH (PF00169)   
Domain families : Pfam (NCBI)pfam01412    pfam00169   
Domain families : Smart (EMBL)ANK (SM00248)  ArfGap (SM00105)  PH (SM00233)  
Conserved Domain (NCBI)ACAP3
DMDM Disease mutations116983
Blocks (Seattle)ACAP3
SuperfamilyQ96P50
Human Protein Atlas [tissue]ENSG00000131584-ACAP3 [tissue]
Peptide AtlasQ96P50
HPRD10820
IPIIPI00465167   IPI00550459   IPI00643360   IPI00384876   IPI00926635   IPI00924553   
Protein Interaction databases
DIP (DOE-UCLA)Q96P50
IntAct (EBI)Q96P50
FunCoupENSG00000131584
BioGRIDACAP3
STRING (EMBL)ACAP3
ZODIACACAP3
Ontologies - Pathways
QuickGOQ96P50
Ontology : AmiGOneuron migration  GTPase activator activity  regulation of neuron projection development  growth cone  positive regulation of GTPase activity  metal ion binding  
Ontology : EGO-EBIneuron migration  GTPase activator activity  regulation of neuron projection development  growth cone  positive regulation of GTPase activity  metal ion binding  
NDEx NetworkACAP3
Atlas of Cancer Signalling NetworkACAP3
Wikipedia pathwaysACAP3
Orthology - Evolution
OrthoDB116983
GeneTree (enSembl)ENSG00000131584
Phylogenetic Trees/Animal Genes : TreeFamACAP3
HOGENOMQ96P50
Homologs : HomoloGeneACAP3
Homology/Alignments : Family Browser (UCSC)ACAP3
Gene fusions - Rearrangements
Fusion : QuiverACAP3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerACAP3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ACAP3
dbVarACAP3
ClinVarACAP3
1000_GenomesACAP3 
Exome Variant ServerACAP3
GNOMAD BrowserENSG00000131584
Varsome BrowserACAP3
Genetic variants : HAPMAP116983
Genomic Variants (DGV)ACAP3 [DGVbeta]
DECIPHERACAP3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisACAP3 
Mutations
ICGC Data PortalACAP3 
TCGA Data PortalACAP3 
Broad Tumor PortalACAP3
OASIS PortalACAP3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICACAP3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DACAP3
Mutations and Diseases : HGMDACAP3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ACAP3
DgiDB (Drug Gene Interaction Database)ACAP3
DoCM (Curated mutations)ACAP3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ACAP3 (select a term)
intoGenACAP3
Cancer3DACAP3(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETACAP3
MedgenACAP3
Genetic Testing Registry ACAP3
NextProtQ96P50 [Medical]
TSGene116983
GENETestsACAP3
Target ValidationACAP3
Huge Navigator ACAP3 [HugePedia]
snp3D : Map Gene to Disease116983
BioCentury BCIQACAP3
ClinGenACAP3
Clinical trials, drugs, therapy
Protein Interactions : CTD116983
Pharm GKB GenePA26408
Clinical trialACAP3
Miscellaneous
canSAR (ICR)ACAP3 (select the gene name)
HarmonizomeACAP3
DataMed IndexACAP3
Probes
Litterature
PubMed13 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineACAP3
EVEXACAP3
GoPubMedACAP3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jul 16 15:46:47 CEST 2020

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