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ACAT2 (acetyl-CoA acetyltransferase 2)

Identity

Alias_namesacetyl-Coenzyme A acetyltransferase 2 (acetoacetyl Coenzyme A thiolase)
acetyl-Coenzyme A acetyltransferase 2
Other alias-
HGNC (Hugo) ACAT2
LocusID (NCBI) 39
Atlas_Id 43642
Location 6q25.3  [Link to chromosome band 6q25]
Location_base_pair Starts at 159761957 and ends at 159779055 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ACAT2 (6q25.3) / ACAT2 (6q25.3)TCP1 (6q25.3) / ACAT2 (6q25.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ACAT2   94
Cards
Entrez_Gene (NCBI)ACAT2  39  acetyl-CoA acetyltransferase 2
Aliases
GeneCards (Weizmann)ACAT2
Ensembl hg19 (Hinxton)ENSG00000120437 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000120437 [Gene_View]  ENSG00000120437 [Sequence]  chr6:159761957-159779055 [Contig_View]  ACAT2 [Vega]
ICGC DataPortalENSG00000120437
TCGA cBioPortalACAT2
AceView (NCBI)ACAT2
Genatlas (Paris)ACAT2
WikiGenes39
SOURCE (Princeton)ACAT2
Genetics Home Reference (NIH)ACAT2
Genomic and cartography
GoldenPath hg38 (UCSC)ACAT2  -     chr6:159761957-159779055 +  6q25.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ACAT2  -     6q25.3   [Description]    (hg19-Feb_2009)
EnsemblACAT2 - 6q25.3 [CytoView hg19]  ACAT2 - 6q25.3 [CytoView hg38]
Mapping of homologs : NCBIACAT2 [Mapview hg19]  ACAT2 [Mapview hg38]
OMIM100678   614055   
Gene and transcription
Genbank (Entrez)AB208993 AF356877 AK055001 AK225089 AK225244
RefSeq transcript (Entrez)NM_001303253 NM_005891
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ACAT2
Cluster EST : UnigeneHs.571037 [ NCBI ]
CGAP (NCI)Hs.571037
Alternative Splicing GalleryENSG00000120437
Gene ExpressionACAT2 [ NCBI-GEO ]   ACAT2 [ EBI - ARRAY_EXPRESS ]   ACAT2 [ SEEK ]   ACAT2 [ MEM ]
Gene Expression Viewer (FireBrowse)ACAT2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)39
GTEX Portal (Tissue expression)ACAT2
Human Protein AtlasENSG00000120437-ACAT2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BWD1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BWD1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BWD1
Splice isoforms : SwissVarQ9BWD1
Catalytic activity : Enzyme2.3.1.9 [ Enzyme-Expasy ]   2.3.1.92.3.1.9 [ IntEnz-EBI ]   2.3.1.9 [ BRENDA ]   2.3.1.9 [ KEGG ]   
PhosPhoSitePlusQ9BWD1
Domaine pattern : Prosite (Expaxy)THIOLASE_2 (PS00737)    THIOLASE_3 (PS00099)   
Domains : Interpro (EBI)Thiolase    Thiolase-like    Thiolase_AS    Thiolase_C    Thiolase_CS    Thiolase_N   
Domain families : Pfam (Sanger)Thiolase_C (PF02803)    Thiolase_N (PF00108)   
Domain families : Pfam (NCBI)pfam02803    pfam00108   
Conserved Domain (NCBI)ACAT2
DMDM Disease mutations39
Blocks (Seattle)ACAT2
PDB (SRS)1WL4    1WL5   
PDB (PDBSum)1WL4    1WL5   
PDB (IMB)1WL4    1WL5   
PDB (RSDB)1WL4    1WL5   
Structural Biology KnowledgeBase1WL4    1WL5   
SCOP (Structural Classification of Proteins)1WL4    1WL5   
CATH (Classification of proteins structures)1WL4    1WL5   
SuperfamilyQ9BWD1
Human Protein Atlas [tissue]ENSG00000120437-ACAT2 [tissue]
Peptide AtlasQ9BWD1
HPRD00006
IPIIPI01014863   IPI00291419   
Protein Interaction databases
DIP (DOE-UCLA)Q9BWD1
IntAct (EBI)Q9BWD1
FunCoupENSG00000120437
BioGRIDACAT2
STRING (EMBL)ACAT2
ZODIACACAT2
Ontologies - Pathways
QuickGOQ9BWD1
Ontology : AmiGO3-hydroxyacyl-CoA dehydrogenase activity  acetyl-CoA C-acetyltransferase activity  acetyl-CoA C-acetyltransferase activity  acetyl-CoA C-acetyltransferase activity  acetyl-CoA C-acyltransferase activity  enoyl-CoA hydratase activity  protein binding  nucleus  nucleolus  cytoplasm  mitochondrion  cytosol  cytosol  cytosol  lipid metabolic process  fatty acid beta-oxidation  cholesterol biosynthetic process  ergosterol biosynthetic process  extracellular exosome  
Ontology : EGO-EBI3-hydroxyacyl-CoA dehydrogenase activity  acetyl-CoA C-acetyltransferase activity  acetyl-CoA C-acetyltransferase activity  acetyl-CoA C-acetyltransferase activity  acetyl-CoA C-acyltransferase activity  enoyl-CoA hydratase activity  protein binding  nucleus  nucleolus  cytoplasm  mitochondrion  cytosol  cytosol  cytosol  lipid metabolic process  fatty acid beta-oxidation  cholesterol biosynthetic process  ergosterol biosynthetic process  extracellular exosome  
Pathways : KEGG   
NDEx NetworkACAT2
Atlas of Cancer Signalling NetworkACAT2
Wikipedia pathwaysACAT2
Orthology - Evolution
OrthoDB39
GeneTree (enSembl)ENSG00000120437
Phylogenetic Trees/Animal Genes : TreeFamACAT2
HOVERGENQ9BWD1
HOGENOMQ9BWD1
Homologs : HomoloGeneACAT2
Homology/Alignments : Family Browser (UCSC)ACAT2
Gene fusions - Rearrangements
Fusion : QuiverACAT2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerACAT2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ACAT2
dbVarACAT2
ClinVarACAT2
1000_GenomesACAT2 
Exome Variant ServerACAT2
ExAC (Exome Aggregation Consortium)ENSG00000120437
GNOMAD BrowserENSG00000120437
Varsome BrowserACAT2
Genetic variants : HAPMAP39
Genomic Variants (DGV)ACAT2 [DGVbeta]
DECIPHERACAT2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisACAT2 
Mutations
ICGC Data PortalACAT2 
TCGA Data PortalACAT2 
Broad Tumor PortalACAT2
OASIS PortalACAT2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICACAT2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDACAT2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch ACAT2
DgiDB (Drug Gene Interaction Database)ACAT2
DoCM (Curated mutations)ACAT2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ACAT2 (select a term)
intoGenACAT2
Cancer3DACAT2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM100678    614055   
Orphanet
DisGeNETACAT2
MedgenACAT2
Genetic Testing Registry ACAT2
NextProtQ9BWD1 [Medical]
TSGene39
GENETestsACAT2
Target ValidationACAT2
Huge Navigator ACAT2 [HugePedia]
snp3D : Map Gene to Disease39
BioCentury BCIQACAT2
ClinGenACAT2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD39
Chemical/Pharm GKB GenePA19
Clinical trialACAT2
Miscellaneous
canSAR (ICR)ACAT2 (select the gene name)
Probes
Litterature
PubMed42 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineACAT2
EVEXACAT2
GoPubMedACAT2
iHOPACAT2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Aug 27 11:07:21 CEST 2018

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